LOCUS       NM_031825               8942 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus fibrillin 1 (Fbn1), mRNA.
ACCESSION   NM_031825
VERSION     NM_031825.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8942)
  AUTHORS   Zhang,Y., Zhang,Y., Tan,Y., Luo,X. and Jia,R.
  TITLE     Increased RBP4 and Asprosin Are Novel Contributors in Inflammation
            Process of Periodontitis in Obese Rats
  JOURNAL   Int J Mol Sci 24 (23), 16739 (2023)
   PUBMED   38069063
  REMARK    GeneRIF: Increased RBP4 and Asprosin Are Novel Contributors in
            Inflammation Process of Periodontitis in Obese Rats.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8942)
  AUTHORS   Feng,X., Zheng,X., Lin,A., Yang,S., Zhang,S., Wu,D., Wu,W. and
            Han,X.
  TITLE     FBN1 knockout promotes cervical artery dissection by inducing
            N-glycosylation alternation of extracellular matrix proteins in rat
            VSMCs
  JOURNAL   Cell Signal 110, 110834 (2023)
   PUBMED   37532137
  REMARK    GeneRIF: FBN1 knockout promotes cervical artery dissection by
            inducing N-glycosylation alternation of extracellular matrix
            proteins in rat VSMCs.
REFERENCE   3  (bases 1 to 8942)
  AUTHORS   Lu,Y., Yuan,W., Xiong,X., Huang,Q., Chen,S., Yin,T., Zhang,Y.,
            Wang,Z., Zeng,G. and Huang,Q.
  TITLE     Asprosin aggravates vascular endothelial dysfunction via disturbing
            mitochondrial dynamics in obesity models
  JOURNAL   Obesity (Silver Spring) 31 (3), 732-743 (2023)
   PUBMED   36693798
  REMARK    GeneRIF: Asprosin aggravates vascular endothelial dysfunction via
            disturbing mitochondrial dynamics in obesity models.
REFERENCE   4  (bases 1 to 8942)
  AUTHORS   Elnagar,A., El-Dawy,K., El-Belbasi,H.I., Rehan,I.F., Embark,H.,
            Al-Amgad,Z., Shanab,O., Mickdam,E., Batiha,G.E., Alamery,S.,
            Fouad,S.S., Cavalu,S. and Youssef,M.
  TITLE     Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression,
            and Behavioral Patterns in Rats' Obesity-Induced Diabetes
  JOURNAL   Front Public Health 10, 777129 (2022)
   PUBMED   35462799
  REMARK    GeneRIF: Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene
            Expression, and Behavioral Patterns in Rats' Obesity-Induced
            Diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8942)
  AUTHORS   Mogulkoc,R., Dasdelen,D., Baltaci,S.B., Baltaci,A.K. and
            Sivrikaya,A.
  TITLE     The effect of thyroid dysfunction and treatment on adropin,
            asprosin and preptin levels in rats
  JOURNAL   Horm Mol Biol Clin Investig 42 (1), 37-42 (2020)
   PUBMED   33781005
  REMARK    GeneRIF: The effect of thyroid dysfunction and treatment on
            adropin, asprosin and preptin levels in rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8942)
  AUTHORS   Francke,U., Berg,M.A., Tynan,K., Brenn,T., Liu,W., Aoyama,T.,
            Gasner,C., Miller,D.C. and Furthmayr,H.
  TITLE     A Gly1127Ser mutation in an EGF-like domain of the fibrillin-1 gene
            is a risk factor for ascending aortic aneurysm and dissection
  JOURNAL   Am J Hum Genet 56 (6), 1287-1296 (1995)
   PUBMED   7762551
REFERENCE   7  (bases 1 to 8942)
  AUTHORS   Roark,E.F., Keene,D.R., Haudenschild,C.C., Godyna,S., Little,C.D.
            and Argraves,W.S.
