LOCUS       NM_001108235            5279 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus F-box and leucine-rich repeat protein 17
            (Fbxl17), mRNA.
ACCESSION   NM_001108235 XM_001071661 XM_237458
VERSION     NM_001108235.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5279)
  AUTHORS   Mena,E.L., Kjolby,R.A.S., Saxton,R.A., Werner,A., Lew,B.G.,
            Boyle,J.M., Harland,R. and Rape,M.
  TITLE     Dimerization quality control ensures neuronal development and
            survival
  JOURNAL   Science 362 (6411) (2018)
   PUBMED   30190310
REFERENCE   2  (bases 1 to 5279)
  AUTHORS   Raducu,M., Fung,E., Serres,S., Infante,P., Barberis,A., Fischer,R.,
            Bristow,C., Thezenas,M.L., Finta,C., Christianson,J.C., Buffa,F.M.,
            Kessler,B.M., Sibson,N.R., Di Marcotullio,L., Toftgard,R. and
            D'Angiolella,V.
  TITLE     SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling
            and medulloblastoma development
  JOURNAL   EMBO J 35 (13), 1400-1416 (2016)
   PUBMED   27234298
REFERENCE   3  (bases 1 to 5279)
  AUTHORS   Tan,M.K., Lim,H.J., Bennett,E.J., Shi,Y. and Harper,J.W.
  TITLE     Parallel SCF adaptor capture proteomics reveals a role for
            SCFFBXL17 in NRF2 activation via BACH1 repressor turnover
  JOURNAL   Mol Cell 52 (1), 9-24 (2013)
   PUBMED   24035498
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Feb 16, 2022 this sequence version replaced NM_001108235.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2727705.1,
                                           SRR26643285.35651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1548              JAXUCZ010000009.1  110652433-110653980 c
            1549-1671           JAXUCZ010000009.1  110641312-110641434 c
            1672-1929           JAXUCZ010000009.1  110637796-110638053 c
            1930-2061           JAXUCZ010000009.1  110624500-110624631 c
            2062-2169           JAXUCZ010000009.1  110534160-110534267 c
            2170-2300           JAXUCZ010000009.1  110513920-110514050 c
            2301-2377           JAXUCZ010000009.1  110380235-110380311 c
            2378-2520           JAXUCZ010000009.1  110245737-110245879 c
            2521-5279           JAXUCZ010000009.1  110227609-110230367 c
FEATURES             Location/Qualifiers
     source          1..5279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q37"
     gene            1..5279
                     /gene="Fbxl17"
                     /note="F-box and leucine-rich repeat protein 17"
                     /db_xref="GeneID:316663"
                     /db_xref="RGD:1309773"
     exon            1..1548
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..2661
                     /gene="Fbxl17"
                     /codon_start=1
                     /product="F-box/LRR-repeat protein 17"
                     /protein_id="NP_001101705.2"
                     /db_xref="GeneID:316663"
                     /db_xref="RGD:1309773"
                     /translation="MGHLLSKEPRNRPSQKGPRCCSWCRRRRPLLRLPHRTPAKASPQ
                     PAAPRSRDCFFRGPCMLCFIVHSPGAPAPAGLEEEPPLSPPPRDGAYATVSSQHLARR
                     YAALAAEDCAAAARRFLLSSAAAAAASSSPASCCKELGLAAAAAWEQQGRSLFLAGVG
                     PVRFLGPPAAVQLFRGSPAPPQAEPTTVLEMVCKRKGAGVPACTPCKQPRCGGGGCGG
                     GGGGGGGPAGGGASPPRPPDAGCCQAPEQPPPPLCPAPASPASECAPIEAAAGDAVRA
                     GGTAPSSAQQQPESGDSDCQEPPENPCDCHREPPPEIPDINQLPPSILLKIFSNLSLD
                     ERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQVTDELLEKIASRSQNIVEINISDCR
                     SMSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEG
                     LKQLGSKCRELKDIHFGQCYKISDEGMVVIAKSCLKLQRIYMQENKLVTDQSVKAFAE
                     HCPDLQCVGFMGCSVTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLSSL
                     NLCLNWIINDRCVEVIAKEGQSLKELYLVSCKITDYALIAIGRYSVTIETVDVGWCKE
                     ITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQQYPHITFSTVLQDCKRTLERA
                     YQMGWTPNMSAATS"
     exon            1549..1671
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1929
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2061
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2169
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2300
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2377
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2520
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..5279
                     /gene="Fbxl17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcctctgg agaggggcgt gagccctaag gcgtccgggc aacctcgccg cgggaggggc
       61 gcgcggccct gtcagcgcgc ggccctgctt ctccccggcg ctccccgccc tgggtgagcc
      121 cccgcgcgcc cccgtccggg cgcgcccccg cggccggctc cgcccccctc ccggagcggg
      181 cggcgcgctc ctgcggcgac gggccgtgtc gcgggcgggc gggcgggcgc gcgcgcgccg
      241 ccggccgagc cgcagttaaa atggtccgag tcgggccagc gttgcccccg ccgcggcgct
      301 gaccgaccga accggctggc ctagccggca gactctctcc ctccctcgcg tccccacagc
      361 tcgcgcccgt ccttctcccg gctccctggg caaagcatgt agcccgcgtc gggcacccgg
      421 gcggcccgca gctgacgccc acccccgccg tcgcgtgtgc cgggtgcgcg gcgcgggcga
      481 cccagccagc ggcctgccca gccgccggag cccgcccctc gggcctccct ctcccgcccc
      541 gtcccggtcg ccctcttcgg ggccttctat atgggccacc ttctctcgaa ggaaccgcgt
      601 aaccgcccga gccagaaggg gcctcgctgc tgcagctggt gtcgccgccg gcgccctctc
      661 ctcagactac cccaccggac tccggccaag gcgtccccgc agcccgcggc gccccggagc
      721 cgggactgct tcttccgcgg gccctgcatg ctctgcttca tcgtgcacag ccccggcgcg
      781 cccgcccccg ccggcctaga ggaggagccg ccgctctcgc cgccgccgcg ggacggggcc
      841 tacgccaccg tctcctcgca gcacctggcg cggcgctacg cggccctggc cgccgaggac
      901 tgcgccgccg ccgctcgccg cttcctcctg tcctcggccg ccgccgccgc cgcctcctcg
      961 tcgcccgcgt cctgctgcaa ggagctgggg ctggccgccg ccgccgcctg ggagcagcag
     1021 ggccggagcc tcttcctggc cggcgtgggg cccgtgcgct tcctgggacc gccggccgcc
     1081 gtgcagctct tccggggatc gccggcgccg ccgcaggccg agcccaccac ggtcctcgag
     1141 atggtttgca agcggaaggg ggccggggtc cccgcctgca ccccatgcaa gcagccccgc
     1201 tgcggcggcg ggggctgcgg cgggggcggc ggcggcgggg gagggcctgc ggggggaggt
     1261 gcctcgccgc cgcggccgcc cgatgccggc tgctgccagg ccccggagca gcccccgccg
     1321 ccgctctgcc ccgcgcccgc ctctcccgcc tccgagtgtg cccccatcga ggccgccgcc
     1381 ggggacgcag tccgagccgg gggcaccgcc ccctcgtctg cccagcagca gcctgagagc
     1441 ggcgactcgg actgtcagga gccccccgaa aacccctgcg actgtcacag ggagccgccc
     1501 cccgaaatcc cagacatcaa ccaactgccg ccgtccatcc tgcttaagat attttccaac
     1561 ttgtccctgg atgaacgttg tctttccgca tcgttggttt gcaagtactg gcgtgacctt
     1621 tgtttagatt tccagttttg gaagcagctg gaccttagta gtcgtcagca ggttactgat
     1681 gaattattgg aaaaaattgc ctccagaagt cagaatatag ttgagatcaa catttctgat
     1741 tgtcgcagta tgtctgacag tggagtgtgt gttctagcat ttaagtgtcc tggacttctt
     1801 aggtacacag cctacaggtg taagcagctt tctgacacct ctatcattgc ggtcgcctct
     1861 cactgtcctt tactgcagaa agtccacgta ggcaaccagg acaaactcac tgatgaagga
     1921 ctcaagcagc tgggctcaaa gtgcagagaa ctcaaagata ttcacttcgg ccagtgttac
     1981 aagatctcgg acgaaggcat ggttgtcata gctaagagct gcctgaagtt gcaaagaata
     2041 tacatgcagg agaacaagtt agtgacagac cagtcagtga aggcctttgc tgagcactgc
     2101 cctgacctcc agtgtgttgg cttcatgggt tgttcagtta cttccaaagg agtcattcac
     2161 ctaaccaagc taagaaacct gtccagccta gacctgcgcc acatcactga actggacaat
     2221 gaaactgtga tggaaatcgt caagaggtgc aaaaatctca gctctctgaa tctctgtctg
     2281 aactggatca taaacgacag gtgtgtggag gttatcgcaa aggagggaca gagcctgaag
