LOCUS       NM_001012238            2960 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus FAM20C, golgi associated secretory pathway kinase
            (Fam20c), mRNA.
ACCESSION   NM_001012238 XM_221975
VERSION     NM_001012238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Tibaldi E, Brocca A, Sticca A, Gola E, Pizzi M, Bordin L, Pagano
            MA, Mazzorana M, Dona G, Violi P, Marin O, Romano A, Angeli P,
            Carraro A and Brunati AM.
  TITLE     Fam20C-mediated phosphorylation of osteopontin is critical for its
            secretion but dispensable for its action as a cytokine in the
            activation of hepatic stellate cells in liver fibrogenesis
  JOURNAL   FASEB J 34 (1), 1122-1135 (2020)
   PUBMED   31914633
  REMARK    GeneRIF: OPN, besides being overexpressed in hepatic stellate
            cells, is substantially phosphorylated by family with sequence
            similarity 20, member C (Fam20C), formerly known as Golgi casein
            kinase (G-CK), which is exclusively resident in the Golgi apparatus
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Oya K, Ishida K, Nishida T, Sato S, Kishino M, Hirose K, Ogawa Y,
            Ikebe K, Takeshige F, Yasuda H, Komori T and Toyosawa S.
  TITLE     Immunohistochemical analysis of dentin matrix protein 1 (Dmp1)
            phosphorylation by Fam20C in bone: implications for the induction
            of biomineralization
  JOURNAL   Histochem Cell Biol 147 (3), 341-351 (2017)
   PUBMED   27614627
  REMARK    GeneRIF: Phosphorylated Fam20C in the pericanalicular matrix may
            play an important role in bone mineralization by recruiting calcium
            ions.
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao
            J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA,
            Pagliarini DJ and Dixon JE.
  TITLE     A Single Kinase Generates the Majority of the Secreted
            Phosphoproteome
  JOURNAL   Cell 161 (7), 1619-1632 (2015)
   PUBMED   26091039
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M and Dixon JE.
  TITLE     A secretory kinase complex regulates extracellular protein
            phosphorylation
  JOURNAL   Elife 4, e06120 (2015)
   PUBMED   25789606
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Acevedo AC, Poulter JA, Alves PG, de Lima CL, Castro LC, Yamaguti
            PM, Paula LM, Parry DA, Logan CV, Smith CE, Johnson CA, Inglehearn
            CF and Mighell AJ.
  TITLE     Variability of systemic and oro-dental phenotype in two families
            with non-lethal Raine syndrome with FAM20C mutations
  JOURNAL   BMC Med Genet 16, 8 (2015)
   PUBMED   25928877
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   Simpson MA, Hsu R, Keir LS, Hao J, Sivapalan G, Ernst LM, Zackai
            EH, Al-Gazali LI, Hulskamp G, Kingston HM, Prescott TE, Ion A,
            Patton MA, Murday V, George A and Crosby AH.
  TITLE     Mutations in FAM20C are associated with lethal osteosclerotic bone
            dysplasia (Raine syndrome), highlighting a crucial molecule in bone
            development
  JOURNAL   Am J Hum Genet 81 (5), 906-912 (2007)
   PUBMED   17924334
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Hao J, Narayanan K, Muni T, Ramachandran A and George A.
  TITLE     Dentin matrix protein 4, a novel secretory calcium-binding protein
            that modulates odontoblast differentiation
  JOURNAL   J Biol Chem 282 (21), 15357-15365 (2007)
   PUBMED   17369251
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Nalbant D, Youn H, Nalbant SI, Sharma S, Cobos E, Beale EG, Du Y
            and Williams SC.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Andrzejewska M, Pagano MA, Meggio F, Brunati AM and Kazimierczuk Z.
  TITLE     Polyhalogenobenzimidazoles: synthesis and their inhibitory activity
            against casein kinases
  JOURNAL   Bioorg Med Chem 11 (18), 3997-4002 (2003)
   PUBMED   12927861
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001522.1.
            
            On Feb 13, 2005 this sequence version replaced XM_221975.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001522.1, BC161825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..2960
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /note="FAM20C, golgi associated secretory pathway kinase"
                     /db_xref="GeneID:304334"
                     /db_xref="RGD:1311980"
     exon            1..1113
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..2263
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /EC_number="2.7.11.1"
                     /note="dentin matrix protein 4; family with sequence
                     similarity 20, member C"
                     /codon_start=1
                     /product="extracellular serine/threonine protein kinase
                     FAM20C"
                     /protein_id="NP_001012238.1"
                     /db_xref="GeneID:304334"
                     /db_xref="RGD:1311980"
                     /translation="MKMILVRRFRVLILVVFLLACALHIAVDLLPKLDRRATRSPGEP