  TITLE     The association of human fibulin-1 with elastic fibers: an
            immunohistological, ultrastructural, and RNA study
  JOURNAL   J Histochem Cytochem 43 (4), 401-411 (1995)
   PUBMED   7534784
REFERENCE   8  (bases 1 to 8942)
  AUTHORS   Corson,G.M., Chalberg,S.C., Dietz,H.C., Charbonneau,N.L. and
            Sakai,L.Y.
  TITLE     Fibrillin binds calcium and is coded by cDNAs that reveal a
            multidomain structure and alternatively spliced exons at the 5' end
  JOURNAL   Genomics 17 (2), 476-484 (1993)
   PUBMED   7691719
REFERENCE   9  (bases 1 to 8942)
  AUTHORS   Sakai,L.Y., Keene,D.R., Glanville,R.W. and Bachinger,H.P.
  TITLE     Purification and partial characterization of fibrillin, a
            cysteine-rich structural component of connective tissue
            microfibrils
  JOURNAL   J Biol Chem 266 (22), 14763-14770 (1991)
   PUBMED   1860873
REFERENCE   10 (bases 1 to 8942)
  AUTHORS   Sakai,L.Y., Keene,D.R. and Engvall,E.
  TITLE     Fibrillin, a new 350-kD glycoprotein, is a component of
            extracellular microfibrils
  JOURNAL   J Cell Biol 103 (6 Pt 1), 2499-2509 (1986)
   PUBMED   3536967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_031825.3.
            
            On Nov 26, 2020 this sequence version replaced NM_031825.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135059.1, SRR26643295.15152.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               JAXUCZ010000003.1  133203227-133203390 c
            165-247             JAXUCZ010000003.1  133177037-133177119 c
            248-346             JAXUCZ010000003.1  133175331-133175429 c
            347-442             JAXUCZ010000003.1  133166433-133166528 c
            443-538             JAXUCZ010000003.1  133164523-133164618 c
            539-736             JAXUCZ010000003.1  133110505-133110702 c
            737-862             JAXUCZ010000003.1  133107669-133107794 c
            863-988             JAXUCZ010000003.1  133102317-133102442 c
            989-1147            JAXUCZ010000003.1  133099383-133099541 c
            1148-1330           JAXUCZ010000003.1  133094501-133094683 c
            1331-1471           JAXUCZ010000003.1  133093813-133093953 c
            1472-1591           JAXUCZ010000003.1  133093159-133093278 c
            1592-1717           JAXUCZ010000003.1  133089744-133089869 c
            1718-1840           JAXUCZ010000003.1  133088123-133088245 c
            1841-1963           JAXUCZ010000003.1  133085196-133085318 c
            1964-2116           JAXUCZ010000003.1  133083997-133084149 c
            2117-2170           JAXUCZ010000003.1  133080262-133080315 c
            2171-2296           JAXUCZ010000003.1  133078729-133078854 c
            2297-2422           JAXUCZ010000003.1  133077082-133077207 c
            2423-2542           JAXUCZ010000003.1  133076435-133076554 c
            2543-2680           JAXUCZ010000003.1  133076076-133076213 c
            2681-2731           JAXUCZ010000003.1  133075632-133075682 c
            2732-2857           JAXUCZ010000003.1  133073961-133074086 c
            2858-3085           JAXUCZ010000003.1  133071846-133072073 c
            3086-3211           JAXUCZ010000003.1  133071014-133071139 c
            3212-3340           JAXUCZ010000003.1  133070772-133070900 c
            3341-3466           JAXUCZ010000003.1  133070382-133070507 c
            3467-3592           JAXUCZ010000003.1  133070170-133070295 c
            3593-3715           JAXUCZ010000003.1  133068948-133069070 c
            3716-3841           JAXUCZ010000003.1  133067809-133067934 c
            3842-3967           JAXUCZ010000003.1  133066480-133066605 c
            3968-4090           JAXUCZ010000003.1  133059167-133059289 c
