LOCUS       NM_001108169            3390 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus family with sequence similarity 83, member B
            (Fam83b), mRNA.
ACCESSION   NM_001108169 XM_001058463 XM_236420
VERSION     NM_001108169.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Cipriano R, Bryson BL, Miskimen KL, Bartel CA, Hernandez-Sanchez W,
            Bruntz RC, Scott SA, Lindsley CW, Brown HA and Jackson MW.
  TITLE     Hyperactivation of EGFR and downstream effector phospholipase D1 by
            oncogenic FAM83B
  JOURNAL   Oncogene 33 (25), 3298-3306 (2014)
   PUBMED   23912460
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Cipriano R, Miskimen KL, Bryson BL, Foy CR, Bartel CA and Jackson
            MW.
  TITLE     FAM83B-mediated activation of PI3K/AKT and MAPK signaling
            cooperates to promote epithelial cell transformation and resistance
            to targeted therapies
  JOURNAL   Oncotarget 4 (5), 729-738 (2013)
   PUBMED   23676467
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Cipriano R, Graham J, Miskimen KL, Bryson BL, Bruntz RC, Scott SA,
            Brown HA, Stark GR and Jackson MW.
  TITLE     FAM83B mediates EGFR- and RAS-driven oncogenic transformation
  JOURNAL   J Clin Invest 122 (9), 3197-3210 (2012)
   PUBMED   22886302
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_236420.4, XM_001058463.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676810
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..3390
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /note="family with sequence similarity 83, member B"
                     /db_xref="GeneID:315829"
                     /db_xref="RGD:1311988"
     exon            1..59
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /inference="alignment:Splign:2.1.0"
     exon            60..559
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3142
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /codon_start=1
                     /product="protein FAM83B"
                     /protein_id="NP_001101639.1"
                     /db_xref="GeneID:315829"
                     /db_xref="RGD:1311988"
                     /translation="METSSMLSSLNDECRSDNYVEPHYKEWYRVAVDTLIEHGLEAYQ
                     EFLVKERVSDFLAEEEINYILKNVQKIAQNTEHGSDSSCDDGSSSGTYWPMQSDVEAP
                     NLDLGWPCVMPGLLGSTHIDLLFHPPRAHLLTIKETVRKMIKDARKVVAIVMDVFTDV
                     DIFKEIVEASTRGISVYILLDESNFNHFLTMTEKQGCQIQRLRNIRVRTVKGQDYLSK
                     TGAKFHGKMEQKFLLVDCQKVMYGSYSYMWSFEKAHLSMVQIITGHLVELFDEEFRTL
                     YARSSVPSCFAQEESTRVKPGKALWENGIYQRSISSLASVSSQRNLFGRQDQIHKLDS
                     SYFKGRGIYPLNEQDKHGMRNHGYKPHFVPNFNGPSAIRHFQPSQINENWKRHSYAGE
                     QSETTPYLLLNRAMNRTNNAPGRWRRPSDSLSVASSLRGGQGSQQNIPAQSFADRLAQ
                     RKTTNLAERNSNVRRSFNGTDNHIRFIQQRMPTLENTTKSFLRSWRIESYLNDNSEAP
                     PDSNGSTLGDRFEGYDNPETVKANAVYTHSRLRSSFVFKPTLPEQKEVNSCTTGSSNS
                     TIIGSQGRDTPKELPESSTNAPPPLTEKPLPESIPKLPTQSEEPKTHSLRVPEKQPEV
                     LNQRTNGRAELNNCIYTKLCVNKPMENAKNQPSDNLLKRRSFPSFDHSKVNLDHGNSK
                     NYVYSTLTRNRIRQPEKPKEDVLKSSKSLHNVTHSTDEDDDEVTKRDPPSASAKSISI
                     AALLDVNKEEPNKELNSKKEGKASPSFLKKGSQKLRSLLSLTPEKRENLAKNKAPAFY
                     RMCSSSDTLVSEGEENQKPKKSEPKGDASPRRKRSSLSNSQGSIHKSKEDIAVSTSPG
                     ISSQVEETRIAPSPRPAERRLSERAGDASAPRFNTEQIQYRDSKEINAVMTPARRPTS
                     SPVLKPSELLRSHSTNQRVYSRFEPFCKIESSIQPASSVTHVNRPEVKSTTMGSYGRS
                     SPMLNYKTGAYQSYSPNENKFRGFMQKFGNFIHKNK"
     exon            560..724
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /inference="alignment:Splign:2.1.0"
     exon            725..849
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /inference="alignment:Splign:2.1.0"
     exon            850..3390
                     /gene="Fam83b"
                     /gene_synonym="RGD1311988"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcttcctg ggcgccacct tcgcagcggc ggcggcggca gcggaggcag tagctgcggg
       61 taccacttgc ctctgcacag atgaacattt gaaagcgccc ccaacaccag caagcatgga
