LOCUS       NM_001191633            3395 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FANCD2 and FANCI associated nuclease 1 (Fan1),
            mRNA.
ACCESSION   NM_001191633 XM_219706
VERSION     NM_001191633.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Wang,R., Persky,N.S., Yoo,B., Ouerfelli,O., Smogorzewska,A.,
            Elledge,S.J. and Pavletich,N.P.
  TITLE     DNA repair. Mechanism of DNA interstrand cross-link processing by
            repair nuclease FAN1
  JOURNAL   Science 346 (6213), 1127-1130 (2014)
   PUBMED   25430771
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Pennell,S., Declais,A.C., Li,J., Haire,L.F., Berg,W.,
            Saldanha,J.W., Taylor,I.A., Rouse,J., Lilley,D.M. and Smerdon,S.J.
  TITLE     FAN1 activity on asymmetric repair intermediates is mediated by an
            atypical monomeric virus-type replication-repair nuclease domain
  JOURNAL   Cell Rep 8 (1), 84-93 (2014)
   PUBMED   24981866
REFERENCE   3  (bases 1 to 3395)
  AUTHORS   Smogorzewska,A., Desetty,R., Saito,T.T., Schlabach,M., Lach,F.P.,
            Sowa,M.E., Clark,A.B., Kunkel,T.A., Harper,J.W., Colaiacovo,M.P.
            and Elledge,S.J.
  TITLE     A genetic screen identifies FAN1, a Fanconi anemia-associated
            nuclease necessary for DNA interstrand crosslink repair
  JOURNAL   Mol Cell 39 (1), 36-47 (2010)
   PUBMED   20603073
REFERENCE   4  (bases 1 to 3395)
  AUTHORS   Kratz,K., Schopf,B., Kaden,S., Sendoel,A., Eberhard,R.,
            Lademann,C., Cannavo,E., Sartori,A.A., Hengartner,M.O. and
            Jiricny,J.
  TITLE     Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes
            cells to interstrand crosslinking agents
  JOURNAL   Cell 142 (1), 77-88 (2010)
   PUBMED   20603016
REFERENCE   5  (bases 1 to 3395)
  AUTHORS   MacKay,C., Declais,A.C., Lundin,C., Agostinho,A., Deans,A.J.,
            MacArtney,T.J., Hofmann,K., Gartner,A., West,S.C., Helleday,T.,
            Lilley,D.M. and Rouse,J.
  TITLE     Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to
            DNA damage by monoubiquitinated FANCD2
  JOURNAL   Cell 142 (1), 65-76 (2010)
   PUBMED   20603015
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jul 17, 2010 this sequence version replaced XM_219706.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1680.1,
                                           SRR26643292.2299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1243              JAXUCZ010000001.1  127354959-127356201 c
            1244-1384           JAXUCZ010000001.1  127354186-127354326 c
            1385-1586           JAXUCZ010000001.1  127352212-127352413 c
            1587-1820           JAXUCZ010000001.1  127350814-127351047 c
            1821-1952           JAXUCZ010000001.1  127348369-127348500 c
            1953-2061           JAXUCZ010000001.1  127347044-127347152 c
            2062-2181           JAXUCZ010000001.1  127345747-127345866 c
            2182-2346           JAXUCZ010000001.1  127340734-127340898 c
            2347-2497           JAXUCZ010000001.1  127339932-127340082 c
            2498-2601           JAXUCZ010000001.1  127334257-127334360 c
            2602-2796           JAXUCZ010000001.1  127333568-127333762 c
            2797-2925           JAXUCZ010000001.1  127332787-127332915 c
            2926-3395           JAXUCZ010000001.1  127330016-127330485 c
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3395
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /note="FANCD2 and FANCI associated nuclease 1"
                     /db_xref="GeneID:309256"
