LOCUS       NM_001127547            2787 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus fibulin 1 (Fbln1), mRNA.
ACCESSION   NM_001127547 XM_001078267 XM_243637
VERSION     NM_001127547.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Ito S, Yokoyama U, Nakakoji T, Cooley MA, Sasaki T, Hatano S, Kato
            Y, Saito J, Nicho N, Iwasaki S, Umemura M, Fujita T, Masuda M, Asou
            T and Ishikawa Y.
  TITLE     Fibulin-1 Integrates Subendothelial Extracellular Matrices and
            Contributes to Anatomical Closure of the Ductus Arteriosus
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (9), 2212-2226 (2020)
   PUBMED   32640908
  REMARK    GeneRIF: Fibulin-1 Integrates Subendothelial Extracellular Matrices
            and Contributes to Anatomical Closure of the Ductus Arteriosus.
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X,
            Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins
            MT, Misra S, Stoughton J and Mayr M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Ge Q, Chen L, Jaffar J, Argraves WS, Twal WO, Hansbro P, Black JL,
            Burgess JK and Oliver B.
  TITLE     Fibulin1C peptide induces cell attachment and extracellular matrix
            deposition in lung fibroblasts
  JOURNAL   Sci Rep 5, 9496 (2015)
   PUBMED   25834989
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Twal WO, Hammad SM, Guffy SL and Argraves WS.
  TITLE     A novel intracellular fibulin-1D variant binds to the cytoplasmic
            domain of integrin beta 1 subunit
  JOURNAL   Matrix Biol 43, 97-108 (2015)
   PUBMED   25661773
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Tran H, VanDusen WJ and Argraves WS.
  TITLE     The self-association and fibronectin-binding sites of fibulin-1 map
            to calcium-binding epidermal growth factor-like domains
  JOURNAL   J Biol Chem 272 (36), 22600-22606 (1997)
   PUBMED   9278415
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Tran H, Tanaka A, Litvinovich SV, Medved LV, Haudenschild CC and
            Argraves WS.
  TITLE     The interaction of fibulin-1 with fibrinogen. A potential role in
            hemostasis and thrombosis
  JOURNAL   J Biol Chem 270 (33), 19458-19464 (1995)
   PUBMED   7642629
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Roark EF, Keene DR, Haudenschild CC, Godyna S, Little CD and
            Argraves WS.
  TITLE     The association of human fibulin-1 with elastic fibers: an
            immunohistological, ultrastructural, and RNA study
  JOURNAL   J Histochem Cytochem 43 (4), 401-411 (1995)
   PUBMED   7534784
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK and Argraves
            WS.
  TITLE     Fibulin binds to itself and to the carboxyl-terminal
            heparin-binding region of fibronectin
  JOURNAL   J Biol Chem 267 (28), 20120-20125 (1992)
   PUBMED   1400330
REFERENCE   10 (bases 1 to 2787)
  AUTHORS   Argraves WS, Tran H, Burgess WH and Dickerson K.
  TITLE     Fibulin is an extracellular matrix and plasma glycoprotein with
            repeated domain structure
  JOURNAL   J Cell Biol 111 (6 Pt 2), 3155-3164 (1990)
   PUBMED   2269669
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before May 23, 2008 this sequence version replaced
            XM_243637.4, XM_001078267.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2787
                     /gene="Fbln1"
                     /note="fibulin 1"
                     /db_xref="GeneID:315191"
                     /db_xref="RGD:1308667"
     exon            1..203
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2242
                     /gene="Fbln1"
                     /note="Fbln1 protein-like"
                     /codon_start=1
                     /product="fibulin-1 precursor"
                     /protein_id="NP_001121019.1"
                     /db_xref="GeneID:315191"
                     /db_xref="RGD:1308667"
                     /translation="MERPAPSRLVPLPLLLLGSLSLLAARANADISMEACCTEGNQMA
                     NQHRDCSLSYTSESKECRMVQEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLE
                     TIFIKRCCHCCMLGRAAQARGQTCEPNLMISYQCGLVFRACCVKGQENSDFVRGDGTD
                     LQDPAKIPEEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCED
                     INECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCP
                     PDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSY
                     TCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGYYF
                     DGISRTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECLNS
                     PCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ
                     CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSA
                     DTFRQEKTDTVRCIKSCRPTDEACMRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVT
                     PLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVGVVRQVRPIVGPFYAVLKLEMNY
                     VLGGVVSHRNVVNVHIFVSEYWF"
     exon            204..309
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..445
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..617
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..674
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..776
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..914
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1052
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1196
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1325
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1451
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1571
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1703
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1827
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1970
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2102
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2787
                     /gene="Fbln1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcctccgg gcgggataat tgaacgcggc gcgcaggaga cttgcgttgg ctgcccaggc
       61 ccggcttgat cgtgtagcgg ctgcccgccg tgcttttgtc cgccgcccga gcccgccagc
      121 cccaatggag cgccccgcgc cgtcgcgcct cgtcccgctg ccgctgctgc tgctcggcag
      181 cctctcgctg ctggcggccc gagcgaatgc agacatctcc atggaggctt gctgcacgga
      241 gggaaatcaa atggctaacc agcacaggga ctgctcgctc tcctacacct cagaatccaa
      301 ggagtgcagg atggtccagg aacagtgttg tcacaaccaa ctggaggagc tgcactgtgc
      361 cacaggcatc aacctggcca gcgaaccaga cggctgcgcc tccctccaca actacaacag
      421 tagcctcgag accatcttca taaagaggtg ctgccactgt tgcatgctgg gaagggcagc
      481 ccaggcccga ggccagacct gtgagcccaa cctcatgata agctaccagt gtggactggt
      541 attccgtgcc tgctgcgtga agggacagga gaattcagac tttgtcagag gcgatggtac
      601 ggaccttcag gacccagcta agattcctga ggaggaggaa caagaagacc catacctgaa
      661 cgaccgctgt cgaggtggcg ggccctgtaa gcagcagtgc cgtgacactg gggatgaggt
      721 catctgctct tgctttgtgg gctaccagct gcagtcggat ggtgtctcct gtgaagatat
      781 caatgaatgc atcaccggca gccataactg ccggctggga gaatcctgca tcaacacagt
      841 gggctctttc cgctgccagc gggacagcag ctgtgggact ggctatgagc tcacagagga
      901 taataactgc aaagatattg acgagtgtga gactggtatt cataactgcc cccccgattt
      961 tatctgtcag aatactctgg gatccttccg ttgcagaccc aagctgcagt gcaagagcgg
     1021 ctttatacag gatgctctag gcaactgcat tgatatcaat gagtgtttaa gtatcagtgc
     1081 cccatgccct gtggggcaga catgcatcaa tacagagggc tcctatacat gtcagaagaa
     1141 tgtgcccaac tgtggccgtg gatatcatct caacgaagag gggacccgct gtgttgacgt
     1201 ggatgagtgc tcaccaccag ccgagccctg tgggaaggga caccactgtt tgaactcccc
     1261 cggcagcttc cgctgcgagt gcaaggccgg gtactatttt gatggcatca gcaggacctg
     1321 tgtggatatc aacgagtgcc agcgctatcc tgggcgcctg tgtggccaca agtgtgagaa
     1381 cacgccaggc tcctaccact gcagctgctc tgcgggcttc cggctgtctg tggacggccg
     1441 gtcttgtgaa gacgtgaacg agtgccttaa cagcccttgc agccaggagt gtgctaacgt
     1501 ctatggctcc taccagtgct actgccgacg aggttatcag ctcagtgacg tggacggggt
     1561 cacctgcgaa gatattgatg agtgtgccct gcccacgggg ggtcacatct gctcctaccg
     1621 ctgcatcaac atcccgggaa gcttccagtg cagctgtccc tcatccggct acaggctagc
     1681 tcccaatggt cgcaactgcc aagacattga cgagtgtgtg accggtatcc acaactgttc
     1741 catcaacgag acctgcttca acatccaggg cagcttccgc tgtctatcct tcgagtgccc
     1801 tgagaactat cgccgctctg cagacacctt tcgccaagag aagacagaca ccgtccgctg
     1861 catcaagtct tgccgtccca ccgatgaggc ctgcatgcgg gaccctgtgc ataccgtctc
     1921 ccacactgtc atctccctgc ccaccttccg agagttcacc cgtccggagg agatcatctt
     1981 tctgagggct gtcacgccgc tgtatcctgc caaccaggct gacatcatct tcgacatcac
     2041 agaagggaac cttcgagact cctttgatat catcaagcgc tatgaggacg gcatgactgt
     2101 gggtgtcgtg cgccaagtgc ggcccatcgt gggcccattt tatgccgtcc tgaagctgga
     2161 gatgaactac gtgttgggag gcgtggtttc ccaccggaac gtcgtcaatg tgcatatctt
     2221 tgtctctgag tactggttct gaggaccggt ttgcagcacg gccaggagtg tacccctccg
     2281 cctggccacg cccttgctcc cagtgactgc caggtgcctg tctgtacccc tcgggcgttc
     2341 cttggtgttt catgttggtt tgtaaggcca catacattaa gctgagccac gtcacttaag
     2401 tccagctgac gtactgtgct gtttaaacat tgctcagtca tgtggttaaa tccttgcttt
     2461 tttttttttt tttttttttt tttttttaat gcaaaggtcg aattttattc tctttccctg
     2521 cctgtgggct aggcaatgct aaggaccaat tgaaggagtt ttcaaagcag cgctccaccc
     2581 aagagccaag aggtagccct tctcactgag tctgcttaag gggtgacatt ttggtacata
     2641 tatatatata tatatatata tatatatata tatatatata tatatgaata tgaatgagaa
     2701 aaaccaactg ggctctgtgt gcttcaaact gatggctgct gtagagcggt gcataaataa
     2761 atatacaata aattctcccc agaagca
//
