LOCUS       NM_017332               9139 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus fatty acid synthase (Fasn), mRNA.
ACCESSION   NM_017332
VERSION     NM_017332.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9139)
  AUTHORS   Harada,N., Yoshikatsu,A., Yamamoto,H. and Nakaya,Y.
  TITLE     2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene Expression
            Via an Endoplasmic Reticulum Stress-Dependent Pathway in HeLa Cells
  JOURNAL   Cell Biochem Biophys 82 (3), 2285-2296 (2024)
   PUBMED   38824236
  REMARK    GeneRIF: 2-Deoxy-D-Glucose Downregulates Fatty Acid Synthase Gene
            Expression Via an Endoplasmic Reticulum Stress-Dependent Pathway in
            HeLa Cells.
REFERENCE   2  (bases 1 to 9139)
  AUTHORS   Abdel-Hamid,M.S., Mansour,A.M., Hassan,M.H., Abdelhady,R.,
            Elsadek,B.E.M., El-Sayed,E.M. and Salama,S.A.
  TITLE     Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular
            Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis
  JOURNAL   Biol Pharm Bull 46 (11), 1558-1568 (2023)
   PUBMED   37914358
  REMARK    GeneRIF: Estrogen Attenuates Diethylnitrosamine-Induced
            Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen
            Receptor/FASN/CD36/IL-6 Axis.
REFERENCE   3  (bases 1 to 9139)
  AUTHORS   Wang,K., Li,L., Jin,J., An,Y., Wang,Z., Zhou,S., Zhang,J.,
            Abuduaini,B., Cheng,C. and Li,N.
  TITLE     Fatty acid synthase (Fasn) inhibits the expression levels of immune
            response genes via alteration of alternative splicing in islet
            cells
  JOURNAL   J Diabetes Complications 36 (6), 108159 (2022)
   PUBMED   35210136
  REMARK    GeneRIF: Fatty acid synthase (Fasn) inhibits the expression levels
            of immune response genes via alteration of alternative splicing in
            islet cells.
REFERENCE   4  (bases 1 to 9139)
  AUTHORS   Yu,W., Ling,J., Yu,H., Du,J. and Liu,T.
  TITLE     AZGP1 suppresses the process of colorectal cancer after
            upregulating FASN expression via mTOR signal pathway
  JOURNAL   Gen Physiol Biophys 39 (3), 239-248 (2020)
   PUBMED   32525817
REFERENCE   5  (bases 1 to 9139)
  AUTHORS   Singh,N., Shafiq,M., Jagavelu,K. and Hanif,K.
  TITLE     Involvement of fatty acid synthase in right ventricle dysfunction
            in pulmonary hypertension
  JOURNAL   Exp Cell Res 383 (2), 111569 (2019)
   PUBMED   31465767
  REMARK    GeneRIF: Involvement of fatty acid synthase in right ventricle
            dysfunction in pulmonary hypertension revealed by inhibition of
            FASN. Inhibition of FAS decreases Right ventricle hypertrophy and
            improves cardiac function associated with Pulmonary hypertension by
            perking up metabolic functions.
REFERENCE   6  (bases 1 to 9139)
  AUTHORS   Amy,C.M., Williams-Ahlf,B., Naggert,J. and Smith,S.
  TITLE     Intron-exon organization of the gene for the multifunctional animal
            fatty acid synthase
  JOURNAL   Proc Natl Acad Sci U S A 89 (3), 1105-1108 (1992)
   PUBMED   1736293
REFERENCE   7  (bases 1 to 9139)
  AUTHORS   Beck,K.F., Schreglmann,R., Stathopulos,I., Klein,H., Hoch,J. and
            Schweizer,M.
  TITLE     The fatty acid synthase (FAS) gene and its promoter in Rattus
            norvegicus
  JOURNAL   DNA Seq 2 (6), 359-386 (1992)
   PUBMED   1339331
REFERENCE   8  (bases 1 to 9139)
  AUTHORS   Clarke,S.D., Armstrong,M.K. and Jump,D.B.
