LOCUS       NM_001108545            3473 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus F-box and leucine-rich repeat protein 7 (Fbxl7),
            mRNA.
ACCESSION   NM_001108545 XM_001064103 XM_342204
VERSION     NM_001108545.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3473)
  AUTHORS   Kamran M, Long ZJ, Xu D, Lv SS, Liu B, Wang CL, Xu J, Lam EW and
            Liu Q.
  TITLE     Aurora kinase A regulates Survivin stability through targeting
            FBXL7 in gastric cancer drug resistance and prognosis
  JOURNAL   Oncogenesis 6 (2), e298 (2017)
   PUBMED   28218735
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3473)
  AUTHORS   Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, Jerome
            J, Chen BB and Mallampalli RK.
  TITLE     The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial
            Function by Mediating the Ubiquitylation and Proteasomal
            Degradation of Survivin
  JOURNAL   J Biol Chem 290 (19), 11843-11852 (2015)
   PUBMED   25778398
REFERENCE   3  (bases 1 to 3473)
  AUTHORS   Coon TA, Glasser JR, Mallampalli RK and Chen BB.
  TITLE     Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora
            A, causing mitotic arrest
  JOURNAL   Cell Cycle 11 (4), 721-729 (2012)
   PUBMED   22306998
REFERENCE   4  (bases 1 to 3473)
  AUTHORS   Ebstein F, Lange N, Urban S, Seifert U, Kruger E and Kloetzel PM.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473992.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342204.3, XM_001064103.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q22"
     gene            1..3473
                     /gene="Fbxl7"
                     /note="F-box and leucine-rich repeat protein 7"
                     /db_xref="GeneID:361907"
                     /db_xref="RGD:1305813"
     exon            1..500
                     /gene="Fbxl7"
                     /inference="alignment:Splign:2.1.0"
     CDS             464..1939
                     /gene="Fbxl7"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 7"
                     /protein_id="NP_001102015.1"
                     /db_xref="GeneID:361907"
                     /db_xref="RGD:1305813"
                     /translation="MGANNGKQYGSEGKGSSSVSSDVSSSTDHTPTKAQKNVATSEDS
                     DLSMRTLSTPSPALICPPALPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIR
                     LASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLT
                     GETINVDRALKVLTRRLCQDTPNVCLMLETVIVSGCRRLTDRGLYTIAQCCPELRRLE
                     VSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRY
                     LDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDC
                     RFVSDFGLREIAKLESRLRYLSIAHCGRITDVGIRYVAKYCSKLRYLNARGCEGITDH
                     GVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFNLKRLSLKSCESITGQGLQIVA
                     ANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF"
     exon            501..590
                     /gene="Fbxl7"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1202
                     /gene="Fbxl7"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..3473
                     /gene="Fbxl7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcaacaagt ggccgccgcg ccctccccgg ggaagccgcg gacgcacggg ggcgcagggc
       61 ggaggcggag gagccggaca gcccggggca ggagcggctt ggctcgcacg gctcgggact
      121 gcggaggcgc atggggaccc cgcggcggag gagcggcgag cctaggggcg gcacccgggc
      181 gcgggctgtg cgtcgcgctg ttcccactcg cgcggagcgt ggaatctgag agccccggcg
      241 gctgccctga gccagcacgc caccctcggg agtgtcaaca gcggacctag cactacccct
      301 cccttcgcag accagtgacg acccccgcaa gcccagatcg cacctcggaa ggggcttggg
      361 cagttaacgg tccgttgctg cctgctttcc tctgccccgc cgcctgggag gtgcgcccca
      421 gccatgcagt gtccagggag aaggcgggca tgacggcgac aggatgggcg cgaacaatgg
