LOCUS       NM_001191684            1653 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus FA complementation group L (Fancl), mRNA.
ACCESSION   NM_001191684 XM_223701
VERSION     NM_001191684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Hodson,C., Purkiss,A., Miles,J.A. and Walden,H.
  TITLE     Structure of the human FANCL RING-Ube2T complex reveals
            determinants of cognate E3-E2 selection
  JOURNAL   Structure 22 (2), 337-344 (2014)
   PUBMED   24389026
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Ali,A.M., Pradhan,A., Singh,T.R., Du,C., Li,J., Wahengbam,K.,
            Grassman,E., Auerbach,A.D., Pang,Q. and Meetei,A.R.
  TITLE     FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein
            required for functional integrity of the FA-BRCA DNA repair pathway
  JOURNAL   Blood 119 (14), 3285-3294 (2012)
   PUBMED   22343915
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Zhang,Y., Zhou,X., Zhao,L., Li,C., Zhu,H., Xu,L., Shan,L., Liao,X.,
            Guo,Z. and Huang,P.
  TITLE     UBE2W interacts with FANCL and regulates the monoubiquitination of
            Fanconi anemia protein FANCD2
  JOURNAL   Mol Cells 31 (2), 113-122 (2011)
   PUBMED   21229326
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Yan,Z., Delannoy,M., Ling,C., Daee,D., Osman,F., Muniandy,P.A.,
            Shen,X., Oostra,A.B., Du,H., Steltenpool,J., Lin,T., Schuster,B.,
            Decaillet,C., Stasiak,A., Stasiak,A.Z., Stone,S., Hoatlin,M.E.,
            Schindler,D., Woodcock,C.L., Joenje,H., Sen,R., de Winter,J.P.,
            Li,L., Seidman,M.M., Whitby,M.C., Myung,K., Constantinou,A. and
            Wang,W.
  TITLE     A histone-fold complex and FANCM form a conserved DNA-remodeling
            complex to maintain genome stability
  JOURNAL   Mol Cell 37 (6), 865-878 (2010)
   PUBMED   20347428
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Longerich,S., San Filippo,J., Liu,D. and Sung,P.
  TITLE     FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL
  JOURNAL   J Biol Chem 284 (35), 23182-23186 (2009)
   PUBMED   19589784
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Alpi,A., Langevin,F., Mosedale,G., Machida,Y.J., Dutta,A. and
            Patel,K.J.
  TITLE     UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited
            independently to chromatin: a basis for the regulation of FANCD2
            monoubiquitination
  JOURNAL   Mol Cell Biol 27 (24), 8421-8430 (2007)
   PUBMED   17938197
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Wreesmann,V.B., Estilo,C., Eisele,D.W., Singh,B. and Wang,S.J.
  TITLE     Downregulation of Fanconi anemia genes in sporadic head and neck
            squamous cell carcinoma
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 69 (4), 218-225 (2007)
   PUBMED   17409780
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Machida,Y.J., Machida,Y., Chen,Y., Gurtan,A.M., Kupfer,G.M.,
            D'Andrea,A.D. and Dutta,A.
  TITLE     UBE2T is the E2 in the Fanconi anemia pathway and undergoes
            negative autoregulation
  JOURNAL   Mol Cell 23 (4), 589-596 (2006)
   PUBMED   16916645
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Lu,B. and Bishop,C.E.
  TITLE     Mouse GGN1 and GGN3, two germ cell-specific proteins from the
            single gene Ggn, interact with mouse POG and play a role in
            spermatogenesis
  JOURNAL   J Biol Chem 278 (18), 16289-16296 (2003)
   PUBMED   12574169
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   Agoulnik,A.I., Lu,B., Zhu,Q., Truong,C., Ty,M.T., Arango,N.,
            Chada,K.K. and Bishop,C.E.
