LOCUS       NM_001106119            3530 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus F-box DNA helicase 1 (Fbh1), mRNA.
ACCESSION   NM_001106119 XM_001069012 XM_214505
VERSION     NM_001106119.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3530)
  AUTHORS   Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C and Hickson ID.
  TITLE     FBH1 influences DNA replication fork stability and homologous
            recombination through ubiquitylation of RAD51
  JOURNAL   Nat Commun 6, 5931 (2015)
   PUBMED   25585578
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3530)
  AUTHORS   Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K,
            Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E and Hickson
            ID.
  TITLE     FBH1 helicase disrupts RAD51 filaments in vitro and modulates
            homologous recombination in mammalian cells
  JOURNAL   J Biol Chem 288 (47), 34168-34180 (2013)
   PUBMED   24108124
REFERENCE   3  (bases 1 to 3530)
  AUTHORS   Masuda-Ozawa T, Hoang T, Seo YS, Chen LF and Spies M.
  TITLE     Single-molecule sorting reveals how ubiquitylation affects
            substrate recognition and activities of FBH1 helicase
  JOURNAL   Nucleic Acids Res 41 (6), 3576-3587 (2013)
   PUBMED   23393192
REFERENCE   4  (bases 1 to 3530)
  AUTHORS   Jeong YT, Rossi M, Cermak L, Saraf A, Florens L, Washburn MP, Sung
            P, Schildkraut CL and Pagano M.
  TITLE     FBH1 promotes DNA double-strand breakage and apoptosis in response
            to DNA replication stress
  JOURNAL   J Cell Biol 200 (2), 141-149 (2013)
   PUBMED   23319600
  REMARK    Erratum:[J Cell Biol. 2013 Jun 24;201(7):1087. Schildkraut, Carl
            [corrected to Schildkraut, Carl L]]
REFERENCE   5  (bases 1 to 3530)
  AUTHORS   Fugger K, Chu WK, Haahr P, Kousholt AN, Beck H, Payne MJ, Hanada K,
            Hickson ID and Sorensen CS.
  TITLE     FBH1 co-operates with MUS81 in inducing DNA double-strand breaks
            and cell death following replication stress
  JOURNAL   Nat Commun 4, 1423 (2013)
   PUBMED   23361013
REFERENCE   6  (bases 1 to 3530)
  AUTHORS   Fugger K, Mistrik M, Danielsen JR, Dinant C, Falck J, Bartek J,
            Lukas J and Mailand N.
  TITLE     Human Fbh1 helicase contributes to genome maintenance via pro- and
            anti-recombinase activities
  JOURNAL   J Cell Biol 186 (5), 655-663 (2009)
   PUBMED   19736316
REFERENCE   7  (bases 1 to 3530)
  AUTHORS   Kim J, Kim JH, Lee SH, Kim DH, Kang HY, Bae SH, Pan ZQ and Seo YS.
  TITLE     The novel human DNA helicase hFBH1 is an F-box protein
  JOURNAL   J Biol Chem 277 (27), 24530-24537 (2002)
   PUBMED   11956208
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473990.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001069012.1, XM_214505.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132265 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.2"
     gene            1..3530
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /note="F-box DNA helicase 1"
                     /db_xref="GeneID:291293"
                     /db_xref="RGD:1306298"
     exon            1..133
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..3261
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /EC_number="3.6.4.12"
                     /note="F-box only protein 18; F-box protein, helicase, 18"
                     /codon_start=1
                     /product="F-box DNA helicase 1"
                     /protein_id="NP_001099589.1"
                     /db_xref="GeneID:291293"
                     /db_xref="RGD:1306298"