  TITLE     Nutritional control of rat liver fatty acid synthase and S14 mRNA
            abundance
  JOURNAL   J Nutr 120 (2), 218-224 (1990)
   PUBMED   2313386
REFERENCE   9  (bases 1 to 9139)
  AUTHORS   Amy,C.M., Witkowski,A., Naggert,J., Williams,B., Randhawa,Z. and
            Smith,S.
  TITLE     Molecular cloning and sequencing of cDNAs encoding the entire rat
            fatty acid synthase
  JOURNAL   Proc Natl Acad Sci U S A 86 (9), 3114-3118 (1989)
   PUBMED   2717611
REFERENCE   10 (bases 1 to 9139)
  AUTHORS   Naggert,J., Witkowski,A., Mikkelsen,J. and Smith,S.
  TITLE     Molecular cloning and sequencing of a cDNA encoding the
            thioesterase domain of the rat fatty acid synthetase
  JOURNAL   J Biol Chem 263 (3), 1146-1150 (1988)
   PUBMED   2891707
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017332.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M76767.1, X62888.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000010.1  106588507-106588581 c
            76-211              JAXUCZ010000010.1  106587186-106587321 c
            212-364             JAXUCZ010000010.1  106586495-106586647 c
            365-538             JAXUCZ010000010.1  106585298-106585471 c
            539-739             JAXUCZ010000010.1  106584909-106585109 c
            740-862             JAXUCZ010000010.1  106584611-106584733 c
            863-978             JAXUCZ010000010.1  106584408-106584523 c
            979-1113            JAXUCZ010000010.1  106584184-106584318 c
            1114-1576           JAXUCZ010000010.1  106583114-106583576 c
            1577-1764           JAXUCZ010000010.1  106582808-106582995 c
            1765-1954           JAXUCZ010000010.1  106582382-106582571 c
            1955-2049           JAXUCZ010000010.1  106581782-106581876 c
            2050-2184           JAXUCZ010000010.1  106581439-106581573 c
            2185-2388           JAXUCZ010000010.1  106581158-106581361 c
            2389-2504           JAXUCZ010000010.1  106580937-106581052 c
            2505-2677           JAXUCZ010000010.1  106580582-106580754 c
            2678-2869           JAXUCZ010000010.1  106580319-106580510 c
            2870-2950           JAXUCZ010000010.1  106580164-106580244 c
            2951-3130           JAXUCZ010000010.1  106579892-106580071 c
            3131-3310           JAXUCZ010000010.1  106579556-106579735 c
            3311-3514           JAXUCZ010000010.1  106579279-106579482 c
            3515-3801           JAXUCZ010000010.1  106578731-106579017 c
            3802-4188           JAXUCZ010000010.1  106577952-106578338 c
            4189-4353           JAXUCZ010000010.1  106577705-106577869 c
            4354-4472           JAXUCZ010000010.1  106577508-106577626 c
            4473-4627           JAXUCZ010000010.1  106577271-106577425 c
            4628-4834           JAXUCZ010000010.1  106576958-106577164 c
            4835-4985           JAXUCZ010000010.1  106576604-106576754 c
            4986-5164           JAXUCZ010000010.1  106576344-106576522 c
            5165-5284           JAXUCZ010000010.1  106576137-106576256 c
            5285-5407           JAXUCZ010000010.1  106575899-106576021 c
            5408-5631           JAXUCZ010000010.1  106575592-106575815 c