            4091-4213           JAXUCZ010000003.1  133058892-133059014 c
            4214-4339           JAXUCZ010000003.1  133057359-133057484 c
            4340-4462           JAXUCZ010000003.1  133055217-133055339 c
            4463-4585           JAXUCZ010000003.1  133053457-133053579 c
            4586-4750           JAXUCZ010000003.1  133052998-133053162 c
            4751-4819           JAXUCZ010000003.1  133051147-133051215 c
            4820-4945           JAXUCZ010000003.1  133050928-133051053 c
            4946-5068           JAXUCZ010000003.1  133049936-133050058 c
            5069-5227           JAXUCZ010000003.1  133049150-133049308 c
            5228-5299           JAXUCZ010000003.1  133048409-133048480 c
            5300-5425           JAXUCZ010000003.1  133045558-133045683 c
            5426-5548           JAXUCZ010000003.1  133042585-133042707 c
            5549-5674           JAXUCZ010000003.1  133039412-133039537 c
            5675-5791           JAXUCZ010000003.1  133037222-133037338 c
            5792-5920           JAXUCZ010000003.1  133035869-133035997 c
            5921-6040           JAXUCZ010000003.1  133034996-133035115 c
            6041-6166           JAXUCZ010000003.1  133031516-133031641 c
            6167-6316           JAXUCZ010000003.1  133028256-133028405 c
            6317-6382           JAXUCZ010000003.1  133027823-133027888 c
            6383-6499           JAXUCZ010000003.1  133027491-133027607 c
            6500-6619           JAXUCZ010000003.1  133025556-133025675 c
            6620-6742           JAXUCZ010000003.1  133024057-133024179 c
            6743-6874           JAXUCZ010000003.1  133023623-133023754 c
            6875-7000           JAXUCZ010000003.1  133022017-133022142 c
            7001-7207           JAXUCZ010000003.1  133021251-133021457 c
            7208-7333           JAXUCZ010000003.1  133019332-133019457 c
            7334-7456           JAXUCZ010000003.1  133018997-133019119 c
            7457-7573           JAXUCZ010000003.1  133016212-133016328 c
            7574-7702           JAXUCZ010000003.1  133015814-133015942 c
            7703-7822           JAXUCZ010000003.1  133014926-133015045 c
            7823-8054           JAXUCZ010000003.1  133013258-133013489 c
            8055-8229           JAXUCZ010000003.1  133010184-133010358 c
            8230-8942           JAXUCZ010000003.1  133008361-133009073 c
FEATURES             Location/Qualifiers
     source          1..8942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..8942
                     /gene="Fbn1"
                     /note="fibrillin 1"
                     /db_xref="GeneID:83727"
                     /db_xref="RGD:620908"
     CDS             1..8619
                     /gene="Fbn1"
                     /codon_start=1
                     /product="fibrillin-1 precursor"
                     /protein_id="NP_114013.2"
                     /db_xref="GeneID:83727"
                     /db_xref="RGD:620908"
                     /translation="MRRGGLLEVALAFTLLLESYTSHGADANLEAGSLKETRANRAKR
                     RGGGGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTC
                     PSGQISPSCGSRSIQHCSIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRC
                     VAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWG
                     HPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAG
                     HKFNEVSQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSPDGTRCVDVRPG
                     YCYTTLTNGRCSNQLPQSITKMQCCCDVGRCWSPGVTVAPEMCPIRSTEDFNKLCSVP
                     LVIPGRPDYPPPPLGPLPPVQPVPGFPSGPVIPVPRPPPEYPYPSPSREPPKVLPFNV
                     TDYCQLVRYLCQNGRCIPTPGSYRCECNKGFQLDIRGECIDVDECEKNPCTGGECINN
                     QGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTR
                     DGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGIC
                     MNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYRRGQCVKPLFGAVTKS
                     ECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGIC
                     ENLRGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFV
                     YKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIKGTCWQ
                     TVIDGRCEININGATLKSECCSSLGAAWGSPCTICQVDPICGKGYSRIKGTQCEDINE
                     CEVFPGVCKNGLCVNSRGSFKCECPSGMTLDATGRICLDIRLETCFLKYDDEECTLPI
                     AGRHRMDACCCSVGAAWGTEECEECPLRNSREYEELCPRGPGFATKDITNGKPFFKDI
                     NECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCV
                     NTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGICHNTEGSYRCECPSGHQ
                     LSPNISACIDINECELSANLCPSGRCVNLIGKYQCACNPGYHPTHDRLFCVDIDECSI
                     MNGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEY
                     RCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTG
                     CTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQH
                     ADCKNTMGSYRCLCKDGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGF
                     VPSADGKACEDINECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLD
                     PTTCISGNCVNTPGSYTCDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSN
                     EIGVGVSKASCCCSLGKAWGTPCELCPPVNTSEYKILCPGGEGFRPNPITVILEDIDE
                     CQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTV
                     GNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYHADNQTCDGELLFNMTKKMCCCSYNI
                     GRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCI
                     NMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRL
                     TSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNADQTMCLDINECERDA
                     CGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCR
                     CNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQNDKCEDID
                     ECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSTGRRCQDLRMSYCYAKFEGGKCSSP
                     KSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAVDMDEC
                     KEPDVCKHGQCINTDGSYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIGGFE
                     CTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKD
                     EDECAEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENG
                     RCLNTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVLQNMCQIGSSNRNPVTKSEC
                     CCDGGRGWGPHCEICPFEGTVAYKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVND
                     RGSYHCICKTGYTPDITGTACVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQED
                     GRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTACIDNNECTSEINLCGS
                     KGVCQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHRCQHGCQNIIGGYRCSCPQG
                     YLQHYQWNQCVDENECLSAHVCGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECG
                     SSQAPCSYGCSNTEGGYLCGCPPGYLRIGQGHCVSGMGMGRGGPEPPASGEMDDNSLS
                     PEACYECKINGYPKRGRKRRSTNETDASDIQDGSEMEANVSLASWDVEKPASFAFNIS
                     HINNKVRILELLPALTTLMNHNKYLIESGNEDGFFKINQKEGVSYLHFTKKKPVAGTY
                     SLQISSTPLYKKKELNQLEDRYDKDYLSGELGDNLKMKIQILLH"
     exon            1..164
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..247
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..346
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..442
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..538
