LOCUS       NM_001398523            2302 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus FAST kinase domains 2 (Fastkd2), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001398523
VERSION     NM_001398523.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Arroyo,J.D., Jourdain,A.A., Calvo,S.E., Ballarano,C.A.,
            Doench,J.G., Root,D.E. and Mootha,V.K.
  TITLE     A Genome-wide CRISPR Death Screen Identifies Genes Essential for
            Oxidative Phosphorylation
  JOURNAL   Cell Metab 24 (6), 875-885 (2016)
   PUBMED   27667664
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Antonicka,H. and Shoubridge,E.A.
  TITLE     Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA
            Processing and Ribosome Biogenesis
  JOURNAL   Cell Rep 10 (6), 920-932 (2015)
   PUBMED   25683715
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.49181.1,
                                           SRR26643284.12405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000009.1  72662031-72662097
            68-889              JAXUCZ010000009.1  72663283-72664104
            890-993             JAXUCZ010000009.1  72666033-72666136
            994-1102            JAXUCZ010000009.1  72666748-72666856
            1103-1226           JAXUCZ010000009.1  72667131-72667254
            1227-1366           JAXUCZ010000009.1  72667544-72667683
            1367-1539           JAXUCZ010000009.1  72668980-72669152
            1540-1703           JAXUCZ010000009.1  72675183-72675346
            1704-1916           JAXUCZ010000009.1  72677314-72677526
            1917-2001           JAXUCZ010000009.1  72679186-72679270
            2002-2116           JAXUCZ010000009.1  72680741-72680855
            2117-2302           JAXUCZ010000009.1  72681801-72681986
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..2302
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /note="FAST kinase domains 2"
                     /db_xref="GeneID:301463"
                     /db_xref="RGD:1307883"
     exon            1..67
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            68..889
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..2224
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /note="isoform 1 is encoded by transcript variant 1; FAST
                     kinase domain-containing protein 2, mitochondrial"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 2,
                     mitochondrial isoform 1"
                     /protein_id="NP_001385452.1"
                     /db_xref="GeneID:301463"
                     /db_xref="RGD:1307883"
                     /translation="MNNRAHTFLWGIRQFRTSIPRSRALRTYSLVFCKPEVIHSKRNP
                     RNHLLNGFDEGLQPSVRYLFQDIFISKSVAGCTQTRGIIHAAGFKLDRILCPRRLSFD
                     AKHSFVSDGTSDHDLMKTNFHHTSTEDVLTKKMRPTPVNYKKLAQECNSLSDVLDTFS
                     KAPTFPGSNYFLAMWIIAKRISEDKRRFEKQLMFSHPAFNQLCEQMMREAKIMRYDHL
                     LFSLNAIVKLGVPQNSLMVQTLLRTIQERISECDERCLSILSTALVTMEPCMNVNALR
                     AGLRILVDQQVWNINDIFTLQTVMRCIGKDAPFALKKKLEMKALKELGRFSVLNSRHM
                     FEVLAAMDHRSVVLLNECSKIVIDNIHGCPFKVLISILQSCRDLRYQNEDLFKSIADY
                     VATTFDIWKLKHVIFFLLSFETLGFRPPGLMDKLLEKVVQEPGSLTVKNIVSVLHVYS
                     SLNHVHNVQNREFLEALASALTGCLHQISSESLLNAVHSFCMMNYFPLAPINQLIKEN
                     IIHELLTSGDTEKNIHKLHVLNTCLKLDESTYKCIHIPLPQLPLTASHPNEKLAEVLS
                     RLLEGDGCFSRNVQLPHNYHIDFEIRMDTNRTQVFSFSEGDASSATNMQRVAVLCVPK
                     SAYCLNSNHLRGLMAMKIRHLNVMGFHVILIHNWELKKLKMEDAVTFVRKKIYSDEAL
