LOCUS       NM_001108769            4460 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus F-box and leucine-rich repeat protein 22
            (Fbxl22), mRNA.
ACCESSION   NM_001108769 XM_001075916 XM_343414
VERSION     NM_001108769.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4460)
  AUTHORS   Spaich S, Will RD, Just S, Spaich S, Kuhn C, Frank D, Berger IM,
            Wiemann S, Korn B, Koegl M, Backs J, Katus HA, Rottbauer W and Frey
            N.
  TITLE     F-box and leucine-rich repeat protein 22 is a cardiac-enriched
            F-box protein that regulates sarcomeric protein turnover and is
            essential for maintenance of contractile function in vivo
  JOURNAL   Circ Res 111 (12), 1504-1516 (2012)
   PUBMED   22972877
REFERENCE   2  (bases 1 to 4460)
  AUTHORS   Ebstein F, Lange N, Urban S, Seifert U, Kruger E and Kloetzel PM.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_343414.3, XM_001075916.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK838934.1, BI296437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132286, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..4460
                     /gene="Fbxl22"
                     /gene_synonym="RGD1311830"
                     /note="F-box and leucine-rich repeat protein 22"
                     /db_xref="GeneID:363083"
                     /db_xref="RGD:1311830"
     exon            1..393
                     /gene="Fbxl22"
                     /gene_synonym="RGD1311830"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..769
                     /gene="Fbxl22"
                     /gene_synonym="RGD1311830"
                     /EC_number="3.4.19.12"
                     /note="F-box/LRR-repeat protein 22"
                     /codon_start=1
                     /product="F-box and leucine-rich protein 22"
                     /protein_id="NP_001102239.1"
                     /db_xref="GeneID:363083"
                     /db_xref="RGD:1311830"
                     /translation="MHITQLNRECLLRLFSFLDKDSRKSLSRTCSQLRDVFEDPTLWS
                     LLHFHSLTELKKDNFRLSPALRSLSICWHSSRVQVCSIEDWLKSAFQRSICSQHENLV
                     NDFLLQVCNRCPNLASVTLSGCGHVTDDCLARLLLGCPRLRALRLENCARVTNRTLAA
                     VAAHGRALQTFHVDFCRNVSAAGLLRLRAACPNLILSAEHSAAMIPDQPPRARASPAS
                     VFSPAPGRQSAPHPTGFY"
     exon            394..4460
                     /gene="Fbxl22"
                     /gene_synonym="RGD1311830"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaagcagg aggcaggtca gacccttgct gggcactcac gtgaggccac cactcaccat
       61 gcacataacc cagctcaatc gggagtgtct gctgcgcctc ttctccttcc tggacaagga
      121 cagtcggaag agtctctcca ggacttgctc ccagctccga gatgtgtttg aggaccccac
      181 cctctggtcc ctgctgcact tccattccct cacagagctc aagaaagaca acttccggct
      241 gagccctgca ctgcgcagcc tgtccatctg ttggcattcc agccgtgtgc aagtgtgtag
      301 catcgaggac tggctcaaga gcgccttcca gaggagcatc tgcagccagc acgagaacct
      361 ggttaatgat ttcctcctgc aggtgtgcaa caggtgcccc aacctggcgt ccgtcacgct
      421 ttcgggctgc ggccacgtca cggatgactg cttagcgcga ctgctgctcg gctgcccgcg
      481 cctgcgcgcg ctgcgcctcg agaactgcgc gcgcgttacc aaccgcacgc tggcggcggt
      541 ggccgcgcac gggcgcgcgc tgcagacatt tcacgtggac ttctgccgca acgtgagcgc
      601 cgccggcctg ctccgcctac gcgccgcctg tccgaacctg atcctgagcg cggaacacag
      661 cgcggccatg ataccggatc agccgccgcg tgcgcgcgca agccctgcct cggttttctc
      721 gcctgcaccg gggagacaaa gcgcacctca tcccacgggt ttctattgag aatgtgcgca
      781 ctattaaacg agcggatgcc agtaaagcgt tctgtggttc tctttaaacg tctgtcccac
      841 ccccgcggct cctgtagggc gcgttcttac tcgccctagc ggcagggctg tgtactaggt
      901 tggcgaggag cctccgaatg gccggaggaa gaactcaaaa tgagggcttc cctcgctgct
      961 ctttgccaga ccctgcaaga tgcacaagcc attctagcaa actcactccc gtccctgcat
     1021 ggctgatagt taccaatatt tctcctgttt ctcacagggg gggaaaatgc atcacttttt
     1081 aaaaagacag catttaaaga taaaagtagt agccctagtt aaaagtactt agatatgaaa
     1141 ctattattag ttgatgcaaa atttctggac ttctaggtca acttcacttt agtcgtcgag
     1201 tccccgtggc caggaccctc tcagttcaca cagcgtccct ctctaggcaa tggacgggca