            5632-5833           JAXUCZ010000010.1  106575042-106575243 c
            5834-5985           JAXUCZ010000010.1  106574776-106574927 c
            5986-6077           JAXUCZ010000010.1  106574573-106574664 c
            6078-6229           JAXUCZ010000010.1  106574254-106574405 c
            6230-6475           JAXUCZ010000010.1  106573928-106574173 c
            6476-6664           JAXUCZ010000010.1  106573540-106573728 c
            6665-6892           JAXUCZ010000010.1  106573133-106573360 c
            6893-7113           JAXUCZ010000010.1  106572824-106573044 c
            7114-7212           JAXUCZ010000010.1  106572607-106572705 c
            7213-7464           JAXUCZ010000010.1  106572172-106572423 c
            7465-9139           JAXUCZ010000010.1  106570415-106572089 c
FEATURES             Location/Qualifiers
     source          1..9139
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..9139
                     /gene="Fasn"
                     /note="fatty acid synthase"
                     /db_xref="GeneID:50671"
                     /db_xref="RGD:620665"
     exon            1..75
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            76..211
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..7602
                     /gene="Fasn"
                     /EC_number="2.3.1.85"
                     /EC_number="2.3.1.38"
                     /EC_number="2.3.1.39"
                     /EC_number="2.3.1.41"
                     /EC_number="3.1.2.14"
                     /EC_number="4.2.1.59"
                     /EC_number="1.1.1.100"
                     /EC_number="1.3.1.39"
                     /note="type I FAS"
                     /codon_start=1
                     /product="fatty acid synthase"
                     /protein_id="NP_059028.2"
                     /db_xref="GeneID:50671"
                     /db_xref="RGD:620665"
                     /translation="MEEVVIAGMSGKLPESENLQEFWANLIGGVDMVTDDDRRWKAGL
                     YGLPKRSGKLKDLSKFDASFFGVHPKQAHTMDPQLRLLLEVSYEAIVDGGINPASLRG
                     TNTGVWVGVSGSEASEALSRDPETLLGYSMVGCQRAMMANRLSFFFDFKGPSIALDTA
                     CSSSLLALQNAYQAIRSGECPAAIVGGINLLLKPNTSVQFMKLGMLSPDGTCRSFDDS
                     GNGYCRAEAVVAVLLTKKSLARRVYATILNAGTNTDGCKEQGVTFPSGEAQEQLIRSL
                     YQPGGVAPESLEYIEAHGTGTKVGDPQELNGITRSLCAFRQSPLLIGSTKSNMGHPEP
                     ASGLAALTKVLLSLENGVWAPNLHFHNPNPEIPALLDGRLQVVDRPLPVRGGIVGINS
                     FGFGGANVHVILQPNTQQAPAPAPHAALPHLLHASGRTMEAVQGLLEQGRQHSQDLAF
                     VSMLNDIAATPTAAMPFRGYTVLGVEGHVQEVQQVPASQRPLWFICSGMGTQWRGMGL
                     SLMRLDSFRESILRSDEALKPLGVKVSDLLLSTDEHTFDDIVHSFVSLTAIQIALIDL
                     LTSMGLKPDGIIGHSLGEVACGYADGCLSQREAVLAAYWRGQCIKDANLPAGSMAAVG
                     LSWEECKQRCPPGVVPACHNSEDTVTISGPQAAVNEFVEQLKQEGVFAKEVRTGGLAF
                     HSYFMEGIAPTLLQALKKVIREPRPRSARWLSTSIPEAQWQSSLARTSSAEYNVNNLV
                     SPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGVKPSCTIIPLMKRDHKDNLEFFLT
                     NLGKVHLTGIDINPNALFPPVEFPVPRGTPLISPHIKWDHSQTWDIPVAEDFPNGSSS
                     SSATVYNIDASSESSDHYLVDHCIDGRVLFPGTGYLYLVWKTLARSLSLSLEETPVVF
                     ENVTFHQATILPRTGTVPLEVRLLEASHAFEVSDSGNLIVSGKVYQWEDPDSKLFDHP
                     EVPIPAESESVSRLTQGEVYKELRLRGYDYGPHFQGVYEATLEGEQGKLLWKDNWVTF
