LOCUS       NM_001107187            5051 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FAM20B, glycosaminoglycan xylosylkinase (Fam20b),
            mRNA.
ACCESSION   NM_001107187 XM_001068245 XM_222770
VERSION     NM_001107187.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5051)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   2  (bases 1 to 5051)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 5051)
  AUTHORS   Ishikawa,H.O., Xu,A., Ogura,E., Manning,G. and Irvine,K.D.
  TITLE     The Raine syndrome protein FAM20C is a Golgi kinase that
            phosphorylates bio-mineralization proteins
  JOURNAL   PLoS One 7 (8), e42988 (2012)
   PUBMED   22900076
REFERENCE   4  (bases 1 to 5051)
  AUTHORS   Koike,T., Izumikawa,T., Tamura,J. and Kitagawa,H.
  TITLE     FAM20B is a kinase that phosphorylates xylose in the
            glycosaminoglycan-protein linkage region
  JOURNAL   Biochem J 421 (2), 157-162 (2009)
   PUBMED   19473117
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5051)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   6  (bases 1 to 5051)
  AUTHORS   Nalbant,D., Youn,H., Nalbant,S.I., Sharma,S., Cobos,E., Beale,E.G.,
            Du,Y. and Williams,S.C.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001068245.1, XM_222770.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760494,
                              SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..5051
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /note="FAM20B, glycosaminoglycan xylosylkinase"
                     /db_xref="GeneID:304885"
                     /db_xref="RGD:1311162"
     exon            1..79
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     exon            80..583
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1436
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /note="family with sequence similarity 20, member B"
                     /codon_start=1
                     /product="glycosaminoglycan xylosylkinase"
                     /protein_id="NP_001100657.1"
                     /db_xref="GeneID:304885"
                     /db_xref="RGD:1311162"
                     /translation="MKLKQRVVVLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRM
                     MTGLRVELVPKLDHTLQSPWEIAAQWVVPREVYPEETPELGAVMHAMATKKIIKADVG
                     YKGTQLKALLTLEGGQKVVFKPKRYSRDYVVEGEPYAGYDRHNAEVAAFHLDRILGFR
                     RAPLVVGRYVNLRTEVKPVATEQLLSTFLTVGNNTCFYGKCYYCRETEPACADGDMME
                     GSITLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDII
                     DTAVFDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSILAPLYQCCII
                     RVSTWNRLNYLKNGVLKSALKSAMAHDPIAPVLSDPHLDTVDQRLLNVLATIKQCTDQ
                     FGMDTVLVEDRMPLSHL"
     exon            584..670
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     exon            671..780
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     exon            781..952
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1144
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1204
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..5051
                     /gene="Fam20b"