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..736
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..862
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..988
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1147
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1330
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1471
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1591
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1717
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1840
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1963
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2116
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2170
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2296
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2422
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2542
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2680
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2731
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2857
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3085
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3211
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3340
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3466
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3592
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3715
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3841
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..3967
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            3968..4090
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4091..4213
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4339
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4462
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..4585
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4750
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4751..4819
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4820..4945
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5068
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5069..5227
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5228..5299
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5425
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5548
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5549..5674
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5675..5791
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5920
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            5921..6040
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6041..6166
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6167..6316
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6317..6382
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6383..6499
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6500..6619
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6620..6742
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6743..6874
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            6875..7000
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7001..7207
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7208..7333
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7334..7456
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7457..7573
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7574..7702
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7703..7822
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            7823..8054
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            8055..8229
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
     exon            8230..8942
                     /gene="Fbn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcggcgag gagggctgct ggaggtcgcg ctggctttca ccctgctcct cgagtcctac
       61 acgagccatg gggcggatgc caatctggag gctgggagcc taaaggagac cagagccaat
      121 cgcgccaaga gacgaggcgg cggaggacac gatgctctga aaggacccaa tgtctgtgga
      181 tctcgttata acgcatactg ttgtcccgga tggaaaacct tacctggtgg aaatcagtgt
      241 attgttccca tttgccggca ttcctgtggg gacggattct gctcaagacc aaacatgtgc
      301 acttgcccat ctggtcagat atcgccttcc tgtggctcca gatccataca acactgtagc
      361 atccgctgta tgaatggggg cagctgcagc gatgaccact gtctgtgcca gaaggggtac
      421 attggcactc actgcggaca acctgtctgt gaaagtggct gtctcaatgg agggaggtgc
      481 gtggccccaa atcggtgtgc atgcacatac ggctttacgg gaccccagtg tgaaagagat
      541 tacagaacag gcccgtgttt tactgtggta agcaaccaga tgtgccaggg acagctcagc
      601 gggattgtct gcaccaaaac actctgctgt gccacagtgg gccgagcctg gggccacccc
      661 tgcgagatgt gtcctgccca gcctcacccc tgccgccgcg gcttcattcc caacatccgc
      721 accggagctt gtcaagatgt ggatgaatgt caggctatcc cggggctgtg tcaaggagga
      781 aattgcatta ataccgttgg atcttttgag tgcaaatgcc ccgctggaca caaatttaat
      841 gaagtgtccc aaaaatgtga agatatcgat gagtgcagca ccatccctgg tgtgtgcgat
      901 ggcggggagt gtaccaacac ggtcagcagt tatttctgca aatgtccccc tggcttttac
      961 acctctcccg atggcaccag atgcgtagat gttcgccctg gttactgcta cacaactctg
     1021 acaaatgggc gctgctctaa ccagctgcca cagtccataa ccaaaatgca gtgctgttgt
     1081 gatgttggcc ggtgctggtc tccaggggtt actgtcgctc ctgagatgtg tcccatcagg
     1141 tcaactgagg acttcaacaa gctgtgctcc gtccctctgg taatccccgg gagaccagac
     1201 tatcctcccc cacccctcgg cccccttcct ccggttcagc ctgttcctgg gtttccttcc
     1261 gggcctgtga taccggtccc ccggccaccg ccagaatacc cgtatccatc tccatcacgg
     1321 gaaccaccaa aggtgctgcc tttcaacgtt actgactact gtcaattggt ccgctatctc
     1381 tgtcaaaatg ggcgctgcat tccaactccc ggtagctacc gctgtgagtg caacaagggc
     1441 ttccagctgg atatccgtgg cgagtgcatc gacgttgatg agtgtgagaa aaacccatgc
     1501 accggtggag aatgtatcaa caaccagggc tcatatacct gtcactgccg agctggctac
     1561 cagagcacac tcaccagaac tgagtgcaga gacatagatg agtgtctgca gaacggccgg
     1621 atctgtaaca acgggcgctg catcaacaca gatggcagct tccactgcgt gtgcaatgca
     1681 ggctttcacg tcacgaggga cggaaagaac tgtgaagaca tggatgagtg cagcatcagg
     1741 aacatgtgcc tgaatgggat gtgcatcaac gaagatggga gtttcaagtg tatttgcaaa
     1801 cctgggttcc aactggcgtc agatggccgc tactgcaaag atatcaatga gtgtgagact
     1861 cctggaatct gcatgaacgg acgatgcgtg aacactgatg gctcctacag atgcgaatgc
     1921 tttcccggat tggctgtggg cctagatgga cgtgtgtgtg ttgacacaca catgcggagc
     1981 acatgctacg gaggctacag gagaggccag tgtgtgaagc cgttgtttgg tgctgttacc
     2041 aaatcggaat gctgttgtgc cagcaccgag tatgccttcg gggaaccctg ccagccgtgc
     2101 cctgcacaga attcagcgga atatcaggca ctttgcagca gtggacccgg aatgacatca
     2161 gcaggctctg atataaatga atgtgcatta gatcctgaca tttgcccaaa tggaatttgt
     2221 gaaaatctcc gtgggaccta caaatgtata tgcaactcgg gatacgaagt agacataact
     2281 gggaaaaact gtgtcgatat taatgagtgt gtgctgaaca gtctactttg tgacaatgga
     2341 caatgtcgaa acacacctgg aagttttgtc tgtacctgcc ccaagggatt tgtgtacaaa
     2401 cctgacttaa agacctgtga agacattgat gaatgtgaat cgagtccttg cattaatgga
     2461 gtctgcaaga acagccctgg gtctttcatt tgcgaatgct ctcctgaaag tactctggat
     2521 ccaacaaaaa ccatctgcat agaaaccatc aagggcactt gctggcagac tgtcattgac
     2581 gggcgatgtg agatcaatat caatggagcc accttgaagt ccgagtgctg ctcctccctt
     2641 ggcgctgcct gggggagccc gtgcactata tgtcaagttg atcccatatg tggtaaaggg
     2701 tactcgagaa ttaaaggcac gcaatgtgaa gatatcaatg agtgtgaagt attcccggga
     2761 gtatgcaaga atggcctgtg tgttaactcc aggggttcct tcaagtgcga gtgtcccagt
     2821 ggaatgactt tggatgctac aggaagaatc tgtcttgata tccgcctgga gacctgcttc
     2881 ctgaagtacg acgacgagga gtgcacgctg cccattgctg gccgccaccg aatggatgcc
     2941 tgctgctgct ccgttggggc agcctgggga acagaagagt gtgaggagtg tccattgaga
