LOCUS       NM_031826               8826 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibrillin 2 (Fbn2), mRNA.
ACCESSION   NM_031826 XM_001069157 XM_577627
VERSION     NM_031826.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8826)
  AUTHORS   Collin,G.B., Hubmacher,D., Charette,J.R., Hicks,W.L., Stone,L.,
            Yu,M., Naggert,J.K., Krebs,M.P., Peachey,N.S., Apte,S.S. and
            Nishina,P.M.
  TITLE     Disruption of murine Adamtsl4 results in zonular fiber detachment
            from the lens and in retinal pigment epithelium dedifferentiation
  JOURNAL   Hum Mol Genet 24 (24), 6958-6974 (2015)
   PUBMED   26405179
REFERENCE   2  (bases 1 to 8826)
  AUTHORS   Hubmacher,D., Reinhardt,D.P., Plesec,T., Schenke-Layland,K. and
            Apte,S.S.
  TITLE     Human eye development is characterized by coordinated expression of
            fibrillin isoforms
  JOURNAL   Invest Ophthalmol Vis Sci 55 (12), 7934-7944 (2014)
   PUBMED   25406291
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8826)
  AUTHORS   Buchan,J.G., Alvarado,D.M., Haller,G.E., Cruchaga,C., Harms,M.B.,
            Zhang,T., Willing,M.C., Grange,D.K., Braverman,A.C., Miller,N.H.,
            Morcuende,J.A., Tang,N.L., Lam,T.P., Ng,B.K., Cheng,J.C.,
            Dobbs,M.B. and Gurnett,C.A.
  TITLE     Rare variants in FBN1 and FBN2 are associated with severe
            adolescent idiopathic scoliosis
  JOURNAL   Hum Mol Genet 23 (19), 5271-5282 (2014)
   PUBMED   24833718
REFERENCE   4  (bases 1 to 8826)
  AUTHORS   Soteriou,D., Iskender,B., Byron,A., Humphries,J.D.,
            Borg-Bartolo,S., Haddock,M.C., Baxter,M.A., Knight,D.,
            Humphries,M.J. and Kimber,S.J.
  TITLE     Comparative proteomic analysis of supportive and unsupportive
            extracellular matrix substrates for human embryonic stem cell
            maintenance
  JOURNAL   J Biol Chem 288 (26), 18716-18731 (2013)
   PUBMED   23658023
REFERENCE   5  (bases 1 to 8826)
  AUTHORS   Rainger,J., Keighren,M., Keene,D.R., Charbonneau,N.L.,
            Rainger,J.K., Fisher,M., Mella,S., Huang,J.T., Rose,L., van't
            Hof,R., Sakai,L.Y., Jackson,I.J. and Fitzpatrick,D.R.
  TITLE     A trans-acting protein effect causes severe eye malformation in the
            Mp mouse
  JOURNAL   PLoS Genet 9 (12), e1003998 (2013)
   PUBMED   24348270
REFERENCE   6  (bases 1 to 8826)
  AUTHORS   Browning,V.L., Chaudhry,S.S., Planchart,A., Dixon,M.J. and
            Schimenti,J.C.
  TITLE     Mutations of the mouse Twist and sy (fibrillin 2) genes induced by
            chemical mutagenesis of ES cells
  JOURNAL   Genomics 73 (3), 291-298 (2001)
   PUBMED   11350121
REFERENCE   7  (bases 1 to 8826)
  AUTHORS   Chaudhry,S.S., Gazzard,J., Baldock,C., Dixon,J., Rock,M.J.,
            Skinner,G.C., Steel,K.P., Kielty,C.M. and Dixon,M.J.
  TITLE     Mutation of the gene encoding fibrillin-2 results in syndactyly in
            mice
  JOURNAL   Hum Mol Genet 10 (8), 835-843 (2001)
   PUBMED   11285249
REFERENCE   8  (bases 1 to 8826)
  AUTHORS   Munroe,R.J., Bergstrom,R.A., Zheng,Q.Y., Libby,B., Smith,R.,
            John,S.W., Schimenti,K.J., Browning,V.L. and Schimenti,J.C.
