LOCUS       NM_139194               2553 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus Fas cell surface death receptor (Fas), mRNA.
ACCESSION   NM_139194 XM_345026 XM_347303
VERSION     NM_139194.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Yang,S., Gao,J., Chen,M., Sun,Y., Qiao,X., Mao,H., Guo,L., Yu,Y.
            and Yang,D.
  TITLE     Let-7a promotes periodontal bone regeneration of bone marrow
            mesenchymal stem cell aggregates via the Fas/FasL-autophagy pathway
  JOURNAL   J Cell Mol Med 27 (24), 4056-4068 (2023)
   PUBMED   37855249
  REMARK    GeneRIF: Let-7a promotes periodontal bone regeneration of bone
            marrow mesenchymal stem cell aggregates via the Fas/FasL-autophagy
            pathway.
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Song,Z., Tian,X. and Shi,Q.
  TITLE     Fas, Caspase-8, and Caspase-9 pathway-mediated bile acid-induced
            fetal cardiomyocyte apoptosis in intrahepatic cholestasis pregnant
            rat models
  JOURNAL   J Obstet Gynaecol Res 47 (7), 2298-2306 (2021)
   PUBMED   33847039
  REMARK    GeneRIF: Fas, Caspase-8, and Caspase-9 pathway-mediated bile
            acid-induced fetal cardiomyocyte apoptosis in intrahepatic
            cholestasis pregnant rat models.
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Tang,H., Zhang,S., Huang,C., Li,K., Zhao,Q. and Li,X.
  TITLE     MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia Through
            Regulating the FAS/FAS-L Signaling Pathway
  JOURNAL   Int Heart J 62 (3), 647-657 (2021)
   PUBMED   33994507
  REMARK    GeneRIF: MiR-448-5p/VEGFA Axis Protects Cardiomyocytes from Hypoxia
            Through Regulating the FAS/FAS-L Signaling Pathway.
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Gul-Kahraman,K., Yilmaz-Bozoglan,M. and Sahna,E.
  TITLE     Physiological and pharmacological effects of melatonin on remote
            ischemic perconditioning after myocardial ischemia-reperfusion
            injury in rats: Role of Cybb, Fas, NfkappaB, Irisin signaling
            pathway
  JOURNAL   J Pineal Res 67 (2), e12589 (2019)
   PUBMED   31155748
  REMARK    GeneRIF: The physiological release and pharmacological
            concentration of melatonin may improve protective effect of RIPerC
            against I/R-induced infarct size by modulating Cybb, Fas, NfkappaB,
            Irisin signaling pathways.
            Erratum:[J Pineal Res. 2019 Nov;67(4):e12609. doi:
            10.1111/jpi.12609.. PMID: 31657078]
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Cubero,F.J., Woitok,M.M., Zoubek,M.E., de Bruin,A., Hatting,M. and
            Trautwein,C.
  TITLE     Disruption of the FasL/Fas axis protects against
            inflammation-derived tumorigenesis in chronic liver disease
  JOURNAL   Cell Death Dis 10 (2), 115 (2019)
   PUBMED   30737368
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Amasaki,Y., Kobayashi,S., Takeda,T., Ogura,N., Jodo,S.,
            Nakabayashi,T., Tsutsumi,A., Fujisaku,A. and Koike,T.
  TITLE     Up-regulated expression of Fas antigen (CD95) by peripheral naive
            and memory T cell subsets in patients with systemic lupus
            erythematosus (SLE): a possible mechanism for lymphopenia
  JOURNAL   Clin Exp Immunol 99 (2), 245-250 (1995)
   PUBMED   7531628
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Kotani,T., Aratake,Y., Kondo,S., Tamura,K. and Ohtaki,S.
  TITLE     Expression of functional Fas antigen on adult T-cell leukemia
  JOURNAL   Leuk Res 18 (4), 305-310 (1994)
   PUBMED   7513372
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Takahashi,T., Tanaka,M., Brannan,C.I., Jenkins,N.A., Copeland,N.G.,
            Suda,T. and Nagata,S.
