LOCUS       NM_001401946            1267 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus family with sequence similarity 237 member A
            (Fam237a), mRNA.
ACCESSION   NM_001401946 XM_017596814
VERSION     NM_001401946.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Iwakoshi-Ukena,E., Shikano,K., Kondo,K., Taniuchi,S., Furumitsu,M.,
            Ochi,Y., Sasaki,T., Okamoto,S., Bentley,G.E., Kriegsfeld,L.J.,
            Minokoshi,Y. and Ukena,K.
  TITLE     Neurosecretory protein GL stimulates food intake, de novo
            lipogenesis, and onset of obesity
  JOURNAL   Elife 6, e28527 (2017)
   PUBMED   28799896
  REMARK    GeneRIF: These results point to NPGL as a novel neuronal regulator
            that drives food intake and fat deposition through de novo
            lipogenesis and acts to maintain steady-state fat level in concert
            with insulin. Dysregulation of NPGL may be a root cause of obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Matsuura,D., Shikano,K., Saito,T., Iwakoshi-Ukena,E., Furumitsu,M.,
            Ochi,Y., Sato,M., Bentley,G.E., Kriegsfeld,L.J. and Ukena,K.
  TITLE     Neurosecretory Protein GL, a Hypothalamic Small Secretory Protein,
            Participates in Energy Homeostasis in Male Mice
  JOURNAL   Endocrinology 158 (5), 1120-1129 (2017)
   PUBMED   28323972
  REMARK    GeneRIF: Distribution of NPGL in the mammalian brain and point to
            an important role for this neuropeptide in energy homeostasis.
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Masuda,K., Ooyama,H., Shikano,K., Kondo,K., Furumitsu,M.,
            Iwakoshi-Ukena,E. and Ukena,K.
  TITLE     Microwave-assisted solid-phase peptide synthesis of neurosecretory
            protein GL composed of 80 amino acid residues
  JOURNAL   J Pept Sci 21 (6), 454-460 (2015)
   PUBMED   25708449
  REMARK    GeneRIF: The synthesis of the entire 80-amino acid peptide sequence
            of rat NPGL was optimized by microwave-assisted solid-phase peptide
            synthesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 3, 2022 this sequence version replaced XM_017596814.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26360181.1333667.1,
                                    SRR26360186.1816246.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760383, SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000009.1  72522278-72522325
            49-207              JAXUCZ010000009.1  72522597-72522755
            208-629             JAXUCZ010000009.1  72524136-72524557
            630-1267            JAXUCZ010000009.1  72528158-72528795
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1267
                     /gene="Fam237a"
                     /gene_synonym="NPGL"
                     /note="family with sequence similarity 237 member A"
                     /db_xref="GeneID:103690541"
                     /db_xref="RGD:9235481"
     exon            1..48
                     /gene="Fam237a"
                     /gene_synonym="NPGL"
                     /inference="alignment:Splign:2.1.0"
     exon            49..207
                     /gene="Fam237a"
                     /gene_synonym="NPGL"
                     /inference="alignment:Splign:2.1.0"
     exon            208..629
                     /gene="Fam237a"
                     /gene_synonym="NPGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..769
                     /gene="Fam237a"
                     /gene_synonym="NPGL"
                     /note="neurosecretory protein GL"
                     /codon_start=1
                     /product="protein FAM237A precursor"
                     /protein_id="NP_001388875.1"
                     /db_xref="GeneID:103690541"
                     /db_xref="RGD:9235481"
                     /translation="MTDPGTRSRNHCPLSLTCLLLIVGMYYVSPVFCHSQTDLLTLNQ
                     ADPQCWESSSMLLLEMRKPRVSNTVSGFWDFMIYLKSSENLKHGALFWDLAQLFWDIY
                     VDCVLSRNHGLGRRELAGEEQRVSKVLPRHLGIKQGAYSQLLRSIYLKKKELIGDLTS
                     MQLQKWGPGFTGKEKLQIKRNRS"
     exon            630..1267
                     /gene="Fam237a"
                     /gene_synonym="NPGL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccaggtc ggctccctcc caccatcccc cagacaggcg tcagagagaa gagacacgct
       61 gcttccagga cgcggaagct ggggacagtc acctgccttg ggaacagccg gagtgcgtcc
      121 tctccgcgca ctcgagggat cgcggttagg gcagttaact gcggagcggc gcccttcaga
      181 cccacagaag aggcgtggaa caaagagttg caggaccatg actgatcctg ggaccagaag
      241 caggaaccac tgccccctga gtctcacctg cctcctgctc attgtgggaa tgtactatgt
      301 gtctcctgtt ttctgtcaca gtcagacaga cctgctgact cttaaccaag ctgatcctca
      361 gtgctgggag tcctcatcaa tgctcctcct ggagatgcgg aagcctcgtg tttctaacac
      421 tgtctctggc ttttgggatt ttatgatcta tctgaagtca tctgagaact tgaagcatgg
      481 tgccctgttt tgggatctgg cccaactctt ctgggacatc tatgtagact gtgtcctctc
      541 taggaaccat ggcttaggaa ggagggaatt ggctggagaa gaacagagag tctcaaaagt
      601 gctgcccagg catttgggga ttaaacaagg tgcatattct cagctcctta gaagcattta
      661 cttaaagaag aaggaattga ttggagattt gacaagcatg caattgcaaa agtggggccc
      721 tgggttcact ggaaaagaga agctgcaaat aaagagaaat cgaagctaat ttcagagtta
      781 actgaagcct tggaataaaa aaaaagaata ttttcctatc aatgatttat gtattttaag
      841 cggtgtaaat gtccaaggat gtcaaatttt ctaagaatcc tattttcagc atcttggttg
      901 ctagctggtc tgttcacatg gtaattactg attgaccacc cctctgtcta caggagctaa
      961 agaatttgct gggatgaggg atttgtctct ttacagtatg ataatttgcc ggggaagggg
     1021 tggcaatgct aatgagctag aaggccacac atttagcata agctacacaa atcacaagcc
     1081 attaactgct gcattgttta tgaaactgga gtggaaggac tatatgcatg agcgggactg
     1141 ctgatggtct gcgattctca accttgtctg ggagaatagt tctgaatatg gaatgaagga
     1201 aaaaaaccac aggggaataa aacattcatc taatgaaaac aaaattaata aaagctttgg
     1261 ctcccaa
//