  TITLE     Mouse mutants from chemically mutagenized embryonic stem cells
  JOURNAL   Nat Genet 24 (3), 318-321 (2000)
   PUBMED   10700192
REFERENCE   9  (bases 1 to 8826)
  AUTHORS   Yang,Q., Ota,K., Tian,Y., Kumar,A., Wada,J., Kashihara,N.,
            Wallner,E. and Kanwar,Y.S.
  TITLE     Cloning of rat fibrillin-2 cDNA and its role in branching
            morphogenesis of embryonic lung
  JOURNAL   Dev Biol 212 (1), 229-242 (1999)
   PUBMED   10419698
REFERENCE   10 (bases 1 to 8826)
  AUTHORS   Zhang,H., Apfelroth,S.D., Hu,W., Davis,E.C., Sanguineti,C.,
            Bonadio,J., Mecham,R.P. and Ramirez,F.
  TITLE     Structure and expression of fibrillin-2, a novel microfibrillar
            component preferentially located in elastic matrices
  JOURNAL   J Cell Biol 124 (5), 855-863 (1994)
   PUBMED   8120105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Mar 18, 2021 this sequence version replaced NM_031826.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135060.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000018.1  53901739-53901992   c
            255-337             JAXUCZ010000018.1  53900809-53900891   c
            338-436             JAXUCZ010000018.1  53896205-53896303   c
            437-532             JAXUCZ010000018.1  53892988-53893083   c
            533-628             JAXUCZ010000018.1  53882410-53882505   c
            629-826             JAXUCZ010000018.1  53846591-53846788   c
            827-952             JAXUCZ010000018.1  53837185-53837310   c
            953-1078            JAXUCZ010000018.1  53813347-53813472   c
            1079-1231           JAXUCZ010000018.1  53804214-53804366   c
            1232-1444           JAXUCZ010000018.1  53803021-53803233   c
            1445-1582           JAXUCZ010000018.1  53801820-53801957   c
            1583-1702           JAXUCZ010000018.1  53797174-53797293   c
            1703-1828           JAXUCZ010000018.1  53796183-53796308   c
            1829-1951           JAXUCZ010000018.1  53795094-53795216   c
            1952-2074           JAXUCZ010000018.1  53793393-53793515   c
            2075-2227           JAXUCZ010000018.1  53787162-53787314   c
            2228-2281           JAXUCZ010000018.1  53786337-53786390   c
            2282-2407           JAXUCZ010000018.1  53784709-53784834   c
            2408-2533           JAXUCZ010000018.1  53782056-53782181   c
            2534-2653           JAXUCZ010000018.1  53777105-53777224   c
            2654-2791           JAXUCZ010000018.1  53773583-53773720   c
            2792-2842           JAXUCZ010000018.1  53773013-53773063   c
            2843-2968           JAXUCZ010000018.1  53772434-53772559   c
            2969-3196           JAXUCZ010000018.1  53768841-53769068   c
            3197-3322           JAXUCZ010000018.1  53768212-53768337   c
            3323-3451           JAXUCZ010000018.1  53764871-53764999   c
            3452-3577           JAXUCZ010000018.1  53763939-53764064   c
            3578-3703           JAXUCZ010000018.1  53762121-53762246   c
            3704-3826           JAXUCZ010000018.1  53761578-53761700   c
            3827-3952           JAXUCZ010000018.1  53761302-53761427   c
            3953-4078           JAXUCZ010000018.1  53760458-53760583   c
            4079-4201           JAXUCZ010000018.1  53758204-53758326   c
            4202-4324           JAXUCZ010000018.1  53755802-53755924   c
            4325-4450           JAXUCZ010000018.1  53754130-53754255   c
            4451-4573           JAXUCZ010000018.1  53751021-53751143   c
            4574-4696           JAXUCZ010000018.1  53749979-53750101   c
            4697-4858           JAXUCZ010000018.1  53747744-53747905   c