                     GCSCAQPAAEAAGPGWAQARSRPGESAGGDAGWPNKHTLRILQDFSSDPASNLTSHSL
                     EKLPPAAEPVDHAPRGQELGSPPPRDSAHRPLLRDPGPGPRVPPHGPRGDGSLLAKLF
                     EHPLYQGAVPPLTEGDVLFNVNSDIRFNPRAAENPDWPLEGAEGAEFLPTGEAAVDLY
                     PNWLKFHIGINRYELYSRHNPAIDALLHDLGSQKITSVAMKSGGTQLKLIMTFQNYGQ
                     ALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRILDFRRVPPVAGRMINMTKE
                     IRDVTRDKKLWRTFFVSPANNICFYGECSYYCSTEHALCGKPDQIEGSLAAFLPDLSL
                     AKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPPYDSGHRILDIMDMTVFDFLMG
                     NMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSILAPLHQCCRIRRSTYLRLQL
                     LAKEEYKLSLLMAESLQHDKVAPVLYQLHLEALDRRLRIVLQAVRDCVEKDGVSSVVE
                     DDLATEHRASTER"
     exon            1114..1292
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1371
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1464
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1580
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1761
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1871
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1953
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2013
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2960
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcgctcc gggtcggccg gctgcacctg ccagatctcc gcttctccct gcgcgccccc
       61 tcgcgctccc cttctcacct cggtctctca gccactacct gacagcgcag aggaatcgct
      121 ttgttgcccg cccagcacca ggcatggccc agcgggagca ccacgctctg gatcggctca
      181 gtcgcgccct ggcggggatg aacagccgcg ccttctgctt acacgcccaa tgagtgtggt
      241 cgccgtcccg gagactctcg tccgcctctg ctttctctgt caccactgcc acccactcca
      301 ccgacgagtg tcactggccg acccccgaga tggcctggag agccggtgct ttggtggcgg
      361 gtgtcctcca cgacgtccaa atctggggac agcccccgag ctggtagctg cttgtacacc
      421 gaatggacct tgacccgcga gtcgttgccg gcttggtgcc aagctgaggg gcaccggtgg
      481 agcgcgcgtc cggaaccccc caagcccgct ggcctgcgcg gtcatgaaga tgatcttggt
      541 gcgcaggttt cgcgtgctca tcttggtggt attcctactg gcttgcgctt tgcacattgc
      601 tgttgacctg ctacccaagc tggaccggcg cgccacaaga tccccggggg agcccggctg
      661 ctcctgcgct cagccggcag cagaggcagc tggtccaggc tgggcccagg caaggagccg
      721 accgggagag tccgccggtg gcgacgcagg ctggcccaac aaacacacac tgcgcatcct
      781 gcaagacttc agctcagatc cagcctctaa cctcacctcc cactccttgg agaagctgcc
      841 tcctgcagcg gagccggtgg atcacgctcc gcggggtcag gagctgggtt ccccgccacc
      901 ccgtgactcc gcgcaccggc cgctgcttcg agaccctggg cccggaccgc gggtgccgcc
      961 ccatggcccc agaggggacg gatcgctctt agccaagttg tttgagcacc cactgtacca
     1021 gggggctgta cctcctctga cagagggcga cgtcctgttt aatgtgaaca gcgacatcag
     1081 atttaacccc agagcagcag agaatcctga ctggccgctg gaaggtgctg aaggtgcaga
     1141 attcttgccg actggtgagg cagcggtgga cctctatcct aactggctca aattccacat
     1201 cggcatcaac cggtatgagc tgtactccag gcacaaccca gccatcgatg ccttactcca
     1261 cgacctcggc tctcagaaga tcaccagtgt cgccatgaag tcagggggca cgcagctgaa
     1321 gctcatcatg accttccaga attacgggca ggcgctattc aaacccatga agcagacgag
     1381 ggagcaggag acgccgcctg acttttttta tttctctgac tacgagaggc acaatgcgga
     1441 gatagctgcc ttccacctgg acaggatcct ggatttccgc agagtgcctc cagtggccgg
     1501 caggatgatc aacatgacca aggagatccg ggatgtcacg agggacaaga agctatggag
     1561 aaccttcttt gtgtctccag ccaacaacat ctgcttctat ggggagtgtt cctactattg
     1621 ttccactgag catgccctgt gtgggaagcc tgaccagata gaaggatccc tggcggcatt
     1681 ccttcctgac ctttcactgg ccaagaggaa gacatggcgg aacccctggc gtcgttccta
     1741 ccacaagcga aagaaggcag agtgggaagt ggaccccgat tactgtgagg aggtgaagca
     1801 gactccaccc tacgacagtg gtcaccgcat cctggacatc atggacatga ctgtctttga
     1861 cttcctcatg gggaacatgg atcggcatca ctacgagacc tttgagaagt tcgggaatga
     1921 gaccttcatc atacacttgg acaacgggcg tgggtttggg aagtactcac acgatgagct
     1981 ttccattcta gcacctcttc accagtgctg caggatcagg aggtccacct acctgcggct
     2041 gcagctgctg gccaaagagg agtacaaact gagcctgctg atggccgagt ccctgcagca
     2101 tgacaaggtg gcacccgtgc tctaccagct gcacctggag gccctggacc ggcggctgcg
     2161 catagtgctg caggctgtgc gagactgtgt ggagaaggat ggtgtgagca gtgtggtgga
     2221 ggacgaccta gccactgagc acagagcctc cacagagagg tagtgaccac gctgccccga
     2281 ggaaggagga gcacagagcc tatccacctg tgaattcagt gaattcggac gggattggtc
     2341 accccccata gggtgacctg cagtagggag catggggtct ccctcatggc tctgataggg
     2401 atgtatgggc ctccggttcc agcagaaacc agcattcaga acatgcagca gagtggccag
     2461 cgctccgtcc ttcccatagg gagggacctt taactcacta ttttgtattt aacaaaaggc
     2521 tcacactcct gtcaatgaag aaccacccag cagaccagag atcacctccg ggccacttca
     2581 aggaccctct gtgatgtgat cacactctgg ccctcaatca caatccactt tctgctcccc
     2641 ccgatcctgg cctctctcaa aggccggaga gctctcgaga ggggaggctg tgatgggcat
     2701 cacggcctgt gtcggagcag atgggcaccc aagagtgggt tttggatgct aatgaccagc
     2761 tatccattgt cggctgctac acagcagtca ggccttacta gttgggtggt gggcaccgcc
     2821 tgccctgtgc tgagctctgg acagtgggtg tcaagacact acacaaagcc catggcgcca
     2881 ggacagcagg ctagccttgg gacctttttg tgggagtagt ttgcagtgag gtaacggtgc
     2941 aataaagtac agcaagcgtg
//
