LOCUS       NM_001401500            8236 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus F-box and leucine-rich repeat protein 20
            (Fbxl20), mRNA.
ACCESSION   NM_001401500 XM_039086779
VERSION     NM_001401500.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8236)
  AUTHORS   Wang,W., Li,Y., Wang,L., Chen,X., Lan,T., Wang,C., Chen,S. and
            Yu,S.
  TITLE     FBXL20 promotes synaptic impairment in depression disorder via
            degrading vesicle-associated proteins
  JOURNAL   J Affect Disord 349, 132-144 (2024)
   PUBMED   38211741
  REMARK    GeneRIF: FBXL20 promotes synaptic impairment in depression disorder
            via degrading vesicle-associated proteins.
REFERENCE   2  (bases 1 to 8236)
  AUTHORS   Yao,I., Takao,K., Miyakawa,T., Ito,S. and Setou,M.
  TITLE     Synaptic E3 ligase SCRAPPER in contextual fear conditioning:
            extensive behavioral phenotyping of Scrapper heterozygote and
            overexpressing mutant mice
  JOURNAL   PLoS One 6 (2), e17317 (2011)
   PUBMED   21390313
  REMARK    Erratum:[PLoS One. 2011;6(6). doi:
            10.1371/annotation/1bf38b37-ee2e-41fb-bad4-ed719b07c6c0]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8236)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   4  (bases 1 to 8236)
  AUTHORS   Yao,I., Takagi,H., Ageta,H., Kahyo,T., Sato,S., Hatanaka,K.,
            Fukuda,Y., Chiba,T., Morone,N., Yuasa,S., Inokuchi,K., Ohtsuka,T.,
            Macgregor,G.R., Tanaka,K. and Setou,M.
  TITLE     SCRAPPER-dependent ubiquitination of active zone protein RIM1
            regulates synaptic vesicle release
  JOURNAL   Cell 130 (5), 943-957 (2007)
   PUBMED   17803915
  REMARK    Erratum:[Cell. 2007 Oct 5;131(1):190]
REFERENCE   5  (bases 1 to 8236)
  AUTHORS   Ilyin,G.P., Rialland,M., Glaise,D. and Guguen-Guillouzo,C.
  TITLE     Identification of a novel Skp2-like mammalian protein containing
            F-box and leucine-rich repeats
  JOURNAL   FEBS Lett 459 (1), 75-79 (1999)
   PUBMED   10508920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001401500.2.
            
            On Feb 14, 2022 this sequence version replaced XM_039086779.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               JACYVU010000220.1  39967391-39967664   c
            275-336             JACYVU010000220.1  39945226-39945287   c
            337-391             JACYVU010000220.1  39932990-39933044   c
            392-466             JACYVU010000220.1  39930462-39930536   c
            467-561             JACYVU010000220.1  39928782-39928876   c
            562-630             JACYVU010000220.1  39927362-39927430   c
            631-726             JACYVU010000220.1  39924034-39924129   c
            727-853             JACYVU010000220.1  39921657-39921783   c
            854-928             JACYVU010000220.1  39920180-39920254   c
            929-1059            JACYVU010000220.1  39919202-39919332   c
            1060-1120           JACYVU010000220.1  39917403-39917463   c
            1121-1165           JACYVU010000220.1  39915723-39915767   c
            1166-1222           JACYVU010000220.1  39914778-39914834   c
            1223-1435           JACYVU010000220.1  39913407-39913619   c