            4859-4927           JAXUCZ010000018.1  53746974-53747042   c
            4928-5053           JAXUCZ010000018.1  53746400-53746525   c
            5054-5179           JAXUCZ010000018.1  53745272-53745397   c
            5180-5332           JAXUCZ010000018.1  53744529-53744681   c
            5333-5401           JAXUCZ010000018.1  53739151-53739219   c
            5402-5527           JAXUCZ010000018.1  53737778-53737903   c
            5528-5653           JAXUCZ010000018.1  53737480-53737605   c
            5654-5779           JAXUCZ010000018.1  53736929-53737054   c
            5780-5896           JAXUCZ010000018.1  53734288-53734404   c
            5897-6025           JAXUCZ010000018.1  53733074-53733202   c
            6026-6145           JAXUCZ010000018.1  53732545-53732664   c
            6146-6271           JAXUCZ010000018.1  53728620-53728745   c
            6272-6424           JAXUCZ010000018.1  53727854-53728006   c
            6425-6490           JAXUCZ010000018.1  53726932-53726997   c
            6491-6616           JAXUCZ010000018.1  53726483-53726608   c
            6617-6736           JAXUCZ010000018.1  53725738-53725857   c
            6737-6859           JAXUCZ010000018.1  53724649-53724771   c
            6860-6991           JAXUCZ010000018.1  53724038-53724169   c
            6992-7117           JAXUCZ010000018.1  53714335-53714460   c
            7118-7324           JAXUCZ010000018.1  53713163-53713369   c
            7325-7450           JAXUCZ010000018.1  53712385-53712510   c
            7451-7573           JAXUCZ010000018.1  53710733-53710855   c
            7574-7690           JAXUCZ010000018.1  53708789-53708905   c
            7691-7819           JAXUCZ010000018.1  53708070-53708198   c
            7820-7939           JAXUCZ010000018.1  53706324-53706443   c
            7940-8171           JAXUCZ010000018.1  53701219-53701450   c
            8172-8349           JAXUCZ010000018.1  53699677-53699854   c
            8350-8826           JAXUCZ010000018.1  53697693-53698169   c
FEATURES             Location/Qualifiers
     source          1..8826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..8826
                     /gene="Fbn2"
                     /note="fibrillin 2"
                     /db_xref="GeneID:689008"
                     /db_xref="RGD:620910"
     CDS             1..8724
                     /gene="Fbn2"
                     /note="fibrillin-2-like"
                     /codon_start=1
                     /product="fibrillin-2 precursor"
                     /protein_id="NP_114014.2"
                     /db_xref="GeneID:689008"
                     /db_xref="RGD:620910"
                     /translation="MGRRRRLCLQPYFVWLGCVALWAQGTDGQPQPPPPKTLRPQPPP
                     QQVRPAGAGSEGGFAGPEYRDEGALAASRVRRRGQQEILRGPNVCGSRFHSYCCPGWK
                     TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISPTCGAKSIQQCSVRCMNGGTCA
                     DDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFT
                     QVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQD
                     VDECQAIPGLCQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSVVPGICETGDC
                     SNTVGSYFCLCPRGFVTSTDGSRCIDQRTGTCFSGLVNGRCAQELPGRMAKAQCCCEP
                     GRCWGIGTIPEACPVRGSEEYRRLCLDGLPMGGIPGSSVSRPGGSGGNSNGYGPGGTG
                     FLPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVS
                     SYRCECNMGYKQDANGDCIDVDECTSNPCSHGDCVNTPGSYYCKCHAGFQRTPTKQAC
                     IDIDECIQNGVLCKNGRCVNTDGRFQCICNAGFELTTDGENCVDHDECTTTNMCLNGM
                     CINEDGSFKCVCKPGFVLAPNGRYCTDVDECQTPGICMNGHCINNEGSFRCDCPPGLA
