LOCUS       NM_012557               2483 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FA complementation group C (Fancc), mRNA.
ACCESSION   NM_012557
VERSION     NM_012557.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2483)
  AUTHORS   Li,X., Li,L., Li,J., Sipple,J., Schick,J., Mehta,P.A., Davies,S.M.,
            Dasgupta,B., Waclaw,R.R. and Pang,Q.
  TITLE     Concomitant inactivation of foxo3a and fancc or fancd2 reveals a
            two-tier protection from oxidative stress-induced hydrocephalus
  JOURNAL   Antioxid Redox Signal 21 (12), 1675-1692 (2014)
   PUBMED   24483844
REFERENCE   2  (bases 1 to 2483)
  AUTHORS   Li,J., Sipple,J., Maynard,S., Mehta,P.A., Rose,S.R., Davies,S.M.
            and Pang,Q.
  TITLE     Fanconi anemia links reactive oxygen species to insulin resistance
            and obesity
  JOURNAL   Antioxid Redox Signal 17 (8), 1083-1098 (2012)
   PUBMED   22482891
REFERENCE   3  (bases 1 to 2483)
  AUTHORS   Thompson,E.R., Doyle,M.A., Ryland,G.L., Rowley,S.M., Choong,D.Y.,
            Tothill,R.W., Thorne,H., Barnes,D.R., Li,J., Ellul,J., Philip,G.K.,
            Antill,Y.C., James,P.A., Trainer,A.H., Mitchell,G. and
            Campbell,I.G.
  CONSRTM   kConFab
  TITLE     Exome sequencing identifies rare deleterious mutations in DNA
            repair genes FANCC and BLM as potential breast cancer
            susceptibility alleles
  JOURNAL   PLoS Genet 8 (9), e1002894 (2012)
   PUBMED   23028338
REFERENCE   4  (bases 1 to 2483)
  AUTHORS   Kim,J.H., Park,B.L., Pasaje,C.F., Bae,J.S., Park,J.S., Park,S.W.,
            Uh,S.T., Choi,J.S., Kim,Y.H., Kim,M.K., Choi,I.S., Cho,S.H.,
            Choi,B.W., Park,C.S. and Shin,H.D.
  TITLE     Association of FANCC polymorphisms with FEV1 decline in aspirin
            exacerbated respiratory disease
  JOURNAL   Mol Biol Rep 39 (3), 2385-2394 (2012)
   PUBMED   21670957
REFERENCE   5  (bases 1 to 2483)
  AUTHORS   Kim,H., Yang,K., Dejsuphong,D. and D'Andrea,A.D.
  TITLE     Regulation of Rev1 by the Fanconi anemia core complex
  JOURNAL   Nat Struct Mol Biol 19 (2), 164-170 (2012)
   PUBMED   22266823
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2483)
  AUTHORS   Carreau,M., Gan,O.I., Liu,L., Doedens,M., McKerlie,C., Dick,J.E.
            and Buchwald,M.
  TITLE     Bone marrow failure in the Fanconi anemia group C mouse model after
            DNA damage
  JOURNAL   Blood 91 (8), 2737-2744 (1998)
   PUBMED   9531583
REFERENCE   7  (bases 1 to 2483)
  AUTHORS   Ching Ying Wong,J., Alon,N. and Buchwald,M.
  TITLE     Cloning of the bovine and rat Fanconi anemia group C cDNA
  JOURNAL   Mamm Genome 8 (7), 522-525 (1997)
   PUBMED   9196001
REFERENCE   8  (bases 1 to 2483)
  AUTHORS   Whitney,M.A., Royle,G., Low,M.J., Kelly,M.A., Axthelm,M.K.,
            Reifsteck,C., Olson,S., Braun,R.E., Heinrich,M.C., Rathbun,R.K.,
            Bagby,G.C. and Grompe,M.