     1261 agcaggctaa atgaacgcaa ccagggggtg cttctctggc tgccagcaat aatcaagact
     1321 ccttcattta tctgcaatca ggccttttca gttttctgag aagtggtttt ccaatctcta
     1381 tccacaggtt tcttaacata ttgcccaaat ggaaaacaag aaaaattctg ttctgttcgc
     1441 acggagcctc tgttcttgtg gagacagtaa ttagtacaaa aggaggctct tggggtggat
     1501 ggagatgact ccgagattga tggcaaccct gggggtgggg aggcactcag aaggggttaa
     1561 ccaaactaaa tctcatggag aaggtgacat ttgagccatg aaacaagaca ggaagccgag
     1621 caagccatat ggaaagtgtt acagtccaag aaactgtagg gcaccaagac taggagcatg
     1681 ccataccagg gctgtgcaac agacatgaga tcagcatggc cgaagcaggg agaggagtgg
     1741 agaacaggat ggaaggaact gtgaaggaca gattatgtgg aggataaaat gagcccttgg
     1801 aggtaacctc atgccagcag gagccagacc accaagcaca aggaaagcct gtgaagttcc
     1861 actgaacaac atccgggcac agcctccaag ggcttccccg gggactgcag agaggctttc
     1921 ctgccgctgc caggctctga gttgcagcgg cgcctagcag gtcctggtct agtataatgt
     1981 cttctaatct ttgggaaggc cagtggatcg cccagtggag tgttccaact gtgatgccta
     2041 cattcccatt ggcaggcaga gctcagcaaa cccatgacac cctcagggaa ggtgggtaag
     2101 ccactaagcc tgtactgaca gcaaaaccag aaaactgggc tctaatttcc catctgtctc
     2161 tgaatgaatg aacccttcaa tgtagttccc tgcttgctca taccaggaaa cttgagtgca
     2221 cagcctctgc acaagtcagg cctctttctt ggctggaaac tgccctaaga ttaccatatc
     2281 aagctggagg ctggagtcga cagagaccag ggccaggagt gcttagatgg tgggctccag
     2341 agtccctggg aaagtctgag gtgggacaca gggggcatgc accagtgtct gcactagctg
     2401 agcctcctgg attctactat ggtagtgctg acctgacatg tagcactttt cccagatctg
     2461 taaagggaag accagatggc ccctaaaacc cctcttgcct gctgctctcc caatcaatgt
     2521 ctaactcatg ctttttgcta aatactgagc ttccagacac agacagcttc ctctggcaaa
     2581 ggtcacactc tgagagaact ggaactaact cacttgttca tggacatctg ggaaaagctt
     2641 gagtttttga aggtagaggg gcttatgttt tcttgaggtt gattaagggc ataaatctgc
     2701 aagtctttgt taactgaaag aggccagcaa tcacagaaac acacaagtca ctacaggagg
     2761 gaatgttaac ccggcaaacc aaatccctgc cctgaggccc aatggttgct ctacagataa
     2821 gggacttcaa gaatcaagag gaggaaaaca aacacaaaca aaaaaaccag aaagcaaaca
     2881 ggcaggtttc tagccaagag gcagcatggt gtaaaagtcc atctgcatct ctgcagacct
     2941 gagacagagg ttaggttcat cttgcaccat cctgctagag gctcccacac tctccaggca
     3001 gaacaaattt ggtgtcaaag gccggaatcc ataggtttaa ggcattattt tcagttataa
     3061 taaactgaga cccacagaag ctacactctc agctcagtaa gagggaaagc agagcctaga
     3121 ggagtcaaag ggaccacaac ctcattcaca tggagcctta ttctctgagt gaaactccct
     3181 ggcccagagg cccaagaagg gcctttctat ttcaagccca gacttgaaag catgtcttta
     3241 tctcgaagcc ccggcatccc ccaggaactt gaatctttct ttagtgtcca attccataca
     3301 aaaacttcaa taaaatgatg cctgaattcg ttatcaggga ttttcactca gattccaaaa
     3361 gacaaacacc tgcctttcca ctgataaatt ctagcacttg ccttcctgtt tctctgcctg
     3421 ctaccttatt tgagcatgct gtcagcaata gcctttccct tgagtccaca ggaagcatcc
     3481 tgtgacacag attaggtggg agggaaagac aagctgccca ctaatctcca actttctggt
     3541 accctgcagc aggagcctca catccagtgg gctcctctcc ccgcagcatc ctctgctgac
     3601 gttcttgcac agatgagcaa ctcccaatga ccacaagggc tgggtttcca aatggggctc
     3661 tttctcaggc cctcatccac acactaaccc ttacatgaat gtacatagtc agcccctcat
     3721 ccacagccac ttactgatgt gtgctgaatc cctgcacagc agtccctctg gaccactgtc
     3781 cctttcgctg ctctttggtg ccatcatggc tcactgtctt ctttaccaca tggcactggc
     3841 acagaggtgc tgcctcacac taggtgcgct gaggctttgc aggaggaggg gggacggcca
     3901 aaaggctctg ctctagggcg agagaacaaa ttgagagaat caggatgcca gaacaaaggg
     3961 aaggaggcac aggagccctg gcttctccac atggtcctgt ggtccttggt aggtttcttt
     4021 tagatgaact atgtccccag ttcttgaatg gcccaaagag caaagggaca ctggcagaca
     4081 gggcacatgt ctgcttcagc tcccagcctg aggctcgcct ggatcaacag cagcccccat
     4141 tctgattcct gaatctgctt tatttctctg cataaggaac cctgcacagg cgaatcaaac
     4201 taaaacaaaa taaatatatg aatatccatg taaaactgtc ctttctaatg aacaattata
     4261 cacaatgtac aatttcattt tcactgggtg ggcttacaaa aatgtatcat tctcaactaa
     4321 aaatgcacca aaatggctcc atgcaaactt acccaaagtg accaaaaata cagaggaaaa
     4381 cctgactgag cagtttgttt ctgctttttg ttttgtacaa tcacagaaaa ataaaaccat
     4441 ctaatttctt tgtttcattt
//
