LOCUS       NM_001108233            3791 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus FERM, ARH/RhoGEF and pleckstrin domain protein 2
            (Farp2), mRNA.
ACCESSION   NM_001108233 XM_001070569 XM_006245532 XM_237444
VERSION     NM_001108233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3791)
  AUTHORS   DiTommaso,T., Jones,L.K., Cottle,D.L., Gerdin,A.K., Vancollie,V.E.,
            Watt,F.M., Ramirez-Solis,R., Bradley,A., Steel,K.P., Sundberg,J.P.,
            White,J.K. and Smyth,I.M.
  CONSRTM   WTSI Mouse Genetics Program
  TITLE     Identification of genes important for cutaneous function revealed
            by a large scale reverse genetic screen in the mouse
  JOURNAL   PLoS Genet 10 (10), e1004705 (2014)
   PUBMED   25340873
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3791)
  AUTHORS   He,X., Kuo,Y.C., Rosche,T.J. and Zhang,X.
  TITLE     Structural basis for autoinhibition of the guanine nucleotide
            exchange factor FARP2
  JOURNAL   Structure 21 (3), 355-364 (2013)
   PUBMED   23375260
REFERENCE   3  (bases 1 to 3791)
  AUTHORS   Takegahara,N., Kang,S., Nojima,S., Takamatsu,H., Okuno,T.,
            Kikutani,H., Toyofuku,T. and Kumanogoh,A.
  TITLE     Integral roles of a guanine nucleotide exchange factor, FARP2, in
            osteoclast podosome rearrangements
  JOURNAL   FASEB J 24 (12), 4782-4792 (2010)
   PUBMED   20702777
REFERENCE   4  (bases 1 to 3791)
  AUTHORS   Kubo,T., Yamashita,T., Yamaguchi,A., Sumimoto,H., Hosokawa,K. and
            Tohyama,M.
  TITLE     A novel FERM domain including guanine nucleotide exchange factor is
            involved in Rac signaling and regulates neurite remodeling
  JOURNAL   J Neurosci 22 (19), 8504-8513 (2002)
   PUBMED   12351724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 27, 2021 this sequence version replaced
            XM_006245532.4, NM_001108233.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.24978.1,
                                           SRR26643293.52276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000009.1  101501127-101501174
            49-259              JAXUCZ010000009.1  101516654-101516864
            260-364             JAXUCZ010000009.1  101548784-101548888
            365-407             JAXUCZ010000009.1  101549679-101549721
            408-486             JAXUCZ010000009.1  101551739-101551817
            487-584             JAXUCZ010000009.1  101556512-101556609
            585-699             JAXUCZ010000009.1  101557997-101558111
            700-847             JAXUCZ010000009.1  101558526-101558673
            848-943             JAXUCZ010000009.1  101562289-101562384
            944-1107            JAXUCZ010000009.1  101564215-101564378
            1108-1176           JAXUCZ010000009.1  101564685-101564753
            1177-1234           JAXUCZ010000009.1  101565674-101565731
            1235-1490           JAXUCZ010000009.1  101567696-101567951
            1491-1669           JAXUCZ010000009.1  101587554-101587732
            1670-1759           JAXUCZ010000009.1  101591466-101591555
            1760-1893           JAXUCZ010000009.1  101592128-101592261
            1894-1963           JAXUCZ010000009.1  101592837-101592906
            1964-2201           JAXUCZ010000009.1  101595538-101595775
            2202-2332           JAXUCZ010000009.1  101597912-101598042
            2333-2401           JAXUCZ010000009.1  101598655-101598723
            2402-2491           JAXUCZ010000009.1  101599389-101599478
            2492-2574           JAXUCZ010000009.1  101604822-101604904
            2575-2693           JAXUCZ010000009.1  101605564-101605682
            2694-2851           JAXUCZ010000009.1  101606055-101606212
            2852-2959           JAXUCZ010000009.1  101607321-101607428
            2960-3111           JAXUCZ010000009.1  101607677-101607828
            3112-3791           JAXUCZ010000009.1  101608413-101609092
FEATURES             Location/Qualifiers
     source          1..3791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..3791
                     /gene="Farp2"
                     /note="FERM, ARH/RhoGEF and pleckstrin domain protein 2"
                     /db_xref="GeneID:316639"
                     /db_xref="RGD:1308003"
