LOCUS       NM_022954              14560 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus FAT atypical cadherin 2 (Fat2), mRNA.
ACCESSION   NM_022954 XM_346393
VERSION     NM_022954.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 14560)
  AUTHORS   Nibbeling,E.A.R., Duarri,A., Verschuuren-Bemelmans,C.C.,
            Fokkens,M.R., Karjalainen,J.M., Smeets,C.J.L.M., de
            Boer-Bergsma,J.J., van der Vries,G., Dooijes,D., Bampi,G.B., van
            Diemen,C., Brunt,E., Ippel,E., Kremer,B., Vlak,M., Adir,N.,
            Wijmenga,C., van de Warrenburg,B.P.C., Franke,L., Sinke,R.J. and
            Verbeek,D.S.
  TITLE     Exome sequencing and network analysis identifies shared mechanisms
            underlying spinocerebellar ataxia
  JOURNAL   Brain 140 (11), 2860-2878 (2017)
   PUBMED   29053796
REFERENCE   2  (bases 1 to 14560)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 14560)
  AUTHORS   Matsui,S., Utani,A., Takahashi,K., Mukoyama,Y., Miyachi,Y. and
            Matsuyoshi,N.
  TITLE     Human Fat2 is localized at immature adherens junctions in epidermal
            keratinocytes
  JOURNAL   J Dermatol Sci 48 (3), 233-236 (2007)
   PUBMED   17900869
REFERENCE   4  (bases 1 to 14560)
  AUTHORS   Nakayama,M., Nakajima,D., Yoshimura,R., Endo,Y. and Ohara,O.
  TITLE     MEGF1/fat2 proteins containing extraordinarily large extracellular
            domains are localized to thin parallel fibers of cerebellar granule
            cells
  JOURNAL   Mol Cell Neurosci 20 (4), 563-578 (2002)
   PUBMED   12213440
REFERENCE   5  (bases 1 to 14560)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB011527.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346393.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011527.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..14560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..14560
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /note="FAT atypical cadherin 2"
                     /db_xref="GeneID:65048"
                     /db_xref="RGD:620656"
     exon            1..114
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            115..3385
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..13182
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /note="protocadherin Fat 2; multiple epidermal growth
                     factor-like domains 1; multiple EGF-like domains protein
                     1; FAT tumor suppressor homolog 2; multiple epidermal
                     growth factor-like domains protein 1; MEGF1"
                     /codon_start=1
                     /product="protocadherin Fat 2 precursor"
                     /protein_id="NP_075243.1"
                     /db_xref="GeneID:65048"
                     /db_xref="RGD:620656"
                     /translation="MTLVLLGLAILLLHRAACEKSLEETIPPLSWRFTHSLYNATIYE
                     NSAPKTYVESPVKMGMYLAEPHWVVKYRIISGDAAGVFKTEEHVVGNFCFLRIRTKSS
                     NTALLNREVRDSYTLIVQASDKSLEFEALTQVVVHILDQNDLKPLFSPPSYRVTISED
                     RPLKSPICKVTATDADLGQNAEFYYAFNARSEVFAIHPTSGVVTVAGKLNVTRRGKYE
                     LQVLAVDRMRKISEGNGFGNLASLVIRVEPVHRKPPAINLVVLNPPEGDEGDIYAIVT
                     VDTNGSGAEVDSLEVVGGDPGKYFKVLRSYAQGNEFNLVAVRDINWAEHPHGFNISLQ
                     THSWSRFPPHSIIRAFHLPSWKLANLRFEKAVYRVKLSEFSPPGSRVALVKVTTALPN
                     LRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVKTSLGQATTTVIIDIVD
                     CNNHAPVFNRSSYEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSIAGPKAVPFSID
                     PLLGVISTTKPMDYELMKRIYTFRVRASDWGSPFRQEKEVSVSLRLKNLNDNQPMFEE
                     VNCTVSLRQDVPVGKSIMAVSAIDMDELQNLKYEIVSGNEQDYFHLNHFSGVISLKRS
