LOCUS       NM_001401015            2817 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FA complementation group F (Fancf), mRNA.
ACCESSION   NM_001401015 XM_574453
VERSION     NM_001401015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Bakker,S.T., van de Vrugt,H.J., Visser,J.A., Delzenne-Goette,E.,
            van der Wal,A., Berns,M.A., van de Ven,M., Oostra,A.B., de
            Vries,S., Kramer,P., Arwert,F., van der Valk,M., de Winter,J.P. and
            te Riele,H.
  TITLE     Fancf-deficient mice are prone to develop ovarian tumours
  JOURNAL   J Pathol 226 (1), 28-39 (2012)
   PUBMED   21915857
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Yan,Z., Delannoy,M., Ling,C., Daee,D., Osman,F., Muniandy,P.A.,
            Shen,X., Oostra,A.B., Du,H., Steltenpool,J., Lin,T., Schuster,B.,
            Decaillet,C., Stasiak,A., Stasiak,A.Z., Stone,S., Hoatlin,M.E.,
            Schindler,D., Woodcock,C.L., Joenje,H., Sen,R., de Winter,J.P.,
            Li,L., Seidman,M.M., Whitby,M.C., Myung,K., Constantinou,A. and
            Wang,W.
  TITLE     A histone-fold complex and FANCM form a conserved DNA-remodeling
            complex to maintain genome stability
  JOURNAL   Mol Cell 37 (6), 865-878 (2010)
   PUBMED   20347428
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Lim,S.L., Smith,P., Syed,N., Coens,C., Wong,H., van der Burg,M.,
            Szlosarek,P., Crook,T. and Green,J.A.
  TITLE     Promoter hypermethylation of FANCF and outcome in advanced ovarian
            cancer
  JOURNAL   Br J Cancer 98 (8), 1452-1456 (2008)
   PUBMED   18414472
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Wreesmann,V.B., Estilo,C., Eisele,D.W., Singh,B. and Wang,S.J.
  TITLE     Downregulation of Fanconi anemia genes in sporadic head and neck
            squamous cell carcinoma
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 69 (4), 218-225 (2007)
   PUBMED   17409780
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Wang,Z., Li,M., Lu,S., Zhang,Y. and Wang,H.
  TITLE     Promoter hypermethylation of FANCF plays an important role in the
            occurrence of ovarian cancer through disrupting Fanconi anemia-BRCA
            pathway
  JOURNAL   Cancer Biol Ther 5 (3), 256-260 (2006)
   PUBMED   16418574
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Dhillon,V.S., Shahid,M. and Husain,S.A.
  TITLE     CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3
            genes in Granulosa cell tumors (GCTs) of ovarian origin
  JOURNAL   Mol Cancer 3, 33 (2004)
   PUBMED   15574200
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   Narayan,G., Arias-Pulido,H., Nandula,S.V., Basso,K.,
            Sugirtharaj,D.D., Vargas,H., Mansukhani,M., Villella,J., Meyer,L.,
            Schneider,A., Gissmann,L., Durst,M., Pothuri,B. and Murty,V.V.
  TITLE     Promoter hypermethylation of FANCF: disruption of Fanconi
            Anemia-BRCA pathway in cervical cancer
  JOURNAL   Cancer Res 64 (9), 2994-2997 (2004)
   PUBMED   15126331
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Marsit,C.J., Liu,M., Nelson,H.H., Posner,M., Suzuki,M. and
            Kelsey,K.T.
  TITLE     Inactivation of the Fanconi anemia/BRCA pathway in lung and oral
            cancers: implications for treatment and survival
  JOURNAL   Oncogene 23 (4), 1000-1004 (2004)
   PUBMED   14647419
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   de Winter,J.P., Rooimans,M.A., van Der Weel,L., van Berkel,C.G.,
            Alon,N., Bosnoyan-Collins,L., de Groot,J., Zhi,Y., Waisfisz,Q.,
            Pronk,J.C., Arwert,F., Mathew,C.G., Scheper,R.J., Hoatlin,M.E.,
            Buchwald,M. and Joenje,H.