                     VGVDGRVCVDTHMRSTCYGEIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK
                     NSAEFHGLCSGGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDASG
                     RNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDVNECESNPCVN
                     GACRNNLGSFHCECSPGSKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLKSECC
                     ATLGTAWGSPCERCELDAACPRGFARIKGVTCEDVNECEVFPGVCPNGRCVNNKGSFH
                     CECPEGLTLDGTGRVCLDVRMEHCFLKWDEDECVHPVPGKFRMDACCCAVGAAWGTEC
                     EECPKPGTKEYETLCPRGPGFANRGDILTGRPFYKDINECKAFPGMCTYGKCRNTIGS
                     FKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFDCECFEGYESGFMMM
                     KNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCIDINECSLSDNLC
                     RNGKCVNMIGTYQCSCNPGYQATPDRQGCSDIDECMIMNGGCDTQCTNSEGSYECSCS
                     EGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMRTCIDVN
                     ECDLNPNICMFGECENTKGSFICHCQLGYSVKKGATGCTDVDECEIGAHNCDMHASCL
                     NVPGSFKCSCREGWVGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGD
                     GFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC
                     VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCP
                     PDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEVGVGVSRSSCCCSLGKAWGNP
                     CETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQC
                     ECPQGYYLSEETRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM
                     DMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC
                     GNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCE
                     DIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGL
                     CVDLQGSYQCICNNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFEL
                     THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVAL
                     PGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQC
                     ICPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDP
                     CELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCE
                     CPMGYNLDYSGVRCVDTDECSIGNPCGNGTCANVIGSFECNCNEGFEPGPMMNCEDIN
                     ECAQNPLLCAFRCMNTFGSYECTCPVGYALREDQKMCKDLDECAEGLHDCESRGMMCK
                     NLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQS
                     SSSGTECLDNRQGLCFAEVLQTMCQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPG
                     TAQYKKICPHGPGYATDGRDIDECKVMPSLCTNGQCVNTMGSFRCFCKVGYTTDISGT
                     ACVDLDECSQSPKPCNFICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQF
                     LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF
                     SLDASGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYVQHYQWNQCVDENECSNP
                     GACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCSYGCSNTEGGYLC
                     GCPPGYFRVGQGHCVSGMGFNKGQYLSVDSEAEDDENALSPEACYECKINGYAKKDGR
                     RKRSAPEPEPASAEEQISLESVAMDSPVNMKFNLSGLGSKEHILELVPAIEPLNNHIR
                     YVISQGNDDGVFRIHQRNGLSYLHTAKKKLTPGTYTLEITSVPLYGKKELRKLEERNE
                     DSYLLGVLGEALRMRLQIQLY"
     exon            1..254
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            255..337
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            338..436
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..532
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..628
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..826
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..952
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1078
