LOCUS       NM_019153               2375 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus fibulin 5 (Fbln5), mRNA.
ACCESSION   NM_019153
VERSION     NM_019153.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2375)
  AUTHORS   Hamner,J., Florian-Rodriguez,M., Acevedo,J., Shi,H. and Word,R.A.
  TITLE     Protease Inhibition Improves Healing of The Vaginal Wall after
            Obstetrical Injury: Results from a Preclinical Animal Model
  JOURNAL   Sci Rep 10 (1), 6358 (2020)
   PUBMED   32286390
  REMARK    GeneRIF: Protease Inhibition Improves Healing of The Vaginal Wall
            after Obstetrical Injury: Results from a Preclinical Animal Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2375)
  AUTHORS   Zhang,W., Wang,Y. and Bi,G.
  TITLE     Limb remote ischaemic postconditioning-induced elevation of
            fibulin-5 confers neuroprotection to rats with cerebral
            ischaemia/reperfusion injury: Activation of the AKT pathway
  JOURNAL   Clin Exp Pharmacol Physiol 44 (6), 656-663 (2017)
   PUBMED   28251683
  REMARK    GeneRIF: upregulation of fibulin-5 is involved in the beneficial
            effect of RIPostC against cerebral I/R injury
REFERENCE   3  (bases 1 to 2375)
  AUTHORS   Guo,J., Cheng,C., Chen,C.S., Xing,X., Xu,G., Feng,J. and Qin,X.
  TITLE     Overexpression of Fibulin-5 Attenuates Ischemia/Reperfusion Injury
            After Middle Cerebral Artery Occlusion in Rats
  JOURNAL   Mol Neurobiol 53 (5), 3154-3167 (2016)
   PUBMED   26021746
  REMARK    GeneRIF: Fibulin-5 overexpression attenuated reactive oxygen
            species expression, which in turn decreased apoptosis and
            blood-brain barrier (BBB) permeability following middle cerebral
            artery occlusion and reperfusion.
REFERENCE   4  (bases 1 to 2375)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 2375)
  AUTHORS   Noda,K., Nakamura,T. and Komatsu,Y.
  TITLE     Fibulin-5 deficiency causes developmental defect of premaxillary
            bone in mice
  JOURNAL   Biochem Biophys Res Commun 466 (3), 585-591 (2015)
   PUBMED   26399686
REFERENCE   6  (bases 1 to 2375)
  AUTHORS   Loeys,B., Van Maldergem,L., Mortier,G., Coucke,P., Gerniers,S.,
            Naeyaert,J.M. and De Paepe,A.
  TITLE     Homozygosity for a missense mutation in fibulin-5 (FBLN5) results
            in a severe form of cutis laxa
  JOURNAL   Hum Mol Genet 11 (18), 2113-2118 (2002)
   PUBMED   12189163
REFERENCE   7  (bases 1 to 2375)
  AUTHORS   Nakamura,T., Lozano,P.R., Ikeda,Y., Iwanaga,Y., Hinek,A.,
            Minamisawa,S., Cheng,C.F., Kobuke,K., Dalton,N., Takada,Y.,
            Tashiro,K., Ross,J. Jr., Honjo,T. and Chien,K.R.
  TITLE     Fibulin-5/DANCE is essential for elastogenesis in vivo
  JOURNAL   Nature 415 (6868), 171-175 (2002)
   PUBMED   11805835
REFERENCE   8  (bases 1 to 2375)
  AUTHORS   Yanagisawa,H., Davis,E.C., Starcher,B.C., Ouchi,T., Yanagisawa,M.,
            Richardson,J.A. and Olson,E.N.
  TITLE     Fibulin-5 is an elastin-binding protein essential for elastic fibre
            development in vivo
  JOURNAL   Nature 415 (6868), 168-171 (2002)
   PUBMED   11805834
REFERENCE   9  (bases 1 to 2375)
  AUTHORS   Nakamura,T., Ruiz-Lozano,P., Lindner,V., Yabe,D., Taniwaki,M.,
            Furukawa,Y., Kobuke,K., Tashiro,K., Lu,Z., Andon,N.L., Schaub,R.,
            Matsumori,A., Sasayama,S., Chien,K.R. and Honjo,T.
