LOCUS       NP_001178613             375 aa            linear   ROD 03-APR-2024
DEFINITION  E3 ubiquitin-protein ligase FANCL [Rattus norvegicus].
ACCESSION   NP_001178613 XP_223701
VERSION     NP_001178613.1
DBSOURCE    REFSEQ: accession NM_001191684.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Hodson,C., Purkiss,A., Miles,J.A. and Walden,H.
  TITLE     Structure of the human FANCL RING-Ube2T complex reveals
            determinants of cognate E3-E2 selection
  JOURNAL   Structure 22 (2), 337-344 (2014)
   PUBMED   24389026
REFERENCE   2  (residues 1 to 375)
  AUTHORS   Ali,A.M., Pradhan,A., Singh,T.R., Du,C., Li,J., Wahengbam,K.,
            Grassman,E., Auerbach,A.D., Pang,Q. and Meetei,A.R.
  TITLE     FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein
            required for functional integrity of the FA-BRCA DNA repair pathway
  JOURNAL   Blood 119 (14), 3285-3294 (2012)
   PUBMED   22343915
REFERENCE   3  (residues 1 to 375)
  AUTHORS   Zhang,Y., Zhou,X., Zhao,L., Li,C., Zhu,H., Xu,L., Shan,L., Liao,X.,
            Guo,Z. and Huang,P.
  TITLE     UBE2W interacts with FANCL and regulates the monoubiquitination of
            Fanconi anemia protein FANCD2
  JOURNAL   Mol Cells 31 (2), 113-122 (2011)
   PUBMED   21229326
REFERENCE   4  (residues 1 to 375)
  AUTHORS   Yan,Z., Delannoy,M., Ling,C., Daee,D., Osman,F., Muniandy,P.A.,
            Shen,X., Oostra,A.B., Du,H., Steltenpool,J., Lin,T., Schuster,B.,
            Decaillet,C., Stasiak,A., Stasiak,A.Z., Stone,S., Hoatlin,M.E.,
            Schindler,D., Woodcock,C.L., Joenje,H., Sen,R., de Winter,J.P.,
            Li,L., Seidman,M.M., Whitby,M.C., Myung,K., Constantinou,A. and
            Wang,W.
  TITLE     A histone-fold complex and FANCM form a conserved DNA-remodeling
            complex to maintain genome stability
  JOURNAL   Mol Cell 37 (6), 865-878 (2010)
   PUBMED   20347428
REFERENCE   5  (residues 1 to 375)
  AUTHORS   Longerich,S., San Filippo,J., Liu,D. and Sung,P.
  TITLE     FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL
  JOURNAL   J Biol Chem 284 (35), 23182-23186 (2009)
   PUBMED   19589784
REFERENCE   6  (residues 1 to 375)
  AUTHORS   Alpi,A., Langevin,F., Mosedale,G., Machida,Y.J., Dutta,A. and
            Patel,K.J.
  TITLE     UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited
            independently to chromatin: a basis for the regulation of FANCD2
            monoubiquitination
  JOURNAL   Mol Cell Biol 27 (24), 8421-8430 (2007)
   PUBMED   17938197
REFERENCE   7  (residues 1 to 375)
  AUTHORS   Wreesmann,V.B., Estilo,C., Eisele,D.W., Singh,B. and Wang,S.J.
  TITLE     Downregulation of Fanconi anemia genes in sporadic head and neck
            squamous cell carcinoma
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 69 (4), 218-225 (2007)
   PUBMED   17409780
REFERENCE   8  (residues 1 to 375)
  AUTHORS   Machida,Y.J., Machida,Y., Chen,Y., Gurtan,A.M., Kupfer,G.M.,
            D'Andrea,A.D. and Dutta,A.
  TITLE     UBE2T is the E2 in the Fanconi anemia pathway and undergoes
            negative autoregulation
  JOURNAL   Mol Cell 23 (4), 589-596 (2006)
   PUBMED   16916645
REFERENCE   9  (residues 1 to 375)
  AUTHORS   Lu,B. and Bishop,C.E.
  TITLE     Mouse GGN1 and GGN3, two germ cell-specific proteins from the
            single gene Ggn, interact with mouse POG and play a role in
            spermatogenesis
  JOURNAL   J Biol Chem 278 (18), 16289-16296 (2003)
   PUBMED   12574169
REFERENCE   10 (residues 1 to 375)
  AUTHORS   Agoulnik,A.I., Lu,B., Zhu,Q., Truong,C., Ty,M.T., Arango,N.,
            Chada,K.K. and Bishop,C.E.
  TITLE     A novel gene, Pog, is necessary for primordial germ cell
            proliferation in the mouse and underlies the germ cell deficient
            mutation, gcd
  JOURNAL   Hum Mol Genet 11 (24), 3047-3053 (2002)
   PUBMED   12417526
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XP_223701.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.52939.1,
                                           SRR26643429.47682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     Protein         1..375
                     /product="E3 ubiquitin-protein ligase FANCL"
                     /EC_number="2.3.2.27"
                     /note="Fanconi anemia, complementation group L"
                     /calculated_mol_wt=42666
     Region          5..93
                     /region_name="FANCL_d1"
                     /note="FANCL UBC-like domain 1; pfam09765"
                     /db_xref="CDD:462888"
     Region          112..197
                     /region_name="FANCL_d2"
                     /note="FANCL UBC-like domain 2; pfam18890"
                     /db_xref="CDD:465900"
     Region          200..295
                     /region_name="FANCL_d3"
                     /note="FANCL UBC-like domain 3; pfam18891"
                     /db_xref="CDD:465901"
     Region          303..371
                     /region_name="FANCL_C"
                     /note="FANCL C-terminal domain; pfam11793"
                     /db_xref="CDD:463350"
     CDS             1..375
                     /gene="Fancl"
                     /coded_by="NM_001191684.1:3..1130"
                     /db_xref="GeneID:305600"
                     /db_xref="RGD:1311427"
ORIGIN      
        1 madteanllr hfplllpqnr ektvyegfis aqgrdfhlri vlpkdqqlkk arllcswqlk
       61 nilneyhqvv qqrmkhspdl msfmmelkii leaalknkqe lyvqppscsf ckdllteiga
      121 igwdklacvd tsfttiklka ddasgrkhli tvklkakypv eppdclvdfp ipfsvswtpq
      181 sslvnvysqf saaletlkaf wdvmdeidek twvlepekpp rsatarrial ghdvsiniev
      241 dprhptmlpe fcflgadhvt kplgmrlsgn ihlwdpensl lqnlkdvlei dfpartvlek
      301 sdfsmdcgic yarhlngaip dqvcnnpqcg qlfhqmclye wlrglsssrq sfnvffgecp
      361 ycskpitlkm sgrkp
//
