LOCUS       NM_001371289            1858 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Rattus norvegicus Fas-activated serine/threonine kinase (Fastk),
            mRNA.
ACCESSION   NM_001371289 XM_006235892 XM_008775649
VERSION     NM_001371289.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1858)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1858)
  AUTHORS   Simarro,M., Mauger,D., Rhee,K., Pujana,M.A., Kedersha,N.L.,
            Yamasaki,S., Cusick,M.E., Vidal,M., Garcia-Blanco,M.A. and
            Anderson,P.
  TITLE     Fas-activated serine/threonine phosphoprotein (FAST) is a regulator
            of alternative splicing
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11370-11375 (2007)
   PUBMED   17592127
REFERENCE   3  (bases 1 to 1858)
  AUTHORS   Izquierdo,J.M. and Valcarcel,J.
  TITLE     Fas-activated serine/threonine kinase (FAST K) synergizes with
            TIA-1/TIAR proteins to regulate Fas alternative splicing
  JOURNAL   J Biol Chem 282 (3), 1539-1543 (2007)
   PUBMED   17135269
REFERENCE   4  (bases 1 to 1858)
  AUTHORS   Tian,Q., Taupin,J., Elledge,S., Robertson,M. and Anderson,P.
  TITLE     Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1
            during Fas-mediated apoptosis
  JOURNAL   J Exp Med 182 (3), 865-874 (1995)
   PUBMED   7544399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and BC083715.1.
            
            On or before Jul 6, 2019 this sequence version replaced
            XM_006235892.3, XM_008775649.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.530825.1,
                                           SRR26360186.1670060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               JAXUCZ010000004.1  11624727-11624894
            169-579             JAXUCZ010000004.1  11625660-11626070
            580-759             JAXUCZ010000004.1  11626519-11626698
            760-899             JAXUCZ010000004.1  11626832-11626971
            900-1113            JAXUCZ010000004.1  11627410-11627623
            1114-1273           JAXUCZ010000004.1  11627722-11627881
            1274-1365           JAXUCZ010000004.1  11627985-11628076
            1366-1501           JAXUCZ010000004.1  11628145-11628280
            1502-1616           JAXUCZ010000004.1  11628358-11628472
            1617-1838           JAXUCZ010000004.1  11628547-11628768
            1839-1858           BC083715.1         1610-1629
FEATURES             Location/Qualifiers
     source          1..1858
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1858
                     /gene="Fastk"
                     /note="Fas-activated serine/threonine kinase"
                     /db_xref="GeneID:296741"
                     /db_xref="RGD:1311601"
     exon            1..168
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1724
                     /gene="Fastk"
                     /EC_number="2.7.11.8"
                     /codon_start=1
                     /product="fas-activated serine/threonine kinase"
                     /protein_id="NP_001358218.1"
                     /db_xref="GeneID:296741"
                     /db_xref="RGD:1311601"
                     /translation="MRRPRGEPGSRAPRPAERVTYAGSGESWSPPPSSMLRILLSAQT
                     SPARLSGLLLIPPVQPCCLGPSKSGDRPFGGGPVQGLQRLLEQARSPGELLRWLSQNP
                     TKVRAHHYPVALRRLGQLLVSQPRPSPVEQATLQDLSQLIIRNCPSFDVHTIHVCLHL
                     AVLLGFPSDGPLLCALEQERRSRVPPKPPSPRQPAIYGGQRLEAALSCPRFLRYPRQH
                     LIRSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQEAQLNSKVVQKL
                     VLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLQRLPFRALQFVFS
                     PSFISHINGTPPSLIVRRYLSLLDTAVELELPGYRGPRLPQRQRVPIFPQPLITDRAR
                     CKYSHKDMVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCVGGSGAVLPMRTQDPFLPY
                     PPRPCQQDQANSNSTTQDPTQRVVLMLRERWHFCRDGRVLLGSRALRERHLGLMGYQL
                     LPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG"
     exon            169..579
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            580..759
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            760..899
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1113
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1273
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1365
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1501
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1616
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1839
                     /gene="Fastk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccccttcc ctagcgccgg gctgcgattg gtgtctgggg acgatccggg ggctgctggg
       61 aagatggcgg actcagtggc ccgctgatga ggaggccccg gggggagccc ggctcccggg
      121 ccccgagacc tgctgagaga gtgacctacg cggggtccgg ggagtcatgg tctccaccac
      181 ccagctccat gcttcgaatc ctgctctctg cccagacttc ccctgctcgg ctgtctggtt
      241 tgctgctcat cccgccagta cagccctgtt gtttgggacc cagcaagtcc ggggaccggc
      301 cttttggagg aggccctgtg caaggccttc aacggcttct ggagcaggca cggagccctg
      361 gggagctgct gcgatggctg agtcagaacc ccaccaaggt tcgagctcat cactaccctg
      421 tggcacttcg tcgtctgggc cagctcttgg tgtctcaacc taggccctct cctgtggagc
      481 aggccacgct gcaggacttg agtcagctca tcatccgaaa ctgcccctcc tttgacgttc
      541 acaccatcca tgtgtgtcta caccttgcag tcttacttgg cttcccatca gatggaccac
      601 tcctgtgtgc cctcgagcag gagcgaaggt cccgtgtccc tccaaaaccg ccctccccac
      661 gtcagcctgc catctacggt ggtcaaaggt tggaagcggc cctgagctgc ccccgtttcc
      721 tgcggtaccc tcgtcagcat ctgatcagaa gcctggcaga ggcaaggcca gaagaactga
      781 ctcctcatgt aatggtgctt ctggcgcagc acctggctcg gcaccggttg cgggaacccc
      841 aacttctgga agccattgct catttcctgg tggttcagga agcccagctc aacagcaagg
      901 tggtacagaa gttggtcctg ccctttggga ggttgaacta cttgcccctg gagcaacagt
      961 ttatgccctg tcttgagagg atcctggctc gggaagcagg ggtggcaccc ttggccacag
     1021 tcaacatctt gatgtcactg tgccagctgc agcgcttgcc cttcagagcc ctgcagtttg
     1081 tcttctcccc cagcttcatc agccacatca atggcacccc tccttctctg attgtgcgac
     1141 gctacctctc tctactcgac acggctgtgg agcttgaact cccaggatac cgaggccccc
     1201 gccttcccca aaggcagaga gtgcccatct tcccacagcc cctcatcact gaccgcgccc
     1261 gctgcaaata cagtcacaag gacatggtag ctgaggggct gcgccagctg ttaggggaag
     1321 aaaaataccg tcaggacctg actgtaccac ccggctactg cacagacttc ctactctgtg
     1381 tgggaggttc tggtgctgtg ctacctatga ggacacagga ccccttcctg ccctacccac
     1441 cacggccctg ccaacaggac caggctaact ctaattccac aacccaagac cctacccaaa
     1501 gggtggtgct gatgctgcga gaacgctggc atttctgccg tgatggcagg gtgctgctgg
     1561 gctctcgggc tctgagggag cggcacctgg gcctaatggg ctaccaactc ctgccgctgc
     1621 catttgaaga actggaatct cagagaggcc tgccccagct caagagctac ctgaggcaga
     1681 agcttcaggc cttaggtctt cgctggggac ctgagggtgg gtgagggagt acacacagta
     1741 cacatggggc acaggatgga tcccctatgg ggaggagggt ggacagtttg cactttggct
     1801 ccctgttatt tttttcatta aaatcccttt ccttcctgaa aaaaaaaaaa aaaaaaaa
//