                     MDTMLQISILGFSKQSLQLPTRVTAIYIDPATHLQKVYMLEGDTQVADVTTSRCLGVT
                     VSGGVYISRLQTTATSRRQQEQLVPTLEKFVFTPHVEPECLSESAILQKELQLCKGLA
                     KALQTKATQQGLKMTVPGLEDLPQHGLPRLLAAACQLQLNGNLQLELGEVLARERLLL
                     PEDPLISGLLNSQALKACIDTALENLSTLKMKVVEVLAGEGHLYSHISALLNTQPMLQ
                     LEYTATDRHPQALKDVQTKLQQHDVAQGQWDPSGPAPTNLGALDLVVCNCALATLGDP
                     ALALDNMVAALKDGGFLLMHTVLKGHALGETLACLPSEVQPGPSFLSQEEWESLFSRK
                     ALHLVGLKKSFYGTALFLCRRLSPQDKPIFLPVEDTSFQWVDSLKSILATSSSQPVWL
                     TAMNCPTSGVVGLVNCLRKEPGGHRIRCILLSNLSSTSHVPKLDPGSSELQKVLESDL
                     VMNVYRDGAWGAFRHFQLEQDKPEEQTAHAFVNVLTRGDLASIRWVSSPLKHMQPPSS
                     SGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWASRDCMLGMEFSGRDKCGRRVMGL
                     VPAEGLATSVLLSPDFLWDVPSSWTLEEAASVPVVYTTAYYSLVVRGRIQHGETVLIH
                     SGSGGVGQAAISIALSLGCRVFTTVGSAEKRAYLQARFPQLDDTSFANSRDTSFEQHV
                     LLHTGGKGVDLVLNSLAEEKLQASVRCLAQHGRFLEIGKFDLSNNHPLGMAIFLKNVT
                     FHGILLDALFEGANDSWREVAELLKAGIRDGVVKPLKCTVFPKAQVEDAFRYMAQGKH
                     IGKVLVQVREEEPEAMLPGAQPTLISAISKTFCPEHKSYIITGGLGGFGLELARWLVL
                     RGAQRLVLTSRSGIRTGYQAKHVREWRRQGIHVLVSTSNVSSLEGARALIAEATKLGP
                     VGGVFNLAMVLRDAMLENQTPELFQDVNKPKYNGTLNLDRATREACPELDYFVAFSSV
                     SCGRGNAGQSNYGFANSTMERICEQRRHDGLPGLAVQWGAIGDVGIILEAMGTNDTVV
                     GGTLPQRISSCMEVLDLFLNQPHAVLSSFVLAEKKAVAHGDGEAQRDLVKAVAHILGI
                     RDLAGINLDSSLADLGLDSLMGVEVRQILEREHDLVLPIREVRQLTLRKLQEMSSKAG
                     SDTELAAPKSKNDTSLKQAQLNLSILLVNPEGPTLTRLNSVQSSERPLFLVHPIEGSI
                     TVFHSLAAKLSVPTYGLQCTQAAPLDSIPNLAAYYIDCIKQVQPEGPYRVAGYSFGAC
                     VAFEMCSQLQAQQGPAPAHNNLFLFDGSHTYVLAYTQSYRAKLTPGCEAEAEAEAICF
                     FIKQFVDAEHSKVLEALLPLKSLEDRVAAAVDLITRSHQSLDRRDLSFAAVSFYYKLR
                     AADQYKPKAKYHGNVILLRAKTGGTYGEDLGADYNLSQVCDGKVSVHIIEGDHRTLLE
                     GRGLESIINIIHSSLAEPRVSVREG"
     exon            212..364
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            365..538
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            539..739
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            740..862
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            863..978
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1113
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1576
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1764
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1954
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2049
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2184
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2388
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2504
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2677
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..2869
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..2950
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3130
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3310
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3514
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3801