                     FMNLTAVRPTIYSLKITASDGKNYASPTTLKVTVVKDPHSEVPVQCDKTGVLTHITKT
                     ILQSAGLQSQELGEEEFTSLSNYQINHHSPQFEDHFPQSIDILEQVPINTPLARLAAT
                     DPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTP
                     PKSSWKLLTVTVKDWNDNPPRFPPGGYQLTISEDTEVGTTIAELKTEDADSEDNRRVR
                     YTLLTPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPTKGHQLFSVTDLIVT
                     LEDINDNPPQCITEHRRLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVEDAHGTF
                     QVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPLSRRTLCHVEVLVMDVNENLHSP
                     HFSSFVYQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGM
                     LETLAPLDREFTPYYWLTVLAVDRGSVPLSAVTEVYIEVTDINDNIPSMSRPVFYPSV
                     LEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDREN
                     KDEYVLEVTVQDNGDPSLRSTSRVVVCILDVNDNPPMFSHKLFNVRLSERLSPLSPEP
                     VYRLVASDPDEGLNGSVTYSIEESDEESFRIDPVTGVVSSSSTFAAGEYNILTIKATD
                     SGQPALSTSVRLHIEWIPQPRPSSIPLSFDESYYSFTVMETDPVNHMVGVISVEGRPG
                     LFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDGFHTIATQVHIF
                     MIANINHHRPQFLQDHYEIRVPQDTLPGVELLRVQATDQDHGKGLIYTILSSQDPGSA
                     NLFQLDPSSGVLVTVGTLELHSGPSQHILTVMVRDQEMPIKRNFVWVTIHVEDGNLHS
                     PHFTQLRYEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLG
                     IITVAQRLYHVHLTRHALTVKAEDQGSPRRHDLALVVIHVHPSDSSAPVFSKDEYFIE
                     IPESVPIGSPILLLSAGSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSY
                     RLRIRGSNMAGVFTEVVALVYIIDENDNPPAFGKPTFLGHISEAAPLHSLILGEDNSP
                     LVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYV
                     HDQGTPILFAPRSAKVIIHVRDVNDSPPRFSEQIYEVAVVEPIHPGMGLLTVQAEDND
                     SRVTYSIKTSNADEAVTIHPTTGQISVVNPATLRLFQKFSIRASDGLYHDTAVVKISL
                     TQVLDKSLQFDQDVYRARVTENTPHRKALVILGVHGNHLNDTLSYFLLNGTDLFHMIE
                     SAGVLQTRGGTFDREQQDTHEVAVEVRDNRVPQRVAQALVRVSVEDVNDNIPEFQHLP
                     YYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYAYFRIDPYVGDISLKKPFD
                     YQALNKYHLRVIARDSGIPPLQTEVEVHVTVRNKSNPLFQSPYYKVKVPENITLYTPI
                     LHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDT
                     ALGSFSEATVEVLVEDINDNPPTFSQLVYTTSVSEGSPAQTPVIQLLASDQDSGQNQD
                     VSYQIVEDGSDVSKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGDPPLTGETL
                     VVVNVSDINDNPPKFREPQYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGN
                     QDRHFSINSTSGIISMFNLCKKQLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPE
                     FQQNVYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPRGQIT
                     TLQKLDRENSTERVIAIKVMARDGGGKVAFCTVKIILTDENDNAPQFKASGYTVSIPS
                     NVSRDSPIIQVLAYDADEGRNADVTYSVDSTEDLAEEIIEVNPTTGVVKVKESLVGLE
                     NRAVDFNIKAQDGGPPHWDSLVPVRLQVVPNEIPLPKFSEPLYTFSAPEDLPEGSEIG
                     SVKAVAAQDPIIYSLVQGTTPESNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMA
                     HCPHEDTDLVSLVSVSIQVEDVNDNRPVFEADPYKAFLTENMPGGTTVIQVTANDQDT
                     GSDGQVSYRLSVEPGSNIHELFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQTI
                     QLSSQALVEVSITDENDNPPRFASEDYRGSVVENNEPGELVATLKTLDADVSDQNRQV
                     TCYITEGDPLGQFSISQVGDEWRISSRKTLDREHIAKYLLRVTASDGKFQASVPVEVF
                     VVDINDNSPQCSQLLYTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSLHGPGAQEF
                     KLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQSCQAEVTLHIEDVNDNAPRFFPS
