LOCUS       NM_012558               1474 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus fructose-bisphosphatase 1 (Fbp1), mRNA.
ACCESSION   NM_012558 XM_346497
VERSION     NM_012558.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Sepa-Kishi,D.M., Katsnelson,G., Bikopoulos,G., Iqbal,A. and
            Ceddia,R.B.
  TITLE     Cold acclimation reduces hepatic protein Kinase B and AMP-activated
            protein kinase phosphorylation and increases gluconeogenesis in
            Rats
  JOURNAL   Physiol Rep 6 (5) (2018)
   PUBMED   29504286
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Gonzalez-Santiago,A.E., Vargas-Guerrero,B., Garcia-Lopez,P.M.,
            Martinez-Ayala,A.L., Dominguez-Rosales,J.A. and Gurrola-Diaz,C.M.
  TITLE     Lupinus albus Conglutin Gamma Modifies the Gene Expressions of
            Enzymes Involved in Glucose Hepatic Production In Vivo
  JOURNAL   Plant Foods Hum Nutr 72 (2), 134-140 (2017)
   PUBMED   28101822
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Droppelmann,C.A., Saez,D.E., Asenjo,J.L., Yanez,A.J.,
            Garcia-Rocha,M., Concha,I.I., Grez,M., Guinovart,J.J. and
            Slebe,J.C.
  TITLE     A new level of regulation in gluconeogenesis: metabolic state
            modulates the intracellular localization of aldolase B and its
            interaction with liver fructose-1,6-bisphosphatase
  JOURNAL   Biochem J 472 (2), 225-237 (2015)
   PUBMED   26417114
  REMARK    GeneRIF: Data suggest energy metabolism (gluconeogenesis versus
            glycolysis) modulates aldolase B and fructose-1,6-bisphosphatase-1
            activities in hepatocytes via their interaction suggesting their
            association confers catalytic advantage for both enzymes.
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Brand,I.A. and Heinickel,A.
  TITLE     Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa
            Zn(2+)-binding protein (parathymosin)
  JOURNAL   J Biol Chem 266 (31), 20984-20989 (1991)
   PUBMED   1834654
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   el-Maghrabi,M.R., Lange,A.J., Kummel,L. and Pilkis,S.J.
  TITLE     The rat fructose-1,6-bisphosphatase gene. Structure and regulation
            of expression
  JOURNAL   J Biol Chem 266 (4), 2115-2120 (1991)
   PUBMED   1846613
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   el-Maghrabi,M.R., Pilkis,J., Marker,A.J., Colosia,A.D.,
            D'Angelo,G., Fraser,B.A. and Pilkis,S.J.
  TITLE     cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence
            for down-regulation of its mRNA by insulin
  JOURNAL   Proc Natl Acad Sci U S A 85 (22), 8430-8434 (1988)
   PUBMED   2847161
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Cerezo Morales,S., Abellan Perez,M., Vilchez Joya,R., Hervas
            Sanchez,J., Montes Puerta,A. and Pena Yanez,A.
  TITLE     [Lipid changes during hemodialysis]
  JOURNAL   Rev Clin Esp 148 (2), 181-185 (1978)
   PUBMED   635271
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Wimhurst,J.M. and Manchester,K.L.
  TITLE     Induction and suppression of the key enzymes of glycolysis and
            gluconeogenesis in isolated perfused rat liver in response to
            glucose, fructose and lactate
  JOURNAL   Biochem J 134 (1), 143-156 (1973)
   PUBMED   4353083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078895.1 and BC078894.1.
