LOCUS       NM_001025643            1208 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus fibrillarin (Fbl), mRNA.
ACCESSION   NM_001025643 XM_214836
VERSION     NM_001025643.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Iyer-Bierhoff,A., Krogh,N., Tessarz,P., Ruppert,T., Nielsen,H. and
            Grummt,I.
  TITLE     SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A
            Methylation and rRNA Synthesis during the Cell Cycle
  JOURNAL   Cell Rep 25 (11), 2946-2954 (2018)
   PUBMED   30540930
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Tessarz,P., Santos-Rosa,H., Robson,S.C., Sylvestersen,K.B.,
            Nelson,C.J., Nielsen,M.L. and Kouzarides,T.
  TITLE     Glutamine methylation in histone H2A is an
            RNA-polymerase-I-dedicated modification
  JOURNAL   Nature 505 (7484), 564-568 (2014)
   PUBMED   24352239
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Brandis,K.A., Gale,S., Jinn,S., Langmade,S.J., Dudley-Rucker,N.,
            Jiang,H., Sidhu,R., Ren,A., Goldberg,A., Schaffer,J.E. and Ory,D.S.
  TITLE     Box C/D small nucleolar RNA (snoRNA) U60 regulates intracellular
            cholesterol trafficking
  JOURNAL   J Biol Chem 288 (50), 35703-35713 (2013)
   PUBMED   24174535
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Sugihara,Y., Sadohara,E., Yonezawa,K., Kugo,M., Oshima,K.,
            Matsuda,T. and Nadano,D.
  TITLE     Identification and expression of an autosomal paralogue of
            ribosomal protein S4, X-linked, in mice: potential involvement of
            testis-specific ribosomal proteins in translation and
            spermatogenesis
  JOURNAL   Gene 521 (1), 91-99 (2013)
   PUBMED   23500592
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Brehm,M.A., Wundenberg,T., Williams,J., Mayr,G.W. and Shears,S.B.
  TITLE     A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate
            2-kinase in the synthesis of ribosomal RNA
  JOURNAL   J Cell Sci 126 (Pt 2), 437-444 (2013)
   PUBMED   23203802
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Yang,Y., Isaac,C., Wang,C., Dragon,F., Pogacic,V. and Meier,U.T.
  TITLE     Conserved composition of mammalian box H/ACA and box C/D small
            nucleolar ribonucleoprotein particles and their interaction with
            the common factor Nopp140
  JOURNAL   Mol Biol Cell 11 (2), 567-577 (2000)
   PUBMED   10679015
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Baran,V., Vesela,J., Rehak,P., Koppel,J. and Flechon,J.E.
  TITLE     Localization of fibrillarin and nucleolin in nucleoli of mouse
            preimplantation embryos
  JOURNAL   Mol Reprod Dev 40 (3), 305-310 (1995)
   PUBMED   7772340
REFERENCE   8  (bases 1 to 1208)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   9  (bases 1 to 1208)
  AUTHORS   Jimenez-Garcia,L.F., Rothblum,L.I., Busch,H. and Ochs,R.L.
  TITLE     Nucleologenesis: use of non-isotopic in situ hybridization and
            immunocytochemistry to compare the localization of rDNA and
            nucleolar proteins during mitosis
  JOURNAL   Biol Cell 65 (3), 239-246 (1989)
   PUBMED   2752212
REFERENCE   10 (bases 1 to 1208)
  AUTHORS   Lischwe,M.A., Ochs,R.L., Reddy,R., Cook,R.G., Yeoman,L.C.,
            Tan,E.M., Reichlin,M. and Busch,H.
  TITLE     Purification and partial characterization of a nucleolar
            scleroderma antigen (Mr = 34,000; pI, 8.5) rich in
            NG,NG-dimethylarginine
  JOURNAL   J Biol Chem 260 (26), 14304-14310 (1985)
   PUBMED   2414294
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099198.1.
            
            On Jul 22, 2005 this sequence version replaced XM_214836.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099198.1, SRR8487231.92465.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1208
                     /gene="Fbl"
                     /note="fibrillarin"
                     /db_xref="GeneID:292747"
                     /db_xref="RGD:1305542"
     exon            1..105
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1079
                     /gene="Fbl"
                     /note="nucleolar protein 1; histone-glutamine
                     methyltransferase; U6 snRNA 2'-O-methyltransferase
                     fibrillarin"
                     /codon_start=1
                     /product="rRNA 2'-O-methyltransferase fibrillarin"
                     /protein_id="NP_001020814.1"
                     /db_xref="GeneID:292747"
                     /db_xref="RGD:1305542"
                     /translation="MKPGFSPRGGGFGGRGGFGDRGGRGGGRGGRGGFGGGRGGFGGG
                     GRGRGGGGGGFRGRGGGGGRGGGFQSGGGRGRGGGRGGKRGNQSGKNVMVEPHRHEGV
                     FICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQ
                     IHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIP
                     VIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCID
                     STASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKAKN"
     exon            106..288
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     exon            289..491
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     exon            492..662
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     exon            663..795
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     exon            796..908
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1054
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1181
                     /gene="Fbl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcgcag gcgctttttt ccacgtgtga aagcctgaga ctcgtggagt ccggcacgcc
       61 gctggttgtc tgagtcgcgc caccagcacg cagtaatgaa gccaggtttc agcccccgtg
      121 ggggcggctt tggtggcaga ggcggctttg gtgacagagg tggtagagga ggaggccgag
      181 gagggagagg aggttttggc ggtggacgag gaggctttgg cggtggaggt cgaggtcgag
      241 gtggaggagg cggtggcttc aggggacgag gaggtggagg tggacgaggt ggaggcttcc
      301 agtctggggg cggccggggt cgaggtggtg gccggggagg caagagagga aaccagtcag
      361 ggaagaatgt gatggtggag ccccatcggc atgaaggagt ctttatctgt cgcggaaagg
      421 aggatgccct tgtcacaaag aatctggttc ctggagaatc tgtgtatgga gagaagagag
      481 tctctatctc cgaaggagat gacaaaattg agtaccgagc ctggaacccc ttccgctcca
      541 agctggccgc agcaatcctg ggtggcgtag accagatcca catcaagccg ggggccaagg
      601 tgctctacct tggggcagcc tcaggcacca ccgtctccca cgtgtctgac attgttggcc
      661 cggatggtct ggtctacgca gttgagttct cccaccgctc tggccgtgac ctcatcaact
      721 tggccaagaa gaggaccaac attattcctg taattgaaga tgctcggcac ccacacaaat
      781 accgcatgct tattgcaatg gtggatgtca tctttgccga tgtggcccag ccagaccaaa
      841 cccgaattgt ggccctgaat gcccacacct tcctgcggaa tggaggacac tttgtgattt
      901 ccattaaggc caactgcatt gactccacag cctcagcaga agctgtgttt gcatctgaag
      961 tgaaaaagat gcagcaagag aacatgaagc ctcaggagca gttgacacta gagccttatg
     1021 aacgagacca cgctgtggtt gtaggtgtgt acaggccacc tcccaaggcg aagaactgaa
     1081 actcgactgt ctggattgaa gaaatgtgtg ttgttgctac tgttgcacat gtggcttttg
     1141 actttttgca ggggattttt ctattaaaag actaatctgt caaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaa
//