            1436-8236           JACYVU010000220.1  39905577-39912377   c
FEATURES             Location/Qualifiers
     source          1..8236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..8236
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /note="F-box and leucine-rich repeat protein 20"
                     /db_xref="GeneID:64039"
                     /db_xref="RGD:621722"
     exon            1..274
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1543
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /note="F-box protein FBL2"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 20"
                     /protein_id="NP_001388429.1"
                     /db_xref="GeneID:64039"
                     /db_xref="RGD:621722"
                     /translation="MRRDVNGVTKSRFEMFSNSDEAVINKKLPKELLLRIFSFLDVVT
                     LCRCAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVENISKRCGGFLRKLSLRGCL
                     GVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLSKFCSKLRHLDLASCTSITNMS
                     LKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGA
                     HCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLR
                     ILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSH
                     CELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQI
                     TRAGIKRLRTHLPNIKVHAYFAPVTPPPSVGGSRQRFCRCCIIL"
     exon            275..336
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..391
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..466
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..561
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..630
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            631..726
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..853
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..928
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1059
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1120
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1165
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1222
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1435
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..8236
                     /gene="Fbxl20"
                     /gene_synonym="Fbl2; Fbxl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgaggcttt gaagaggacc gagctagcga ctggcagtcg tcgcggccgc ggacgccgcg
       61 ggcggtggtg gaggcccccg cgggacttga gcggtgtctc ctccgcgtcg ggcgggcgaa
      121 ccgcgcctta ccgccgccgc ctcccgctcc cggaactccg gggcctgccc tggcccctgt
      181 ctttgcactc cgcacgccgc agcgccctgc ccgggccgca cccgctggcc tcatgaggag
      241 ggacgtgaac ggagtgacca agagcaggtt tgagatgttc tcaaacagtg acgaagccgt
      301 aatcaataaa aaacttccca aagaactcct gctaaggata ttttctttcc tggatgttgt
      361 taccctttgt cgctgtgctc aggtctccag ggcctggaat gtcctagctc tggatggcag
      421 taactggcaa cggatagacc tgttcgattt ccagagggac attgagggcc gggtagtgga
      481 aaatatttct aaacgatgcg gaggcttttt acggaagtta agtcttcgtg ggtgtctcgg
      541 agtaggagac aatgcactga ggacctttgc acaaaactgt aggaatattg aagtactaag
      601 tctcaacgga tgtacaaaga cgacagacgc cacctgcact agccttagca agttctgctc
