LOCUS       NM_001013139            1782 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phenylalanyl-tRNA synthetase 2, mitochondrial
            (Fars2), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001013139 XM_225279
VERSION     NM_001013139.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Li,B., Liu,F., Chen,X., Chen,T., Zhang,J., Liu,Y., Yao,Y., Hu,W.,
            Zhang,M., Wang,B., Liu,L., Chen,K. and Wu,Y.
  TITLE     FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial
            Homeostasis and the Mitochondrial Quality Control System
  JOURNAL   Circulation 149 (16), 1268-1284 (2024)
   PUBMED   38362779
  REMARK    GeneRIF: FARS2 Deficiency Causes Cardiomyopathy by Disrupting
            Mitochondrial Homeostasis and the Mitochondrial Quality Control
            System.
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Yang,Y., Liu,W., Fang,Z., Shi,J., Che,F., He,C., Yao,L., Wang,E.
            and Wu,Y.
  TITLE     A Newly Identified Missense Mutation in FARS2 Causes
            Autosomal-Recessive Spastic Paraplegia
  JOURNAL   Hum Mutat 37 (2), 165-169 (2016)
   PUBMED   26553276
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Bullard,J.M., Cai,Y.C., Demeler,B. and Spremulli,L.L.
  TITLE     Expression and characterization of a human mitochondrial
            phenylalanyl-tRNA synthetase
  JOURNAL   J Mol Biol 288 (4), 567-577 (1999)
   PUBMED   10329163
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078956.1.
            
            On Apr 20, 2005 this sequence version replaced XM_225279.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078956.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1782
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /note="phenylalanyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:306879"
                     /db_xref="RGD:1309416"
     exon            1..86
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..164
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..797
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1604
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /EC_number="6.1.1.20"
                     /note="phenylalanyl-tRNA synthetase, mitochondrial; pheRS;
                     phenylalanine-tRNA synthetase 1 (mitochondrial);
                     phenylalanine-tRNA synthetase 2 (mitochondrial)"
                     /codon_start=1
                     /product="phenylalanine--tRNA ligase, mitochondrial"
                     /protein_id="NP_001013157.1"
                     /db_xref="GeneID:306879"
                     /db_xref="RGD:1309416"
                     /translation="MVCLAFIRAAHEHLYLVRKVSHVCRCHQHRAWGSRPAASQFAVQ
                     GAPGRVLELLGKSYPQDDHTNLTQKVLSKVGRNLHNQKFHPLWLIKERVKEHFYQQYM
                     GRSRTPLFSVYDQLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRGHMLRAHTSAHQ
                     WDLLHAGLNAFLVVGDVYRRDQIDSQHYPVFHQLEGVRLFSKHELFAGVKDGESLQLF
                     EESSRSAHKQETHTMEAVKLVEFDLKQVLTRLVTHLFGDGLEVRWVDCYFPFTHPSFE
                     MEINFRGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMVLYDIPDIRLFWS
                     EDERFLKQFRLSDINQSVKFQRWFFQEERATGIQRKMGRQLCPFSKYPAVFNDISFWL
                     PSENYTENDFYDIVRTVGGDLVEKVDLIDKFEHPKTHRTSHCYRITYRHMERTLSQRE
                     VSSVHQAVQEAAVQLLGVEGRF"
     exon            798..957
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1089
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1250
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1313
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1465
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1757
                     /gene="Fars2"
                     /gene_synonym="Fars1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaagctca gcgactaccg attgaacgtg tggccgcgtt gcggacttcg aaacacccgc
       61 gtttgtgttt ccccggcgta ggctggggta ctgtttcctg tgaaggccgc ctgactctgc
      121 attctcacaa gcaagtgcac aggcttccag gccccacctc ggagagtttg tgagaagctt
      181 ctataatggt ctgtttggcc ttcatcagag ctgcccatga gcacctctac ctggtgagga
      241 aagtcagtca tgtctgcaga tgtcatcaac atcgggcttg gggctcaagg ccagctgcat
      301 cgcagtttgc tgtccaaggt gctccaggcc gtgtgctgga gctgcttggt aaatcctacc
      361 ctcaagatga ccacactaac ctcacccaga aagtcctttc caaggtgggc aggaacctgc
      421 acaaccagaa gttccaccct ctgtggctga ttaaggagcg ggtgaaggag cacttctacc
      481 agcagtacat ggggcgatcc aggacacctc tgttctccgt ctatgaccag ctttccccag
      541 tggtcaccac ctggcagaac ttcgatagcc tgctaatccc agctgaccac cccagcagga
      601 agaaggggga caactattac ttgaatcggg gacacatgct gagagcacac acatcagcac
      661 atcagtggga cttgctgcat gcggggctca atgccttcct cgtggtaggt gatgtgtatc
      721 ggcgtgacca gattgattcc cagcactacc cagttttcca ccagctggag ggcgtccgac
      781 tcttctccaa gcatgagtta tttgctggtg taaaggatgg agaaagcttg cagctctttg
      841 aagaaagttc tcgttctgct cataagcaag agacacacac catggaggct gtgaagcttg
      901 tggaatttga ccttaaacaa gtactcacta ggcttgtgac acatcttttt ggagatgggc
      961 tggaggtccg gtgggtggac tgctactttc cctttaccca cccttccttc gagatggaga
     1021 tcaacttccg tggagaatgg cttgaagtcc tcggctgcgg ggtgatggaa caacagcttg
     1081 tcaattcagc tggtgctcag gatcggatcg gctgggcttt tggcctggga ttagagagac
     1141 tggctatggt cctctacgac atcccggaca tccgcctttt ctggagtgag gatgagcgct
     1201 tcctgaagca gttccgccta tcagacatca atcaaagcgt caagtttcag agatggttct
     1261 tccaagaaga aagggccaca ggaatacaaa ggaagatggg aagacagctc tgtcctttta
     1321 gcaagtaccc cgctgtgttc aatgacattt cattctggct gccctccgag aactacacgg
     1381 agaatgattt ctatgacatt gtccgaacag tcggaggaga cctggtggaa aaggttgatc
     1441 ttatagacaa gtttgaacat ccaaagacac acagaaccag ccattgctac cgcattacct
     1501 accggcacat ggaacggaca ctgtcccaga gagaagtcag cagtgtccac caggctgtgc
     1561 aggaggccgc tgtgcagcta ctgggtgtgg aaggccgttt ttgatatcat gcattacata
     1621 ggctgcagcc ctcacggagc tccaggactc gccagaaagg ggaaacacat tgtttgtgaa
     1681 ctggagtgtc tgtcctcgtt tgataaatgg gtctgcttta ggactttcag gaaataaagg
     1741 atcacttttt agaagcaaaa aaaaaaaaaa aaaaaaaaaa aa
//