                     HCDVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLTDSADGQFSIDATSGVIRLEKP
                     LQVRASSAVELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPIFLNAEHSTQVPEDAP
                     IDMEVLHLATLTRPGSEKTGYHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLS
                     IECSRKSSSSLSDVTTIVINVTDVNEHHPRFTHDLYTVRVLENAVVGDVILTVSASDD
                     DGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPPL
                     HEDTEVAVEVVDVNDNPPRFFQLNYSTSVQENSPIGIKVLQLILDDPDSPQNGPPYFF
                     RITEGNTGSVFRVTPDGWLVTAASLSKKAREWYQLHIEVSDSGLPPLSSSTLVRVQVT
                     EQSRYPPSTLPLEISITKGEEEFQGGMIGKIHATDRDPQDTLTYSLEQEGGLDRYFTV
                     GASDGKIIASQGLPHGRYSFNVTVSDGTFTTTTGVHVHVWHMEPEVPQQAVWLGFHQL
                     TPEELVSDHWRNLQRFLSNLLDVKRANIHLASLQPAEVTAGVDVLLVFERHSGTSYDL
                     QELASAIAHSVREIEHSVGIRMRSALPVVPCQGQSCQDQTCQETVSLEPRVGPSYSTA
                     RLSILTPRHHLGRNCSCNGTTLRFSGQSYVQYRPLEAQNWQIHFYLKTLQPWALLMFT
                     NETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDI
                     TDNASLVIPEECQGLRTERQLLLGGLVPSNPSSNVSLGFEGCLDAVVVNGERLELLGR
                     EKKMEGRLETWALSQCCWPGTACSQSPCLNGGSCSPALGSGYLCRCPPPFSGRNCELG
                     RENCTSAPCQEGGTCVSSPEGTSCNCPHPYTGDRCEMEARGCSGGHCLITPEIKRGDW
                     GQQEFLVITVALPLVIIATVGLLLYCRRRKSHKPVTMEDPDLLARSIGVDTQASPAIE
                     LDPLNTSSCNNLNQPEPSKTSVPNELVTFGPSSKQRPMVCSVPPRLPPAAVSSHPGHE
                     PIIKRTWSGEELVYPSGAAVWPPTYSRKKHWEYPHPETMQGTLPPSPRRHVGPAVMPD
                     PTGLYGGFPFPLELENKRAPLPPRYSNQNLEDLMPPRPPSPREHLLAPCLNEYTAISY
                     YHSQFRQGGGGPCLAEGGYKGVSMRLSRAGPSYADCEVNGGPATGRSQPRAPPNYEGS
                     DMVESDYGSCEEVMF"
     exon            3386..3700
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..3759
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            3760..4071
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4282
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            4283..4422
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            4423..4704
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4915
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            4916..8974
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            8975..9171
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            9172..9325
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            9326..9559
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            9560..9943
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            9944..10158
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            10159..10296
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            10297..10440
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            10441..10638
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            10639..11449
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            11450..11595
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            11596..12037
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            12038..12191
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            12192..12649
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     exon            12650..14560
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      14560
                     /gene="Fat2"
                     /gene_synonym="Fath2"
                     /note="31 a nucleotides"
ORIGIN      
        1 gttggctcct gctcctccgt ccttccctct ggagccttca gctaagccct ggggacagga