     3001 aacagccggg agtatgagga actctgtccc cgaggacccg ggtttgccac gaaagacata
     3061 acaaatggga aacctttctt caaagacatt aatgagtgca agatgatacc cagcctctgt
     3121 acccacggca agtgtaggaa caccattggc agcttcaagt gcaggtgtga cagtggcttt
     3181 gctttggact ctgaagagag gaactgcaca gacattgacg agtgccgcat atctcctgac
     3241 ctctgtggcc gaggccagtg tgtgaacacc ccgggggatt tcgaatgcaa gtgtgacgaa
     3301 ggctatgaaa gtggcttcat gatgatgaag aactgtatgg atattgatga atgccagaga
     3361 gatcctctcc tctgtcgagg aggcatctgc cacaacacag agggaagtta tcgctgtgaa
     3421 tgtccttctg gccaccaact gtctcccaac atctctgcgt gcattgacat caacgagtgt
     3481 gaactgagtg ccaacctctg tcccagcggg cgttgtgtga acctcattgg gaagtaccag
     3541 tgtgcctgca acccgggcta tcaccccact cacgataggc ttttctgtgt cgacattgat
     3601 gagtgcagca taatgaatgg tggttgtgag accttctgca caaactctga cgggagctat
     3661 gaatgtagct gtcagccagg cttcgcgctg atgccagacc agcgatcgtg cacagacatt
     3721 gatgagtgtg aagataaccc caatatctgt gatggtggcc agtgcacaaa cattcctgga
     3781 gagtacaggt gcttgtgcta tgatgggttc atggcgtctg aagacatgaa gacttgtgtt
     3841 gatgtcaatg aatgtgacct gaatcccaac atctgcctca gtgggacctg cgagaacact
     3901 aaaggctcct tcatctgcca ctgtgatatg ggctactcag ggaaaaaagg aaaaacgggc
     3961 tgcacagata tcaatgaatg tgagattgga gcacacaact gtggcagaca tgctgtgtgc
     4021 acaaatacag cagggagctt caagtgcagc tgcagtcctg gctggattgg agatggcatt
     4081 aagtgcacag atctggatga atgctctaat ggaacccaca tgtgcagcca acacgcagac
     4141 tgcaagaaca ccatggggtc atatcgctgt ctctgtaagg atggctacac aggggatggc
     4201 ttcacctgca cagaccttga cgagtgctct gagaacctga acctctgtgg caatggccag
     4261 tgcctcaatg cccctggcgg gtaccgctgt gaatgcgaca tgggcttcgt gcccagtgct
     4321 gatgggaagg cctgtgaaga tatcaacgag tgctcccttc caaacatctg tgtctttgga
     4381 acttgccaca atctcccggg cctcttccgc tgcgagtgtg agattggcta cgagctggac
     4441 cgaagtggag ggaactgcac agatgttaat gagtgtctgg atcctaccac ctgcatcagt
     4501 gggaactgtg tcaacactcc aggcagttac acatgcgact gtccacctga ttttgagctg
     4561 aatccaactc gagtgggctg tgtcgatact cgctctggaa actgctatct ggatatccgg
     4621 ccccggggag acaatgggga tacggcctgc agcaatgaaa ttggagttgg tgtttctaag
     4681 gcttcctgct gttgctctct gggtaaagct tggggaaccc catgtgagct gtgtcctcct
     4741 gtgaacacat ccgagtataa aattctctgc cccggaggag aaggttttcg tccaaatccc
     4801 atcaccgtta tattggaaga catcgatgag tgccaggagc tcccagggct gtgccaaggg
     4861 gggaagtgca tcaacacctt tggcagcttc cagtgtcgct gtccaacggg ttactacctg
     4921 aatgaagaca cacgggtgtg tgatgatgtg aacgaatgtg agactcccgg aatctgtggt
     4981 ccggggacat gttacaacac cgttggcaac tatacctgca tttgtcctcc agactacatg
     5041 caagtgaatg gggggaataa ttgcatggac atgagaagaa gcctgtgcta cagaaactat
     5101 catgctgaca accagacctg cgatggagaa ctgctcttca acatgaccaa gaagatgtgt
     5161 tgctgctcct acaacatcgg ccgtgcctgg aataagccct gtgaacagtg tcccatccca
     5221 agcacagatg aatttgctac cctctgtgga agccagaggc caggcttcgt gattgacatt
     5281 tacacaggtt tacctgtgga tattgatgaa tgccgggaga tcccaggggt ttgtgaaaat
     5341 ggagtgtgca tcaacatggt tggcagcttc cggtgtgagt gccctgtggg attcttctac
     5401 aacgacaagt tgctggtttg tgaagatatc gatgagtgtc agaatggccc cgtgtgccag
     5461 cgcaatgcgg agtgcatcaa caccgcaggc agctaccgct gtgactgcaa acccggctac
     5521 cgcctcacct ccacgggtca atgcaacgat cgaaacgagt gccaagaaat cccgaacata
     5581 tgcagtcatg gccagtgcat cgacactgtg ggaagcttct actgcctctg tcacacaggc
     5641 ttcaaaacaa acgcagatca gaccatgtgc ttggacataa atgagtgtga gagagacgcc
     5701 tgtgggaatg ggacttgcag aaacacaatt ggttccttca actgccgctg caaccatggc
     5761 ttcatactct ctcacaacaa tgactgcata gacgttgatg aatgtgcaac tggaaacggg
     5821 aacctttgta gaaatggcca gtgcgtcaac acggtggggt cctttcagtg caggtgcaat
     5881 gaaggctacg aggtggctcc agacggcagg acctgtgtgg atatcaatga atgtgttctg
