LOCUS       NM_053716               1277 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus fructose-bisphosphatase 2 (Fbp2), mRNA.
ACCESSION   NM_053716
VERSION     NM_053716.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Bakshi,I., Suryana,E., Small,L., Quek,L.E., Brandon,A.E., Turner,N.
            and Cooney,G.J.
  TITLE     Fructose bisphosphatase 2 overexpression increases glucose uptake
            in skeletal muscle
  JOURNAL   J Endocrinol 237 (2), 101-111 (2018)
   PUBMED   29507044
  REMARK    GeneRIF: Overexpression of FBP2 significantly increased
            insulin-stimulated glucose uptake in tibialis of chow animals
            (control 14.3 +/- 1.7; FBP2 17.6 +/- 1.6 micromol/min/100 g) and
            High fat diet animals (control 9.6 +/- 1.1; FBP2 11.2 +/-
            1.1micromol/min/100 g).
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Bertinat,R., Pontigo,J.P., Perez,M., Concha,I.I., San Martin,R.,
            Guinovart,J.J., Slebe,J.C. and Yanez,A.J.
  TITLE     Nuclear accumulation of fructose 1,6-bisphosphatase is impaired in
            diabetic rat liver
  JOURNAL   J Cell Biochem 113 (3), 848-856 (2012)
   PUBMED   22021109
  REMARK    GeneRIF: Insulin and not hyperglycemia plays a crucial role in the
            nuclear accumulation of FBPase in vivo.
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1277)
  AUTHORS   Gizak,A., Majkowski,M., Dus,D. and Dzugaj,A.
  TITLE     Calcium inhibits muscle FBPase and affects its intracellular
            localization in cardiomyocytes
  JOURNAL   FEBS Lett 576 (3), 445-448 (2004)
   PUBMED   15498578
  REMARK    GeneRIF: Ca2+ appears to be a strong inhibitor of muscle FBPase
REFERENCE   6  (bases 1 to 1277)
  AUTHORS   Song,S., Andrikopoulos,S., Filippis,C., Thorburn,A.W., Khan,D. and
            Proietto,J.
  TITLE     Mechanism of fat-induced hepatic gluconeogenesis: effect of
            metformin
  JOURNAL   Am J Physiol Endocrinol Metab 281 (2), E275-E282 (2001)
   PUBMED   11440903
REFERENCE   7  (bases 1 to 1277)
  AUTHORS   Verge,V. and Hevor,T.K.
  TITLE     Regulation of fructose-1,6-bisphosphatase activity in primary
            cultured astrocytes
  JOURNAL   Neurochem Res 20 (9), 1049-1056 (1995)
   PUBMED   8570009
REFERENCE   8  (bases 1 to 1277)
  AUTHORS   Wimhurst,J.M. and Manchester,K.L.
  TITLE     Induction and suppression of the key enzymes of glycolysis and
            gluconeogenesis in isolated perfused rat liver in response to
            glucose, fructose and lactate
  JOURNAL   Biochem J 134 (1), 143-156 (1973)
   PUBMED   4353083
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053716.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ005046.1, SRR22582416.1738819.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               JAXUCZ010000017.1  2242008-2242239
            233-395             JAXUCZ010000017.1  2243746-2243908
            396-488             JAXUCZ010000017.1  2245845-2245937
            489-629             JAXUCZ010000017.1  2249824-2249964
            630-767             JAXUCZ010000017.1  2254982-2255119
            768-887             JAXUCZ010000017.1  2256560-2256679
            888-1277            JAXUCZ010000017.1  2258982-2259371
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1277
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /note="fructose-bisphosphatase 2"
                     /db_xref="GeneID:114508"
                     /db_xref="RGD:620930"
     exon            1..232
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1082
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /EC_number="3.1.3.11"
                     /note="fructose-1,6-bisphosphatase 2; FBPase 2;
                     D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; muscle
                     FBPase"
                     /codon_start=1
                     /product="fructose-1,6-bisphosphatase isozyme 2"
                     /protein_id="NP_446168.1"
                     /db_xref="GeneID:114508"
                     /db_xref="RGD:620930"
                     /translation="MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKA
                     ISSAVRKAGLANLYGIAGSVNVTGDEVKKLDVLSNSLVINMLQSSYSTCVLVSEENKE
                     AVITAKERRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTTEDEPSEKDALQPGRNI
                     VAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDIRIKKKGKIFSLNEGYAK
                     YFDAATAEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFMYPANQKSPNGKL
                     RLLYECNPVAYIIEQAGGMATTGTQPVLDVKPESIHQRVPLILGSPEDVQEYLSCVQR
                     NQAGR"
     exon            233..395
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
     exon            396..488
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
     exon            489..629
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
     exon            630..767
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
     exon            768..887
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1277
                     /gene="Fbp2"
                     /gene_synonym="FBPase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttgagaga gcaaggattc ctacgaggag gaaagggagg ctttgaagtt tcacttgcca
       61 caatgacgga cagaagcccc tttgagacag acatgctgac cctgacccgt tacgttatgg
      121 aaaaggggcg acaggccaaa gggaccggag aactcaccca gctgctcaac tcgatgctga
      181 ctgccatcaa agccatctct tccgctgtgc gaaaggccgg cctggccaac ctgtatggga
      241 ttgcgggaag cgtgaatgtg acaggggatg aggtgaagaa actggatgtg ctgtccaatt
      301 ccctggtgat caacatgctt cagtcctcct acagcacctg tgtgcttgtc tcagaagaga
      361 ataaagaggc tgtgatcaca gccaaggaga ggagggggaa atatgtggtt tgctttgacc
      421 cactggatgg atcttcaaac attgactgcc tggcttccat tggaactata tttgctatct
      481 acagaaagac cacagaggat gagccttccg agaaggatgc cttgcagcct ggacgcaata
      541 tcgtggctgc aggttatgca ctgtatggta gtgcaaccct ggtggctctt tctacagggc
      601 aaggagtgga tctcttcatg ctggacccgg ctcttggaga attcgtgcta gtggaaaaag
      661 atatccggat taagaagaaa gggaaaattt ttagcctcaa tgagggctat gccaagtatt
      721 ttgatgctgc taccgctgag tatgtacaga aaaagaagtt ccctgaggat ggcagtgcac
      781 cttacggggc aaggtacgtg ggttccatgg tggctgatgt gcatcgcacc ctggtctatg
      841 gaggaatctt catgtaccca gccaaccaga agagtcctaa tggcaagctc cggctcctgt
      901 atgaatgcaa tcctgtagcc tatatcattg agcaggcagg aggcatggca accacaggca
      961 cccagccggt actggatgta aagcctgaga gcattcacca gcgagtcccc ctcattctgg
     1021 ggtccccgga agatgtgcaa gaatatctca gctgtgtgca aagaaaccag gcaggcaggt
     1081 agtgatcctg aactcatgag cccacttccc tttgtctttg acaaatgaaa aactagatga
     1141 atggagatgg gggtaaagac aagcatgcca cgctcaacag gttaccttca gaacagcgct
     1201 tagctggcaa gcacagggtt agaagccaga ggtaaagata tgattgaagg gctaaaataa
     1261 aaatatgaat gtgaaaa
//