  TITLE     Generalized lymphoproliferative disease in mice, caused by a point
            mutation in the Fas ligand
  JOURNAL   Cell 76 (6), 969-976 (1994)
   PUBMED   7511063
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Kimura,K., Wakatsuki,T. and Yamamoto,M.
  TITLE     A variant mRNA species encoding a truncated form of Fas antigen in
            the rat liver
  JOURNAL   Biochem Biophys Res Commun 198 (2), 666-674 (1994)
   PUBMED   7507668
REFERENCE   10 (bases 1 to 2553)
  AUTHORS   Davidson,W.F., Roths,J.B., Holmes,K.L., Rudikoff,E. and Morse,H.C.
            3rd.
  TITLE     Dissociation of severe lupus-like disease from polyclonal B cell
            activation and IL 2 deficiency in C3H-lpr/lpr mice
  JOURNAL   J Immunol 133 (2), 1048-1056 (1984)
   PUBMED   6610701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139194.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.2175.1,
                                           SRR26643292.6226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000001.1  241212155-241212238
            85-238              JAXUCZ010000001.1  241230473-241230626
            239-376             JAXUCZ010000001.1  241238414-241238551
            377-485             JAXUCZ010000001.1  241239575-241239683
            486-550             JAXUCZ010000001.1  241241627-241241691
            551-607             JAXUCZ010000001.1  241241844-241241900
            608-672             JAXUCZ010000001.1  241242342-241242406
            673-697             JAXUCZ010000001.1  241243219-241243243
            698-2553            JAXUCZ010000001.1  241243919-241245774
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2553
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /note="Fas cell surface death receptor"
                     /db_xref="GeneID:246097"
                     /db_xref="RGD:619831"
     exon            1..84
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1029
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /note="tumor necrosis factor receptor superfamily member
                     6; Fas receptor; apoptosis-mediating surface antigen FAS;
                     apo-1 antigen; CD95 antigen; FASLG receptor; Tumor
                     necrosis factor receptor superfamily, member 6; Fas
                     antigen (ATP1); Fas (TNF receptor superfamily, member 6)"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 6 precursor"
                     /protein_id="NP_631933.2"
                     /db_xref="GeneID:246097"
                     /db_xref="RGD:619831"
                     /translation="MLWIMAVLPLVLAGPELNVRMQGTDSISEGLELKRSVRETDNNC
                     SEGLYQVGPFCCQPCQPGERKVKDCTTSGGAPTCHPCTEGEEYTDRKHYSDKCRRCAF
                     CDEGHGLEVETNCTRTQNTKCRCKENFYCNASLCDHCYHCTSCGLEDILEPCTRTSNT
                     KCKKQSSNYKLLWLLILPGLAILFVFIYKRYRKRQPGDPESGIPSPESVPMNVSDVNL
                     NKYIWRTAEKMKICDAKKFARQHKIPESKIDEIEHNSPQDAAEQKIQLLQCWYQSHGK
                     TGACQALIQGLRKANRCDIAEEIQAMVWEDHENSISNSRNENEGQSLE"
     exon            85..238
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            239..376
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            377..485
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            486..550
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..607
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            608..672
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            673..697