     5941 gatcctggga aatgtgcacc tggaacctgt cagaacttgg acggctccta cagatgcatt
     6001 tgcccacctg ggtacagtct acagaatgac aaatgtgaag atattgatga gtgtgtcgaa
     6061 gagccagaaa tctgtgcttt ggggacctgc agcaacactg aaggcagctt caaatgtctg
     6121 tgtccagaag ggttctccct gtcctctact ggaagaaggt gccaagactt gagaatgagc
     6181 tactgctacg cgaagtttga aggtgggaag tgttcgtcgc ccaaatccag gaatcattcc
     6241 aagcaggaat gctgctgcgc tttgaaggga gaaggctggg gagacccttg tgagttgtgt
     6301 cccactgagc cagatgaggc tttccgccag atatgcccct ttggaagtgg gatcatcgtg
     6361 ggccctgatg actcggcagt tgatatggat gaatgcaaag aacctgatgt ctgtaaacat
     6421 gggcagtgca tcaacacaga cggctcctat cgctgcgagt gtccctttgg ttatattcta
     6481 gaagggaatg agtgtgtgga taccgatgaa tgctccgtgg gcaatccttg tggaaatggg
     6541 acctgcaaga atgtgattgg aggttttgaa tgtacctgtg aggagggatt cgagcctggt
     6601 ccaatgatga catgtgaaga tataaatgaa tgtgcccaga atcccctact ctgcgccttc
     6661 cgctgtgtaa atacctatgg gtcctatgaa tgcaagtgcc ctgttggata tgttctgcga
     6721 gaagacagga ggatgtgtaa agatgaggat gagtgtgcag aggggaagca cgactgtact
     6781 gaaaagcaaa tggagtgcaa gaacctcatc ggtacctaca tgtgcatctg cggcccaggg
     6841 taccagcgaa gacctgatgg agagggctgc atagatgaga atgaatgtca gaccaagcct
     6901 gggatctgtg agaacgggcg ttgcctcaac accctgggga gctacacctg tgagtgtaat
     6961 gatggcttca cagccagccc cactcaggat gagtgcttgg acaaccggga agggtactgc
     7021 ttttctgagg tactgcagaa catgtgccag attggatcaa gcaacagaaa ccccgtcacc
     7081 aagtccgagt gctgctgtga tggagggaga ggctggggac cccactgtga gatctgcccc
     7141 ttcgagggca cagtggctta caagaaactg tgtccccacg gccgaggatt catgaccaac
     7201 ggagcagata ttgatgagtg caaggtaatc cacgatgttt gccgaaacgg ggagtgtgtc
     7261 aatgacagag gatcatatca ctgcatctgt aaaactggct acactccgga cataacaggg
     7321 accgcctgtg tagatctaaa tgagtgcaac caggctccca aaccctgcaa tttcatatgc
     7381 aaaaacacag aagggagtta ccagtgttcc tgccccaagg gctatattct gcaagaggat
     7441 ggaaggagct gcaaagatct tgacgagtgt gcaaccaagc agcataactg tcagttcctg
     7501 tgtgttaaca ccatcggcgg cttcacatgc aaatgccctc ctgggttcac ccagcaccac
     7561 actgcctgca ttgataacaa tgaatgcact tctgagatca acctgtgtgg gtccaagggc
     7621 gtttgccaga atacaccagg aagcttcacc tgtgaatgcc agcggggatt ctccctcgat
     7681 cagagtggtg ccagctgtga agatgtggac gagtgtgagg gtaaccaccg ctgccaacat
     7741 ggctgccaga acatcattgg aggctatagg tgcagctgcc cccagggcta cctccagcac
     7801 taccagtgga accagtgtgt agacgaaaac gagtgcctga gtgcacatgt ctgtggggga
     7861 gcctcctgcc acaacaccct ggggagttac aagtgcatgt gtcctgctgg cttccagtac
     7921 gaacagttca gtggaggctg ccaagatatc aacgagtgtg gctcatccca ggccccctgc
     7981 agttatggtt gctctaatac tgagggtggc tacctatgtg gctgtcctcc aggatacctc
     8041 cggataggcc aagggcattg tgtttctgga atgggcatgg gccgaggtgg cccagagcca
     8101 cctgccagtg gcgagatgga tgacaactca ctgtccccag aggcctgcta tgagtgtaag
     8161 atcaatggct acccaaaacg aggcaggaaa cggagaagca cgaatgaaac agatgcctct
     8221 gacatccagg atgggtctga aatggaagcc aacgtgagcc tcgcgagctg ggatgtggag
     8281 aagccagcta gctttgcttt caatatttcc catatcaata acaaagtccg aatcctagag
     8341 ctcctgccgg cccttacaac tctgatgaac cacaacaaat acttgatcga gtctggaaat
     8401 gaagatggct tctttaaaat caaccagaaa gaaggggtca gctacctcca cttcacgaag
     8461 aagaagccag tggctggaac ctactcctta caaatcagca gtactccact ttataaaaag
     8521 aaagaactta accagttaga agacagatat gacaaagact acctcagcgg tgaactgggc
     8581 gataacctga agatgaaaat tcagatcttg ctgcattaac ttaccatcca gagaccaaat
     8641 aattaaaaaa gaaaaagcaa ctttaggtag gtaggattat attttcccca agccagaacc
     8701 tgcatggtac aatcattcac cgagtcgatc tgtgtaaatg agcaccattc ttggatggca
     8761 acaccaaggt acagcgacga tcctagttca aacaaccact ctctcaagct tctcgtgagt
     8821 agctcagcta ccctgtcatg ggtattgatt cctgagaact gggacatgag tatcggcgga
     8881 agttggccgt gcgtgccgac cggccatctt tccagccgcc ccacagaagc atgtttccat
     8941 ct
//
