LOCUS       NM_001395576            2524 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus F-box and leucine-rich repeat protein 4 (Fbxl4),
            transcript variant 1, mRNA.
ACCESSION   NM_001395576 XM_006237942
VERSION     NM_001395576.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Gai,X., Ghezzi,D., Johnson,M.A., Biagosch,C.A., Shamseldin,H.E.,
            Haack,T.B., Reyes,A., Tsukikawa,M., Sheldon,C.A., Srinivasan,S.,
            Gorza,M., Kremer,L.S., Wieland,T., Strom,T.M., Polyak,E., Place,E.,
            Consugar,M., Ostrovsky,J., Vidoni,S., Robinson,A.J., Wong,L.J.,
            Sondheimer,N., Salih,M.A., Al-Jishi,E., Raab,C.P., Bean,C.,
            Furlan,F., Parini,R., Lamperti,C., Mayr,J.A., Konstantopoulou,V.,
            Huemer,M., Pierce,E.A., Meitinger,T., Freisinger,P., Sperl,W.,
            Prokisch,H., Alkuraya,F.S., Falk,M.J. and Zeviani,M.
  TITLE     Mutations in FBXL4, encoding a mitochondrial protein, cause
            early-onset mitochondrial encephalomyopathy
  JOURNAL   Am J Hum Genet 93 (3), 482-495 (2013)
   PUBMED   23993194
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jul 20, 2021 this sequence version replaced XM_006237942.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.20624.1, BC161859.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000005.1  40752521-40752650
            131-240             JAXUCZ010000005.1  40764227-40764336
            241-822             JAXUCZ010000005.1  40765069-40765650
            823-1168            JAXUCZ010000005.1  40775426-40775771
            1169-1413           JAXUCZ010000005.1  40783200-40783444
            1414-1627           JAXUCZ010000005.1  40793748-40793961
            1628-1699           JAXUCZ010000005.1  40814644-40814715
            1700-2012           JAXUCZ010000005.1  40818761-40819073
            2013-2524           JAXUCZ010000005.1  40825643-40826154
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..2524
                     /gene="Fbxl4"
                     /note="F-box and leucine-rich repeat protein 4"
                     /db_xref="GeneID:313101"
                     /db_xref="RGD:1305724"
     exon            1..130
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..240
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            241..822
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2176
                     /gene="Fbxl4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-box/LRR-repeat protein 4"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 4 isoform 1"
                     /protein_id="NP_001382505.1"
                     /db_xref="GeneID:313101"
                     /db_xref="RGD:1305724"
                     /translation="MSPVFPMLTVLTMFYYMCLRRRARTATRGDMMSSHRTIVSNSRT
                     SPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGT
                     WWDQCPSASLPFRRTPSSFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSAN
                     PYSPNPPAEVRWETLWSERPTKVNASQARQFKPRIKQINFPTNLIRLEVNSSLLDYYT
                     ELDAVVLHGTKDKPLLSLKTALVDMNDLEDDDYEEKDGCEMDALNKKFSSATLGDGPS
                     NGYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIHLNLQPYWAKLDD
                     TSLEFLQARCALVQWLNLSWTGNRGFISVSGFSRFLKVCGSELVRLELSCSHFLNDAC
                     LEVISEMCPNLQDLNLSSCDKLPPQAFGHIAKLRSLKRLILYRTKVEQTALLSILNFC
                     AELQHLSLGSCVMIEDYDVIASMIGAKCKSLRTLDLWRCKNITENGIAELASGCALLE
                     ELDLGWCPTLQSSTGCFARLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDI
                     LGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSFTQ"