            
            On Oct 13, 2007 this sequence version replaced NM_012558.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078895.1, J04112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1242              BC078895.1         1-1242
            1243-1474           BC078894.1         1225-1456
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1474
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /note="fructose-bisphosphatase 1"
                     /db_xref="GeneID:24362"
                     /db_xref="RGD:2595"
     exon            1..386
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1308
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /EC_number="3.1.3.11"
                     /note="FBPase 1; D-fructose-1,6-bisphosphate
                     1-phosphohydrolase 1; fructose-1,6- biphosphatase 1;
                     Fructose-16- biphosphatase; liver FBPase"
                     /codon_start=1
                     /product="fructose-1,6-bisphosphatase 1"
                     /protein_id="NP_036690.2"
                     /db_xref="GeneID:24362"
                     /db_xref="RGD:2595"
                     /translation="MVDHAPFETDISTLTRFVLEEGRKAGGTGEMTQLLNSLCTAIKA
                     ISSAVRQAGIAQLYGIAGSTNVTGDQVKKLDILSNDLVINMLKSSYATCVLVSEEDTH
                     AIIIEPEKRGKYVVCFDPLDGSSNIDCLASIGTIFGIYRKTSANEPSEKDALQPGRNL
                     VAAGYALYGSATMLVLAMNCGVNCFMLDPSIGEFILVDRDVKIKKKGNIYSINEGYAK
                     DFDPAINEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKNPSGKL
                     RLLYECNPIAYVMEKAGGLATTGNEDILDIVPTEIHQKAPVIMGSTEDVQEFLEIYNK
                     DKAKSRPSLPLPQSRARESPVHSICDELF"
     exon            387..549
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
     exon            550..642
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
     exon            643..783
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
     exon            784..921
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1041
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1455
                     /gene="Fbp1"
                     /gene_synonym="Fdp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaggcagt tggtggagga agggcgcaaa gggggtgttt cctgggacag ggggcggaga
       61 cctggagatt ataggctccc ccaggactca agttcactga gcttctgcag acactgtata
      121 gcgttcagtc ctcctgctgt gactatcacc tgggggactc acctgcctgc acctttagcc
      181 agcacctaca gacagtacct gtgccagacc ccagcaatgg tggaccatgc gcccttcgaa
      241 acggatatca gcaccctgac ccgcttcgtc ctggaggagg gcaggaaggc tgggggcacg
      301 ggcgagatga cccagctgct gaattcgctc tgcaccgcga tcaaagccat ctcgtcagcg
      361 gtgcgccagg ccggcatcgc tcagctctat ggcatcgctg gctcaaccaa tgtgactggg
      421 gatcaagtga agaagctgga catactttcc aatgacctgg tgatcaatat gctgaagtcg
      481 tcctatgcta cctgtgtcct tgtgtcggaa gaagatacac acgccatcat aatagagccc
      541 gagaagaggg gcaaatatgt tgtctgtttt gatcccctcg atggctcatc caacatcgac
      601 tgcctcgcgt ccatcggaac catctttggc atttacagaa agacatctgc taatgagcct
      661 tcggagaaag atgctctgca gccaggcagg aacctggtgg cagcaggcta tgcactctat
      721 ggcagcgcca ccatgttggt cctggccatg aattgtggcg tcaactgctt catgctggac
      781 ccgtccattg gagaattcat tttggtggac agggatgtga agatcaagaa gaaaggtaac
      841 atctacagca ttaatgaggg ctatgctaag gactttgacc ctgccatcaa tgagtatatc
      901 cagaggaaaa agttccctcc ggataattca gctccctatg gtgcccggta tgtggggtcc
      961 atggtggctg atgttcaccg cactctggtg tatggaggga tcttcttata ccctgccaac
     1021 aagaaaaatc catctggaaa gctgcggctg ctgtacgagt gcaatcccat cgcttacgtc
     1081 atggagaagg ccggtggact tgccacgacg gggaatgaag acatattaga catcgtcccc
     1141 actgagatcc accagaaggc accagttatc atggggtcca ccgaagacgt gcaggagttc
     1201 ctggagatct acaataagga caaagccaaa tcaaggccgt ccctgcccct gccccagagc
     1261 agagctcgag agtcaccggt ccattctatc tgtgacgaac ttttctagaa acaaacccaa
     1321 cagcgcggat agtttcaggg ccgaatgcct tgcaatgccc aaggttgcct cgcctagatg
     1381 ctataatgcc actgtatcag gtactatata tttcgaatag gtgaaggaga aataaacata
     1441 ttcttccttc ataaaaaaaa aaaaaaaaaa aaaa
//