      481 caaacagtac ggcagtgagg gcaagggcag ctcaagcgtc tcatccgacg tgagttcaag
      541 cacagatcac acaccaacca aagcccagaa aaatgtggcc accagcgaag attctgactt
      601 gagcatgcgc acactgagca cgcccagccc agccttgata tgtccaccag ctttgccagg
      661 atttcagaat ggaaggggct cgtccacatc ttcatcctcc atcactgggg agacagtggc
      721 tatggttcat tccccacccc cgacccgtct cactcaccca ctcattcggc tcgcttccag
      781 accccagaaa gagcaagcca gcatagaccg actcccggac cactccatgg tgcagatctt
      841 ctccttcctg cccaccaacc agctatgtcg ctgtgcacgt gtgtgccgcc gctggtacaa
      901 cctggcctgg gacccgcgcc tctggaggac tatccgtctc actggcgaga ccatcaatgt
      961 ggaccgtgcc ctgaaagtac tgacccgcag gctttgccag gacactccca atgtgtgtct
     1021 gatgttggaa actgtcattg tcagtggctg ccggcggctc acagaccgag ggctttatac
     1081 cattgcacag tgctgtccgg aactgaggcg cctggaagtc tcaggatgtt acaatatctc
     1141 caatgaggcg gtctttgatg tggtgtccct ctgccccaat ctggagcatc tggatgtgtc
     1201 aggatgctcc aaagttacgt gcatcagctt gacccgggag gcctccatta aactgtcccc
     1261 cttgcatggc aaacagattt ccatccgata ccttgatatg acggactgct tcgtgctgga
     1321 ggacgaaggc ttgcacacca tcgcagctca ctgcacgcag ctcacacacc tctatctgcg
     1381 ccgctgtgtc cgtctcacgg atgagggtct ccgctacctg gtgatctact gcacttccat
     1441 caaggagcta agtgtaagcg actgccgctt tgtcagtgac tttggcctgc gggagattgc
     1501 taaactggag tcccgcttga ggtacctcag catcgcccat tgcggccgca tcacggatgt
     1561 gggcattcgt tacgtggcta aatactgcag caaattgcgc tacctcaacg cgaggggctg
     1621 cgagggaatc acggaccatg gtgtggagta ccttgccaag aactgcacaa aacttaagtc
     1681 tctggacatt ggcaaatgtc ccctggtctc tgacacaggc ctggaatccc tggcattgaa
     1741 ctgcttcaat ctcaagaggc taagcctcaa gtcctgtgag agcatcactg gccagggcct
     1801 gcagatcgtg gctgccaact gctttgacct gcaaatgtta aatgtccagg actgtgaagt
     1861 ttcggtagag gccctgcggt ttgtgaagcg ccattgcaag cgctgtgtca ttgagcatac
     1921 caaccctgct ttcttctgaa gggacagctc tcactgtgca atgagaacca aacagtgctt
     1981 tgtaaaagtg tcccacataa gcacccatac ctattcacag cagctatttt tctttcagta
     2041 aggttcttag gagtctggat tttattttat ttttattttt actttttatt tctcatgagc
     2101 aaaagtggtc aaacaatgaa gatgaacccc aaatttctag ttctggtcag ttaatgttta
     2161 gataaatgtc actaaggatg cagctcggca acctggctgc tcactgtgtc tcagaaatgc
     2221 accttactcc ttttcccctt ctcccttccc actcctgtac acatgccaca ccctaaagtt
     2281 ccacactcac atcttccaac cctgcagcag ctgcaacatt agccattgaa gaaggctctc
     2341 tcaagctgct ccttaaacta ctcgatggtc agtaaacccc actcttaaat cccacagcaa
     2401 gcaaatgatg gttaaagtga tattaacact tcgtgtgtgc aaagagctgt cctatgttca
     2461 cacattatgg caaaccttat ggagtaagag gaaacacgtt ttctcaccca agtaactagc
     2521 cttgtgaccc tggtcaaaag acttcacctt tctgagattt ccaccactag aggccagatt
     2581 tgggggatta gagtcatgcc cattttcaaa ctgagagatg ctctgctcag agatgccatt
     2641 gagcagagcg ctctgtagaa agcacacact ggtggcactt gtgagagaac tggatatgta
     2701 aacgagttat gtttccagga ggttccatgg gctcactgta agtcctcact gggttctggt
     2761 gaggtctcct tgtgctctta tccgagaacc accgcatctg tacagtggac taggcctcta
     2821 ttcttcctct gcaaggctgg atgggtagac ttacattcac acttgcttta gcattccctc
     2881 accccaccac atcccattca gacaggaggg tgtctcatca caggaagctc ctatctctgt
     2941 cagcttgcgt cctctgagca ttttcaaacc caagtaagaa cccttataat ttttaattaa
     3001 caagtgagtc ccaagggatc ccatgtcctt aaaggttttt ctaaaccttc tcagtgcaca
     3061 tatgctatgc ttcaggcaca tctgtcctgc caccagcagg gacaggtgcc ttggtcctgt
     3121 cattcacgtt tcattttgac ttctgtcttc tatttatttc tccatcacac gaagcctcct
     3181 ggggttaagt ttacaagtgt ttaattgtac aaacaccacc tcgcccgctg tctgtgtgtt
     3241 ttttattaat ggatgtaaat cagacatcca ggtgtttcaa tactgttcat tcaaggtgcc
     3301 aggcacagag aagaggcact ggtgagagac agatgctggt ccacccacca cggtcttgga
     3361 acagaacatt gaaatcattt caaaatttga attttaagtg gatgggctct taagtggtcc
     3421 cttctgaata gaaactaatt tgctagttta atttcttaag gagtcagata gca
//