     2341 gagctgtact tggtgtcctg taagatcact gactatgcac tgatagccat tgggcgatac
     2401 agcgtgacca tagagactgt ggatgttgga tggtgtaaag aaatcacaga tcaaggagcc
     2461 accctgattg cacagagcag caagtccctg agatacttgg gcctgatgag atgtgataaa
     2521 gtcaacgagg taacagtgga gcagctggta cagcagtacc ctcacatcac cttcagcact
     2581 gtcctgcagg actgcaagag gaccttggag agagcctacc agatgggctg gacccccaac
     2641 atgtccgcag ccacctccta actctcttcc catgcccagg cctactcgga cccttcagca
     2701 gagcagagaa atggggggct ggaacagggg tcttccggaa aggttttaac cgtcacctgt
     2761 ctgtgtctgt ccccaagtgt tccatttatg tcttgtttgc attctgccta gcgaaagtgc
     2821 gctgttactt cccccaggtg agctggcttc ttccccaaac ggaagattat gaaaaccaca
     2881 acctttttgg gttttttttt tttccaattc aaaagttcat ttctcttaaa tagaactttg
     2941 tggaatctca agtcagaaaa ctgggtgtat aatcttgagc ttctaagttc tgacgcagcc
     3001 tggaaatgct caccaaaagc ctttgttttg tgatggacta ccttgtacac ttctgagagg
     3061 aacagaggtg acgttcctct aactagaagc ctggagacta gaacccccac aatcccggaa
     3121 cacacacgtc atgcttacac acacacacat gctaggtcaa gttcttgctt ggtaaattac
     3181 ctcctgacag aggaaccttc ctgggtcatg aagagagcac accatccact gtggtgccca
     3241 cggtggacat gttgctgtct tgtaggtaac ttaggatgta gactgaataa agccttttgt
     3301 caattcgtat atggaggcaa cagtctgaag tcccctggcc agctcacaaa agttaattct
     3361 tcattagtct ataaatgcat tctgttaagt aataaatatt ttagttggtt tttcattaac
     3421 actgttttag cttttacttt gtggatagtt actggtcaag atgtatttta gtgacatttg
     3481 gggctaatct tggcattatc tacattgaag ccacgaatgt aattaatggt gtgcagttat
     3541 tttaaaactt ttacagatca tttcattatt ttggtaatta tgaaaatata tcctgaagtg
     3601 gggtagttat actggtagaa gattaatgaa tgagatgtac gtagacaatc ttcctgttgt
     3661 attttttcct ttgctttgag gtttagaaca ggttttttga atatatgcat gctatcagtt
     3721 tgaatagttc ttactgcaaa gatccactgt tagctgacgt atgagctaag gagagaattt
     3781 agaaaatctg ttcattaaga ttctgtttac acttgccaga aatgcgtatt ttagtttaat
     3841 taaatattac cagcttttag ttatgtcagt acctatcaga aaatgagtct gttttgattt
     3901 cacacatctc aacagttaat tcgttgcagg gactcaggct ctgatgacct ctcctgtgtc
     3961 tggatttata atcaggcagc agggagcctt tttaagctaa agagtgatta tctttcgtag
     4021 aaggagaagc aaaaccttga cttttgaact tgctatttat tctccccata tgtggtcttt
     4081 ggtctttaac aattctaatg aggtctgagt ttgttcccca taaatcccag caccactgaa
     4141 gagatgctag gtgtaagaca cagaggcagc cttgcattct aatggcactc acgtgtgtat
     4201 aaaactcctt ctctgtagaa aatgtttgtt tccctccagt gtgtcaactt gcttctgatg
     4261 tggcattttt tttgttttaa tcccaatcag ttaaaaacag atctactgcg caagttctag
     4321 gaataccttt ttcataacca aacgggttgc tagtttaatt tgatggaaat gaaatttaag
     4381 aaaaagctgt ttaccattag aaaaccacat ttcttcttat atattgaact gtatcatttt
     4441 atatccattt ctccactact aaaaaatgtt atttcataat attttaactg gtttttaacc
     4501 caaaactaat ttataagaca gtatgtatag taatagttgc ttaagcgaat aaacaaaagt
     4561 ttaattttta tatacgtcac actatatttt aaatagttac aaaaaaagac aaaagaaggg
     4621 aactccatcc ttgatagaga cggtacaatt tcagttcaaa gttgtagtaa tcttggagtg
     4681 ttgccgtcta gttgtcaacg gtttcagagt gtacaattga ttttttttaa acgttgcatt
     4741 ctttgaacct aaagtccagc actataaaaa tgctttagct tggggtgggg gggtgcactt
     4801 attctccaag acgctgacta atacagaaac cctgacgcaa cagaacccgg aaaactgcct
     4861 tggttcattt gtagaaatct gtagaaatat catatccagc ctcaaagcat taatctttta
     4921 aaagaagcag ccaggaaaag catcacctca agtgatcctg gggaggttgt gggatgtgct
     4981 ctcattagat gctttgaaat gaggcttaaa atactttttt ctgggcaata tagtcccttt
     5041 ttttcttaga ctgtcataaa tacatgtgaa cacatttaat gcagggcttt ttagcctctc
     5101 caaatgtcaa cagtattttc agaaaaaagc ctatgaaata tattgctgta gtggaaaatt
     5161 ccggcccttt gtctttaatg cccttttgaa tgaataaaga aaatctaccc agtttgtagt
     5221 ttctatattt ctgtgaatct tttgaccttg caatgggttg caataaaaga gaaacaaaa
//