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1231
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1444
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1582
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1702
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1828
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1951
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2074
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2227
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2281
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2407
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2533
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2653
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2791
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2842
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2968
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3196
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3322
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3451
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..3577
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3703
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3826
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3827..3952
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4078
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4201
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4202..4324
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4450
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4573
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..4696
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4858
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4859..4927
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5053
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5179
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5180..5332
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5333..5401
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5402..5527
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5528..5653
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5654..5779
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5780..5896
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            5897..6025
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6026..6145
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6146..6271
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6272..6424
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6425..6490
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6491..6616
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6617..6736
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6737..6859
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..6991
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            6992..7117
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7118..7324
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7325..7450
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7451..7573
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7574..7690
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7691..7819
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7820..7939
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            7940..8171
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            8172..8349
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
     exon            8350..8826
                     /gene="Fbn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggagac ggcggcggtt gtgtctccag ccctacttcg tgtggctggg ttgcgtggcg
       61 ctctgggcgc agggcacaga tggccagccc cagcctccgc caccaaagac gctccggccc
      121 cagccgcccc cgcaacaggt ccggcccgca ggagcgggct ccgaaggtgg cttcgcgggg
      181 cctgagtaca gggacgaggg cgcgttagcg gcgagccggg tccgcaggcg aggacagcag
      241 gaaatactcc gagggcccaa cgtgtgcggt tctagattcc actcctattg ctgcccggga
      301 tggaagacgc tcccaggagg aaatcagtgc attgtcccca tttgcaggaa cagctgtgga
      361 gacggattct gttcccgccc caacatgtgt acttgttcca gcggacaaat atccccgacc
      421 tgtggagcaa aatcaattca gcagtgtagt gtgaggtgca tgaacggtgg gacctgtgcg
      481 gatgaccact gtcagtgcca gaagggatac atcgggacct actgtggaca acctgtctgt
      541 gagaatggat gccagaatgg tgggcgttgc atcggcccta accgctgtgc ttgtgtttat
      601 ggattcaccg ggccacagtg cgaaagagat tacaggacag gcccatgttt cactcaagtc
      661 aataatcaga tgtgccaggg gcagctgaca ggcatcgtct gtacgaagac gctgtgctgt
      721 gccaccattg ggcgagcctg gggtcatcct tgtgagatgt gcccagccca gcctcagccc
      781 tgccgccggg gcttcatccc caacatccgc actggagcat gtcaggatgt tgacgaatgc
      841 caggcgattc caggattgtg ccagggcgga aactgtatca acacagtggg ctcttttgaa
      901 tgcagatgcc ctgctggcca caagcagagt gaaaccacac agaaatgtga agacatcgac
      961 gagtgcagcg tggttcctgg aatctgtgag acaggcgact gttccaacac cgtgggaagc
     1021 tatttttgtc tctgtccacg cggcttcgtt acctcaacag atggctcccg gtgcattgat
     1081 cagagaactg gcacatgctt ctccggcctg gtgaatggcc gctgtgctca agaactccca
     1141 ggcagaatgg caaaagctca gtgctgttgc gagcccggcc gttgctgggg catcgggacc
     1201 attcctgagg cctgtcctgt cagaggttct gaagagtacc gtagactgtg cctggatggt
     1261 cttccaatgg gcggtattcc ggggagttca gtttctagac ctggagggtc tggaggcaac
     1321 agcaatggtt atggcccagg aggaacaggc ttcctgccca tccctggagg caatggcttt
     1381 tctcctggtg ttggaggagc tggagtagga gctggagggc agggacccat catcacggga
     1441 ctaacaattc tcaaccagac aatagacatc tgtaagcacc atgccaactt gtgtttgaac
     1501 ggacgttgca tacctactgt ttccagctac agatgcgaat gtaacatggg ctacaagcag
     1561 gatgctaatg gagattgtat agatgttgat gaatgtacat caaacccctg cagtcatgga
     1621 gattgtgtta acacacctgg atcctattac tgtaaatgtc acgctggatt ccagaggact
     1681 cctacgaagc aagcatgtat cgacattgat gagtgcatcc agaatggggt cctgtgtaaa
     1741 aatggccgat gcgtgaacac agatggacgc ttccagtgca tttgcaatgc tggctttgag
     1801 ttaaccacag atggagaaaa ctgtgttgac cacgatgaat gtacaacgac caacatgtgc
     1861 ttgaacggga tgtgtatcaa tgaagatggc agcttcaagt gcgtgtgcaa gccaggcttt
     1921 gtcctggctc caaatggccg ctactgcaca gacgtggacg agtgccagac cccgggcatc
     1981 tgcatgaatg ggcactgcat caacaacgaa gggtccttcc gctgtgactg tcctcccggc
     2041 ctggctgtgg gtgtggatgg acgtgtatgt gttgacacgc atatgcgcag cacctgctat
     2101 ggggaaatca agaaaggagt gtgtgtgcgg cccttcccgg gtgcagtgac caagtctgaa
     2161 tgctgctgtg ctaatccaga ctatggtttt ggagagccct gccagccttg tcctgctaaa
     2221 aattcagcgg agttccatgg tctttgtagc ggtggcgtag gcatcactgt ggatggaaga
     2281 gatatcaatg agtgtgcttt ggatcctgac atatgtgcca acgggatctg tgaaaacttg
     2341 cgaggcagct accggtgtaa ctgcaacagt ggctatgagc cagacgcctc aggaagaaat
     2401 tgcattgaca ttgatgagtg cttggtaaac aggctgcttt gtgacaatgg cctatgcaga
     2461 aatacccctg gcagttacag ctgcacgtgt ccccctggct atgtgttccg gacagagaca
     2521 gagacctgcg aagatgtcaa tgagtgtgaa agcaacccgt gtgtcaatgg ggcctgcagg
     2581 aacaacctgg gctctttcca ctgcgagtgc tcgcctggga gcaagctcag ctccacggga
     2641 ctgatctgca tcgacagcct gaaagggacc tgctggctca acatccagga caaccgctgc
     2701 gaagtgaaca ttaacggagc caccctgaaa tctgaatgct gcgccacgct tggaactgcc
     2761 tgggggagcc cctgtgagcg ctgcgagcta gatgcagctt gcccgagagg gttcgccagg
     2821 atcaaaggtg tgacctgcga agacgttaat gagtgcgagg tgtttcctgg cgtctgtcca
     2881 aatggacgct gtgtcaacaa caaaggctct ttccactgtg aatgccctga aggccttact
     2941 ctggatggca caggccgggt gtgtctggat gtccgcatgg agcactgctt cctgaagtgg