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            3802..4188
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4353
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            4354..4472
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            4473..4627
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..4834
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            4835..4985
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            4986..5164
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5284
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            5285..5407
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5631
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            5632..5833
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            5834..5985
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            5986..6077
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            6078..6229
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            6230..6475
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            6476..6664
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            6665..6892
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            6893..7113
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            7114..7212
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            7213..7464
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
     exon            7465..9139
                     /gene="Fasn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacggca gcagcgtccc gtccagttcg cctgccgcgc tcctcgcttg tcgtctgcct
       61 ccagatccca gacagagaag agccatggag gaggtggtga tagccggtat gtccgggaaa
      121 ttgcccgagt cagagaacct gcaggagttc tgggccaacc tcattggcgg tgtggacatg
      181 gtcacagacg atgacaggag gtggaaggct gggctctatg ggttgcctaa gcggtctgga
      241 aagctgaagg atctgtccaa gttcgacgcc tccttttttg gggtccaccc caagcaggca
      301 cacacaatgg acccgcagct ccggctgctg ctggaagtca gctatgaagc tattgtggac
      361 ggaggtatca acccggcctc actccgagga acaaacactg gtgtctgggt gggtgtgagt
      421 ggttccgagg cgtcggaggc cctgagcaga gatcctgaga ctcttctggg ctacagcatg
      481 gtgggctgcc agagagcaat gatggccaac cggctctctt tcttcttcga cttcaaagga
      541 cccagcattg ccctggacac agcctgctcc tctagcctac tggcactaca gaatgcctat
      601 caggctatcc gcagtgggga gtgccctgct gccattgtgg gcgggatcaa cctgctgcta
      661 aagcctaaca cctctgtgca gttcatgaag ctaggcatgc tcagccccga tggcacctgc
      721 agatcctttg atgattcagg gaacgggtat tgccgtgctg aggctgtcgt ggcagttctg
      781 ctgactaaga agtccttggc tcggcgagtc tatgccacta ttctgaatgc cgggacgaac
      841 acagatggct gcaaggagca aggcgtgaca ttcccctctg gagaagccca ggaacaactc
      901 atccgttctc tgtatcagcc gggcggtgtg gcccccgagt ctcttgaata tattgaagcc
      961 catggcacgg gcaccaaggt gggggacccc caggaactga acggcattac tcggtccctg
     1021 tgtgctttcc gccagagccc tttgttaatt ggctccacca aatccaacat gggacaccct
     1081 gagcctgcct cggggcttgc agccctgacc aaggtgctgt tatccctaga aaatggggtt
     1141 tgggccccca acctgcattt ccacaacccc aaccctgaaa tcccagcact tcttgatggg
     1201 cggctgcagg tggtcgatag gcccctgcct gttcgtggtg gcatcgtggg catcaactcg
     1261 tttggcttcg gaggtgccaa tgttcacgtc atcctccagc ccaacacaca gcaggcccca