  TITLE     The Fanconi anaemia gene FANCF encodes a novel protein with
            homology to ROM
  JOURNAL   Nat Genet 24 (1), 15-16 (2000)
   PUBMED   10615118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 1, 2022 this sequence version replaced XM_574453.7.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR21887623.1635168.1,
                                        SRR22582419.2996454.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2817              JAXUCZ010000001.1  110585054-110587870 c
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2817
                     /gene="Fancf"
                     /gene_synonym="RGD1561456"
                     /note="FA complementation group F"
                     /db_xref="GeneID:499155"
                     /db_xref="RGD:1561456"
     exon            1..2817
                     /gene="Fancf"
                     /gene_synonym="RGD1561456"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1033
                     /gene="Fancf"
                     /gene_synonym="RGD1561456"
                     /note="Fanconi anemia, complementation group F"
                     /codon_start=1
                     /product="Fanconi anemia group F protein"
                     /protein_id="NP_001387944.1"
                     /db_xref="GeneID:499155"
                     /db_xref="RGD:1561456"
                     /translation="MEPLVQYTERFSELLAVSCGTLVSTWDAATVRRALQWARYLFHV
                     YRRFASRGRVREALERRLHVRRGPLGLRSFAALESGDVRLALRLLRNRALAPAAARAL
                     PGLLFPGPAADNVDDVPQSRLVLLARRGSALHLLFRLGGDAPKGALLRTHAELLYARL
                     QELGGADSTAARKLLDTLWEHGPREHVLSVMAEALLREADPEPAQAADSAGADETQKL
                     LHWLLESTEVLAAFCRHLPAKRLASVAGCHHALSRAYLDLLTAWATRLHYDLQKGAWV
                     PTQLEDMPWEELCLRLQSLCQAQPFLQEEVLVTLRSCKALDGDFEVPGMSIWTDLLLA
                     LPGGA"
ORIGIN      
        1 ggaagtggcc gccatggagc cgcttgtgca gtatacagag cgcttctcag agctgctggc
       61 cgtgtcgtgc gggacgctgg tgagcacgtg ggacgccgcg accgtgcgca gggcactgca
      121 gtgggcgcgc tatttgttcc acgtgtaccg acgctttgcg agccgcggcc gcgtgcggga
      181 ggcgctagag aggcggctcc acgtgcggag agggcctctc ggcctgcgta gctttgcggc
      241 gctggagtct ggggacgtgc ggctcgccct acgcctgctg cgtaaccgcg cgctcgcgcc
      301 cgccgccgcc cgcgcgttgc caggcttgct cttcccaggc cctgccgcag acaacgtaga
      361 cgacgtgccg cagtcccgct tggtcctcct ggcacgccgc ggaagcgcgc tgcacctgct
      421 gttccgcctc ggcggggacg cgcctaaggg cgcgctgctg cgcacgcacg cggagctgct
      481 gtacgcgcgc cttcaggagc tgggcggtgc ggactctacg gccgcgcgca aactcctgga
      541 tacgctgtgg gagcacgggc cgcgggagca cgtgctcagc gtgatggcgg aagctctgtt
      601 gcgcgaggcg gacccggagc cagcccaggc cgcagactct gcgggagcgg atgaaacaca
      661 aaaactactg cactggcttc tagaaagtac cgaggtactg gccgcttttt gccgccatct
      721 gccagctaag cgcctggcct ctgtggcggg ctgccaccac gcactgtctc gtgcctacct
      781 ggacctgctc acagcgtggg ccacgcggct gcattatgat ctgcagaagg gcgcctgggt
      841 tcccacacag ctggaggaca tgccctggga agagctgtgt ctaaggctgc agagcttgtg
      901 ccaggcccag ccatttctgc aggaagaggt gctggtgacc ctgcgttcct gcaaagcctt
      961 ggatggcgat tttgaggttc ctggcatgag catctggaca gacctcctgc tggccctgcc
     1021 tggtggtgct tgagtgtcat gctagaggag gttctcaggt cccaggctgg gcatctggac
     1081 agaccctatc ccatggaggg aacaagcata cttctcacaa agcctctatg cacagcaccc
     1141 tgctactact tgacagttta gaaactgaca gtgttttcgc ctactcccta tatatacatg
     1201 ttcccaaaac ctaattgctt tggtgccaat tttaaatggt tcgtaataca aatatataca
     1261 tttatatata catgtatatg tacactatat atataaaaca tatatatatt atatgtaata
     1321 tatatatagt tatttccgtc cttgtggtgg ttccaggact ctgcctattt tagacagagc
     1381 tcaccactga gctatattcc ctagccttgt aagtattatt aaagccattg aattttcagc
     1441 ttgttttata taaagccaat ttgtaagaat actaaaagta gacacacgca ctttaaaaag
     1501 agaagactgc ttcaaatttt ccaagaagga cactttttat ctgtatgatt tactcgtttc
     1561 ctgacactgt tcagtagtac aaagttttgt ttaaccagca gcatgtgtta gcatcaaatg
     1621 ctaacttcag agcagactag gctgaagtta aaacactagg cttggtttcc ttaacctgtt
     1681 tgccaacctt aatgcccatt aaagttacat tgttcagaaa gttttgtttg tacagttcac
     1741 tactgtgaaa gtcaaaataa cagtaaatta gtttaaagca tgtcttgagt acacacttaa
     1801 gtgtttagag cacaataaat acaaatatat cccgttgggt gtctgggttg gatgataaga
     1861 gttaagagaa tagaggccac tactgccatt tatcaaggta atagccctaa cctgatgtca
     1921 ttactatggt gtttaaactt ctgattctgt ttttcctcct gattgctgga tggagatgat
     1981 tcggagtgtt tgttttctga ctaacaaccc aactttgctg ggcagtggtg gtacaggcct
     2041 ttaatcccag cattagggag gcagaggcag gcagatctag ttcaagacta gcctagtcta
     2101 cagaacaagt tccaggacag ccagagctac acaaagagaa aagctgtctg ggaaaaaaca
     2161 gacaaagcaa ctgagtctgg ttgagggttt aaacttaatg ataaatagtt ttgatagtaa
     2221 ataactggct aagtaaattt ccagggatca acacactttc tccacagtaa atgccagtaa
     2281 ctcagaaaat taattcctaa ttctagaaat ggaaataaag caaaaggata tatgatgcag
     2341 aattctaatt ctgctttagg gcacaggtat aaacaaacag tacaattatc tgaagagagc
     2401 aatatcattt ttttttcttc ctgtgatcag attcctctct ctagcacttt ttcatctgcg
     2461 gtgttctgac ttggattcct tagtgctgtt atacacagga gtgacaactg agccatgctg
     2521 ccattctgtt ttgttgtttg agggtctcgc tctagcccag gttgctctgg aactcactgt
     2581 ctgcccatgc tagcctcaga cttagtggat cctccttcct cggattccta aatggtgaga
     2641 ttacaggtgt taggtggcac atacagccgt ggttttgttt cggtggtttt gaagttttaa
     2701 tcctgatgcc tctcactcac tctctgctgt ttgacttctg tttgctagaa gagaaaccaa
     2761 agtttcatac aataaagaac atctgaattt tcttacagtt ttatcagtcc catttca
//
