LOCUS       NM_001399241            2918 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus filamin binding LIM protein 1 (Fblim1),
            transcript variant 1, mRNA.
ACCESSION   NM_001399241 XM_008764275
VERSION     NM_001399241.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2918)
  AUTHORS   Calderwood,D.A., Campbell,I.D. and Critchley,D.R.
  TITLE     Talins and kindlins: partners in integrin-mediated adhesion
  JOURNAL   Nat Rev Mol Cell Biol 14 (8), 503-517 (2013)
   PUBMED   23860236
  REMARK    Review article
REFERENCE   2  (bases 1 to 2918)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   3  (bases 1 to 2918)
  AUTHORS   Ithychanda,S.S., Das,M., Ma,Y.Q., Ding,K., Wang,X., Gupta,S.,
            Wu,C., Plow,E.F. and Qin,J.
  TITLE     Migfilin, a molecular switch in regulation of integrin activation
  JOURNAL   J Biol Chem 284 (7), 4713-4722 (2009)
   PUBMED   19074766
REFERENCE   4  (bases 1 to 2918)
  AUTHORS   Lad,Y., Jiang,P., Ruskamo,S., Harburger,D.S., Ylanne,J.,
            Campbell,I.D. and Calderwood,D.A.
  TITLE     Structural basis of the migfilin-filamin interaction and
            competition with integrin beta tails
  JOURNAL   J Biol Chem 283 (50), 35154-35163 (2008)
   PUBMED   18829455
REFERENCE   5  (bases 1 to 2918)
  AUTHORS   Takafuta,T., Saeki,M., Fujimoto,T.T., Fujimura,K. and Shapiro,S.S.
  TITLE     A new member of the LIM protein family binds to filamin B and
            localizes at stress fibers
  JOURNAL   J Biol Chem 278 (14), 12175-12181 (2003)
   PUBMED   12496242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 5, 2022 this sequence version replaced XM_008764275.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1576473.1,
                                           SRR26643287.14865.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000005.1  159196769-159196816 c
            49-101              JAXUCZ010000005.1  159192799-159192851 c
            102-365             JAXUCZ010000005.1  159192132-159192395 c
            366-550             JAXUCZ010000005.1  159183597-159183781 c
            551-668             JAXUCZ010000005.1  159183011-159183128 c
            669-838             JAXUCZ010000005.1  159177969-159178138 c
            839-1017            JAXUCZ010000005.1  159176016-159176194 c
            1018-1135           JAXUCZ010000005.1  159173765-159173882 c
            1136-2918           JAXUCZ010000005.1  159167004-159168786 c
FEATURES             Location/Qualifiers
     source          1..2918
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2918
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /note="filamin binding LIM protein 1"
                     /db_xref="GeneID:362650"
                     /db_xref="RGD:1359551"
     exon            1..48
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            49..101
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            102..365
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1249
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CSX-associated LIM; heterogeneous nuclear
                     ribonucleoprotein L"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein L
                     isoform 1"
                     /protein_id="NP_001386170.1"
                     /db_xref="GeneID:362650"
                     /db_xref="RGD:1359551"
                     /translation="MASKQEKRVASSVFITLAPPRRDVAVTEEVTQAVCEARRARPWE
                     TLPTKTPGAAVGRSPKTWTPSGRTTASLPEVPPQLSNGGCSLPPPPLNEEDLDLLPPP
                     PPPPSAYLPLPEEEPPVVPGSSLISDLEQLHLPPPPPPPLLQAPSKGSSVQPQPVQVR
                     PSEEELPPPPEEPVTLPEREASTDVCGFCHKPVSPRELAVEAMKRQYHAQCFTCRTCR
                     RQLAGQRFYQKDGRPLCEPCYQDTLEKCGKCGEVVQEHVIRALGKAFHPPCFTCVTCA
                     RCISDESFALDNQNQVYCVTDFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHEN
                     CYRCEDCSVLLSVEPTDQGCYPLNDHLFCKPCHMKRSAAGCC"
     exon            366..550
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            551..668