      661 caaactcagg cacctcgacc tggcttcctg tacgtcaata acaaacatgt ctctcaaagc
      721 tctgagtgag ggctgtccac tgttggagca gttgaacatc tcctggtgtg accaagtaac
      781 caaggatggc attcaagcac tagtgagagg ctgtgggggt ctcaaggcct tattcttaaa
      841 aggctgcact cagctagaag atgaagctct caagtacata ggtgcacact gccctgagct
      901 ggtgactttg aacttgcaaa cttgcttaca aatcacagat gaaggcctca tcaccatatg
      961 cagagggtgt cataagttgc agtctctctg tgcctctggg tgctccaaca tcacagatgc
     1021 catcctgaat gctctaggtc agaactgccc tcggcttaga atattagaag tggccagatg
     1081 ttcccagtta acagatgtgg gctttactac cctggccagg aattgccatg aacttgaaaa
     1141 gatggaccta gaagaatgtg tgcagatcac agatagcaca ttaatccagc tttccataca
     1201 ctgtcctcgg cttcaagtgt tgagtctttc tcactgcgag ctgatcacag atgacgggat
     1261 tcgtcaccta gggaatggag cctgtgccca cgaccaactg gaggtgattg agctggacaa
     1321 ttgcccacta atcacagatg catccctgga gcacttgaag agctgccaca gccttgagcg
     1381 gatcgaactc tatgactgcc agcagatcac ccgggctggc atcaagagac tcaggaccca
     1441 tttacccaat attaaagtcc acgcctactt cgcccctgtc actccaccgc catcagtagg
     1501 gggcagcaga cagcgcttct gcagatgctg catcatccta tgacagtgga ggggtcagcc
     1561 ttggtgaact gagtatttaa tgacacttct agacataccg tggagtctct ccggtggaag
     1621 caaccccagc gttctgggca agggttacaa agcacgggca gcgtccagat ccccagagcc
     1681 acacatgcac agcacatgcg tcctcacccc catctgctgt agtgctgtgg ccatggcact
     1741 gaagctcaca ctgctgtaac aagtggactg gtaaaacctg accattccag gtggacatgc
     1801 ccaggggcag tcgtaggccg tggtggaggg aggggcattc cagcagagtc cagggtcact
     1861 gcttctgtgg tttctttatt ttgttagggg gtttctgtgg ggggtttgaa acaataacta
     1921 tgatcctcca gggtgagagg tagcatggag aacaatatat gacgtatcca gggaccagaa
     1981 agaaaacttc tgcctcctag aaatggtagc catccgttgg agatgcctac acaacttctg
     2041 ggcttccgtg ttcccatgct gacatactga gcatgctcac aaagaaggct catccattca
     2101 tctggtgttt taggatttga cccagaggtt ttttttagcg gctgcattga aatcactggg
     2161 gtccaaatac aattactttt cttacctgct cagttcgtca ctgtatgtca ctgtgcaccc
     2221 gtcttccgtt ctcttgctca ctgccacgcg ctctcgtcca gtctgtcctc ctcagtatgc
     2281 tgcccactca attgttacct gttgctgttg tgtttacagt ttgcattttg gatgaattag
     2341 ttggggtcac caaacatttt taaaagaaac atcaataaat atttttttaa tctaactttt
     2401 accatcaggg gaccctgcct gaatctttgc cagtctggaa aaaaagttta acaaaagcag
     2461 gaaagttatg ataagaaata gtcagattgt ttggatggaa agaaacttta ccttttggtt
     2521 tttgtcgtac cctgtgctgt gtgctccctt gcatggtgtg cgcactgtgc tgtccgctcc
     2581 accccctcca cccccacccc acccaacgca ccccagcaca aactcgttga gcttactaag
     2641 acaagagaag tgcattagta gtgtggagtg ggtgacgaat ccccataccg agcctgggag
     2701 cccccactgc ccaagctcaa gcacaaatga ccaacctcct gtgccaacag gcatgtggtg
     2761 tgatctctgc ctgtgtccca agttacttga gttacttgct ttgcagcagt gctgctgggg
     2821 tgggggttgc tgttgttttt ttgagccctt cccacagtta ctcccatcag gggtacatga
     2881 agagccctgt aacagctggc tacctgtgtg ttaacagaag acctgagcgt atcagctgtc
     2941 tctgcagact tcctatgaaa ggtgatgtga aggcagccag gtaggagcac tggggcagcc
     3001 agagagcctg gagagggagt agggacccag aggctatgcc aagcctgggc atctgacacc
     3061 agagctgagg gagcagtgtt agtacctgtg gctcagagtc aagaaaaagc ctcttcaaag
     3121 aaaaacacag aaaatgagag aaattaaatg agtttctaag gcatatttgt aaaccccaat