     1321 gcacctgccc cacatgctgc cctaccgcat ttgctgcatg ccagtggacg gaccatggag
     1381 gcagtgcagg gcctgctgga acagggccgc cagcacagtc aggacttggc ctttgtgagc
     1441 atgctcaatg acattgcagc aacccctaca gcagccatgc ccttcagagg ttacactgtg
     1501 ttaggtgttg agggccatgt ccaggaagtg cagcaagtgc ctgccagcca gcgcccactc
     1561 tggttcatct gctcagggat gggcacacag tggcgtggaa tggggctgag ccttatgcgc
     1621 ctggacagtt tccgtgagtc catcctgcgc tctgatgagg ctctgaagcc cttgggagtc
     1681 aaagtgtcag acctgctgct gagcactgat gagcacacct ttgatgacat cgtgcattcc
     1741 tttgtgagcc tcaccgccat ccagattgcc ctcatcgacc tgctgacgtc tatggggctg
     1801 aaacctgatg gcatcattgg gcactccttg ggagaggttg cctgtggcta tgcagatggc
     1861 tgtctctccc agagagaggc tgtgcttgca gcctactgga gaggccagtg cattaaggat
     1921 gccaaccttc cggctggatc catggcagct gttggtttgt cctgggaaga atgtaaacaa
     1981 cgctgccctc ctggtgtggt gcctgcctgc cacaactctg aggacactgt gaccatctct
     2041 ggacctcagg ctgcagtgaa tgaatttgtg gagcagctaa agcaagaggg cgtgtttgcc
     2101 aaggaggtgc gaacaggtgg cctggccttc cactcctact tcatggaagg aattgccccc
     2161 acgctgctgc aggctctcaa gaaggtgatc cgggagccac ggccacgctc agcacgctgg
     2221 ctcagcacct ctatccctga ggcccagtgg cagagcagcc tggcccgcac atcttctgct
     2281 gagtacaacg tcaacaacct ggtgagccct gtgctcttcc aggaagcact gtggcacgtc
     2341 cccgagcacg ccgtggtgct ggagattgca ccccatgcac tgttgcaggc tgtcctgaag
     2401 cgaggcgtga agcctagctg caccatcatc cccttgatga agagggacca taaagataac
     2461 ttggagttct tcctcaccaa cctcggcaag gtgcacctca caggcatcga catcaaccct
     2521 aatgccttgt tcccacctgt ggaattcccg gttccccgag ggactcctct catctcccct
     2581 cacatcaagt gggaccacag tcagacttgg gatatcccag ttgctgaaga cttccccaac
     2641 ggttccagct cctcctcagc tacagtctac aacattgacg ccagttccga gtcatctgac
     2701 cactacctgg tcgaccactg cattgacggc cgtgtcctct tccctggcac tggctacctg
     2761 tacctggtgt ggaagacact ggctcgaagc ctgagcttgt ccctagaaga gacccctgtg
     2821 gtgtttgaga acgtgacatt tcatcaggcc accatcctgc ccaggacagg aaccgtgcct
     2881 ctggaggtgc ggctgctaga ggcctcacat gcatttgagg tgtctgacag tggcaacctg
     2941 atagtgagcg ggaaagtgta ccagtgggaa gaccctgact ccaagttatt cgaccaccca
     3001 gaagtcccga tccccgccga gtccgagtct gtctcccgct tgacgcaggg agaagtatac
     3061 aaggagctgc ggctacgtgg ctatgactat ggccctcatt tccagggcgt ctatgaggcc
     3121 accctcgaag gtgagcaagg caagctgctc tggaaagaca actgggtgac cttcatggac
     3181 acaatgctgc agatatccat cctgggcttc agcaagcaga gtctgcagct acccacccgt
     3241 gtgactgcca tctatattga ccctgcaacc cacctgcaga aggtgtacat gctggaggga
     3301 gacactcaag tggctgacgt gaccacgagc cgctgtctgg gcgtgaccgt ctctggtggt
     3361 gtctacattt cgagactaca gacaacagca acctcacggc ggcagcagga acagctggtc
     3421 cccaccctgg agaagtttgt cttcacaccc catgtggagc ctgagtgcct gtctgagagt
     3481 gctatcctgc agaaagagct gcagctgtgc aagggtctgg caaaggctct gcagaccaag
     3541 gccacccagc aagggctgaa gatgacagtg cctgggctag aggaccttcc ccagcatgga
     3601 ctgcctcgac tcttggctgc tgcctgccag ctgcagctca acgggaacct gcaactggag
     3661 ttaggtgagg tactggctcg agagaggctc ctgctgccag aagaccctct gatcagtggc
     3721 ctccttaact cccaggccct caaggcctgc atagacacag ccctggagaa cttgtctact
     3781 ctcaagatga aggtggtgga ggtgctggct ggagaaggcc acttgtattc ccacatctca
     3841 gcactgctca acacccagcc tatgctgcaa ctggagtata cagccaccga ccggcacccc
     3901 caggccctga aggatgttca gaccaagctg cagcagcatg atgtagcaca gggccagtgg