       61 gccccagccc agcatccact ccttccaggc accctctcca cctgaggagg acaggagttt
      121 ttcatcatga ctcttgtcct gctgggtcta gccatcctgt tgctccaccg tgcagcctgt
      181 gagaagtccc tagaagaaac catccccccc ttgtcttggc gcttcacgca ttccttgtac
      241 aacgccacca tctatgaaaa ctctgctccc aagacctatg tggagagccc agtgaagatg
      301 ggcatgtatc tggcagagcc ccactgggtg gtgaaatacc ggatcatctc tggcgatgca
      361 gccggagtat ttaagacgga ggagcatgtg gtaggcaact tctgctttct gagaataagg
      421 accaagagca gcaacacggc acttctcaac agggaggtgc gagacagcta cacactcatc
      481 gtgcaagcct cagacaagag cctggagttc gaagcgctga cccaagtggt ggtccacatc
      541 ctggatcaga atgacctgaa gcccctcttt tccccacctt cctacagagt caccatctcg
      601 gaggacaggc ccctcaagag ccccatctgc aaagtgactg ccacagatgc cgatctgggc
      661 cagaacgctg agttctatta tgcctttaat gccaggtcag aggtctttgc catccacccc
      721 accagtgggg tggtcactgt ggctggaaag ctgaatgtca cacggcgagg caagtatgag
      781 ctccaggtgc tggctgtgga ccgcatgaga aaaatctcgg agggcaatgg atttggcaac
      841 ttggcttcgt tggtaattcg tgtggagcct gtgcacagga agcccccagc tatcaactta
      901 gtggtcctga atccaccaga aggtgatgaa ggtgacatct atgccatcgt cacggtggac
      961 acaaacggtt caggagctga agtagattcc ctggaagtgg ttggtggtga ccctggaaag
     1021 tacttcaagg tcctcaggtc ctatgcccaa ggcaatgagt tcaatttggt ggcagtcagg
     1081 gacattaatt gggcagaaca ccctcatggc ttcaacatca gcctccagac ccacagttgg
     1141 agcagatttc caccccactc catcatcagg gccttccatc tcccatcgtg gaaactggcc
     1201 aacctcagat tcgagaaagc agtttacaga gtaaagctca gtgaattctc tcctcctgga
     1261 agccgtgtgg cattggtgaa ggtcaccacg gctctcccca atttgcgtta ttctctaaag
     1321 ccatcctcca ggaacacagc attcaagttg aatgctcgaa caggcctgat caccaccacg
     1381 aagcttgtgg acttccatga acaaaaccag taccagctcc atgtcaaaac ttccctgggt
     1441 caggccacca ccaccgtgat cattgatatt gtggactgta acaaccatgc cccagtcttc
     1501 aacagatctt cctatgaagg gaccttggat gagaacatcc cccctggcac cagtgttttg
     1561 actgtgacag ccacagacca ggaccatggg gacaatggac acatcaccta ttccatcgct
     1621 ggccccaaag ctgtgccgtt ctctatcgac cctctcctgg gggtcatctc caccaccaaa
     1681 cccatggact atgaactcat gaagagaatt tatacctttc gggtccgagc gtcagactgg
     1741 gggtcccctt ttcgccagga gaaggaggtg tccgtttctc tgaggctcaa gaatttgaat
     1801 gacaatcagc ctatgtttga ggaagtcaac tgtactgtgt ccctccgtca agatgtgccg
     1861 gttgggaagt cgataatggc tgtgtctgca atagacatgg acgaacttca gaacctgaaa
     1921 tatgaaattg tgtctggcaa cgaacaagac tatttccatc tcaaccattt ctcgggagtg
     1981 atatctctca aacgctcttt tatgaacctc actgctgttc ggcccaccat ctattctctg
     2041 aagattacag cctctgatgg gaagaactat gcctctccca caactctgaa agtcactgtg
     2101 gtgaaggacc ctcactccga ggtccctgta cagtgtgata aaacaggagt gctgacccat
     2161 atcacaaaaa ccatcctcca atctgctggg cttcagagcc aagagttggg tgaagaggaa
     2221 tttacctccc ttagcaacta tcagatcaac catcactctc cccagtttga ggaccacttc
     2281 ccccagtcca ttgacattct ggagcaggtt cccatcaaca cccccttggc ccgcctggca
     2341 gccactgatc cagatactgg ctttcatggc aagctggtct acgtgatttc ggatggcaat
     2401 gaggaaggtt gttttgacat tgagctggag acggggctgc tcatggtggc agcagccttg
     2461 gactatgaga ccaccagctt ctatgtcctc aatgtgaccg tgtatgacct gggcactcct
     2521 ccgaagtcct cctggaagtt gttgacagtg acagtgaaag actggaatga taacccaccc
     2581 aggtttcctc caggtgggta ccaactcacc atttctgagg acacggaagt tggaaccaca
     2641 attgcagagc taaagacaga ggacgctgac tcagaggaca acaggagggt tcgctacacc
     2701 ctactgaccc ccacagagaa gttctctctc cacccattta ctggggagtt ggttgtcaca
     2761 ggacaccttg acagggaatc cgagtctcag tacatactca aggcagaggc cagggaccag
     2821 cccacgaagg gccaccagct cttctctgtc accgacttga tagtcacgtt ggaggatatc
     2881 aatgacaacc ctccccaatg tatcacagag cacaggagac tgaaggtgcc cgaggacatg