                     /db_xref="RGD:1566323"
     CDS             1..3063
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /EC_number="3.1.4.1"
                     /note="coiled-coil domain-containing protein MTMR15;
                     myotubularin related protein 15; FANCD2/FANCI-associated
                     nuclease 1"
                     /codon_start=1
                     /product="fanconi-associated nuclease 1"
                     /protein_id="NP_001178562.1"
                     /db_xref="GeneID:309256"
                     /db_xref="RGD:1566323"
                     /translation="MMSQKSSPAQKRPRKSLSTGKTTKSQSHSITSYFNSVPPAKLAC
                     SICHKMVPRYDLIRHLDESCANNGEIVQNEPAQAGLINSTVPTSDLPSTPLEDMTPQK
                     LSPPKRRLISAQCGSKLGVRQQTSPYFKKALVCKNQNKLPNQSVEIRSLGSLSSKLSR
                     RYVKAKKSLSKNEGLASHCPPTSPSPPGPSLVDNCPEMDNKDEILNSSQKENIYSCAP
                     LEEETASEQKVKSSKRMGDGSQKASGGEPALTPASPEQAPTLLSSDLTLVNNTDSSSG
                     DALEQEGAGRVGVGVDEQLAACSHEEVQMTVDAEVGTLVSGGAESNSPADNDDDDAST
                     WSNNPELREAGSALKRQRACSPLEQGASCVPSVTAQPQPSHPYYLRSFLVVLQAILEN
                     EEDMKLFDDQEKGVIAKFYQLSASGQKLYVRLFQRKLTWIKVSKLEYEEIASDLTPVV
                     EELKNLGFLQTESELQELSDVLELLSAPELKALAKTFHLVSPGGQKQQLVDAFLKLAR
                     QRSVYTWGKTQPGIRAVILKRAKDLAGPSLRVCKGPRAVFCRLLLLFSLTDTMEDEEA
                     ACGGQGQLSTVLLVNLGRMEFPQYSISRKTQIFRDREDLIRYAAAAHMLSDISAAMAS
                     GNWEEAKELSQIAKRDWDQLKSHPSLRYHEALPLFLRCFTVGWIYTRISSRAVEVLER
                     LHMYEEAVKELENLLAQKVYCPDSRGRWWDRLALNLHQHLKRLEEAIWCIKEGLADPQ
                     VRTGHRLSLYQRAVRLRESPSCKKYRHLFSQLPEVTVGDVKHVTITGRLCPQHGMGKS
                     VFVIEGGDPTNPTTILCSVEELALDYYRRSGFDQGIHGEGSTFSTLCGLLLWDIIFMD
                     GIPDVFRNAYQASPLDLLTDSFFSSREQALEARLQLIHSAPAESLRAWVTEAWQAQQG
                     RAASLVSWDRFTSLQQAQDLVSCLGGPVLSGVCRRLAADFRHCRGGLPDLVVWNSQSH
                     HCKLVEVKGPSDRLSCKQMIWLDELQKLGADVEVCHVVAVGAKSKGLG"
     exon            1..1243
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1384
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1586
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1820
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1952
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2061
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2181
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2346
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2497
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2601
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2796
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2925
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3395
                     /gene="Fan1"
                     /gene_synonym="Mtmr15; RGD1566323"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatgtcac aaaagagctc acctgctcaa aaaagacccc gtaaaagctt atctaccggc
       61 aaaactacga aaagccaatc tcattccatt acttcgtatt ttaacagtgt accacctgct
      121 aaacttgcat gttcaatttg tcataaaatg gtgcccaggt atgacttaat ccggcacctt
      181 gatgagtctt gtgctaacaa tggtgaaatc gttcaaaatg agcctgctca ggctggttta
      241 attaactcaa ctgtgcctac atcagattta cccagtactc ctttagaaga tatgacacct
      301 cagaagttat caccaccaaa gagacgttta atctctgccc agtgtggttc aaaactgggc
      361 gtgcgacagc agaccagtcc ctactttaaa aaagccttgg tgtgcaaaaa tcaaaataag
      421 cttccaaatc agagtgtgga aatcaggtct ttgggaagtc tgtcatcaaa actgtccaga
      481 aggtacgtaa aagctaaaaa atcactctct aagaacgagg ggctagccag tcattgccca
      541 ccgacttctc cgtccccacc tggccccagc ctggttgata actgtccaga gatggacaac
