LOCUS       NM_001011933            1752 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fatty acyl CoA reductase 1 (Far1), mRNA.
ACCESSION   NM_001011933 XM_215022
VERSION     NM_001011933.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1752)
  AUTHORS   Marsh,K.G., Arrieta,A., Thuerauf,D.J., Blackwood,E.A.,
            MacDonnell,L. and Glembotski,C.C.
  TITLE     The peroxisomal enzyme, FAR1, is induced during ER stress in an
            ATF6-dependent manner in cardiac myocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 320 (5), H1813-H1821 (2021)
   PUBMED   33666503
  REMARK    GeneRIF: The peroxisomal enzyme, FAR1, is induced during ER stress
            in an ATF6-dependent manner in cardiac myocytes.
REFERENCE   2  (bases 1 to 1752)
  AUTHORS   Honsho,M., Asaoku,S., Fukumoto,K. and Fujiki,Y.
  TITLE     Topogenesis and homeostasis of fatty acyl-CoA reductase 1
  JOURNAL   J Biol Chem 288 (48), 34588-34598 (2013)
   PUBMED   24108123
REFERENCE   3  (bases 1 to 1752)
  AUTHORS   Bharti,P., Schliebs,W., Schievelbusch,T., Neuhaus,A., David,C.,
            Kock,K., Herrmann,C., Meyer,H.E., Wiese,S., Warscheid,B., Theiss,C.
            and Erdmann,R.
  TITLE     PEX14 is required for microtubule-based peroxisome motility in
            human cells
  JOURNAL   J Cell Sci 124 (Pt 10), 1759-1768 (2011)
   PUBMED   21525035
REFERENCE   4  (bases 1 to 1752)
  AUTHORS   Honsho,M., Asaoku,S. and Fujiki,Y.
  TITLE     Posttranslational regulation of fatty acyl-CoA reductase 1, Far1,
            controls ether glycerophospholipid synthesis
  JOURNAL   J Biol Chem 285 (12), 8537-8542 (2010)
   PUBMED   20071337
REFERENCE   5  (bases 1 to 1752)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. II. Expression cloning of wax synthase
            cDNAs encoding a member of the acyltransferase enzyme family
  JOURNAL   J Biol Chem 279 (36), 37798-37807 (2004)
   PUBMED   15220349
REFERENCE   6  (bases 1 to 1752)
  AUTHORS   Cheng,J.B. and Russell,D.W.
  TITLE     Mammalian wax biosynthesis. I. Identification of two fatty
            acyl-Coenzyme A reductases with different substrate specificities
            and tissue distributions
  JOURNAL   J Biol Chem 279 (36), 37789-37797 (2004)
   PUBMED   15220348
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082015.1.
            
            On Feb 11, 2005 this sequence version replaced XM_215022.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1752
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /note="fatty acyl CoA reductase 1"
                     /db_xref="GeneID:293173"
                     /db_xref="RGD:1306647"
     exon            1..12
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            13..58
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            59..252
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1611
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /EC_number="1.2.1.84"
                     /note="male sterility domain-containing protein 2; male
                     sterility domain containing 2"
                     /codon_start=1
                     /product="fatty acyl-CoA reductase 1"
                     /protein_id="NP_001011933.1"
                     /db_xref="GeneID:293173"
                     /db_xref="RGD:1306647"
                     /translation="MVSIPEYYEGKNILLTGATGFLGKVLLEKLLRSCPKVNSVYVLV
                     RQKAGQTPQERVEEILSGKLFDRLRDENPDFRQKIIAINSELTQPKLALSEEDKEIII
                     DSTNVIFHCAATVRFNENLRDAVQLNVIATRQLILLAQQMKNLEVFMHVSTAYAYCNR
                     KHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIGDRPNTYIYTKALAEYVVQQE
                     GAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILRTMRASNNALADLV
                     PVDVVVNTSLAAAWYSGVNRPRNIMVYNCTTGSTNPFHWGEVGDYLNHSFKTNPLNQV
                     FRHPYVKFYSNNLMLHYWKGVKHTVPALLLDLALRLTGQKPWMMKTITRLHKAMVFLE
                     YFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYVLNEEM
                     SGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSYFR
                     ASSTMRY"
     exon            253..428
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..608
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..786
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..831
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..950
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1018
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1190
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1320
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1448
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1727
                     /gene="Far1"
                     /gene_synonym="Mlstd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgcgctg agatttggtg actgaggaag ggacccagag actccttgaa caactaagtc
       61 acaatggtct caatcccaga atactatgaa ggcaaaaaca tcctcctcac aggagccact
      121 ggtttcttag ggaaggtgct tctggaaaag ttgctgagat cttgtcctaa ggtgaattca
      181 gtctatgttt tggtgaggca aaaagctgga cagacacccc aagagcgagt ggaagaaatc
      241 ctcagtggca agctttttga caggttgaga gatgaaaatc cagattttag acagaaaatt
      301 atagcaatca acagtgaact cacccaacct aaactggctc tcagtgaaga agataaggag
      361 atcattatag attctaccaa tgtcatattt cactgtgcag ctactgtaag atttaatgaa
      421 aatttaagag atgctgttca gttaaatgtg attgctacac gacagctcat tctccttgca
      481 cagcaaatga agaatctgga agtgttcatg catgtctcaa cagcatacgc ctactgcaat
      541 cgaaagcata ttgacgaagt agtttatcca ccccctgtag atcccaagaa gctgattgat
      601 tccttagaat ggatggatga tggcctagta aatgatatta caccaaaatt gataggcgac
      661 agacctaata catacatata caccaaggcg ttggcagaat atgttgtgca gcaagaagga
      721 gcaaagctaa atgttgcaat tgtaaggccg tcgattgttg gtgccagttg gaaagaacct
      781 tttccaggat ggattgataa ctttaatgga ccaagtggtc tcttcattgc ggcagggaaa
      841 ggaattcttc gaacaatgcg tgcctccaac aatgcccttg cagatctcgt tcctgtagat
      901 gtagttgtca acacgagcct tgctgcagcc tggtattccg gagttaatag accaagaaac
      961 atcatggtgt ataattgcac aacaggcagc actaatcctt tccactgggg ggaagttgga
     1021 gattatctaa atcattcctt caagacgaat cctttaaacc aagtattcag gcacccctat
     1081 gttaagttct attccaacaa cctaatgctt cattattgga agggtgtcaa acatacagta
     1141 cctgcattat tgctcgatct tgcactcagg ttgacaggtc agaaaccgtg gatgatgaaa
     1201 acaatcactc gtcttcacaa agccatggta ttccttgaat attttacaag taactcttgg
     1261 gtttggaata ctgataatgt caatatgtta atgaaccagc taaaccctga agataaaaag
     1321 acctttaata ttgatgtacg acagttacat tgggcagaat atatagagaa ctactgcatg
     1381 gggactaaaa aatatgtatt gaatgaagag atgtcgggcc tccctgcagc tagaaagcat
     1441 ctgaacaagt tgcggaatat ccgttatggt ttcaatacaa tccttgtgat acttatctgg
     1501 cgcattttta ttgcaagatc acaaatggca agaaacatct ggtactttgt ggttagtctg
     1561 tgttacaaat ttctgtcata cttccgagca tccagcacta tgagatactg aagaccaaga
     1621 atttagcatt agaacatcta tgcatatgat gatctaaatg cataaaatgt aaaatgtact
     1681 taagtcatct cacctttcgt taagacatta aaccatctta aattggaaaa aaaaaaaaaa
     1741 aaaaaaaaaa aa
//