     2941 cccctcggga cggtcttaac attcctagat gcctctgacc ctgacctggg ccctgcaggt
     3001 gaagtgaaat atatcctggt ggaggatgcc cacggaactt tccaggtgca cccgatgact
     3061 ggagctctga gtctggaaaa agagttggac tttgagagac gggctggata caatctgagc
     3121 ttttgggcca gtgacagtgg gaagcctcta tcccgcagga ccctctgcca cgtagaagtg
     3181 ttagtcatgg atgtaaatga gaatctccac tctccccact tttcctcctt tgtgtaccag
     3241 ggccaggtac aggagaacag ccctgcaggg accccggtaa tggtagtcac agctcaggat
     3301 gatgacagtg gcttggatgg agagctccag tacttcctac gggctggcac tggcctggaa
     3361 accttcagca tcaaccaaga cacaggaatg ctcgagactc tggcacctct ggaccgagaa
     3421 ttcacaccct actactggtt gacagtgttg gctgtggaca gaggctccgt tcccctctct
     3481 gctgtcactg aagtctacat tgaagttaca gatatcaatg acaacattcc ctcgatgtct
     3541 agacctgtgt tctacccctc tgtcctggaa gatgccccct tgggtacctc tgtgcttcag
     3601 ctggaggcct gggacccaga ctccagctcc caagggaagc tgaccttcaa cctcaccagt
     3661 gggaaccact tgggacattt catcgttcac ccatttacag gtctcctgac cactgccaag
     3721 caactggacc gagagaacaa ggatgagtat gtcctagagg tgactgtgca ggacaacggg
     3781 gacccctcac taaggtccac ctccagggtg gtggtgtgca tcctggatgt caatgacaac
     3841 ccacccatgt tctcccacaa gctctttaac gtccgccttt cagaaagact aagccccctc
     3901 tccccggagc ctgtgtacag gctggtagct tcagatccag atgaaggtct caacggcagc
     3961 gtcacctaca gcattgagga gagtgatgag gagagcttca ggatcgaccc tgtcacagga
     4021 gttgtgtctt ctagcagcac ctttgcagcg ggagagtaca atatcctaac gatcaaggca
     4081 acagacagtg ggcagccagc actctccacc agtgtccggc tacacatcga atggattccc
     4141 cagcctcggc catcctccat cccactgtcc tttgatgagt catactacag ctttacagtc
     4201 atggagacag accccgtgaa ccacatggtg ggagtcatca gtgtagaggg acggcctggc
     4261 ctcttctggt tccacatctc agatggggat aaggacatgg acttcgacat tgagaagacc
     4321 acagggagca tcgtgatagc cagacctctt gatacaagga gaaagtcgag ctataacttg
     4381 actgtggagg tgacagatgg gttccacacc attgccaccc aggtccacat ctttatgatt
     4441 gccaacatca accaccaccg gcctcagttc ctgcaggatc actatgaaat cagggtcccc
     4501 caagacacgc tgcctggggt tgaactcctc cgggtccagg ccacagatca agaccatggc
     4561 aagggcctca tctataccat actcagcagc caggaccctg gaagtgccaa cctcttccag
     4621 ctggatccaa gcagtggagt gttggtgaca gtggggacat tggaactgca ctccgggcct
     4681 tctcagcaca ttctgacagt tatggtgcga gaccaagaga tgcccatcaa gaggaacttc
     4741 gtgtgggtga ccattcatgt ggaggatgga aatctccact cacctcactt cactcagctt
     4801 cgttatgagg caaatgttcc tgacaccacc gcccctggca cagagctact gcaggtccga
     4861 gctgtggacg ctgaccgggg agccaacgct gaaatccact attccttcct aaaagggaac
     4921 agtgacggtt tcttcaacat tgactccctc ctgggcatca tcacagtcgc tcagagactt
     4981 tatcatgtcc atctcactag gcatgcattg accgtgaagg cagaagacca aggctcccca
     5041 cggcggcatg acctggctct ggtggtcatt catgtccacc cctctgacag cagtgctcct
     5101 gtgttttcaa aggatgagta tttcatagag atcccggaat cggtccccat cggctcgccg
     5161 atcctcctcc tctctgctgg cagctcctct gaagtcacct atgagctaag agaggggaac
     5221 aaggacagtg tattctccat gaactcctac tctggcctca tctccactca gaaacgctta
     5281 gaccatgaga aagtcccgtc gtaccgactg agaatccggg gtagcaacat ggccggcgtg
     5341 ttcacggagg tggtggcgct ggtctacatc atcgatgaga atgacaatcc tcctgcattc
     5401 gggaagccaa cttttctggg gcacatcagt gaggcggctc ctctgcacag cctgatcctg
     5461 ggggaagaca acagcccctt agtcgtccgg gcctcagaca gtgaccggga agctaattcc
     5521 ttgttggtct acaaaatctt ggaaccggag gccttaaagt ttttcaaaat tgaccccagc
     5581 atgggaaccc taactactac atcagagctg gattttgagg acacaccctt gttccaattc
     5641 aacatctatg tccatgacca agggacaccc atcttatttg cacccagatc tgccaaggtc
     5701 atcatccatg tccgagatgt gaatgactct cctcccaggt tctcagagca gatatacgaa
     5761 gtggcggtgg tggaacccat ccaccctggc atgggcctcc tcacagtgca ggctgaggat
     5821 aatgactcga gagtcaccta tagcatcaaa accagcaacg ctgatgaagc tgttaccatt