     3181 ggtagaggtc ttgcgtgatg cttattgggg aactggagga agggactttg aggacatggt
     3241 gtgcaagcct gtgatcccgg cgcattaggg ctgttctgat gcggtaggag cacattctgc
     3301 cagaaaacat aggaataagt ctgatttatt tctccatcaa tgtagaaaac aatcagatga
     3361 aaggtcctca aattctatac taccagattt atttatcaca ttaaacttat ttaaaattta
     3421 ttttattatg ctcttttgaa agctaaatta cttgtgtttc tattcctttt cttttctgtt
     3481 caaatgacct tgcaagaaat ttcttttttc ctctgagatt ctcttgttac attgctcgcc
     3541 cgactggtct caggcacctg ggctccagtt acctccactt taacacccca cgccctgtgt
     3601 ggccgggact tcggtggcca gtgctgcttt acctgacagg ggtatttgtg tggcccctcc
     3661 ccccacaaag tcttactctg tagccctggc aggcctggga tttgtggttc tcttttgcct
     3721 tggcctccta aatgctggga tcatgaagtt agactcggtg cacacacact catcaacaca
     3781 cttccagatg tgtttagatg tagatcccct aggactttca gacaaaacca aaagaaaccg
     3841 agggactgtc agctgtaaac tatgttgttt gatttttttt tcccctaagt gcctaacaag
     3901 ttgacagtaa ggcctgaata ccaagcaggc agtggacaca gattcgactg ccctagtcta
     3961 ggtcattcag gtacttcttt tcccattaga gtttgaacga gtctcttatt tactagtgtg
     4021 tcaaaggcct tgagaatgcc gtctgtctcc tcagagagcc acacgaggga gggtccattg
     4081 gctttgtcct ggtgacccca gctggtaagg ccaggaacac gtcaaccgga tgaggtctgc
     4141 tgaggctgca tatgtcctgc agcaggcttc tcgtgcttgg aggagtgtgg agaaacactg
     4201 acctctgaac ccaagtgcca gcccccacac acagagtgct cctgagagct cagcaggctt
     4261 cggtttgtgg ttaggactgc ggatggaaac cagggccttc tcaagcacta agcacatgct
     4321 gtaccactga gctgtgtatc ctcttcagcc ctagtaaagc ttaacgtgga aaatccctgt
     4381 ttagagagcc tactgggctg ccactgactg gaaggtgaag tgcttgccag gcagtcctgc
     4441 cagagtcaag cttgcagagc cacacaggag ctttgtgagt ctacagttac agcacttcct
     4501 gtagccagat gggcggtggg gacagaatag cccagaagct tgaggaccct ccgtcctgga
     4561 gcacgtaaca ctgacagaag caaaatagac cctgccttaa cacggtgcgg aaggacagaa
     4621 tgactccaga aagttgacct ttgacctcca tacaaggtgt ggtgtgtgcg tgtgcctgca
     4681 ctttcataat gaaatgtaac aaggaaggaa atgaggtttg tgtttatatc tcaacacaaa
     4741 agatgcagag gccggaggat tgctgcaagt gtcaggccag attggaatac atagcaaggg
     4801 actggtgggg tggggagagc ctgttggtcc gtttgtctca tcttatgccc attccagaac
     4861 ttgcctttta cagtggggga gaggggtgag gggcaaaaag ccctagaatg agatggggcc
     4921 tccgggctca ggtttgagag gaaaaggctc ttgagtctga ggttaacctc agctacactg
     4981 tgactgtttt cagccaagca aaaagaacaa ggcaccctca gagatgttgt cccaagcctc
     5041 cagatggcca ggaggggttc cgttgtgtct ggagaaagtt gctgagtatg tagacaacct
     5101 cagctgtagg ccccgctccc tatgtcctgt gtgatatcca cacccggctg caggtctctc
     5161 ccgttcttcc agcacccgcc ctgccctccg tctaaagccc tctgtctgtc gcactgtggg
     5221 acatctccag tctagcatct tcggattccg ttccctggtc acagcaagct ttcacggtca
     5281 gaactgaatg cagtacggtc agtggaagta gcttggggta tttcttacgg ggtgatccgc
     5341 ggtgtttggt tttttggctt tgagttgaat ttgaggtata actgatggct cccccccccc
     5401 cccccccgtg tttggaacgg aaatattaaa acgctttgct tactgtttca gaaatgcgtt
     5461 ttactgcccc tgcttttacc ttgatcgctt ttctgggtgt gaaagtatcc ctcagattat
     5521 ttatgtaaat ttctggtgag atttctatgt ctactaggtt gatttagcag acacgtaagt
     5581 cagaaatggt ggttcaaaca tttcccaggg aaagttggtg agtaactgag cacgctttat
     5641 tagggtattc ttagctgttt agaatgtttg ttgtgggccc ctcatgtgta tttgacattt