                     /translation="MRRFKRKHLTVVDCQQLARSHLAATQPFSQRWTNRDPNHGLYPR
                     ARTKGRNRGRGCQRYISEFFLASHQHCTNDMAKSNSVGQDSCQDSENDMIFPAESSCS
                     LPQVENGEVRLGSPGSAQPARKRPRSLEEATESGQWDGVTKKTPRHRLFPSCARLREV
                     RQGAEDGLSQSSPVHGEAAQDIEDIGPDPLPDSYYGLLGTLPCQEVPSHICRLPSEVL
                     RHIFAFLPVEDLYWNLSLVCHLWREIVNDPLFIPWKKLYHRYLINEEQAVSKVDGILS
                     SHGIEKDSDLCVLNLIRYTATTKCSPSVDPERVLWSLRDHPLLLEAEACMRQQLPDLY
                     AAAGGINVWALVAAMVLLSSCVNDIQHLLFCLRRPRSTVTMPDVTETLYCIAVLLYAM
                     REKGINISNRIHYNIFYCLYLQENSCTQATKVTEEPSVWPGKKTSIQLTHEQQLILNH
                     KMEPLQVVKIMAFAGTGKTSTLVKYAEKWSQSRFLYVTFNKSIAKQAELVFPSNVICK
                     TFHSMAYSHVGRKYQLKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKTLENFFASA
                     DEELTIDHVPIWCKNSQGQRVMVEQSEKLNGVLEASRLWDNMRKLGECKEEAYQMTHD
                     GYLKLWQLSKPLLASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQQIYTFRGA
                     VNALFTVPHTHVFYLTQSFRFGVEIAYVGATILDVCKRVRKKTLVGGNHQSGIRGDVK
                     GQVALLSRTNANVFDEAVRVTEGESPARIHLIGGIKSFGLDRIIDIWTLLQPEEERRK
                     RDLIIKDRFIRRWVHKEGFSGFKRYVTAAEDKELEAKIAVVEKYNVRIPELVERIERC
                     HIEDLDFAEYILGTVHKAKGLEFDTVHVLDDFVKVPCARHNLGQLPHFRVESFSEDEW
                     NLLYVAVTRAKKRLIMTKSLENILTLAGEYFLQAELTSNVLKTGVVHCCVGQCNNTIP
                     VDTILTMRKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAMERTVEDLV
                     LPRHEALLFLVF"
     exon            134..289
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            290..879
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1010
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1146
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1337
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1430
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1525
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1694
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1917
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2005
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2092
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2229
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2329
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2451
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2527
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2725
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2851
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2958
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3090
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3530
                     /gene="Fbh1"
                     /gene_synonym="Fbxo18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaggaag tctgcagtcg tctctgctcg ctgcctgggc cgaaggaggg gcttgctggt
       61 cggggaaagg ctggatgtcc agcggcatcg gccgggtggt gtcggcggcg gggaccaggg
      121 ccgggccgcc atatgagacg gtttaagcgg aagcatctta cagtggtcga ctgccagcaa
      181 ctggcccgga gtcatttggc tgcgactcag cccttcagtc agagatggac aaacagagac
      241 cctaaccatg gtctctatcc tagagccaga acaaaaggac ggaatagggg tcgaggatgt
      301 cagagataca tttctgagtt cttcctagct agccaccagc attgtaccaa tgacatggcc
      361 aaaagcaatt ctgttggcca ggacagctgt caggactctg agaatgatat gatttttcct
      421 gccgagagca gttgttctct gcctcaggtg gaaaatggag aagtgaggct gggctcacca
      481 ggatctgctc agcccgccag gaagcggcct cgttccttgg aggaagccac agagagcggc
      541 cagtgggatg gggttactaa gaagacgcca cgccatcgtt tgttcccatc gtgtgcaagg
      601 cttagggagg tcaggcaagg agcagaggat ggtttgtcac agagctctcc agtacatgga