                     /gene_synonym="RGD1311162"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggacatgaa ttagctccct ttgactacca tttcagcctg aagccagaaa cttcagcctt
       61 cagattgatt tcacacctgg aaccgtggag gtgctgcagt gaagaaatgt gtaatcatgg
      121 agtctccttg ctaatcgtcg ccacctgtcc cccgtgataa gccggcaggg accagcaggg
      181 acgtgggtcg aggaggagag gccaccatga agctgaagca gcgggttgtg gtgttagcaa
      241 tcctgctcgt catttttatc ttcaccaaag tgttcctgat agacaattta gacacatcag
      301 ctgccaaccg agaggaccag agggcgtttc accgcatgat gaccggcttg cgggtggagc
      361 tggtgcccaa gctggaccac accctgcagt ctccttggga gattgcagcc cagtgggtgg
      421 tgccccggga agtgtaccct gaagagaccc cagagctggg agcagtcatg catgccatgg
      481 ccactaagaa aatcatcaaa gctgacgtgg gctacaaagg gacacagctg aaagctttac
      541 tgactcttga aggaggacag aaagttgtct tcaagcctaa gcggtacagc agagactatg
      601 tggtagaagg ggagccatac gctggttacg acagacacaa cgcagaggtg gcggccttcc
      661 atttggacag gattctgggt ttccgccgag ctcccttggt cgttggcaga tatgttaacc
      721 tgcgaacaga agttaagcct gtggccacgg agcagctgct cagcaccttc ctcactgtag
      781 gaaacaatac ttgtttctat gggaagtgct actattgccg agaaacagag ccagcatgtg
      841 ctgatggaga catgatggag ggctccatca cactttggct tccagatgtg tggcctctgc
      901 agaagcatcg gcatccctgg ggcaggactt accgagaggg caaattggcc aggtgggaat
      961 atgacgagag ttactgcgac gctgtgaaga aaacatcccc ctatgactca ggcccacgcc
     1021 tcctcgacat cattgacacg gctgtctttg attacttgat tggcaacgct gaccgccatc
     1081 actatgaaag ctttcaagat gacgaaggcg ctagcatgct tattcttctg gataatgcca
     1141 aaagctttgg gaacccctcg ctggatgaga gaagcatcct tgcccctctc tatcagtgtt
     1201 gcatcattcg ggtttcaact tggaatagac tgaattatct aaagaatgga gtactaaagt
     1261 ctgccttaaa atctgccatg gcccatgacc ccatcgcccc tgtgctctcc gatccacact
     1321 tggacactgt ggaccagcgg cttctgaatg tcctggccac catcaagcag tgtaccgacc
     1381 agtttgggat ggatactgtg ctggtggaag acaggatgcc tctctcccac ttgtaactct
     1441 caaacaagtg gaactgattt ttacaaagat agagaaacag cacaatcaat tccaaatggc
     1501 atgtgatggc ctgcaagtgg ccacagcagg tgctggtgat agaagacgtg gccctgggag
     1561 tgctcggtgt tttctgcagt gcaagctaaa ggccacagat cagcagggcg tctgtgcggg
     1621 gtcagctctc aaactcagac agccactctg cccagtcttc gttaccaccc acaccagagg
     1681 actggcaggt tgatatcggc taaggaatgg gttccagagt atgtgtctgg ggctagcctt
     1741 gctctccttt ctcacagcca tggattctct gaaaacactt tgtagtccct gtgtctttaa
     1801 aaaacaaaaa accagaacta gtcagattga aaaacagact gttcctccag agtggcatca
     1861 gacagaatag cagtctgctc cgggaaaccc gtttttaggg tagattggag gatggggaag
     1921 ggcaggaaga tcttggaact ctaggctatt gagtagcatg gatttgacat ctcagggaag
     1981 agaagaggga ggggctcact ctatagaacc aggaagataa ttgacttagt gaaaacagct
     2041 tcctctaggg cttaggttct tagatatgtc caaagcaaac agtcgtcccc ggctatgttc
     2101 acactaacca cagtcatctc tagaggaaat attattacaa cccaagcatg atcctccatg
     2161 gacactaatt taccccatgc ccaccttttg cccaaagttg caaaacaaat tgaaactgtg
     2221 ctctctgccc tccccccaca cacacctttc cccccctttc aatggcattg tttattttga
     2281 ggtaggctat agcctcttat tgtagcctgt gctgatccgg aacttaactg tataacccag
     2341 ctcactttga actggcagca gtgccgtggc ctcagccttc cccatgctag gatgataggt
     2401 gtgaactaca tgcccagctc tctcatgtct gaagtgcgct cacaccctgt gaggtgaatg
     2461 gcttgtaagg catttgatca atggtgctgt tcctaggagg ttagtggcct tgtctgtgcc