  TITLE     DANCE, a novel secreted RGD protein expressed in developing,
            atherosclerotic, and balloon-injured arteries
  JOURNAL   J Biol Chem 274 (32), 22476-22483 (1999)
   PUBMED   10428823
REFERENCE   10 (bases 1 to 2375)
  AUTHORS   Kowal,R.C., Richardson,J.A., Miano,J.M. and Olson,E.N.
  TITLE     EVEC, a novel epidermal growth factor-like repeat-containing
            protein upregulated in embryonic and diseased adult vasculature
  JOURNAL   Circ Res 84 (10), 1166-1176 (1999)
   PUBMED   10347091
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019153.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078845.1, AF137350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840112 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000006.1  126742465-126742706 c
            243-297             JAXUCZ010000006.1  126738049-126738103 c
            298-349             JAXUCZ010000006.1  126735950-126736001 c
            350-604             JAXUCZ010000006.1  126733458-126733712 c
            605-727             JAXUCZ010000006.1  126687664-126687786 c
            728-844             JAXUCZ010000006.1  126683628-126683744 c
            845-964             JAXUCZ010000006.1  126679965-126680084 c
            965-1087            JAXUCZ010000006.1  126676532-126676654 c
            1088-1214           JAXUCZ010000006.1  126675452-126675578 c
            1215-1410           JAXUCZ010000006.1  126672045-126672240 c
            1411-2375           JAXUCZ010000006.1  126664100-126665064 c
FEATURES             Location/Qualifiers
     source          1..2375
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2375
                     /gene="Fbln5"
                     /note="fibulin 5"
                     /db_xref="GeneID:29158"
                     /db_xref="RGD:2594"
     exon            1..242
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1572
                     /gene="Fbln5"
                     /note="EVEC; dance; FIBL-5; embryonic vascular EGF
                     repeat-containing protein; developmental arteries and
                     neural crest EGF-like protein"
                     /codon_start=1
                     /product="fibulin-5 precursor"
                     /protein_id="NP_062026.2"
                     /db_xref="GeneID:29158"
                     /db_xref="RGD:2594"
                     /translation="MPGLKRILTVTILALWLPHPGNAQQQCTNGFDLDRQTGQCLDID
                     ECRTIPEACRGDMMCVNQNGGYLCIPRTNPVYRGPYSNPYSTSYSGPYPAAAPPVPAS
                     NYPTISRPLVCRFGYQMDEGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYW
                     LLEGQCLDIDECRYGYCQQLCANVPGSYSCTCNPGFTLNDDGRSCQDVNECETENPCV
                     QTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSEFLCQHECVNQPGSYFCSCPPG
                     YVLLEDNRSCQDINECEHRNHTCTPLQTCYNLQGGFKCIDPIVCEEPYLLIGDNRCMC
                     PAENTGCRDQPFTILFRDMDVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREF
                     YMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF"
     exon            243..297
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            298..349
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            350..604
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            605..727
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            728..844
