LOCUS       NM_001192003            2657 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FA complementation group B (Fancb), mRNA.
ACCESSION   NM_001192003 XM_576954
VERSION     NM_001192003.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Kim,T.M., Son,M.Y., Dodds,S., Hu,L., Luo,G. and Hasty,P.
  TITLE     RECQL5 and BLM exhibit divergent functions in cells defective for
            the Fanconi anemia pathway
  JOURNAL   Nucleic Acids Res 43 (2), 893-903 (2015)
   PUBMED   25520194
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Yan,Z., Delannoy,M., Ling,C., Daee,D., Osman,F., Muniandy,P.A.,
            Shen,X., Oostra,A.B., Du,H., Steltenpool,J., Lin,T., Schuster,B.,
            Decaillet,C., Stasiak,A., Stasiak,A.Z., Stone,S., Hoatlin,M.E.,
            Schindler,D., Woodcock,C.L., Joenje,H., Sen,R., de Winter,J.P.,
            Li,L., Seidman,M.M., Whitby,M.C., Myung,K., Constantinou,A. and
            Wang,W.
  TITLE     A histone-fold complex and FANCM form a conserved DNA-remodeling
            complex to maintain genome stability
  JOURNAL   Mol Cell 37 (6), 865-878 (2010)
   PUBMED   20347428
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Smith,I.M., Mithani,S.K., Mydlarz,W.K., Chang,S.S. and
            Califano,J.A.
  TITLE     Inactivation of the tumor suppressor genes causing the hereditary
            syndromes predisposing to head and neck cancer via promoter
            hypermethylation in sporadic head and neck cancers
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 72 (1), 44-50 (2010)
   PUBMED   20332657
REFERENCE   4  (bases 1 to 2657)
  AUTHORS   Wreesmann,V.B., Estilo,C., Eisele,D.W., Singh,B. and Wang,S.J.
  TITLE     Downregulation of Fanconi anemia genes in sporadic head and neck
            squamous cell carcinoma
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 69 (4), 218-225 (2007)
   PUBMED   17409780
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000021.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001192003.2.
            
            On Jul 17, 2010 this sequence version replaced XM_576954.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.62287.1,
                                           SRR26643292.65229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676810 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-936               JAXUCZ010000021.1  33048964-33049899   c
            937-1089            JAXUCZ010000021.1  33045815-33045967   c
            1090-1182           JAXUCZ010000021.1  33044719-33044811   c
            1183-1326           JAXUCZ010000021.1  33041318-33041461   c
            1327-1490           JAXUCZ010000021.1  33040090-33040253   c
            1491-1918           JAXUCZ010000021.1  33036855-33037282   c
            1919-2153           JAXUCZ010000021.1  33036503-33036737   c
            2154-2465           JAXUCZ010000021.1  33035579-33035890   c
            2466-2493           JAXUCZ010000021.1  33035551-33035578   c
            2494-2657           JAXUCZ010000021.1  33035387-33035550   c
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..2657
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /note="FA complementation group B"
                     /db_xref="GeneID:501552"
                     /db_xref="RGD:1561555"
     CDS             1..2562
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /note="Fanconi anemia, complementation group B"
                     /codon_start=1
                     /product="Fanconi anemia group B protein"
                     /protein_id="NP_001178932.1"
                     /db_xref="GeneID:501552"
                     /db_xref="RGD:1561555"
                     /translation="MPFNEQAKFLCYNGEVLVFQLSGGEFADLEKPTDPSVLGVKRMI
                     FDRETSTFLLISTVFLNINEKDSHLKILCCNCVSDFRTRINLPCILIQCRKYNSKAFK
                     YYILFLHSPNQLEKLLSFELNHALDERAKIFDGPIVFWQYLNQFFYISSEIGKVTNIS
                     VSLSSIEWIGEIENFGLGFLGLADPSGDKYKCTRKLSESDYEFSNSSFCAYALKSQEM
                     LSNSYLIPLAYSTVVTRVHVCAAEMVNKQLKMSLIALTRKNQLILFQNGIPVRTCQLP
                     FLDPRSVQILDAGKRNRFFIVSFLSKACAVSEKKFKVVAKWEQLSLVLVNDFAGVGTE
                     QVLVVFEDSLDADQLTSFTVTDFVKIWYSTKPLDCCEDPLAEEEHENYYLVLPALEAQ
                     LDNSFIFLNQFQQHISFKDKFIANSWKALLNSVYGNVDSMPSDEEVQLEQGGLVPFCD
                     EDENSVPTPEENLPDNFPEPEHVIEQTWCHVLDDDLVVGVKVTSLKPSDGMTLSLIMD