     5881 caccccacca caggccaaat atctgtggtt aatcctgcta ctctgaggct ttttcagaag
     5941 ttcagtatta gggcttctga tggtctgtat catgataccg cagtggtaaa aatatctttg
     6001 acccaagtcc tcgataaaag cttacagttt gaccaggatg tctacagggc aagagtgaca
     6061 gagaatacac cacacagaaa ggcactggta attcttggtg tccatggaaa ccatttgaat
     6121 gacacccttt cctacttcct cttgaatggc acagacttat ttcacatgat cgagtcagca
     6181 ggtgtgctgc aaaccagagg agggacattt gatcgggagc agcaggacac tcatgaagtg
     6241 gcagtggaag tgagggataa ccgggtccct cagcgggtgg ctcaggctct tgtcagggtc
     6301 tctgtggaag atgtcaatga caacatccct gagtttcagc atctgcccta ttatacagtc
     6361 atccaagatg gcactgaacc cggggacgtc ctctttcagg tatctgccac tgataaggat
     6421 ttgggagcca acgggagtgt cacatatggg tttgcagaag attatgccta tttccggatt
     6481 gacccctatg ttggggacat atcactcaag aaaccctttg attatcaagc tttgaataag
     6541 tatcacctca gagtcattgc tcgagattca ggtattccac ccctccaaac tgaagtggag
     6601 gtacacgtta ctgtcagaaa taaatccaac ccattgtttc agagtccata ctacaaagtg
     6661 aaagtccctg aaaatatcac actctatacc ccgattcttc acacacaggc ccggagtcca
     6721 gagggcctga ggctcatcta caacattgta gaggaagagc ctttgatgtt gtttaccact
     6781 gactttaaaa ctggtgtcct tacagtgaca ggacccctgg actatgagtc aaagaacaaa
     6841 catgtgttca cagtgagagc cacagacacg gctctggggt ccttttctga agccacagtg
     6901 gaagtcttag ttgaggacat caatgataac cctcccactt tttcccagtt ggtatatacc
     6961 acttcggttt ccgagggctc acctgctcag actcctgtaa ttcaactgtt ggcttctgac
     7021 caagactcag gacagaacca agatgtctcc tatcagattg tagaggatgg ttcagatgtt
     7081 tctaagttct tccggatcaa tgggagcaca ggggagatat tcaccatcca agagctggac
     7141 tatgagactc accaacactt tcgtgtgaag gtcagggcca tggataaagg agatccccct
     7201 ctcactggtg aaacacttgt ggttgtcaat gtgtcagaca tcaatgataa tcccccaaag
     7261 ttcagagaac ctcagtacga agccaacgtc agtgagctag caacctgtgg ccacctagtt
     7321 ctaaaagttc aagctcttga ccccgatatc ggggacacct ctcgcctgga gtacctgatt
     7381 ctttctggca accaggaccg acatttctcc atcaatagca catcgggaat catttctatg
     7441 ttcaaccttt gcaaaaagca gctggactca tcttacaact tgagagttgg tgcttctgat
     7501 ggggtcttcc gagcaacggt gccagtatat atcaacacta ccaatgccaa caagtatagt
     7561 ccggagttcc agcaaaacgt ctatgaagct gaattagctg agaatgcaaa ggtggggaca
     7621 aaggtgattg agctgctagc catagacaaa gacagtggtc cctatggtac agtggactac
     7681 accatcatca ataaactagc tggggaaagg ttcttcataa atccccgtgg tcagatcacc
     7741 acccttcaga aactggaccg ggaaaattca acggaaaggg tgattgctat taaggtcatg
     7801 gcaagggatg gaggagggaa agtggccttc tgcaccgtga agatcattct cactgatgaa
     7861 aatgacaatg ccccacaatt caaagcatcc gggtacactg tgtccatccc atccaatgtc
     7921 agcagagact cccccattat ccaggtgctg gcttacgatg cagacgaagg tcggaatgca
     7981 gacgttacct actcagtaga ctcaaccgag gaccttgcgg aagagatcat tgaagtcaac
     8041 cccaccaccg gtgtggtcaa ggtgaaggag agcctggtgg gactggaaaa cagggctgtt
     8101 gatttcaaca tcaaagccca ggatggtggt cctcctcact gggactctct ggtaccagta
     8161 cggctgcaag tggttcctaa tgaaatccct ttgcccaagt tttctgaacc tctgtatact
     8221 ttctctgcac ctgaagacct tccagaaggc tctgaaattg ggtctgtgaa ggcagtagct
     8281 gctcaagatc cgatcatcta cagtctggtt cagggtacca ctccagagag caacagtgat
     8341 gatgtcttct ccttggacca agacacggga gtcctaaagg tgaggaaagc catggatcat
     8401 gagtccacta aatggtacca gattgacctg atggcacatt gccctcatga ggatactgac
     8461 ctggtgtcat tggtctctgt cagcattcaa gtggaagatg tcaatgacaa taggcctgtg
     8521 tttgaggctg atccatataa ggctttcctc acggagaata tgccaggagg gaccacagtc
     8581 attcaggtga ctgccaatga ccaggacact ggaagtgatg gacaggtgag ctacaggctg
     8641 tcagtggagc ctggtagcaa catccacgaa ctctttgctg ttgacagtga gagcggctgg
     8701 atcaccacac tccaagaact cgactgtgag actcagcaga cttaccgttt ctacgtggtg
