LOCUS       NP_001012238             579 aa            linear   ROD 23-MAR-2023
DEFINITION  extracellular serine/threonine protein kinase FAM20C [Rattus
            norvegicus].
ACCESSION   NP_001012238 XP_221975
VERSION     NP_001012238.1
DBSOURCE    REFSEQ: accession NM_001012238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 579)
  AUTHORS   Tibaldi E, Brocca A, Sticca A, Gola E, Pizzi M, Bordin L, Pagano
            MA, Mazzorana M, Dona G, Violi P, Marin O, Romano A, Angeli P,
            Carraro A and Brunati AM.
  TITLE     Fam20C-mediated phosphorylation of osteopontin is critical for its
            secretion but dispensable for its action as a cytokine in the
            activation of hepatic stellate cells in liver fibrogenesis
  JOURNAL   FASEB J 34 (1), 1122-1135 (2020)
   PUBMED   31914633
  REMARK    GeneRIF: OPN, besides being overexpressed in hepatic stellate
            cells, is substantially phosphorylated by family with sequence
            similarity 20, member C (Fam20C), formerly known as Golgi casein
            kinase (G-CK), which is exclusively resident in the Golgi apparatus
REFERENCE   2  (residues 1 to 579)
  AUTHORS   Oya K, Ishida K, Nishida T, Sato S, Kishino M, Hirose K, Ogawa Y,
            Ikebe K, Takeshige F, Yasuda H, Komori T and Toyosawa S.
  TITLE     Immunohistochemical analysis of dentin matrix protein 1 (Dmp1)
            phosphorylation by Fam20C in bone: implications for the induction
            of biomineralization
  JOURNAL   Histochem Cell Biol 147 (3), 341-351 (2017)
   PUBMED   27614627
  REMARK    GeneRIF: Phosphorylated Fam20C in the pericanalicular matrix may
            play an important role in bone mineralization by recruiting calcium
            ions.
REFERENCE   3  (residues 1 to 579)
  AUTHORS   Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao
            J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA,
            Pagliarini DJ and Dixon JE.
  TITLE     A Single Kinase Generates the Majority of the Secreted
            Phosphoproteome
  JOURNAL   Cell 161 (7), 1619-1632 (2015)
   PUBMED   26091039
REFERENCE   4  (residues 1 to 579)
  AUTHORS   Cui J, Xiao J, Tagliabracci VS, Wen J, Rahdar M and Dixon JE.
  TITLE     A secretory kinase complex regulates extracellular protein
            phosphorylation
  JOURNAL   Elife 4, e06120 (2015)
   PUBMED   25789606
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 579)
  AUTHORS   Acevedo AC, Poulter JA, Alves PG, de Lima CL, Castro LC, Yamaguti
            PM, Paula LM, Parry DA, Logan CV, Smith CE, Johnson CA, Inglehearn
            CF and Mighell AJ.
  TITLE     Variability of systemic and oro-dental phenotype in two families
            with non-lethal Raine syndrome with FAM20C mutations
  JOURNAL   BMC Med Genet 16, 8 (2015)
   PUBMED   25928877
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 579)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (residues 1 to 579)
  AUTHORS   Simpson MA, Hsu R, Keir LS, Hao J, Sivapalan G, Ernst LM, Zackai
            EH, Al-Gazali LI, Hulskamp G, Kingston HM, Prescott TE, Ion A,
            Patton MA, Murday V, George A and Crosby AH.
  TITLE     Mutations in FAM20C are associated with lethal osteosclerotic bone
            dysplasia (Raine syndrome), highlighting a crucial molecule in bone
            development
  JOURNAL   Am J Hum Genet 81 (5), 906-912 (2007)
   PUBMED   17924334
REFERENCE   8  (residues 1 to 579)
  AUTHORS   Hao J, Narayanan K, Muni T, Ramachandran A and George A.
  TITLE     Dentin matrix protein 4, a novel secretory calcium-binding protein
            that modulates odontoblast differentiation
  JOURNAL   J Biol Chem 282 (21), 15357-15365 (2007)
   PUBMED   17369251
REFERENCE   9  (residues 1 to 579)
  AUTHORS   Nalbant D, Youn H, Nalbant SI, Sharma S, Cobos E, Beale EG, Du Y
            and Williams SC.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 579)
  AUTHORS   Andrzejewska M, Pagano MA, Meggio F, Brunati AM and Kazimierczuk Z.
  TITLE     Polyhalogenobenzimidazoles: synthesis and their inhibitory activity
            against casein kinases
  JOURNAL   Bioorg Med Chem 11 (18), 3997-4002 (2003)
   PUBMED   12927861
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001522.1.
            
            On Feb 13, 2005 this sequence version replaced XP_221975.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001522.1, BC161825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     Protein         1..579
                     /product="extracellular serine/threonine protein kinase
                     FAM20C"
                     /EC_number="2.7.11.1"
                     /note="dentin matrix protein 4; family with sequence
                     similarity 20, member C"
                     /calculated_mol_wt=65484
     Region          35..>154
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          349..560
                     /region_name="FAM20C_C"
                     /note="C-terminal putative kinase domain of FAM20C (also
                     known as Dentin Matrix Protein 4, DMP4); cd10471"
                     /db_xref="CDD:198462"
     Site            order(446,453,473)
                     /site_type="active"
                     /note="putative catalytic residues [active]"
                     /db_xref="CDD:198462"
     Site            450..458
                     /site_type="active"
                     /note="putative catalytic loop [active]"
                     /db_xref="CDD:198462"
     Site            order(458,473)
                     /site_type="other"
                     /note="putative metal binding site [ion binding]"
                     /db_xref="CDD:198462"
     Site            473..495
                     /site_type="other"
                     /note="putative activation loop"
                     /db_xref="CDD:198462"
     CDS             1..579
                     /gene="Fam20c"
                     /gene_synonym="RGD1311980"
                     /coded_by="NM_001012238.1:524..2263"
                     /db_xref="GeneID:304334"
                     /db_xref="RGD:1311980"
ORIGIN      
        1 mkmilvrrfr vlilvvflla calhiavdll pkldrratrs pgepgcscaq paaeaagpgw
       61 aqarsrpges aggdagwpnk htlrilqdfs sdpasnltsh sleklppaae pvdhaprgqe
      121 lgsppprdsa hrpllrdpgp gprvpphgpr gdgsllaklf ehplyqgavp pltegdvlfn
      181 vnsdirfnpr aaenpdwple gaegaeflpt geaavdlypn wlkfhiginr yelysrhnpa
      241 idallhdlgs qkitsvamks ggtqlklimt fqnygqalfk pmkqtreqet ppdffyfsdy
      301 erhnaeiaaf hldrildfrr vppvagrmin mtkeirdvtr dkklwrtffv spannicfyg
      361 ecsyycsteh alcgkpdqie gslaaflpdl slakrktwrn pwrrsyhkrk kaewevdpdy
      421 ceevkqtppy dsghrildim dmtvfdflmg nmdrhhyetf ekfgnetfii hldngrgfgk
      481 yshdelsila plhqccrirr stylrlqlla keeyklsllm aeslqhdkva pvlyqlhlea
      541 ldrrlrivlq avrdcvekdg vssvveddla tehraster
//