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            669..838
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1017
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1135
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..2918
                     /gene="Fblim1"
                     /gene_synonym="Cal; hnRNP L; Hnrnpl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaggcg cagcgccggc cgaggccggg gaatggggcg cgcggcagtg gagctggcct
       61 gaactttgga ccttgccttc cagtaggaat cagtatctca gccccacagg agctgatcat
      121 ggcctccaag caagagaaga gggtggcctc ctctgtcttc atcaccctgg cccccccacg
      181 cagagatgtg gcagtgactg aggaagtgac ccaggcagtt tgtgaagccc gacgtgctcg
      241 accctgggag acccttccca caaagacacc tggggctgca gtgggcagga gccccaagac
      301 ctggacgccc tctggcagga ccactgcctc actccctgaa gtcccacctc agctctccaa
      361 tggaggatgc tctctcccac ctcctcccct gaatgaggag gacttagacc tcctcccgcc
      421 tcctccacca cccccttctg cctacctgcc tctcccagaa gaggagcctc ctgtcgtgcc
      481 cggatcatcg ctcatttctg acttggagca actgcacctg cccccacccc cacctccacc
      541 cctgctacag gctccatcaa agggatcttc ggtccagcct cagcctgttc aggtcaggcc
      601 ctcggaagag gagcttcctc cccctccaga agagcctgtt actcttccag agagagaagc
      661 atccacagat gtctgtggtt tctgtcacaa gcccgtgtcc cctcgagagc tggctgtcga
      721 ggccatgaag aggcagtacc atgcccagtg cttcacctgt cgtacctgcc gccgccagtt
      781 ggctggacag agattctacc agaaagatgg acgtcccctg tgcgaacctt gctaccagga
      841 tactctggag aagtgtggca agtgtggaga ggtagtccaa gagcatgtca tccgggccct
      901 tggcaaggcc ttccacccac cctgcttcac ctgcgtgacc tgtgcccggt gcatcagcga
      961 tgagagcttc gcgctggaca accagaacca ggtgtactgt gtgactgact tctacaggaa
     1021 atttgcccct gtgtgcagca tctgtgagaa tcccatcatc ccccgagacg ggaaggacgc
     1081 cttcaaaatc gagtgcatgg gaaggaattt ccatgaaaac tgttaccgtt gtgaggactg
     1141 cagtgtcctc ctgtctgtgg agcccaccga ccaaggctgc tacccgctga atgaccacct
     1201 cttctgcaaa ccttgtcaca tgaagcggag tgctgctggg tgctgctgaa gagtcccgat
     1261 ggctggcccg cccttccctg acttggtttc ccctcccgac ctttcttgca tacgttcctt
     1321 ttgagcctca ctgggcacta gcgcactgca ctgtccaaat gcatgggcct gagacactgg
     1381 ggcatggcct cctagtacat acacagcacc ctccagacag acttccaact cctctccctc
     1441 cattgaccag gaggcccctc accaccagag tgggaccctg gtccttccct agtgctggcc
     1501 tgatgtgttt atggggacag gtctcagggt gatgcctgtg tctctgacca tggtgcttaa
     1561 ctgcctggca gaaggtgctg aggcctcagc ttggagggtg gagctgagtt gtgtgaagtg
     1621 cgccatggtg gcacacacct ttaatcccag gacttgagag ggtgtctaca ttcccggcta
     1681 gtctgatcta cagagtgggt tctatttaaa tgatgcaaaa caatattctt tggattgggg
     1741 ggagagaaat ctcttaattt ttcttttctt ttttggtggg gtaaaatcac taaatatctt
     1801 cccttggttc gggggctgcc aagctggctc agcggttaag agcgtttgct ccttttgcag
     1861 aagaccagag ttcatttccc agacccacca tggaggctca taaaactacc tgtcctgtaa
     1921 ctccagttcc aggaggtctg gtgccctcta ctggcctctt tggaacctga ctgaacatgg
     1981 cgtacacacg cacgcacgca cacacacacc tttaatccca gtacttggga ggcagaggca
     2041 ggtggatctc tgcattggaa ggcagccaga gctacaacgt ttaaaaacca aaccaaacaa
     2101 aaaacctacc tgggtttggt ggtgcatacc tatgacccca gtgcttggga gaattgccag
     2161 aagcttgaga cctgcttggt cttcatagaa ttccacatca gtcttggcag cgttcagagt
     2221 ctctgtctca gaaataaata aacaaactat aaatacataa gaatgtgaag tagtgaccac
     2281 tcagcctccc tgcctctgaa acacctgctg acttggagct gggctcatgg aggagaggga
     2341 ggttgatgag cagcctcctc ctgcttccgg accctgctgt gagcttttgg agtagctcac
     2401 agacttggat taagtgcctt tgacttgcta gggaacacat ttggggctga gcctctttcc
     2461 tccagacttc ttcactgtga ctgtggcctc aacaagtaca tacatgtgtg tggttgtgaa
     2521 cacacacaca cacacacccc agaatgaggc cagagaaagt cacatctctg gcctcccatt
     2581 tgtatcttcc agccctcact tcagctcttc agctaggctg ctcaaaacca ctgcctctgt
     2641 gaggccacac ctagaacatt cttccttttg atgactcagc tggtcatcaa agaggccctt
     2701 gactccaagt ctgatgaccc gagttccatc tctgggaccc acaaggaagg agagaacgaa
     2761 ctcccacaag ctgtcctctg gtttacacct gcacaccaag atacacatct gtgcacacac
     2821 atctaataga gataaaatgt aaagtagaaa aaaatcacgt ttgtgctttg taacttctga
     2881 ggtgcacgta gaaaaattaa acctattttc ctggcttg
//