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            845..964
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1087
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1214
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1410
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..2375
                     /gene="Fbln5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgttcatt tttaacattc ctcctccaat tggcttaatg ctgaattact gaagggggtt
       61 aagcgaaacc aggtgccggc ggcgagggct ctgcagtggc tcccagcacc cggcactgtc
      121 cccggccctc cgcgcagccc cgttcggccc ctcggaaacc aagctgcccg gtcccgcgca
      181 gagcctgcct tcctcaaatc acctctcctc ccgcgcatct tggatatgcc aggattaaaa
      241 aggatactca ctgtcaccat cctggcactg tggcttccac atcctgggaa tgcacagcaa
      301 cagtgcacca acggctttga cctggaccgc cagacaggac agtgtttaga tattgatgaa
      361 tgtcggacca tccctgaggc ttgccgtggg gacatgatgt gtgtcaacca gaatggcggg
      421 tatctgtgca tccctcgaac caacccagtg tatcgagggc cctactccaa tccctactct
      481 acatcctact caggcccata cccagcagct gcaccaccag tgccagcttc caactacccc
      541 acgatttcca ggcctcttgt ctgtcgcttt gggtatcaga tggatgaagg caaccagtgt
      601 gtggatgtgg acgagtgtgc gacagattca caccagtgca accctaccca gatctgtatc
      661 aacacggaag gagggtacac ctgctcctgc actgatgggt actggcttct ggaagggcag
      721 tgcctagata ttgatgaatg tcgctatggt tactgccagc agctctgtgc gaatgttcct
      781 ggatcctatt cctgtacgtg taaccctggc ttcaccctca acgatgatgg aaggtcttgc
      841 caagatgtga acgagtgtga aactgagaac ccctgtgttc agacctgcgt caacacctat
      901 ggttctttca tctgccgctg tgacccagga tatgaactgg aggaagatgg cattcactgc
      961 agtgatatgg atgagtgcag cttctccgag ttcctctgtc aacatgagtg tgtgaaccag
     1021 ccgggctcat acttctgctc atgccctcca ggctacgtct tgttggaaga taaccgaagc
     1081 tgccaggata tcaatgaatg tgagcaccgg aaccacacat gcactcccct gcagacttgc
     1141 tacaatctgc aagggggctt caaatgtatc gaccccatcg tctgcgagga gccttatctg
     1201 ctgattgggg ataaccgctg tatgtgccct gctgagaata ctggctgcag ggaccagcca
     1261 ttcaccatct tgtttcggga catggatgtg gtatcaggac gctctgttcc tgctgacatc
     1321 ttccagatgc aagcaacgac ccgataccct ggcgcctatt acattttcca gatcaaatct
     1381 gggaacgagg gtcgagagtt ctacatgcgg caaacagggc ctatcagtgc caccctggtg
     1441 atgacacgcc ccatcaaagg gcctcgggac atccagctgg acttggagat gatcaccgtc
     1501 aacactgtca tcaacttcag aggcagctcc gtgatccgac tgcggatata cgtgtcccag
     1561 tatccgttct gagcctcggg ttaaggcctc tgacactgcc ttttaccagc gccgagggac
     1621 aggaggagag aagaaaccag caagaatgag agcgagacag acattgcacc tttcctgctg
     1681 aacatctccc tggggcatca gcctagcatc ctgaccccta cctgtactat cgcagactgt
     1741 cactctgaag gacaccatgc ccccagttcc tatgatgcag ttatccaaaa gtattctcct
     1801 tgacccctga tgtgaggttg caagtgactc tccaaggcct tccatttatt tctatttttt
     1861 ttttaaaaaa aggaaaatag attaggtttg ctggggtagg agtctgtgtt caaagactga
     1921 gcagcttgtt cttgcctctg cccctccttc ctctatctct tgctgcattg ctgctttgca
     1981 aaagtcctca tgagctcatg ggaaatgctg ggtatagcta ttttgcttct tgcatgtgct
     2041 gagaaggcta tgggaacacg tcacagcagg atcgaaggtt tttaaagagt ctattttaaa
     2101 atcacgtctg gtattttcag cataagagaa gttttagttg ttcttacaat ttgtatgagt
     2161 gtttaacctt ttctcgttca ttttgagttt ttaaagtgat agaattcctt ccagaaggcc
     2221 tcagatacat gttatgttca gtctttctaa cctcagcctt ccctgcgtct tagcccagtt
     2281 tttatgaaga cccctttaat catgctttct taagagtttt tacccaactg ggttggaaga
     2341 cagaggtatc cggactgatt aaatatttga agaaa
//