     8761 gcctttgatc atggacagac catccagctg tcttctcagg ccctggttga ggtctccatc
     8821 acagacgaga atgacaaccc ccctcggttt gcttccgaag actatagagg ctctgtggtg
     8881 gagaacaatg agcctggtga acttgtggct acactgaaga ctttggatgc tgacgtctct
     8941 gaccagaata ggcaggtcac ctgctatatc acagagggag accccctggg tcaatttagc
     9001 atcagtcaag ttggggatga atggagaatc tcctcaagga agactctgga ccgagaacac
     9061 atagccaagt atctactcag agtcacagca tcagatggca agttccaggc ttcggtcccc
     9121 gtggaggtct ttgtcgtgga catcaacgat aacagcccgc agtgctcaca gcttctctac
     9181 actggcaagg tccgtgagga tgtcaccccc ggacatttca tcttgaaagt ttctgccata
     9241 gatgtggaca tggacaccaa tgctcagatc acatactctc tgcatggacc cggggcccag
     9301 gaattcaagc tggaccctca cacaggggag ctgaccacac tcacagtcct ggaccgggaa
     9361 aggaaggatg tatacaacct tgttgctaag gcaacagatg gagggggcca atcatgccag
     9421 gcagaggtga ctctccacat tgaggatgtg aatgataacg ccccgaggtt cttccccagt
     9481 cactgtgatg tggctgtctt tgacaacacc acagttaaga cccctgtggc tgtggtcttt
     9541 gcccgggacc ctgaccaggg tgccaacgct caggtggtgt actcactgac ggactctgct
     9601 gatggccagt tctccattga tgccacctca ggagtgattc gcctggagaa gcctctgcag
     9661 gtcagagcaa gctcagctgt ggagctcacg gtccgtgcct cagacctagg caccccaata
     9721 ccactgtcca cattgggcac tgttacagtc tccgtagtgg gcctggagga ctaccttccc
     9781 atcttcctga acgcggagca cagcacacag gtgcctgagg atgctccaat agacatggag
     9841 gtgctacacc tggctaccct cacacgtccc ggctcagaga agactggtta ccacatcacc
     9901 ggagggaatg agcaggggaa gttccggctg gatgctcaca caggaatcct gtatgtcaat
     9961 gggagcctgg actttgagac aaaccccaag tacttcctgt ccattgaatg cagccggaag
    10021 agctcttcct ccctcagcga tgtgaccacc atcgtgatta atgtcaccga tgtcaatgaa
    10081 caccaccccc gattcaccca tgacctgtac actgtgaggg tcttagagaa cgccgttgtg
    10141 ggcgatgtca tcttgacggt gtcagcatct gatgacgatg gacctgttaa tagtgccatt
    10201 acctatagcc tggtaggagg aaaccagctt ggacacttca ccatcaaccc caagaaaggg
    10261 aaactccagg tggccaaggc actggactgg gaacagaccc ccagctactc cctgaggctc
    10321 cgagccacag acagtgggca gccaccattg catgaggaca cagaagtggc tgttgaagtg
    10381 gttgatgtta atgacaaccc gcccaggttc ttccagctca actacagcac ttctgtccag
    10441 gagaactccc ccattggcat caaagtcctg cagctgatcc tggatgatcc tgactcccca
    10501 cagaatgggc ctccctactt cttccggatc actgagggga acactgggtc tgtgttccgg
    10561 gtgactccag atggctggct ggtgacagct gcaagcctga gcaagaaggc ccgggagtgg
    10621 tatcagcttc acatcgaggt gtcagacagt ggcctcccgc ccttatcatc ttccacattg
    10681 gtcagagtac aagtcacgga gcagagccgc tacccgccct ctacactccc actggaaatc
    10741 tccatcacaa agggggagga ggaatttcag ggtggcatga taggtaaaat ccatgccaca
    10801 gaccgagacc cacaggacac gctgacctac agcctggagc aggagggagg cctggacagg
    10861 tacttcacag tgggtgcatc cgatggcaaa attattgcct ctcaaggact gcctcatggc
    10921 cgatactcgt tcaatgtcac agtcagtgat gggaccttca ccaccaccac tggggtccat
    10981 gtccacgtgt ggcacatgga gccggaggtt ccgcagcaag ctgtgtggct gggcttccac
    11041 cagctcactc ccgaggagct cgtgagtgac cactggcgca acctgcagag attcctcagc
    11101 aacctcctgg acgtcaaacg agccaacatc cacttggcca gcctgcagcc tgcggaggtc
    11161 acagctgggg tggatgtact cctggtcttc gagaggcatt ctgggacctc ctatgatctc
    11221 caggagctgg cgtctgccat agcccactca gtcagagaga tagaacactc agtaggaatt
    11281 cggatgaggt cagctctgcc cgtggttccg tgccaagggc aaagctgcca ggatcaaacc
    11341 tgccaagaga cagtgtctct ggagcccagg gttggaccct cttacagcac agccaggctc
    11401 agtatcctga caccacgaca tcacctgggg agaaactgct cctgcaatgg taccaccttg
    11461 aggttcagtg gtcagagcta cgtgcagtat aggcccctag aggctcagaa ctggcagatc
    11521 catttctacc tgaaaactct ccagccatgg gcccttctaa tgttcaccaa tgaaacagcc
    11581 tctatttcct tgaagctggc caatggcttc tctcacctgg aataccattg tcctggtggt