     3961 gacccttctg gtcctgctcc taccaacctg ggtgctcttg accttgtggt gtgcaactgt
     4021 gcgttagcca ccctggggga tccagccctg gccctggaca acatggtagc tgccctcaag
     4081 gatggtggtt tcctgctaat gcacacagtg ctcaaaggac atgcccttgg ggagaccctg
     4141 gcctgcctcc cttctgaggt gcagcctggg cccagcttct taagccagga agagtgggag
     4201 agcctgttct caaggaaggc actgcacctg gtgggcctta aaaagtcatt ctacggtact
     4261 gcgctgttcc tgtgccgccg tctcagccca caggacaagc ccatcttcct gcctgtggag
     4321 gatactagtt tccagtgggt ggactctctg aagagcattc tggccacatc ctcctcccag
     4381 cctgtgtggc taacagccat gaactgcccc acctcaggtg tggtaggctt ggtgaactgt
     4441 ctccgaaaag agccgggtgg acaccggatt cggtgtatcc tgctgtccaa cctcagcagc
     4501 acatctcacg tccccaagct ggaccctggc tcttcagagc tacagaaggt gctagagagt
     4561 gatctggtga tgaacgtgta cagggacggt gcctggggtg ccttccgtca cttccagtta
     4621 gagcaggaca agcccgagga gcagacagca catgcctttg taaacgtcct tacccgaggg
     4681 gaccttgcct ccatccgctg ggtctcttct cccctgaaac acatgcagcc gccctcgagc
     4741 tcaggagcac agctctgcac tgtctactat gcctcactga acttccgaga tatcatgctg
     4801 gccacgggca agctgtcccc tgatgccatt ccaggtaaat gggccagccg ggactgcatg
     4861 cttggcatgg agttctcagg ccgtgataag tgcggccggc gtgtgatggg gctggtaccc
     4921 gcagaaggcc tggccacctc agtcctgtta tcacccgact tcctctggga tgtaccctct
     4981 agctggaccc tggaggaggc ggcttctgtg cctgttgtct acaccaccgc ctactactcc
     5041 ttagtagtgc gtggtcgtat tcagcacggg gaaactgtgc tcattcactc gggctccggt
     5101 ggtgtgggcc aagcggccat ttccattgcc cttagcctgg gctgccgagt cttcaccact
     5161 gtgggctccg ctgagaagcg agcttacctc caggccagat tccctcagct ggatgacacc
     5221 agctttgcta actctcgaga cacatcgttt gagcagcatg tgttactgca cacaggtggc
     5281 aaaggggtgg acctggtcct caactccctg gcagaagaga agctgcaggc cagtgtgcgg
     5341 tgcttggctc agcatggccg cttcctagag atcggcaaat ttgatctttc taacaaccac
     5401 cctctgggca tggccatctt cttgaagaac gtcactttcc atgggatcct gctggatgca
     5461 ctttttgagg gggccaacga cagctggcgg gaggtggcag agctgctgaa ggccggcatc
     5521 cgtgatgggg ttgtgaagcc tctcaagtgt acagtgtttc ccaaggccca ggtggaggac
     5581 gccttccgat acatggctca aggaaaacat attggcaaag tccttgtcca ggtacgggag
     5641 gaggagcccg aggctatgct gccaggggct cagcccaccc tgatttccgc catctccaag
     5701 accttctgcc cagagcataa gagttacatc atcactggtg gcctaggtgg ctttggcctg
     5761 gaactggccc ggtggcttgt gcttcgtggg gcccaaaggc ttgtactaac ttcccgatct
     5821 ggaatccgca caggctacca agccaagcac gttcgggagt ggaggcgcca gggcatccat
     5881 gtgctagtgt cgacaagcaa tgtcagttca ctggaggggg cccgtgctct catcgctgaa
     5941 gccacaaagc ttgggcccgt tggaggtgtc ttcaacctgg ccatggtttt aagggatgcc
     6001 atgctggaga accagactcc agaactcttc caggatgtca acaagcccaa gtacaatggc
     6061 accctgaacc ttgacagggc gacccgggaa gcctgtcctg agctggacta ctttgtggcc
     6121 ttctcctctg taagctgcgg gcgtggtaat gctggccaat ccaactatgg cttcgccaac
     6181 tctaccatgg agcgtatttg cgaacagcgc cggcacgatg gcctcccagg tcttgccgtg
     6241 caatggggtg ccattggtga cgtgggcatt atcttggaag cgatgggtac caatgacaca
     6301 gtcgttggcg gcacactgcc acagcgcatc tcctcctgca tggaggtgct ggacctcttc
     6361 ctgaatcagc cccacgcagt cctgagcagt tttgtgctgg ctgagaagaa agctgtggcc
     6421 catggtgatg gtgaagccca gagggatctg gtgaaagcag tggcacacat cctaggcatc
     6481 cgcgacctcg cagggattaa cctggacagc tcgctggcag acctcggcct ggactcgctc