                     QANRSSFHLMKCQSQLISLSMNSFPETYLLSKETGPEIKRMKLTSGSQEEESSFCGQS
                     AKAESTYVITAITSLSPLLVFNKLSCTVLLNVSDRDNPKNTVHDYVFCGHLDFNLQDL
                     FSKNHLLAFPKKQSIEQTENLFSLLTALPKYAFCVTSPTHAPNLMKVWLLKHMKCAKI
                     QECTEIYLYKKLRNCEALFSWEQRTAFEGILTIYCRSLGVLFQCLDHLIKVIPEICSF
                     KYLRFENEDFLVDHLSSTLEAELVTFCSVSTSAFEYVRGGCMYNCSTSKTDNRATTFS
                     GRRAKIRHYKRQVQREKILKHLNRTVNVSSYAEMTLALAEIQLRSDLIVKTLTDL"
     exon            1..936
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1089
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1182
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1326
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1490
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1918
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2153
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2657
                     /gene="Fancb"
                     /gene_synonym="RGD1561555"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccattta atgagcaagc aaagttcttg tgctataatg gggaagtcct tgtttttcag
       61 ttgtctggag gagagtttgc agatttagaa aagcctacag atccatctgt cttaggtgtc
      121 aaaaggatga tatttgacag agaaactagt acattccttc tgatatccac agttttttta
      181 aacatcaatg agaaagattc tcatttaaaa attctgtgtt gtaactgtgt gtcagatttc
      241 agaactagaa ttaaccttcc ttgcattttg atacaatgta gaaaatacaa tagcaaagct
      301 ttcaaatatt atatactgtt tcttcacagt cccaaccagt tggaaaaact tttgagtttt
      361 gaactaaacc atgcattgga cgagagggca aagatctttg atggccctat agttttttgg
      421 caatatctca atcaattctt ctatatctct tccgaaattg ggaaagttac taatatatca
      481 gttagccttt cctcaatcga gtggataggt gagattgaaa attttggctt aggtttcttg
      541 gggctagcag atccatctgg ggataaatat aaatgtaccc gcaagctttc agaatcagat
      601 tatgaatttt ccaattccag cttttgtgca tatgctctta aaagtcaaga aatgttaagc
      661 aatagttacc tgatccctct ggcttacagt actgtggtaa ctcgtgtgca tgtctgtgca
      721 gccgagatgg tgaacaagca gttaaaaatg tctctgattg ccctgacgcg aaagaatcag
      781 cttattttgt tccagaatgg cattcccgta agaacttgtc agcttccatt tctagatccc
      841 cgttcagttc aaattctaga tgcagggaaa agaaaccgat ttttcatcgt gtcattcctg
      901 tccaaggctt gcgctgtttc agaaaagaaa tttaaggttg tggctaagtg ggaacaactt
      961 agcttggtac tggttaatga ctttgctgga gttggaactg agcaagtcct ggtcgttttt
     1021 gaggactctc tggatgcaga tcagctgacc tcatttacag taacagattt tgtcaaaata
     1081 tggtattcaa ccaaaccact ggattgctgt gaagaccctc tggctgaaga ggaacatgaa
     1141 aattattatt tggtgcttcc agcactggaa gcccaattag acaattcttt tatttttctt
     1201 aaccaattcc agcagcatat ctcatttaag gataaattta ttgcaaactc ttggaaggct
     1261 cttttaaact cagtttatgg gaacgttgat agtatgccaa gtgacgagga ggtacagtta
     1321 gaacagggtg gtcttgttcc cttctgtgat gaagatgaaa acagtgtccc tacccctgag
     1381 gaaaacttac cagacaattt tccagagcca gaacatgtta tagagcagac atggtgccat
     1441 gtgctagatg atgacttagt tgttggcgtg aaagtcacat ctttgaagcc gtctgatggg
     1501 atgactttat cactgataat ggatcaagcc aacaggtcca gttttcatct tatgaagtgt
     1561 caaagtcagt tgattagttt gagtatgaat tcttttccag aaacatactt gttgtcaaag
     1621 gaaacaggac cagagatcaa aaggatgaag ctgacctctg gtagccagga agaggaaagc
     1681 tctttttgcg gacagtcagc taaggcagaa tctacatacg taatcactgc tataacgtct
     1741 ctttctccac tgttagtatt caacaaattg tcttgcactg tgctgctaaa cgttagtgac
     1801 agagataacc ctaaaaatac tgtgcatgat tatgttttct gtggccacct tgattttaat
     1861 ctgcaagatc tttttagtaa gaaccaccta ctggcattcc cgaagaagca atcaatagaa
     1921 cagacggaga atcttttttc acttctcaca gcattgccca agtatgcctt ctgtgtcacg
     1981 tcacctaccc atgcccccaa tttaatgaag gtatggctct taaaacacat gaaatgtgca
     2041 aaaatccaag aatgcacaga aatatacctt tataaaaagc tacgaaattg tgaagcactc
     2101 ttctcctggg agcagagaac agcatttgaa ggaattttaa caatatattg caggagccta
     2161 ggagttttgt tccagtgtct cgaccatctc atcaaagtta ttcctgaaat atgttccttc
     2221 aaatatctga ggtttgaaaa tgaggatttc ttagttgatc atttgtcatc cactttggag
     2281 gcagaactgg ttaccttttg ctctgtttct acttctgcct tcgagtatgt tagaggtgga
     2341 tgtatgtata actgtagcac aagcaaaaca gataataggg ccacgacttt ttcagggaga
     2401 agggccaaaa tccgtcacta caagcgccaa gttcagagag aaaaaatatt gaagcacctg
     2461 aataggacag taaatgtcag cagctatgcc gagatgactt tggcattagc tgagatacag
     2521 ttgcgatcag acctcattgt aaagacactg actgatttgt aattgcactt taaaaatcat
     2581 gatttaaagt gtttcataat tattggcctc tcttgttatc ctttgttaat ataaatataa
     2641 aagtttatta tatagtc
//