     2521 tttcttatga gaaagtgtcc tggtggctgg actaagcttg tgatgtgtgc cctgcaggta
     2581 acagagtgaa agattttaag cctctgagcc ttgaaactga ggagatcaca aagagcctta
     2641 atattttggt tcataccaaa tccaaattta ctttcattcg gagttccgag cccatggtgt
     2701 agtagaattc ttcatctctg agtcagggtc agcgttagtt ctgtgctctg tcatttgata
     2761 ggtaagcagc tgccacatgg ctagggaatg tgtctgggac agtagctgca ctcagactgt
     2821 gttcccttga catcttgtcc agttctgcac ttatgtcacg agaagccttt ccacactggc
     2881 ttgacattta atgccagcca cagagcctgg cttgaggcaa ctcccttttg agtttatccc
     2941 cctacccctt cccgtttctc acattaaaac ctagtggcaa gtaaccactt ttctcttttt
     3001 ttcttttttt ctttttctct tttttctttt tttttctttt tctctttttt ttcttttttt
     3061 tcagagctgg ggaccgaacc cagggccttg tgcttgctag gcaagcactc taccactgag
     3121 ctaaatcccc aagtaaccac ttttaaatgg catgaaatta ggaaaatttg tacatttaat
     3181 gtacactttg aggtaggtta agaaatactg catatttctt tttctaaatt gtggatattg
     3241 aacttaagaa aacaaacatt agcacaaaac actaacatag tgttaacaaa ggagatattg
     3301 agccgggcag tggtggcaca cccctttagt cctagcattc aggaggcaga gacaggcaga
     3361 tctctgagtt caaggccagc ctggtctaca gagttctagg accaaaccca aaaaacaaaa
     3421 ggaggtatta agtttccagg ctgcttgctg tgtacatcaa gaaaattcac agttgaattt
     3481 tgagattagc tggttattag caatttctgc ctggagccag cagggtgggt ggacaacagt
     3541 gcgccctccc cccattgctg atgaagctgc agctcagcgt tccctcgggc acctcagtga
     3601 agaggtgcgc ccagacaagc agcctcactc actcatgttc cttcagagca gttagagaaa
     3661 agtcctctca cacttcattt tcccactcat ggccctagaa ggtgctcagc tccacagtgg
     3721 acagagttag tcagggcggc tcggcagtta gagtataaag ttgtgttcta actgggattg
     3781 gactaagtta ggaaaggtac atttgagtga attttggcgt ggcaggagga ggtcggctgt
     3841 atgcttccag ccccaaattt atagacagaa acaaagttct gtcggggaaa aagagatata
     3901 tattttttaa agtattgtaa ctccagcctc tttttgggtc gtttactgga ttaggactgt
     3961 tacaatcaag gccctggggg atttcggtca gctctaaatt agtttagcca actgaacctc
     4021 tgcatagatg gatgcactca atacaaagcc aagaaatccg aatccattgc tatttcctcc
     4081 cacttcttaa atatatatgt attctgaggt ggaaatgggg gagatttgaa tatagaattt
     4141 ttattctcaa actctactta atctaaggct gcattgtact ttgggagagc tctaagcacc
     4201 tttaaaacag tcgtctctaa tttgctgtag atgtttggta ttttttaagg tttgtctccc
     4261 tgtttgcact cagggttaaa gtgtcagact aaacttttag aagaaaatag agaaattcag
     4321 gacctcatta cagattattc agcaaagtgg accctgatgc tttctcgatt tccccagtgc
     4381 tggagacagc atctccatcc aaagaaacac attttcttta aaactctcac actgtcttct
     4441 cccccctgct tcctgttcct tcagcctccc tccccttccc tccctgatac ctctgattat
     4501 cttgtgatca cctgctgtcg tcacactctc ctgagccctg agagcagggt tttgggatag
     4561 gaggtggagg tttgggttaa tatggccgtg tatgcattct accaaggaaa atgttcttac
     4621 gttgacacaa ggaagtactg actcactggc actgagaaag gactcggcta cttagggttg
     4681 gcatgcacac ccagcctttc ctgggcagcc tgctaagcca ggtgactgtg tgctctgtgg
     4741 ggggctggct cttctcccct tatttctcta gtctgggtgg tgagtggggg ctgtcactct
     4801 actgtcacgg tttttaggac ctaaggtgat cctcataaac tcttggggga agctgggagt
     4861 aacttactgg gaagctaatt tatttgtctg aagggtggtg gagggatcac tgccctttga
     4921 tctgcctatg gtttcctctt ggagctgttg tgcagatagg ggttgtactt ggtaagacac
     4981 caaacagatt tctaatgtgt tctatgggtt tcagttctga aaaaaaaata aaagatttta
     5041 atatattatt g
//