  TITLE     Germ cell defects and hematopoietic hypersensitivity to
            gamma-interferon in mice with a targeted disruption of the Fanconi
            anemia C gene
  JOURNAL   Blood 88 (1), 49-58 (1996)
   PUBMED   8704201
REFERENCE   9  (bases 1 to 2483)
  AUTHORS   Chen,M., Tomkins,D.J., Auerbach,W., McKerlie,C., Youssoufian,H.,
            Liu,L., Gan,O., Carreau,M., Auerbach,A., Groves,T., Guidos,C.J.,
            Freedman,M.H., Cross,J., Percy,D.H., Dick,J.E., Joyner,A.L. and
            Buchwald,M.
  TITLE     Inactivation of Fac in mice produces inducible chromosomal
            instability and reduced fertility reminiscent of Fanconi anaemia
  JOURNAL   Nat Genet 12 (4), 448-451 (1996)
   PUBMED   8630504
REFERENCE   10 (bases 1 to 2483)
  AUTHORS   Gavish,H., dos Santos,C.C. and Buchwald,M.
  TITLE     A Leu554-to-Pro substitution completely abolishes the functional
            complementing activity of the Fanconi anemia (FACC) protein
  JOURNAL   Hum Mol Genet 2 (2), 123-126 (1993)
   PUBMED   8499901
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168147.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132303, SAMN06680426
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2483
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2483
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="FA complementation group C"
                     /db_xref="GeneID:24361"
                     /db_xref="RGD:2593"
     exon            1..215
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            216..412
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1921
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /note="Fanconi anemia, complementation group C"
                     /codon_start=1
                     /product="Fanconi anemia group C protein homolog"
                     /protein_id="NP_036689.2"
                     /db_xref="GeneID:24361"
                     /db_xref="RGD:2593"
                     /translation="MAQEPADLASDYQFWLQKLSAWEQASSKETQRDTCLHLSRFQEF
                     LRQMYELLKEMDSDAILERFPSIGQLLAKTCWNPLILAYDESQKIVIWCLCCLMNKAP
                     RTSAESGRNSWIQGLLSHVLSAFRFDMKEVCLFTKSLGYESIDYYPSLLKNMVLSLVS
                     ELRGSHLNGLNTQSRMAPERMMSLSQVCVPLVTLPDIEPLVEALLTYHGHEPQEVLSA
                     EFFEAVTEAFLSEKIVLPTSSVVSLWFRHLPSLEKATLHLFEKLFSSKRNCLRRMECC
                     IKESLLPQAACQPAIFRIVDEMFRFVLLETDGAPAVLAALQIFTSCLVEALRKENKQL
                     KFALKTYFPYSAPCLTAALSQQPEAIPQGHRLQPLLHISQLLREAVEDCTDGSHRNPF
                     ESWFLFVHFGGWVDLAVEELLLREEAEPPAGLLWLLVFYYSPQDRSQQREQSMVELKV
                     LVNRLLKLLRSGPLSAMDLLEAAESPREDPRPVCGQLVRRLLLSLLFWTPEGHAIVWE
                     AVTHMAHTDAVTHEIVGFLDQTLYRSHHLCVEASRKLARELLKELQAQV"
     exon            413..497
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            498..592
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            593..706
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            707..771
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            772..936
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1093
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1146
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1246
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1322
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1404
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1582