    11641 ttctatggaa acctttcctc ccgttatcct gtgaatgatg gacagtggca ctccatgctg
    11701 ttggaggaga gggacacgtc tgttcatctg ttggtcgaca tcacagacaa tgcttccctt
    11761 gtcatcccag aggaatgtca gggtctgagg actgagcgac aactactgct gggtggcctt
    11821 gtcccctcaa atccttcctc aaatgtctcc ctgggctttg aaggctgcct ggatgctgtt
    11881 gtggtcaacg gtgagaggtt agagttgctt ggccgtgaaa agaagatgga gggccggcta
    11941 gagacatggg ccctcagcca gtgctgctgg cccggcactg cctgcagcca gagcccatgt
    12001 ctcaatggtg ggagctgttc gcctgccctt ggatcaggct acctgtgcag atgccctcct
    12061 ccattctctg gcaggaactg cgaacttgga agggagaatt gtacttctgc gccctgccaa
    12121 gaaggtggca catgtgtctc ctcccctgaa ggcacttcct gcaactgccc tcacccttac
    12181 acaggtgaca gatgtgagat ggaagcaaga ggttgctccg gaggacactg tctcatcact
    12241 cctgagatta agagagggga ctggggacag caggagtttc tggtaatcac agtagcctta
    12301 cctctcgtca tcattgccac tgtgggactc ctcctctact gccgtcgtcg caaatctcac
    12361 aaaccggtga ccatggagga cccggacctc ctagcaagga gcattggtgt tgacacccaa
    12421 gcttcgcctg ccatcgagct cgaccccctt aacaccagct cctgcaacaa cttaaaccaa
    12481 ccggagccca gcaagacctc ggttccaaat gaactcgtca ccttcggacc tagctctaaa
    12541 cagcggccga tggtgtgcag cgtgcctcca aggctcccac cagctgcagt ctcctcccac
    12601 cctggccacg agcccatcat caagagaacc tggtcaggcg aggagctggt gtacccaagt
    12661 ggagctgcag tctggcctcc cacttactcc cggaagaagc attgggaata cccacatcct
    12721 gaaacaatgc agggaactct gccaccctct cctcggcgcc atgttggtcc tgccgtgatg
    12781 ccagatccca ctgggctcta tgggggcttc cctttcccct tggaactgga aaacaaacgg
    12841 gcacccctcc caccccgtta cagcaatcag aacctggaag acctgatgcc tccacggcct
    12901 cccagccccc gggaacattt gcttgccccc tgtctcaacg agtacacagc tatcagctac
    12961 taccattcac agttccgcca gggagggggt gggccctgcc tggcagaggg gggctataag
    13021 ggggtgagca tgcgtctcag cagagctgga ccttcctatg ctgactgtga ggtgaatggt
    13081 gggcctgcca cagggcggag ccaacctcga gcgcccccca actacgaggg ctcagatatg
    13141 gtagagagtg actatggaag ttgcgaggaa gtcatgttct agcttcctgc tttcagagga
    13201 aagcatgggg aagcccaggc cccacactgt cttccagtgt cacgggaagt aagttgggtg
    13261 tggctggaag aaacgggaag ctaccacatc cccagtccac atgtccatct cttaaaatgt
    13321 gctcttcggg tccccagctt gtccttgagg gtgaagggaa gctgagggga gagctgtaaa
    13381 attcgcagta gggccccagg aaagaggagg tacccagccc ggtgcacgcg ggggtgagaa
    13441 ctaggagtgt aatcgctcag atctgccagt gcccagcccc agcaagaaag agctccaagc
    13501 accagctcag cgtgtttggg ccacattctt acagcttctc acaggcccat catggggcac
    13561 gcgggtttgt gcccaatagg caactatgca tgcatctact gtggaggaga gaccagggtc
    13621 gtttgagatc catgcagtgg cctcctaggg gccgataagc agtctgcaag caggtattca
    13681 cccgagtatc tgctttgtgt gtgtgtgtac ctttgggaca tctatgcaaa gtgtctcatg
    13741 tcagcctcat tctgggcaca ggcagcaaga acactcttgg aagttgagcc acttggactg
    13801 ccatcttctg gaagtcttgt ccttgaagct tcaggactta ttccacctct gccggtggga
    13861 tcttgcctgg aaacttttgt gctgaagacg tgcgatctca tggaatgctc agttaatcgt
    13921 tccaaacttc ccaggcactt ttggccaaga gcaagaagga tgtagttcat ttgaaaattt
    13981 cttaggcact ttttaacctt gctctctggc tgtgttttcc caagagggtt tcttcttgtt
    14041 tagacacaag gaattcaact gccatccaga cccaggtaga ggtggagagc cagtcagcgg
    14101 atccaggcca gacaccctgc cttctccctc ccccttcatc acagatgcct gccaatcaag
    14161 tgttacccac actgaccctg ccctgtgcat ggagggtcag tgtgggcaca tgtctacaca
    14221 tgtgggtacc catggaccat gtgtatgcac atatgtgtag aaagttatgt agctgggagt
    14281 ggcagagact ggaagccagg gaggcctata gtggcctcag ccccctgtcc tctgccagtc
    14341 cctctctggt ccactgcgct ttcacgtgtg tgggtttgga gttagaagtc aagaggaaga
    14401 gccacagaga ctcccaccta cagagctgtt cagagagact gctgtgtagg aggaggcatt
    14461 cgtcggccat gtgtgactgt gggtgtgact gatggattga acaagtggct ttggtggcca
    14521 tttgattttt tttttaacaa taaatatctt ttttactgtt
//