     exon            1..48
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            49..259
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3259
                     /gene="Farp2"
                     /note="FERM, RhoGEF and pleckstrin domain-containing
                     protein 2; FERM, RhoGEF and pleckstrin domain protein 2"
                     /codon_start=1
                     /product="FERM, ARHGEF and pleckstrin domain-containing
                     protein 2"
                     /protein_id="NP_001101703.1"
                     /db_xref="GeneID:316639"
                     /db_xref="RGD:1308003"
                     /translation="MGEIEGTYRTLPTSGTRLGGQTAIGVSTLEPEQALSPKMQEKHM
                     HIRVKLLDSTVEIFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPM
                     KPIIRQVRKPKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLRRDLLEERLTCTATTS
                     ALLISHLLQSEIGDYDETLDREHLKANDYLPNQEQSLDKILDFHQRHTGQTPADSDFQ
                     VLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFK
                     RKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEHHTFFRLSDQPKPKAKAVF
                     FSRGSSFRYSGRTQKQLVDYIRDGGTKRIPYERRHSKTRTSLHTLTGDLPKQSISFTD
                     GLRTSASLSSANASFYPPPTSLSSPGLPSVKDSSSSPVDPQAPHIKSTAAERSSRPSS
                     SEGPSTQSAHLPGPPVLQPGPGFSVDSPQPSPSSLKSRLSLSPERQASLSTAEQGSSP
                     VLSPVLSGTGTARMDNQEEQKHKHTSEDEAYFIAKEIVATERTYLKDLEVITVWFRSV
                     VIKEEAMPAALMTLLFSNIDPIYEFHRGFLHEVEQRLALWEGPSSGDHQRIGDILLRN
                     MRQLKEFTSYFQRHDEVLTELEKATKHCKRLEAVYKEFELQKVCYLPLNTFLLKPVQR
                     LVHYRLLLNRLCTHYSPEHEDYTDCHEALKAITEVTTELQQSLTRLENLQKLTELQRD
                     LVGVENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYTSKSVTGASQFRIRGF
                     LPLRGMLVEDSENEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMQDLNAAIQAAKSAG
                     DTPAVLLGGPVYTRSPRSSDEVSLEDSEDGRGTRGSLEGNSQHRANTTMHVCWYRNTS
                     VSRADHSAAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLL
                     GYSVSLPREADSIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIKRASSSPGRPPSF
                     TQDCSHLSPGLEAEVREKEACPSLCLDKNL"
     exon            260..364
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..407
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..486
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..584
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..699
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..847
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..943
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1107
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1176
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1234
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1490
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1669
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1759
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1893
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1963
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2201
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2332
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2401
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2491
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2574
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2693
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2851
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2959
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3111
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3791
                     /gene="Farp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacgtggag gaggcctggc tggcggcgtc gcaggccggt gtggcacgtg tttccttcag
       61 tttcaactaa tgaagaatgg gggagataga aggaacatac agaactttac caacgtcagg
      121 gacacgcttg ggtggccaga ccgccattgg agtgagtacc ctggaaccag agcaggccct
      181 ctctcccaag atgcaggaga agcacatgca catcagagtg aagctgctgg acagtactgt
      241 ggaaatattt gacattgagc ctaagtgtga cggacaggtc ttattgacgc aagtgtggaa
      301 gcatttgaat ctgattgaat gtgactactt tggtctggag ttcaagaacg tccagtctta
      361 ctggatttgg cttgaaccta tgaaacccat cattcggcaa gtgcgaaagc ctaagaatgc