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1783
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..2461
                     /gene="Fancc"
                     /gene_synonym="Facc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaagttcc gtgaggtcgt gccaagtttt caagccgcag aagccgggag gtggcttctt
       61 ttccgccgcg gcccagtctg ctgagggagc tctgggtgag gaccacccgg gaaggctgcc
      121 gctttccgcc agggcaggga agactcgcga gaacgtgcgc cgagtctcaa cgtgggcaag
      181 cagcgctccc tcggcgctct gtctgaagct ggaaggctgc ggtgaaggga cagcgctgct
      241 ctcagagatg gctcaggagc ctgcagacct tgcttctgac tatcagtttt ggctgcagaa
      301 gctttctgca tgggaacagg cctcttccaa ggagacccag cgggacactt gtcttcactt
      361 gtcccggttc caagagttcc tgaggcagat gtatgaactc ttgaaggaga tggattctga
      421 tgcaatcctg gaacggttcc cctcaattgg tcaactgttg gcaaaaactt gttggaatcc
      481 tctcatcttg gcatatgacg aaagccaaaa gattgtaata tggtgcttat gttgtctgat
      541 gaacaaagca ccacggactt ctgcagagtc aggacgtaac tcatggatcc agggtttgtt
      601 gtctcatgta ctttctgcat tcagattcga catgaaagaa gtttgtcttt ttaccaaaag
      661 tcttggatat gaatctattg attactatcc tagtttgctt aaaaatatgg ttttgtcgtt
      721 agtgtctgag ctcagaggga gtcatcttaa tggactgaac actcaaagtc ggatggctcc
      781 tgagcgcatg atgtccctgt cacaagtctg tgtccctctt gttactctgc ctgatattga
      841 acccctggta gaggctctcc taacctacca tggacatgag ccccaagaag tcctgtctgc
      901 tgagttcttt gaagctgtaa ctgaggcctt cttatcggaa aaaattgtcc tgcccacgtc
      961 ctctgtggtc agcctctggt ttcggcatct ccccagcctt gaaaaagcaa cgctgcatct
     1021 ttttgaaaag ctgttctcca gcaagagaaa ttgcctgaga aggatggagt gctgtataaa
     1081 agagtcatta ctgcctcaag cagcctgcca acctgccatc tttagaattg ttgatgaaat
     1141 gttcaggttt gtgctactgg aaactgatgg ggccccagca gtgctagctg ctcttcagat
     1201 tttcacatcc tgcttggtag aagctctgag gaaagaaaac aagcagctga agtttgccct
     1261 caagacctac tttccctaca gtgctccgtg tcttactgca gcgctgtccc agcagcctga
     1321 agctatccca cagggacatc ggctccagcc tctgctgcac atttcccaac tcctcagaga
     1381 agcagttgaa gactgtactg atgggtctca tcgaaatccc tttgagagct ggtttttgtt
     1441 tgttcacttt ggaggatggg ttgatctggc tgtggaggag ttgctgctca gggaggaagc
     1501 tgagcctcct gcaggccttc tgtggctctt ggtcttctat tacagcccac aggacaggag
     1561 tcagcagaga gagcagagca tggtggagtt gaaggtatta gtcaaccgtc tcctgaagct
     1621 gctcagaagt ggccccctct cagctatgga cctgctggaa gcagctgaga gccccaggga
     1681 agaccccaga cctgtatgtg gacagctggt cagacgcctt cttcttagtc tcttgttctg
     1741 gaccccagaa ggccatgcga ttgtctggga agctgtcacc catatggccc acacagatgc
     1801 tgtaacccac gagattgttg gctttcttga ccagaccttg tacagatcac atcatctttg
     1861 tgttgaagcc tcaagaaaac tggctagaga gctcctaaag gagctgcaag ctcaggtcta
     1921 gcaggccaca cagaatgtgt ggacacctgc aggaggcacc tgtctggtga agctcccaca
     1981 gtggatgaga tgctgttcct aaggcaagaa caagtgagag tgggacgtcc gtgccttggc
     2041 ctgatggagt aatgtgtgcg accaaccatg cactctatac tgcttggccc aggacgtcca
     2101 tgagtattat gaagggaaag gcccagactg cctgttatgt cccagccatt catgacaaga
     2161 gctagcactg gctgatgtgc tgactccctt tatgcctccc actctgatga aggtgctcgt
     2221 gatggtggga ggatgtccag aagcaggaga catgggccct gcaggaggtg aggctacata
     2281 gggataacct gcctcagccg tgactgtggc tcagtgcagg aattgatgca aggcacccac
     2341 tgtagtggga ggaccaggga tggccaggga agggtcatta cttcctcccc taaacctcca
     2401 aagagccaaa ctctgcttcc tgggtgacct ttgtgtagta aacaggattt ggaaactgaa
     2461 aaaaaaaaaa aaaaaaaaaa aaa
//