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..2553
                     /gene="Fas"
                     /gene_synonym="FasR; Tnfrsf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtggggct cacagactgc cctaggcggg gaactgcttt ctctttctgc agatatgctg
       61 tggatcatgg ctgtcctgcc tctggtgctt gctggccccg agttaaatgt tcgaatgcaa
      121 gggactgata gcatctctga gggtttggag ttgaagagga gcgttcgtga aaccgacaac
      181 aactgctcag aagggttata tcaagtgggc ccattttgct gtcaaccgtg tcagcctggt
      241 gaacgaaaag ttaaggactg cacaacaagt ggaggtgcac caacctgcca tccgtgcaca
      301 gaaggggagg agtacacgga caggaaacac tattctgata aatgcagaag gtgcgccttc
      361 tgtgatgaag ggcatggttt agaagtggaa acgaactgca cccggaccca gaataccaag
      421 tgcaggtgca aagaaaactt ctattgcaat gcttctctct gtgaccactg ttatcactgc
      481 acctcgtgtg gacttgaaga catccttgag ccttgcacac gaaccagcaa caccaaatgc
      541 aagaaacaaa gttccaatta taagctcctt tggctgctga tcctccccgg tttggcaatt
      601 ctatttgtgt tcatatataa aaggtaccgg aagaggcaac ctggtgaccc tgaatctgga
      661 atcccaagtc ctgaaagtgt gccaatgaat gtctcagatg ttaacttgaa taaatacatc
      721 tggagaactg ccgaaaaaat gaaaatctgt gacgctaaaa aatttgctcg gcagcacaag
      781 atcccggaaa gcaagatcga tgagatcgag cacaacagcc cccaagatgc agctgagcag
      841 aaaatccagc tgctccagtg ctggtatcaa tctcacggga agactggtgc gtgtcaagct
      901 ttaatccagg gtctcagaaa agctaaccgc tgcgacatcg cagaggaaat tcaagccatg
      961 gtctgggagg accatgaaaa ctcaatctca aacagcagaa atgaaaatga aggacaaagt
     1021 ctggagtgaa aactacctcg gttccagcca caaagagagg agagagcctg ccacctatga
     1081 cgggcaccaa aatgaaagcc aactgcatcg acaccggcaa ttcctggcgt gttctttttg
     1141 ccagcaaatg gtagcctgtg ctcagcgagg gtccaatgac ctgcaggttc cagagattac
     1201 atctgttatt ctgcacaggt gttgagagga accgtttcct cagtctcatt tcctcagtct
     1261 tccgctattt tgtgactttt acgttcaaac ctccatggaa gtcatgctaa atgtgaattg
     1321 gaatccgcag tgtttgtgtt tatgttcata atactgtgaa ctgaggcgtc ttataaacgg
     1381 aaacaaagac cttcctctgg tggattgttc ttttcctctc tatatggaaa tgtggaatag
     1441 aagaaatact ttttaaatta acgtatcgtt tttgcatttc tagttgccta ttatagaaat
     1501 gtgtaataga agaaataatg ttttaaatta acctatcgtt ttttgcattt ctagttgcct
     1561 gttatggaaa tgcaaaatag aagaaatact ttttaaatta agatatcgtt tttgtatttc
     1621 tagttgcctg ttgttttctt gttattttac ttttctttac tctaatgacc caccaaacat
     1681 tgtctgctca atgagtcgtt aaaggtggat ttgatctctt agggggaaat tcctttgcaa
     1741 agcctttcca cagttaagtg gttcattccg tgactgctac tgtggagaag actttagctg
     1801 ggcagatgtc tgatattctt aaggaatctc actaccatga tctcaaaagt gcatgtaagt
     1861 agaaagagta cacgtcttgg ggatttgcct acaattttct ctgagggatg accgtcttgg
     1921 ctgtcccgtc cagctttcta gttggaaaga accgaaggac aaacccagta gcgttcagcg
     1981 atgaaactcc catgtttaaa ggtgaaatta aacatgagaa catcctgtgc ctactttgag
     2041 gagtttgaac ttgaaccaag aactttgagt cccttttaca aagcttcgta cttgaggatg
     2101 tgagtctttt ccccctggct tcacccagag gctccaggaa tgactgctct gacatcaata
     2161 atcatggctg tgttctggac ttaaagtgac ttctagttcc aaagttacct tggcttagtg
     2221 attgcatctc gtttgtggta gacatcatga gcagggatac actcaaatat cacttacagg
     2281 ctgcagaaaa aaaaagacta tctacaaaag gaggacagag accctgcggg ccttgcatac
     2341 ttaaacatct agacattctt tgttagcacc taaggagtcc tctggtattt gaccaggtcc
     2401 tgtgcagtgc cacattgtta atttctgcgt agtgatctag atgtgcagtg tctgcaatta
     2461 tttcccatgc tctcttctga atggaaattt atctgcatta gaattttata ccaggagctg
     2521 ggaggtaact cagtagtaaa ttaccttcaa gca
//