     5701 tcagttgttt tttaaaatat gtttgaagca tgccttggct tggcattgtc aggacataga
     5761 agagttgtca ctgaagagga gaggggcccc ctgcctgtct gtgggcagcc tcataggtga
     5821 cagcattgag acatggaagt cctcacagat ggtgactgat cttgggctgt tgaggtggct
     5881 gggcaggtaa agactgtttg cgggccaagt ctgacaacct gacttgttga cggtgaaggg
     5941 gcagaactga cgtctggaaa ttattctgcc tggcttggaa gagccatggt gtctgtgtgt
     6001 tcacatgtgt ttaataaaag attagtcaaa aagcaaggct tgctgctcct aaggcaggca
     6061 gctcctctag tctagtgaga gggtggacaa gcaaagtgct ctgctgagcc tttcctgaac
     6121 cgtacaggtg ggtttctctg cagaccagag ggtaacccta gccttctcag ggaagagcta
     6181 atgcttgatt ggagggcttg gagcagaaac ccttatatga cctaaggaca aaaatgtcag
     6241 aaggatgagg cacagtggga atcttaaacc tcctcagcct tatttttatc ttagtctgca
     6301 tcagaagaca cagaaggcag tgttagcata gggtgtgctt agccctgctg atttgggaat
     6361 aaaatttgcc tgtaaaaaca atatccatat gacctaacac cttcattctc caacaaaaag
     6421 aaaaaggaaa aaatatatat atacacatac acatatatat gtatgtgtat gtacacacac
     6481 acacacacac acacacacac acacacacac cctttcactt gagtctgaat gaatcttggg
     6541 agttcaaaaa gttctgccta ctatttgaga gggaaaagct tctgttatac aaaccaccag
     6601 tggtacattg gagaacctac agttctttgg tctctgccac atgagtgttt ggtctaaggc
     6661 tttggagtca agcttacagc agcgtcagga cttctcagcc agagtgactt atagaacaag
     6721 aaccatgagc aagcagaaac ctagtgatgc ccaccatctt cccactgtat cttccaggca
     6781 aggttcatgg gaggatgctt tgcctcagga agagggtctg tcctgagctc ctaggactgt
     6841 tcccttccca tgtgacacat ttactgtttt ttggttttgt tttatttttt cccccacggc
     6901 atcaagttta agtcctttcg gtggcaagaa gggcttcctt gcttctgggg acagcattag
     6961 taccaggaaa ggagagtgga cagtggacca cagtcttccc cctaggaaga ggccaggaac
     7021 cagatctgag atcttttgaa gttacatcct tctactccat ttatggtgtt agctccgatc
     7081 tgtcccatat tgctgcatac ctgtgtttct tcctgtagcc taacatttct ctcagctccc
     7141 caaaacatcc agccacccgt ttgtagcact ggaaaagggg gacctgtgaa gtcttgaaaa
     7201 tgagtgatgt agctcattag ttcgctcgct cctctcccca gagacgcgcg ctcctgctca
     7261 ctccgtgctg cgggtgctgc ggcgggcatg agcaagccga gccttgctgc cgaggtctgg
     7321 gtttacatag gaaggcttgc tccttgtgag gatcatttct gacgactgtt aatctctaac
     7381 aagtacaagt agtgagcctg attcctgtga cgccctccct gctgcactca gatgtgacat
     7441 actaacacct agaccttgtt ggcgtggccc agaatcttta ggccagttct tcctccctgg
     7501 tgtgacccca aaactgaccc caccagagat caccacccga aagggtatct ggaagaggct
     7561 tgagctcacg ctcttctggc cacctccttt ttcctcccag aaactgtttc ccgtttacca
     7621 tttcctggtg gttctgttca cccctgccca ccttccggtg accctgaggg cacagacctg
     7681 agcgacctgt gtggcctgtg cgagctcaga gcactgtgag gaccgcccct tcctgtcagg
     7741 ctgctcaggg acagatggat tggtacctgg tgctgtctgc agaactcggt cttcagccct
     7801 gcacccccac tccgctgact ccgaggggta gcagggcagt cctggtgtga tccctgtgcc
     7861 ccggctgctg ggcctgacct ggactttgct gtatgggggc tgctgcttgc ttgttttctc
     7921 accaggcctg cgccaacact tggccactcc ccaggcctcg aactgttccc cagtggggac
     7981 ttaacaccac gttccattag ctaagtgact gtatgtacac ctcctacttc cagcatccga
     8041 ggatgtgggg gtgaggagga atgtttaaat aaaatccaag gaggcagtag acgattcttt
     8101 ttgctttaaa aaatctttgg actaaagcta tgttttatat ataaatatat aaagtaaatt
     8161 gttatgtaac tattattgtt tcctgtatgt tctaattttg ttttatgatg taattaaagg
     8221 aagtgcgcta cggaga
//