  TITLE     A novel gene, Pog, is necessary for primordial germ cell
            proliferation in the mouse and underlies the germ cell deficient
            mutation, gcd
  JOURNAL   Hum Mol Genet 11 (24), 3047-3053 (2002)
   PUBMED   12417526
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_223701.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.52939.1,
                                           SRR26643429.47682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                JAXUCZ010000014.1  104450987-104451084
            99-157              JAXUCZ010000014.1  104458004-104458062
            158-218             JAXUCZ010000014.1  104459941-104460001
            219-275             JAXUCZ010000014.1  104462527-104462583
            276-376             JAXUCZ010000014.1  104466528-104466628
            377-473             JAXUCZ010000014.1  104478787-104478883
            474-542             JAXUCZ010000014.1  104483995-104484063
            543-693             JAXUCZ010000014.1  104509368-104509518
            694-777             JAXUCZ010000014.1  104511536-104511619
            778-823             JAXUCZ010000014.1  104511860-104511905
            824-905             JAXUCZ010000014.1  104511987-104512068
            906-1022            JAXUCZ010000014.1  104512755-104512871
            1023-1094           JAXUCZ010000014.1  104514308-104514379
            1095-1653           JAXUCZ010000014.1  104514739-104515297
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1653
                     /gene="Fancl"
                     /note="FA complementation group L"
                     /db_xref="GeneID:305600"
                     /db_xref="RGD:1311427"
     exon            1..98
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1130
                     /gene="Fancl"
                     /EC_number="2.3.2.27"
                     /note="Fanconi anemia, complementation group L"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase FANCL"
                     /protein_id="NP_001178613.1"
                     /db_xref="GeneID:305600"
                     /db_xref="RGD:1311427"
                     /translation="MADTEANLLRHFPLLLPQNREKTVYEGFISAQGRDFHLRIVLPK
                     DQQLKKARLLCSWQLKNILNEYHQVVQQRMKHSPDLMSFMMELKIILEAALKNKQELY
                     VQPPSCSFCKDLLTEIGAIGWDKLACVDTSFTTIKLKADDASGRKHLITVKLKAKYPV
                     EPPDCLVDFPIPFSVSWTPQSSLVNVYSQFSAALETLKAFWDVMDEIDEKTWVLEPEK
                     PPRSATARRIALGHDVSINIEVDPRHPTMLPEFCFLGADHVTKPLGMRLSGNIHLWDP
                     ENSLLQNLKDVLEIDFPARTVLEKSDFSMDCGICYARHLNGAIPDQVCNNPQCGQLFH
                     QMCLYEWLRGLSSSRQSFNVFFGECPYCSKPITLKMSGRKP"
     exon            99..157
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            158..218
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            219..275
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            276..376
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            377..473
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            474..542
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            543..693
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            694..777
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            778..823
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            824..905
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1022
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1094
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1653
                     /gene="Fancl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccatggcgga cacggaagca aacctgttgc gccatttccc gctgctgctt cctcagaatc
       61 gggagaaaac tgtgtatgag ggcttcattt cggctcaggg acgggatttc cacctcagga
      121 tagtgctgcc caaagaccag cagctgaaga aggcgagatt actgtgtagc tggcagctga
      181 aaaatatact taatgaatat catcaagtag tccaacagag aatgaagcac tctccggatc
      241 taatgagctt catgatggag ttgaagatca ttttggaagc agctttaaag aataaacaag
      301 agttatatgt gcaaccacct tcttgcagtt tctgcaaaga ccttcttact gagataggag
      361 ccattggctg ggataaactc gcatgtgtgg atacgtcctt caccaccatc aagttaaaag
      421 cagatgacgc ttccggtaga aagcacctaa tcactgtcaa gttgaaggca aagtaccctg
      481 tagagccacc agattgcctt gtggactttc ctattccatt ttctgtttcc tggacaccac
      541 agagctcctt ggtaaatgtt tacagtcagt tctcggcagc gttagagaca ctgaaggcat
      601 tctgggatgt tatggatgaa attgatgaga agacttgggt gctggaaccg gagaaacctc
      661 cccgaagcgc gacagcacgc aggattgcat tagggcatga tgtctccata aacatagagg
      721 tagaccccag gcaccctacc atgcttcctg agttttgctt tcttggagct gaccatgtga
      781 caaagcccct aggaatgagg ctgagtggga acattcattt atgggatcca gaaaatagtc
      841 tgttacagaa tttgaaagat gttttagaaa ttgatttccc agctcgtact gtcctggaaa
      901 aatctgactt cagcatggac tgtggtatct gttatgcccg tcacctgaat ggtgccatcc
      961 ctgatcaagt gtgtaacaat ccccagtgtg gacagctttt ccatcaaatg tgcttgtatg
     1021 agtggctgag agggctgagc agcagtcgac agagtttcaa cgtcttcttt ggtgaatgtc
     1081 cctactgtag taagccaatt accttgaaaa tgtctgggag aaaaccctga atggaatcca
     1141 cctgtgaaga gatggaatgc ttaaaaactg tttaaagatt aaaaacaaaa gcaaaagcca
     1201 gtttattcag tgacttcaga gaaaacacaa agcaagacat actaatgtga gcaggcagaa
     1261 tatagtgagt ccatagtagt acacatctgc ctttgcctct tcactcagag tcagctgaag
     1321 aactgcaggc cagaatcttg gagagctttc caagtcggtg acacccagat tgcccgtggg
     1381 cttggatcca tactggggca ggggtctcgg cttcctgatg ggatctctcc tggtgcagtc
     1441 cagatagggc ttacagtgtg agccttggaa acgtggatag ctctgtgtct gtcggaaact
     1501 cagcatttca ctgaaagtat cagaatactc acgtactttc cttgttctgg agttttccta
     1561 tgattatgaa agagatattt tgttagattt gagttattga ggcatttatt gtgtactctt
     1621 taacaatgct aaataaaaca atacaccaag cta
//