      601 aaagatgaga ttttaaacag ttcccagaag gaaaacattt actcgtgtgc acctctagag
      661 gaagagaccg cttcagaaca gaaggtaaag agcagtaaaa ggatgggaga tggaagtcag
      721 aaagcttccg gtggggagcc ggccctcacg cctgcatccc cagagcaggc ccccacatta
      781 ctgtcctcag acttaactct tgtcaataac acggattcct cttcgggaga tgctctcgaa
      841 caagaaggtg ctggaagggt aggtgtaggg gttgatgaac agcttgcggc atgcagccat
      901 gaagaagtac aaatgactgt tgatgctgag gtgggaacgc tggtgtcagg gggggcggaa
      961 tcaaacagtc ctgctgacaa cgacgacgat gacgcatcta catggagtaa caacccagag
     1021 cttagggaag ctggcagtgc cttaaagaga caaagggctt gcagtcctct ggagcagggc
     1081 gccagttgtg ttcccagtgt gacagctcaa ccccaaccga gtcacccgta ctacctgagg
     1141 agcttcctgg tggttctgca ggccatcctt gagaacgaag aggacatgaa gctcttcgat
     1201 gaccaggaga agggcgttat agctaagttt taccagctgt cagccagtgg tcagaagttg
     1261 tatgtgaggc tcttccaacg taaattaacc tggattaaag tgagtaaact ggagtatgaa
     1321 gagattgcct cggacttaac ccctgtggtt gaagaattga agaacttagg ctttctacag
     1381 acagaatctg agttgcaaga actctctgat gtacttgaac tcctttctgc tcctgagctg
     1441 aaagccctgg ccaaaacctt ccacttggtg agtcccggtg ggcagaagca gcagctggta
     1501 gacgccttcc tcaaactggc cagacagcgc tcagtctaca cttggggcaa gactcagcct
     1561 ggaatcagag cggtgatttt aaagagagct aaagacttgg ctggcccgtc ccttcgagtc
     1621 tgtaaaggcc ctagggctgt gttttgccgc ctcctgcttc tgttctcgtt gactgatacc
     1681 atggaagacg aagaagctgc gtgtgggggt caaggtcagc tgtctactgt gctattggtc
     1741 aatctgggcc gaatggagtt tcctcagtac agcatcagcc ggaagaccca gatcttcagg
     1801 gacagagagg atcttatcag atacgcagcc gccgcgcaca tgctgagtga catctcagct
     1861 gccatggcca gtgggaactg ggaagaagct aaggagcttt ctcagattgc aaagagagac
     1921 tgggaccaac tgaaaagcca cccttccctg agataccacg aggccttgcc actctttctg
     1981 cgctgtttta ctgttgggtg gatctacaca aggatttcct ctcgggctgt tgaagtacta
     2041 gagagacttc acatgtacga ggaagctgtc aaggaacttg aaaacctcct cgctcagaaa
     2101 gtctattgtc ctgacagcag aggccgctgg tgggaccgcc tggctcttaa cctgcaccag
     2161 cacctgaagc gtctggaaga ggcaatttgg tgcatcaagg aaggcctggc agatccacaa
     2221 gtgaggacag gacaccgact ttctctttat cagcgagctg tgcgccttcg agagtctccg
     2281 agctgtaaaa agtacaggca cctattcagc cagctgccag aagtcactgt gggagacgtt
     2341 aagcatgtga ccatcacagg caggctgtgc ccacagcatg ggatgggcaa gtctgtgttt
     2401 gtcattgagg gtggagaccc caccaacccc accacaatcc tgtgttctgt ggaggaactg
     2461 gcactggact attacaggcg gagtggcttt gaccaaggga ttcacggaga agggtccacc
     2521 ttcagcaccc tgtgtggcct cctgctgtgg gatatcatct tcatggatgg aataccagat
     2581 gtcttcagaa atgcctacca ggcctccccc ctggatttgc tcacagacag cttcttctca
     2641 agcagggagc aggccctgga agccaggctg cagctgatcc acagcgcccc tgctgagagc
     2701 ctgcgggcct gggtgactga agcatggcag gcccagcaag gcagggcggc ttctctggtc
     2761 agctgggatc gcttcacttc ccttcagcaa gctcaggacc ttgtctcctg cctcgggggt
     2821 cctgtcctca gcggtgtgtg caggcgcctg gctgctgact ttcggcactg ccgaggaggc
     2881 ctccctgatt tggtggtgtg gaattctcag agccaccatt gcaagctggt ggaagttaaa
     2941 ggccccagtg atcgcctgtc atgtaagcag atgatctggc tggatgaact acaaaagctg
     3001 ggggcagacg tagaagtatg ccatgtggtt gcagttggtg ctaagagcaa aggtcttggc
     3061 tgaaagatgt cacactgggg acatctggcc atctactggg acaagatctt caagtggata
     3121 aaaatgtcac actgaggaca tctggccatc cactgggata agaccttcag tcggataaaa
     3181 atgtcacaca ggggacatct ggccatccac tgggacaaga ctgtcaagag gataaagcta
     3241 tttgcactgt gtccactttg gcttgcccga cacctgagat gggcgggtgg actgttgaaa
     3301 atgtagaagt ctgcatggga gctgtaggag ctgactgcct ccatgttgtt aagcttttaa
     3361 aaaaaaagcc agagggaaaa tgaacatggt ggact
//