     6541 atgggtgtgg aagtgcgcca gatcctggaa cgtgaacatg atctggtgct acccattcgt
     6601 gaagtacggc aactcacact gcggaagctt caggaaatgt cctccaaggc tggctcagac
     6661 actgagttgg cagcccccaa gtccaagaat gatacatccc tgaagcaggc ccagctgaat
     6721 ctgagtatcc tgctggtgaa ccctgagggc cctaccttaa cacgactcaa ctcagtgcag
     6781 agctctgagc ggcctctgtt cctggtgcac cccattgaag gttccatcac tgtgttccac
     6841 agcctggctg ccaagctcag tgtgcccacc tacggtctgc agtgcaccca agcggccccc
     6901 ctggacagca ttccaaacct ggctgcctac tacattgatt gcatcaagca ggtgcagcct
     6961 gaggggccct accgagtggc tgggtattct tttggagctt gtgtagcctt cgagatgtgc
     7021 tcccagctgc aggcccagca gggcccagcc cccgcccaca acaacctctt cttgtttgat
     7081 ggctcacaca cctacgtatt ggcgtacacc cagagctacc gggcaaagct gaccccaggc
     7141 tgtgaggctg aggctgaagc tgaagccata tgcttcttca ttaagcagtt tgttgatgca
     7201 gagcatagca aggtgctaga ggccctgcta ccactgaaga gcctggagga ccgggttgct
     7261 gctgctgtgg acctcatcac tagaagccac cagagcctgg accgccgtga cctgagcttt
     7321 gctgccgtgt ccttctacta caagcttcga gccgccgacc agtataaacc caaggccaag
     7381 taccacggca atgtgatcct gctgcgggcc aagacaggtg gcacctacgg cgaggacttg
     7441 ggtgccgatt acaacctgtc ccaggtgtgt gatgggaagg tgtctgtgca catcattgag
     7501 ggtgaccatc gtacgctgct ggagggcagg ggcctggagt ctatcatcaa catcatccac
     7561 agctccctgg ctgagcctcg agtgagtgta cgggagggct agacctgcct accatgaagc
     7621 cacgacccac accggccacc agagatgctc cgatccccac cacaccctga gtgcagggac
     7681 tggggagggt cctgctggtg ggaccccctc accccagtgg cccagcacca ccccctcccc
     7741 tggtggctgc tacaaacagg accatcacat gtgtcccagc cacttagtgg ggttcccaga
     7801 gccactgact tggaggcacc ctggtctgtg aagagtcagt ggaggccagc aagagccaaa
     7861 ctgagccttt tctgccaagt gacatttgtc acactggttg tttctccatt aaattctcat
     7921 atttattgca ttgctgggaa agaccgccca ccccagggtt aactcattcc agaaccccta
     7981 aagtgggaaa agccatgtgg ggaaggctgc tggctggagc ccctttttgt cttagccctg
     8041 tacccgctca ctgcagggca gggtatggag agggctggtt cccggggaac gaggacccca
     8101 gcagacactg tagcccatgg cccttggtcc ccagcactcc cggctgcacc catgatgcag
     8161 ggcctaccag actctgcgga ccgcaccggg cactcactgt atttgttttc caagattcaa
     8221 attgctgctt gggttttgaa tttactgcag ctgtcagtgt aaagaaacat gtctgaactg
     8281 tgtccttttt acaccaacct ggtaaaaatg ctcttgatgc tgtcccgttg ccacaattaa
     8341 actgcacgtg agctctggct tccgttcagt ctctttccag tcccagacct gagtccccag
     8401 agcctccaca gctcttacag tgagaatcaa attggcccac tccttggaag gcgtggcatt
     8461 ctgtcagagt aaaaggaaag tagagtgtgc tgattcacgt tcagcgtgtg gggctggcta
     8521 gagaccttgg cactgtagtg aacagaatgt gtccaccttt aagtcaccct gaaggcatca
     8581 ccatagctac agcctcaccc aggggtagag aatagtactg tctacttgtt gactacctgg
     8641 cagttggtgc cagcccctat agaggaaaac agcagtgtgt ggccactgtg agaagcatat
     8701 ccctggaaac aggtgaccag agcagagggc taatgcctac ctgagtcaca caaaactgac
     8761 caggcttgag tgtccagaag agtctatcag aaggccacag cattcagtcc tatccacaga
     8821 gagcagcaga ctaagttgtc tccttgccag cttagaaaac tgcagtgctg gggtacaggt
     8881 agggtgttca ggaggtccgg gccccagtga ttagtctaag actgaagcat ctggttggct
     8941 gtggtcccac ctagaaaatt cttaaagctc ttgtcatgta cttcctggga aggacctacc
     9001 ctgtctcaat aatgtctcta gctcgttgga gtctactgac tcaaacattt ataaagtgtc
     9061 ctagaaaggc ctgactcccc tacaaggctg tgtgatcctt caaactcaca tatgtgagcc
     9121 aataaaacct tgagactct
//