      421 agtgcttcgc ctggcagtaa aatttttccc acctgaccct ggtcagttgc aagaagagta
      481 cacaaggtac ctgtttgcct tgcaacttag gagagacctc ctagaggaac gcctgacctg
      541 cacggccacc acttccgccc ttctcatatc ccaccttctg cagtcggaaa tcggagatta
      601 tgatgaaacc ctggatcgag aacacctcaa agccaatgac tacttgccca accaggagca
      661 atccctggac aagatactcg acttccatca aaggcacacg ggccagactc ctgcggactc
      721 agatttccag gtgcttgaga ttgcaagaaa gttggaaatg tatggcatca ggtttcacat
      781 ggcttctgac agagaaggga ccaagattaa tctggcagtt tctcacatgg gcgtcctcgt
      841 gttccagggc accaccaaaa tcaatacttt caactggtcc aaagtccgta aactaagctt
      901 caagaggaaa aggtttctta tcaaactcca ccctgaggtc catgggccct accaggacac
      961 gttagagttc ttgttgggta gcagagatga atgtaagaat ttctggaaga tatgtgtaga
     1021 acaccacacc tttttcagac tctctgacca gcctaagcca aaggcaaaag ctgtcttctt
     1081 cagtcggggc tcctccttca gatacagtgg aagaactcag aaacaactgg tagactatat
     1141 cagagacggt gggacgaaga gaattccata cgaaagacgg cacagtaaga ctcggacgtc
     1201 tcttcatact ctgactggag atctgcctaa acagagcatc tcattcaccg atggcttgag
     1261 aacttctgcc tccctgtctt cagcaaatgc ctccttttat ccacccccta cttctttgtc
     1321 ctctcctggt ctgcccagtg tgaaggacag cagcagctcc cctgtggatc cccaggctcc
     1381 ccacatcaag agcacagcag cagagaggag cagcagacca tcatcatctg aaggccccag
     1441 cacacagtcg gcccatctcc ctggaccccc tgtgctccag cctggtccag gcttttctgt
     1501 ggatagtcct cagccttctc cctccagcct gaagagccgc ctgagcctga gccctgagcg
     1561 tcaggcctct ctgagcacag ctgagcaggg ttcgtcccct gtgctaagcc ctgtcctcag
     1621 tggcactggg acagccagga tggacaacca agaagagcag aaacacaagc acacatcgga
     1681 agacgaggcc tatttcatag ccaaggagat tgttgccaca gagcgaacct acctgaagga
     1741 cctagaagtt atcactgtgt ggttccgaag tgtggtgatc aaggaggagg ccatgcctgc
     1801 agccctgatg accctgcttt tctccaacat tgatcccatc tacgagttcc atcgaggctt
     1861 ccttcacgag gtggaacaga ggctggcact ctgggaaggg ccatctagcg gtgatcatca
     1921 acggattggg gacatcctcc tcaggaacat gcggcagtta aaggaattta ctagctactt
     1981 ccaaagacac gatgaggtcc taacagaact ggaaaaggcc acaaaacact gtaaaaggct
     2041 ggaggcggtc tacaaagagt ttgagctcca gaaggtttgc tacctgcctc tcaacacgtt
     2101 cctgctgaag cccgtccaga ggctcgtgca ctaccgtctg ctgctaaacc ggctgtgtac
     2161 tcactactca cctgagcacg aggactacac tgactgccac gaggcactga aggccatcac
     2221 agaagtgacc actgagctcc agcagagcct tacccggctg gaaaacctac agaagctgac
     2281 agagctgcag cgagacctgg ttggtgtaga aaacctcatc gctcctggaa gggagttcat
     2341 ccgtgagggc tgccttcaca agctcaccaa gaagggcctg caacagagga tgttttttct
     2401 gttctcagat atgttgctgt atacaagcaa aagtgtcaca ggggccagtc agttccggat
     2461 tcgtggcttc cttccactcc gtggcatgct ggtagaagac agtgagaacg aatggtctgt
     2521 tcctcattgc ttcactatct atgcagctca gaaaacaatc gtggtggcag ccagcactcg
     2581 gctagaaaag gagaagtgga tgcaggacct gaatgcagca atccaggcag ccaagagcgc
     2641 tggtgacaca cccgccgtgc tgctgggtgg cccggtgtat actcgtagcc ccagatcttc
     2701 tgatgaagtc tctctggaag attcagaaga tggtcgagga acccggggct ccctagaggg
     2761 gaacagtcag caccgggcca ataccacaat gcatgtgtgc tggtatcgga acacgagtgt
     2821 gtccagagcg gaccacagtg cagctgttga gaaccagctt tcaggatatc tgcttaggaa
     2881 gttcaagaac agtaatggct ggcagaagct ctgggtggtc tttaccaact tctgcttgtt
     2941 tttctataaa acacatcagg atgactaccc cctggccagc ctcccactac tgggttacag
     3001 tgtgagcctc cccagagagg ctgacagcat ccacaaagac tatgttttca agctccaatt
     3061 caaatctcac gtctacttct tccgggctga gagcaagtac acatttgaaa ggtggatgga
     3121 agtcatcaaa agagccagca gctcaccagg gagaccccca agtttcactc aggactgttc
     3181 acatctttct ccagggctgg aggcagaagt cagagaaaag gaggcatgtc cttcactctg
     3241 cttggacaag aacctatgac agatgcttgt aaggagccta agaatcatcc taagtactga
     3301 acaactggtg tcatcttcct accagatgac aggtggcgcg gaccctagaa tgggccttaa
     3361 aagacctcta gcaggggttc tatcttcctc cagaaacatc gaaaactcat gatggctggg
     3421 acacatgtct gaggttcatg aaaggaaagt gggggctcct tagttccatg aacatggccc
     3481 tgctgagaac agcccaaata caggttgggt ggtctccact tctacctgta gcctcagact
     3541 agcagtacac tcgggcttat gtgatcagct cgtgtcactc aagggttagc ctccagatca
     3601 tagcaaagca agggtgtggc aaaggctgct ctgatcccat cccacatacc ttctagacca
     3661 tcacctccaa caaggcctgg gagggtgagg cctctcatca atccccaatg gtttctcatt
     3721 atagggcagg cctgatgcct gttcacccgt gtgaattcaa ataaaaggat atctcctcac
     3781 ccaccaacat c
//