                     ATTDESV"
     exon            890..993
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1102
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1366
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1539
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1703
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1916
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2001
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2116
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2302
                     /gene="Fastkd2"
                     /gene_synonym="RGD1307883"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacgcgccg cttgaggcgg aactgtcatg gctgcgcccg tgtgtagtca cggggttctg
       61 ttctaaggac agcccatggc atgtgccctt tttcagaaag aagttaactt gtgttgcact
      121 ttgggtattt gaaagtgcgt ttgcagatat caaaatgaat aacagagcac ataccttctt
      181 atggggcatc agacaattca ggacttcaat tccaagaagc agagctttga ggacatattc
      241 tttggtattt tgcaaaccag aagtaattca ttcaaaacgg aacccaagga accatctgct
      301 aaatggtttt gatgagggat tgcagccatc tgttagatac ctctttcagg atatatttat
      361 ttcaaaatca gtagctggct gtactcaaac tagaggcata atccatgcag ctggttttaa
      421 acttgataga atactttgtc ctagaagact gtcctttgac gcaaaacatt cttttgtctc
      481 tgatgggaca tctgatcatg atttaatgaa aacaaacttt catcatacct ccactgaaga
      541 tgtgctcacc aagaaaatga gaccaactcc tgtgaattat aaaaagctgg cccaggagtg
      601 caactctctg agcgatgtgc tggacacatt ttcaaaagcg cctacatttc ctggtagtaa
      661 ctatttctta gccatgtgga taattgccaa aaggatttca gaagacaaga ggcgctttga
      721 gaaacaactg atgttcagtc accccgcctt taaccagctg tgtgagcaaa tgatgagaga
      781 agccaagatt atgcgctatg accacctttt gttcagtctt aatgctatcg tgaagcttgg
      841 agttcctcag aattctctta tggtacagac tttgctgagg acaattcagg agcgcatcag
      901 tgagtgtgat gagagatgtc tttcaatttt gtcgactgct ttagtgacca tggagccgtg
      961 catgaatgtg aacgcgcttc gagcagggtt gcgaatccta gttgatcagc aagtttggaa
     1021 cataaatgat atcttcactt tacaaacggt gatgagatgt attgggaaag atgcaccatt
     1081 tgctcttaag aagaaattgg agatgaaagc cttgaaggaa ttaggcagat tttctgtctt
     1141 gaatagccgg catatgtttg aagtcttagc tgccatggat caccgctctg tcgtccttct
     1201 gaatgagtgc agtaagattg tcatagataa tatccatggg tgtcctttta aagtattaat
     1261 cagcatactg cagtcctgta gagacctccg ataccaaaat gaagatcttt tcaaaagcat
     1321 cgcagattat gtggctacaa cctttgacat ctggaagttg aaacacgtta tctttttcct
     1381 cttgtcattt gaaactcttg gttttcgacc tcctggtttg atggacaagc ttctggagaa
     1441 agtagtccag gagcctggct ctctgaccgt gaagaacatt gtttctgtcc ttcatgtgta
     1501 ttcttctctc aatcatgtcc acaatgtcca gaacagagag ttcctagaag ctctggcaag
     1561 tgcgctgact ggctgtcttc accagatctc ttctgaaagc ctgttgaatg ctgtgcattc
     1621 gttttgcatg atgaattatt tccccctggc ccctattaac cagcttatca aagagaacat
     1681 catccacgaa ctgctgactt caggtgacac agagaagaat attcataagc ttcatgtttt
     1741 gaatacttgt ctgaaacttg atgaaagtac ttacaaatgt atacatatac cgttgccaca
     1801 gctgccactg acagcctcac atccaaacga gaagcttgca gaggtgctca gcaggctttt
     1861 ggaaggggat ggatgcttct cgagaaatgt gcagttgcca cataattatc acattgattt
     1921 tgaaatcaga atggatacta acaggaccca agtattttca ttttctgagg gagatgcaag
     1981 ttctgccaca aacatgcaga gagtggccgt gctgtgtgtt cctaagtctg cttactgttt
     2041 aaattcaaac cacctcagag gattgatggc catgaaaatt cgacatttga atgtaatggg
     2101 cttccatgtc atcttgatcc ataactggga gctgaagaaa ctaaagatgg aggatgcggt
     2161 cacatttgtg aggaagaaga tctattcaga tgaagcactt gccactactg acgaaagcgt
     2221 gtaaagctcg tattaaatca gacacttgtc cgaacatgca cagttgtgaa atgactttaa
     2281 taaagtctgt gattcagtca tc
//