      121 gacttcatca atgctttcct cactaaatga tgagtgcagg tctgacaact atgtcgagcc
      181 gcactacaag gagtggtacc gtgtggcagt tgatactcta attgaacatg ggctagaagc
      241 ctaccaagag ttccttgtca aggagcgagt ctcagacttc ctggctgagg aagaaattaa
      301 ttatattttg aaaaatgtcc agaagattgc acaaaataca gaacatggct ctgatagttc
      361 ctgtgatgac ggctcgtctt cagggactta ctggcccatg cagtcggacg tggaggctcc
      421 aaatcttgat ttgggatggc cgtgtgtgat gcccggactc ttagggagca cccatataga
      481 cctcctcttt catccacccc gggcacatct acttacaata aaggaaactg ttcggaagat
      541 gatcaaagac gcaagaaagg tggttgctat agtgatggat gtttttactg atgtggatat
      601 tttcaaagaa atagtagagg catccactcg aggaatatcc gtatacattt tacttgatga
      661 gtccaatttt aatcattttc taacaatgac tgaaaaacag ggttgtcaaa ttcagcgtct
      721 caggaacatt cgtgtacgga cagtaaaagg ccaagattat ctttcaaaaa caggagcaaa
      781 attccatgga aaaatggaac agaaattttt gttagttgac tgccagaaag tgatgtatgg
      841 ttcttacagt tacatgtggt catttgaaaa agctcatctc agcatggttc agataatcac
      901 aggacacctt gtagagttat ttgatgaaga atttcgaaca ctctatgcca ggtccagtgt
      961 cccaagttgt tttgctcaag aagaatcaac gagggtgaag ccgggcaaag ccttatggga
     1021 gaatggcatt taccagcgat ccatttcttc attagcttct gtttccagcc agagaaacct
     1081 ttttggcaga caagaccaaa ttcataaact agattctagt tacttcaaag gcagagggat
     1141 atatccccta aatgaacagg acaaacacgg catgagaaac catggctaca agcctcattt
     1201 tgttccaaac ttcaatggtc cgagtgcaat ccgtcacttc caacccagtc agatcaatga
     1261 aaactggaag aggcatagtt atgctgggga acaatcggaa acaaccccgt acctgctgct
     1321 caacagagct atgaatcgga ccaataatgc ccctggacgc tggagaaggc cttcagatag
     1381 tctcagtgtg gcatcctcct tacggggagg acagggaagc cagcaaaaca tacctgctca
     1441 gagttttgct gataggctcg cccagagaaa aacaacaaat cttgcagaga ggaattcaaa
     1501 tgtacgcagg tcatttaacg ggacagataa tcatatccgc tttatacaac aacggatgcc
     1561 aactctggag aataccacga agtctttcct gcggagctgg agaattgaat cgtacttaaa
     1621 cgataattca gaagccccac ctgattcaaa tggctccacc ctgggtgaca gatttgaagg
     1681 ctacgacaac cctgagaccg tgaaagccaa tgcggtctat actcattcaa ggctccgctc
     1741 ctcctttgtg tttaaaccaa ctttaccgga acaaaaagaa gtcaatagct gtacaactgg
     1801 ctcctcaaat tccaccatca tcggttctca aggaagggat acacccaagg agctcccaga
     1861 gagctccaca aatgctcctc cacccctgac agaaaagccc ttgccggaat caatccccaa
     1921 gctcccaaca cagtcagagg aaccaaaaac gcacagcttg cgggttcccg aaaagcaacc
     1981 ggaagtctta aaccaaagaa ccaacggccg agcggaacta aacaactgta tttatacaaa
     2041 actgtgcgtc aataagccaa tggagaacgc aaaaaatcag ccaagcgaca atctgctcaa
     2101 aaggcggagt ttcccgtcct tcgaccactc aaaagtcaac ttggatcacg gaaatagcaa
     2161 gaattatgtt tatagtaccc ttaccagaaa tcgcattcgg caaccagaaa aacccaagga
     2221 ggatgtgctg aagagttcta agagcttgca caatgtgacc cacagcacgg atgaagacga
     2281 cgacgaggtt actaagagag accctccaag tgcctctgcc aagtctattt ccatcgctgc
     2341 tttgctggac gtgaataagg aagaacccaa caaagaactc aattctaaaa aggaaggcaa
     2401 agcctccccg agttttctga aaaaggggtc tcagaaatta aggtccttac ttagtctcac
     2461 cccagagaag agagagaacc tagctaaaaa caaggcgccg gcgttttaca gaatgtgtag
     2521 tagctccgac actttggttt ctgagggtga agagaatcaa aagcccaaaa aatccgagcc
     2581 caaaggtgac gcatctccta gaagaaagcg ttcctctttg tcgaattctc aaggcagcat
     2641 ccacaagagc aaggaggaca tagcagttag cacatctccg ggaataagtt cccaagtaga
     2701 ggaaactaga atagccccct ctccaaggcc cgctgagagg agactttcag agagagctgg
     2761 agacgcctct gccccaagat ttaataccga acagatccaa taccgtgatt ccaaggagat
     2821 caacgcagtc atgacccctg ccagacggcc aacctcttct ccggtgctaa aacccagtga
     2881 gcttctgaga tcccattcaa ccaaccagcg cgtttacagt cgattcgagc cgttttgtaa
     2941 gatcgagagc tcgattcagc cagcgagcag cgttacacat gtcaaccgcc cggaagtcaa
     3001 atccacaacc atgggcagct acggcaggtc cagcccgatg ctgaattata agactggtgc
     3061 ttatcaatcc tactccccaa atgagaacaa gttccgggga tttatgcaaa agtttgggaa
     3121 cttcatacac aaaaacaagt gaaatacttc catttcaaat tgtaattgaa atatacagtg
     3181 aatgtggctg tacacatttg cccaaagaac actctgcaca cttttttaga ccatgccaag
     3241 agtgttctgt atgagaactg gagaaataca taacagtata cagaaaagtt attgttttgt
     3301 gctcaaacca gttgcacttg gttactccac aaagcgctat cccagtcaac atattaaaaa
     3361 ttttttaaat agcaatagat gggattcatt
//