     3001 gatgaggatg agtgcgtcca ccccgtcccc gggaagttcc gcatggacgc ctgctgctgt
     3061 gcggtcgggg cggcttgggg cacagagtgt gaagagtgtc ccaaacctgg caccaaggaa
     3121 tatgagaccc tgtgtccccg gggccccggc tttgctaaca gaggggacat cctcactggg
     3181 cgtccatttt acaaagatat caacgagtgc aaggcctttc ctgggatgtg cacctatggg
     3241 aagtgtagaa acacaatcgg aagcttcaag tgtcgttgca acagtggctt tgccctggac
     3301 atggaggaga ggaactgtac tgacattgat gagtgcagga tctcccctga cctctgtggc
     3361 agtggcatct gtgtcaacac gccaggcagc tttgactgcg agtgctttga gggctacgag
     3421 agcggcttca tgatgatgaa gaattgcatg gacattgacg aatgtgaacg taaccctctc
     3481 ctttgtaggg gtggcacctg tgtgaacact gagggaagct ttcagtgtga ctgcccactg
     3541 ggacacgagc tgtcgccgtc acgcgaggac tgcatagata ttaacgagtg ctccctgagc
     3601 gacaatctct gcagaaatgg caaatgtgtg aacatgatcg gaacctacca gtgttcttgc
     3661 aatcctgggt accaggccac gccagaccgc cagggctgtt cagatatcga tgagtgtatg
     3721 ataatgaacg ggggctgcga cacccagtgc accaactcag aaggaagcta cgaatgcagc
     3781 tgcagcgaag ggtacgcact gatgccagac ggacgatcgt gcgcagatat cgacgaatgt
     3841 gaaaacaacc ccgacatctg tgacggcggc cagtgtacca acattccggg ggagtatcgc
     3901 tgcctctgct acgatggctt catggcgtcg atggacatga gaacatgcat cgatgtgaac
     3961 gagtgtgacc tgaatcccaa catctgcatg tttggggagt gtgagaacac aaagggctcc
     4021 ttcatttgcc actgccagct gggctactca gtgaagaagg gggccacggg atgcacagac
     4081 gtggacgagt gtgaaattgg cgcccacaac tgcgacatgc atgcctcgtg cctgaatgtc
     4141 cctgggagct tcaaatgcag ctgcagagaa ggctgggtgg gaaatggcat caaatgcatt
     4201 gatctggatg aatgctcgaa tggaacccat cagtgcagca taaacgccca gtgtgtcaac
     4261 accccaggct cgtaccgatg tgcctgctcg gagggtttca cgggagacgg ctttacttgc
     4321 tcagacgttg atgagtgcgc ggaaaacata aacctttgtg agaatggcca gtgcctgaac
     4381 gtcccgggag cttaccgctg cgaatgtgag atgggcttca ccccagcctc agacagcagg
     4441 tcctgccaag atattgacga atgctccttc caaaatatct gcgtcttcgg gacatgcaac
     4501 aatctgcccg ggatgtttca ctgcatctgt gacgatggtt acgaactgga cagaacagga
     4561 ggcaactgca cagatattga cgagtgcgca gatcccataa actgtgtcaa tggcctatgc
     4621 gtgaacacac ctggtcgcta tgagtgtaac tgcccgcctg actttcagct gaaccccact
     4681 ggtgtgggct gcgttgacaa ccgagtgggc aactgttacc tgaagtttgg tcctcgagga
     4741 gatgggagtc tgtcctgcaa cacagaggtc ggcgtgggtg tcagtcgctc ctcctgctgc
     4801 tgctccctgg ggaaggcctg gggaaacccc tgtgagacgt gcccccctgt aaacagcact
     4861 gagtactata cgctgtgtcc tggtggggaa ggctttaggc cgaaccccat cacgatcatc
     4921 ttagaagaca ttgacgaatg tcaggagtta ccagggctct gccagggtgg aaactgtatc
     4981 aacactttcg ggagcttcca gtgtgagtgt ccacagggtt actacctcag tgaagaaacc
     5041 cgcatctgtg aagatattga tgagtgcttc gcccatcccg gcgtgtgcgg acctggaacc
     5101 tgctacaaca ctctggggaa ttacacttgc atttgcccgc ccgagtacat gcaagtcaac
     5161 ggaggacaca actgcatgga catgaggaaa agcttttgct acagaagcta caacgggacc
     5221 acttgtgaaa acgagttgcc ttttaatgtg acaaagagga tgtgctgctg cacgtacaac
     5281 gtcggcaagg cctggaacaa accttgtgag ccatgcccta cgccggggac agctgacttt
     5341 aaaactatat gtggaaatat tcccggattc acctttgaca ttcacacagg aaaagctgtt
     5401 gacattgacg agtgtaaaga gattccgggc atctgtgcaa acggtgtgtg cattaaccag
     5461 atcggcagtt tccgctgtga atgcccgaca ggcttcagtt acaacgacct gctcttggtc
     5521 tgtgaagaca tcgatgagtg cagcaatggt gacaacctgt gccaacgcaa cgcggactgc
     5581 atcaacagcc caggcagcta ccgctgcgag tgtgcggcgg gcttcaagct ctcccccaac
     5641 ggggcctgtg tagatcgcaa tgagtgtttg gagattccta atgtttgcag tcatgggctg
     5701 tgtgttgatt tgcaaggaag ttaccagtgc atctgcaaca acggcttcaa ggcgtctcaa
     5761 gaccagacca tgtgcatgga tgttgatgag tgtgagaggc acccatgtgg aaacgggact
     5821 tgtaagaaca ctgtcgggtc ctacaactgt ctgtgctacc ctggcttcga gctcacccac
     5881 aacaacgact gcctagacat agacgagtgc agctcgttct ttggccaggt gtgcagaaac