      661 gaagctgccc aagacattga ggacattggt cctgatccct tgcctgattc atactatggg
      721 cttcttggaa cgttgccttg ccaggaagtg cccagccaca tctgcaggct gccaagtgaa
      781 gtcctgaggc acatctttgc tttcctgcca gtggaggacc tctactggaa cctcagcctg
      841 gtgtgccacc tgtggaggga aatagtcaat gacccgctgt tcattccttg gaagaagctg
      901 tatcatcggt acttgatcaa cgaagagcag gctgtcagca aagtggacgg cattctctcc
      961 agccacggca tagaaaagga ttcggacttg tgtgtgctga acctcatacg atacacagcc
     1021 accaccaagt gctccccaag tgtggaccct gagagggtgc tatggagcct gagggatcac
     1081 cctctacttt tggaggctga ggcgtgcatg cgtcaacaac tacctgacct ctatgcagct
     1141 gctgggggca ttaacgtctg ggccttggtg gccgccatgg tgctcctctc cagctgtgtg
     1201 aacgacatcc agcacctgct cttctgcctc aggagaccca ggtccacagt gaccatgcca
     1261 gacgtcaccg agaccttata ctgcatagct gtgctcctct atgccatgag ggagaagggg
     1321 attaacatca gcaacaggat tcactacaac attttctatt gcctatatct tcaggagaat
     1381 tcctgtactc aggccaccaa agttacagag gagccgtctg tctggccagg caagaaaaca
     1441 tctatccaac taacacatga acagcagctg attctgaacc ataagatgga gcctctccag
     1501 gtggtaaaaa ttatggcatt tgcaggcacc gggaagacgt ctaccctggt caagtatgct
     1561 gagaagtggt ctcagagcag gtttctgtat gtcaccttca acaagagcat cgccaagcag
     1621 gcagagcttg tcttccccag caacgtcatc tgcaaaacct tccactccat ggcctacagt
     1681 cacgtcgggc ggaagtacca gctgaagaag aagctcaatc tcttcaagct gacacccttc
     1741 atggtcaact ctgtccttgc tgaaggaaaa ggtggattca taagggccaa gttagtgtgt
     1801 aagacattag aaaacttctt tgcatcagct gatgaagagc ttactatcga tcatgtgccc
     1861 atttggtgca agaatagcca aggacagaga gtcatggttg aacagagtga gaagctgaat
     1921 ggtgttcttg aagcaagccg actctgggac aacatgagga agctggggga atgcaaagaa
     1981 gaggcatacc aaatgacaca tgacggctat ttgaaactct ggcagctgag caaacctttg
     2041 cttgcctctt ttgacgccat ctttgtggat gaggcccagg actgtacccc agctatcatg
     2101 aacatagttc tgtctcagcc atgcgggaag atctttgtag gagaccccca ccaacagatc
     2161 tataccttcc gaggtgcagt gaatgccctg ttcacagtcc cccacactca cgtcttctat
     2221 ctcacacaga gctttaggtt tggtgtggaa atagcctatg tgggagctac cattttggat
     2281 gtctgcaaga gagtcaggaa aaagacgctg gttggaggga accatcagag tggcataaga
     2341 ggtgatgtaa agggacaagt ggctctgctg tctcggacca atgccaatgt gtttgacgag
     2401 gccgtccggg tgacagaagg agaatcgcct gcacggatac atttgatcgg cgggattaaa
     2461 tcatttggat tggacagaat cattgacatt tggactcttc ttcaaccaga ggaagaacgg
     2521 aggaaacgag acctcatcat taaagacagg ttcatcagaa gatgggtgca taaagaaggc
     2581 ttcagtggct tcaagaggta tgtgactgct gcagaggaca aggagctgga agcgaagatc
     2641 gcagtagttg aaaaatacaa tgtcaggatc ccagaactgg tagaaaggat agagagatgc
     2701 cacatagaag atttggactt tgcagagtac attttgggca ccgtgcacaa agccaaaggg
     2761 ttagagtttg acacggtgca tgttttggat gatttcgtga aagtgccttg tgccaggcat
     2821 aaccttggtc agcttcctca cttcagagtt gagtcgtttt ctgaggatga atggaattta
     2881 ctctatgttg ctgttactcg tgccaagaag cggcttataa tgaccaaatc actggagaac
     2941 attctgactc tggctgggga gtatttcttg caggcagagc tgacaagtaa cgtcttgaaa
     3001 acaggagtgg tccactgctg tgtggggcag tgcaacaaca ccatccctgt ggacaccatc
     3061 cttaccatga ggaaactgcc tatcacctat agcaacagga aggaaaacaa aggtggctac
     3121 ctgtgccact cctgcgcaga acagcggatc gggcctttgg cattcctgac tgcctcccca
     3181 gagcaggtgc gcgccatgga acgcacggtg gaagacctcg tgctgcccag gcacgaggcc
     3241 ctgctcttcc tcgtcttctg aggctgtgac tcccatgctg aaggagccat gccaggctgc
     3301 attcctgctc atgggagcct ctctgaggag gaagatacca gccagagttg gtcctgccat
     3361 ttctccgttc cttacagata gccagttccc acttgcctgt cctccacatg catcaggtca
     3421 gggaagtgga agaagttctt ttgataaaaa atcattttat gtatttaaac ttttattaca
     3481 tggtttcaat taaacaggca tcgcccagtg gcgtgccact gtgaagtctc
//
