LOCUS       NM_001107102             954 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FAM3 metabolism regulating signaling molecule B
            (Fam3b), mRNA.
ACCESSION   NM_001107102 XM_001055622 XM_006248157 XM_221623
VERSION     NM_001107102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 954)
  AUTHORS   Zhang,W., Chen,S., Zhang,Z., Wang,C. and Liu,C.
  TITLE     FAM3B mediates high glucose-induced vascular smooth muscle cell
            proliferation and migration via inhibition of miR-322-5p
  JOURNAL   Sci Rep 7 (1), 2298 (2017)
   PUBMED   28536423
  REMARK    GeneRIF: Data show that family with sequence similarity 3, member B
            protein (FAM3B) inhibited miR-322-5p expression, and enforced
            expression of miR-322-5p antagonized FAM3B-induced vascular smooth
            muscle cells (VSMCs) proliferation and migration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 954)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 954)
  AUTHORS   Zhu,Y., Xu,G., Patel,A., McLaughlin,M.M., Silverman,C., Knecht,K.,
            Sweitzer,S., Li,X., McDonnell,P., Mirabile,R., Zimmerman,D.,
            Boyce,R., Tierney,L.A., Hu,E., Livi,G.P., Wolf,B.,
            Abdel-Meguid,S.S., Rose,G.D., Aurora,R., Hensley,P., Briggs,M. and
            Young,P.R.
  TITLE     Cloning, expression, and initial characterization of a novel
            cytokine-like gene family
  JOURNAL   Genomics 80 (2), 144-150 (2002)
   PUBMED   12160727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On or before Nov 24, 2020 this sequence version replaced
            XM_006248157.3, NM_001107102.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.554165.1,
                                           SRR26643299.47633.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760434,
                                           SAMN12840120 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JAXUCZ010000011.1  50333182-50333296   c
            116-259             JAXUCZ010000011.1  50328602-50328745   c
            260-383             JAXUCZ010000011.1  50311387-50311510   c
            384-442             JAXUCZ010000011.1  50307728-50307786   c
            443-493             JAXUCZ010000011.1  50305967-50306017   c
            494-581             JAXUCZ010000011.1  50305308-50305395   c
            582-714             JAXUCZ010000011.1  50304878-50305010   c
            715-954             JAXUCZ010000011.1  50300926-50301165   c
FEATURES             Location/Qualifiers
     source          1..954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..954
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /note="FAM3 metabolism regulating signaling molecule B"
                     /db_xref="GeneID:304050"
                     /db_xref="RGD:1311662"
     exon            1..115
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..804
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /note="cytokine-like protein 2-21; family with sequence
                     similarity 3, member B"
                     /codon_start=1
                     /product="protein FAM3B"
                     /protein_id="NP_001100572.2"
                     /db_xref="GeneID:304050"
                     /db_xref="RGD:1311662"
                     /translation="MRPVTAGIFKALLFIFSSLCAWYSGYLLAELIPDVPLSNTLYNI
                     RSIGERPVLKAPVPKRQKCDHWSPCPPDTYAYRLLSGGGLDKYAKICFEDEMLLGEKT
                     GNVARGINIAVVDYETGKVISTKYFDMYEGDNSEPMTKFIQSIPSKSLLFMVTHDDGS
                     HKLQAQAKDAIEALGSKEIKNIKFRSSWVFVAAKGFELPSEMEREKINHSDQSRNRYS
                     GWPAEIQIEGCIPKGLR"
     exon            116..259
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     exon            260..383
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     exon            384..442
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     exon            443..493
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     exon            494..581
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     exon            582..714
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
     exon            715..954
                     /gene="Fam3b"
                     /gene_synonym="RGD1311662"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccattctat gtgcagctca ggcaggttgg ccagctaata caggtccctg agaattacag
       61 ccgggagctg ggtaggaaga aagcagtttc tggaagatgc gtccagttac agcaggtatc
      121 ttcaaggcac tactgtttat tttctcctcc ctgtgcgcct ggtattctgg gtacctgctc
      181 gcggagctca ttcctgacgt gcccctgtcc aacactctct acaacatccg aagcattggg
      241 gagagacctg ttctcaaagc cccagtcccc aaaagacaaa aatgtgacca ttggtcccca
      301 tgtcctcctg acacctatgc ctaccggctg ctcagtggtg gtggcctaga caagtatgcc
      361 aagatctgct ttgaggatga aatgctatta ggagagaaga cggggaatgt ggcaagaggg
      421 ataaacatcg ctgttgttga ctatgagacg gggaaagtaa tatcaacaaa gtactttgac
      481 atgtacgaag gtgataactc tgagccaatg actaagttta ttcagagcat cccttcgaaa
      541 tccctgctgt tcatggtgac tcatgatgac ggaagccaca aactgcaggc tcaagcaaag
      601 gatgccatag aagcccttgg aagcaaagaa atcaagaaca taaagttcag atcaagctgg
      661 gtgtttgttg cagcaaaggg ctttgagctc ccttcagaaa tggagagaga aaaaatcaac
      721 cactcagatc aatccaggaa cagatactcc ggctggccag cagagatcca gatcgaagga
      781 tgcataccca aagggctgag ataacggcgc ttgcacctca gtagacctgt ttcgtacaga
      841 tacgctcagc tggaacatca caggattctg ttccttcgag tccagctgtg aaggaaaggg
      901 ctgatgtgga tttgcagttt gttgtaaaca ataagacatt gttggtgaca ctga
//