     5941 gggcggtgct tcaatgaaat cggctccttc aaatgtctgt gcaacgaggg ctacgaactt
     6001 actccggacg gcaagaactg tatcgatact aatgagtgtg tcgcacttcc tggctcctgc
     6061 tcccctggga cctgtcagaa tttggaggga tccttcaggt gcatctgtcc ccccggatat
     6121 gaagtgaaaa gcgaaaattg cattgatata aatgaatgtg acgaggaccc caacatttgc
     6181 ctctttggtt cctgcaccaa caccccaggg ggcttccaat gcatctgtcc ccctggcttt
     6241 gtcttgtctg acaacggacg gagatgcttc gatacccgcc agagcttctg cttcaccaac
     6301 tttgaaaacg gaaagtgttc tgtacccaaa gccttcaaca ccaccaaagc aaaatgctgt
     6361 tgcagcaaga tgccaggcga gggctggggg gacccgtgtg agctgtgccc caaagacgat
     6421 gaagttgcct tccaggatct gtgtccatat ggccatggga cagtccctag tcttcatgac
     6481 acacgtgaag atgtcaatga gtgccttgag agcccaggca tttgctcaaa cggtcagtgc
     6541 attaacactg acggatcctt ccgatgtgag tgtccgatgg gctacaatct ggattacagt
     6601 ggagtccggt gtgtggacac tgatgagtgt tcgatcggta atccctgtgg gaacgggacc
     6661 tgcgccaacg tgatcgggag tttcgaatgc aattgcaatg agggctttga gccggggccc
     6721 atgatgaact gtgaagacat caacgagtgt gcccagaacc cgctgctctg cgctttccgc
     6781 tgcatgaaca cctttggatc ctatgaatgc acatgcccag ttggctacgc cctcagggaa
     6841 gaccaaaaga tgtgtaaaga tctggatgaa tgcgctgagg ggcttcacga ctgtgagtcc
     6901 agaggcatga tgtgtaagaa tctgatcggc accttcatgt gcatctgccc ccctggcatg
     6961 gcccgcaggc cagacggaga aggctgcgta gacgaaaacg aatgcaggac caagcccggc
     7021 atctgtgaaa atggacgctg cgttaacatc attggaagct acaggtgtga gtgcaacgaa
     7081 ggattccagt caagctcctc gggcaccgaa tgccttgaca accgacaggg cctgtgcttc
     7141 gcagaggtgc tgcagacaat gtgtcagatg gcctccagta gccgtaacct cgtcacaaag
     7201 tcagaatgct gctgtgatgg cgggcgaggc tggggccacc agtgtgagct ctgcccactt
     7261 cctggaactg cccagtacaa aaagatctgc ccccatggcc caggatatgc cactgacgga
     7321 agagatattg acgaatgtaa ggtgatgcca agcctctgta ctaatggcca gtgtgtcaac
     7381 accatgggct ccttccggtg cttctgcaag gttggctaca ccacagacat cagcgggaca
     7441 gcttgtgtag acctggatga atgttcccag tctccaaaac catgcaactt catctgcaag
     7501 aacaccgagg gcagttacca gtgctcctgc ccacggggtt acgtcctgca ggaagacggc
     7561 aagacgtgca aagacctcga tgaatgtcaa accaaacagc acaactgcca gttcctctgt
     7621 gtcaacaccc tgggggggtt cacctgtaaa tgtccacccg gtttcaccca gcatcacacg
     7681 gcttgcattg ataacaatga gtgtgggtcc cagccttccc tctgtggagc aaaggggatc
     7741 tgtcagaaca ctcctgggag cttcagctgc gaatgccaaa gaggcttctc cctggatgcc
     7801 tctgggctga actgcgaaga tgttgacgaa tgtgacggaa accacaggtg ccaacatggc
     7861 tgccagaaca tcctgggggg ttaccggtgc ggctgcccgc agggatatgt ccagcactac
     7921 cagtggaacc agtgtgtcga tgagaatgaa tgttccaacc ccggtgcctg tggctcggcc
     7981 tcttgctata acaccctggg gagttacaag tgcgcctgcc cctcgggctt ctccttcgac
     8041 cagttctcca gtgcctgtca cgacgtgaac gagtgctcct cctccaagaa cccgtgcagc
     8101 tatggctgct ccaacacgga aggaggctac ctctgtggct gcccaccagg ctacttcaga
     8161 gtgggacagg gccactgtgt ctcgggaatg ggcttcaaca aaggacagta cctgtcagtg
     8221 gattcggagg cagaggacga cgaaaacgct ctgtccccag aagcatgcta cgagtgcaaa
     8281 atcaacggct acgccaagaa agatggccgg cggaagagga gcgcgccaga gcctgagccc
     8341 gcctcagcag aggagcaaat cagcctagaa agcgttgcca tggacagccc agtcaacatg
     8401 aagttcaacc tctccggcct cggctccaag gagcacatcc tagaactggt ccccgccatt
     8461 gagcccctca acaaccacat ccgttacgtc atctcccaag ggaatgacga tggtgtcttc
     8521 cgaatccatc aaaggaatgg gctcagctac ctgcacacag ccaagaagaa gctcactccc
     8581 ggcacataca cactggaaat caccagcgtc cctctttatg ggaagaagga gcttaggaaa
     8641 ttggaggaac gcaatgagga tagctacctc ctgggggtgc tgggggaggc tctcagaatg
     8701 aggttgcaga ttcagctgta ttagcccttt gcagacttgg gtcccagctc aaatcccagc
     8761 acagccagcc ttcagaagtg tttggaacgt cactgactaa ttttgaagag gaaaaaaaaa
     8821 caaaaa
//