     exon            823..1168
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1413
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1627
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1699
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..2012
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2524
                     /gene="Fbxl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttccttccg ggtcgcgctg ggccgggctc gccgccgcgg cagcagcacg ggatactggg
       61 agcagcctcc tgctgcccac gctgcgggct tgtggcgaag ctctgctcgc ccagtcccgg
      121 accctgcagg gctgtctcat ttcagcatct gtaggcgaaa gcagtatgcg tgtttcagac
      181 acgtgcatgg gtaccagctc ctgcgttccc cgagtgtgtc acgtgaccct tcgagctggg
      241 accatccttc agagttcatg catctcaccg aggacacctg accttttgaa gcttcataat
      301 tcacgactag atgtcaccag tgtttcccat gttaacagtt ctgaccatgt tttattatat
      361 gtgccttcgg cgtcgagcca ggacagctac gagaggagat atgatgagca gccataggac
      421 tatagtatca aacagccgga cttcccctct caatgcagag gtggtccagt atgctaagga
      481 agtggtggat ttcagttccc actacggcag cgagaacagc atgtcctata ccatgtggaa
      541 tttggcaggt gtaccaaatg tcttcccaag ttctggcgac ttcacgcaga cggctgtgtt
      601 tcgaacttac ggaacatggt gggatcagtg tcctagtgca tccttgccat tcagaagaac
      661 gccgtccagt tttcagagcc aggactatgt ggaactgact tttgagcaac aagtgtatcc
      721 cacagctgtc catgtgctgg agacctacca tcctggagca gtcatcagaa ttctggcctg
      781 ctcggcaaat ccctactccc caaatcctcc agcagaagta agatgggaga ctctttggtc
      841 cgagagaccc acgaaggtga atgcttccca ggctcgccag tttaaacctc gtattaagca
      901 aataaatttc cccacaaacc ttatacgact ggaagtaaac agttctcttc tggattatta
      961 caccgaatta gatgcagttg tgctacatgg tacgaaggac aagccactgc tctctctcaa
     1021 gactgcactt gtagacatga atgatctaga agatgatgac tatgaagaga aggacggctg
     1081 tgaaatggac gctcttaaca aaaagtttag cagtgctacc cttggggatg ggccaagtaa
     1141 cgggtatttt gataaactac catatgagct cattcaactg attctgaatc atctttcact
     1201 accagacctg tgtagattag cacagacttg caggctcctc caccagcatt gctgtgaccc
     1261 tctacagtat atccacctca acctgcagcc atactgggcc aagctagatg atacttcact
     1321 ggagttccta caggctcgct gtgctcttgt ccagtggctt aatctgtctt ggactggcaa
     1381 cagagggttc atctctgtgt caggatttag caggtttctg aaggtgtgtg gatctgaatt
     1441 agtacgcctt gagttgtctt gcagccactt tcttaatgac gcttgcttgg aggtgatttc
     1501 tgaaatgtgc ccaaatctac aagacttaaa tctctcatcc tgcgataaac tgccacctca
     1561 ggcttttggc catattgcca agttacgcag cctcaagagg ctcattctct atcggacaaa
     1621 agtagagcaa acagcactgc tgagcatttt gaacttctgt gcagagcttc agcacctcag
     1681 cctgggcagc tgcgtgatga ttgaagacta tgatgtgata gccagcatga ttggagccaa
     1741 gtgtaaaagc ctccggacct tggatctctg gagatgcaag aatattacgg agaatgggat
     1801 cgcagagttg gcttccgggt gtgctcttct tgaggaactt gaccttggct ggtgccccac
     1861 ccttcagagc agtactgggt gctttgccag actggcacgc cagctcccaa acttgcagaa
     1921 actctttctt acagctaaca ggtctgtgtg tgacacagac atagaagaac tggcatctaa
     1981 ttgtaccaga ttacagcaac tggacatatt aggaacaaga atggtaagtc cggcctcctt
     2041 gagaaaactc ctggaatctt gcaaagatct ttccctactt gacgtgtcct tctgttctca
     2101 gattgataac agggctgtgt tggaactcaa cgcaagcttt ccaaaagtat tcataaaaaa
     2161 gagctttact caatgagtcc acacccactc accactaaaa tcatgctttg gtggctcttg
     2221 tgggcggtgg ttttgtttgt tgtttagttt ttattatact gagaattaag acatttatag
     2281 aatgtaaact taaatgtaaa attatctatt gaatcaagta aaaatgtaaa gaatgctcct
     2341 taaaatattg caggcacttt tctttaggaa tgtatgaatc tctgatgtta tttcctatca
     2401 tgtgatcagt ggtatgcttt aatcagtaat tgtatgttaa aggaataata tggaaatatt
     2461 ctaatttatt ttaagggaaa aagtaatcat aatatttatg aaaataaagt tgattttaca
     2521 catc
//
