LOCUS       NM_001012237            2454 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus FAM20A, golgi associated secretory pathway
            pseudokinase (Fam20a), mRNA.
ACCESSION   NM_001012237 XM_221067
VERSION     NM_001012237.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2454)
  AUTHORS   Cui,J., Xiao,J., Tagliabracci,V.S., Wen,J., Rahdar,M. and
            Dixon,J.E.
  TITLE     A secretory kinase complex regulates extracellular protein
            phosphorylation
  JOURNAL   Elife 4, e06120 (2015)
   PUBMED   25789606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2454)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 2454)
  AUTHORS   Cabral,R.M., Kurban,M., Rothman,L., Wajid,M., Shimomura,Y.,
            Petukhova,L. and Christiano,A.M.
  TITLE     Autosomal recessive gingival hyperplasia and dental anomalies
            caused by a 29-base pair duplication in the FAM20A gene
  JOURNAL   J Hum Genet 58 (8), 566-567 (2013)
   PUBMED   23697977
REFERENCE   4  (bases 1 to 2454)
  AUTHORS   Wang,S.K., Aref,P., Hu,Y., Milkovich,R.N., Simmer,J.P.,
            El-Khateeb,M., Daggag,H., Baqain,Z.H. and Hu,J.C.
  TITLE     FAM20A mutations can cause enamel-renal syndrome (ERS)
  JOURNAL   PLoS Genet 9 (2), e1003302 (2013)
   PUBMED   23468644
REFERENCE   5  (bases 1 to 2454)
  AUTHORS   Tagliabracci,V.S., Engel,J.L., Wen,J., Wiley,S.E., Worby,C.A.,
            Kinch,L.N., Xiao,J., Grishin,N.V. and Dixon,J.E.
  TITLE     Secreted kinase phosphorylates extracellular proteins that regulate
            biomineralization
  JOURNAL   Science 336 (6085), 1150-1153 (2012)
   PUBMED   22582013
REFERENCE   6  (bases 1 to 2454)
  AUTHORS   Cho,S.H., Seymen,F., Lee,K.E., Lee,S.K., Kweon,Y.S., Kim,K.J.,
            Jung,S.E., Song,S.J., Yildirim,M., Bayram,M., Tuna,E.B., Gencay,K.
            and Kim,J.W.
  TITLE     Novel FAM20A mutations in hypoplastic amelogenesis imperfecta
  JOURNAL   Hum Mutat 33 (1), 91-94 (2012)
   PUBMED   21990045
REFERENCE   7  (bases 1 to 2454)
  AUTHORS   Jaureguiberry,G., De la Dure-Molla,M., Parry,D., Quentric,M.,
            Himmerkus,N., Koike,T., Poulter,J., Klootwijk,E., Robinette,S.L.,
            Howie,A.J., Patel,V., Figueres,M.L., Stanescu,H.C., Issler,N.,
            Nicholson,J.K., Bockenhauer,D., Laing,C., Walsh,S.B.,
            McCredie,D.A., Povey,S., Asselin,A., Picard,A., Coulomb,A.,
            Medlar,A.J., Bailleul-Forestier,I., Verloes,A., Le Caignec,C.,
            Roussey,G., Guiol,J., Isidor,B., Logan,C., Shore,R., Johnson,C.,
            Inglehearn,C., Al-Bahlani,S., Schmittbuhl,M., Clauss,F.,
            Huckert,M., Laugel,V., Ginglinger,E., Pajarola,S., Sparta,G.,
            Bartholdi,D., Rauch,A., Addor,M.C., Yamaguti,P.M., Safatle,H.P.,
            Acevedo,A.C., Martelli-Junior,H., dos Santos Netos,P.E.,
            Coletta,R.D., Gruessel,S., Sandmann,C., Ruehmann,D., Langman,C.B.,
            Scheinman,S.J., Ozdemir-Ozenen,D., Hart,T.C., Hart,P.S.,
            Neugebauer,U., Schlatter,E., Houillier,P., Gahl,W.A., Vikkula,M.,
            Bloch-Zupan,A., Bleich,M., Kitagawa,H., Unwin,R.J., Mighell,A.,
            Berdal,A. and Kleta,R.
  TITLE     Nephrocalcinosis (enamel renal syndrome) caused by autosomal
            recessive FAM20A mutations
  JOURNAL   Nephron Physiol 122 (1-2), 1-6 (2012)
   PUBMED   23434854
REFERENCE   8  (bases 1 to 2454)
  AUTHORS   O'Sullivan,J., Bitu,C.C., Daly,S.B., Urquhart,J.E., Barron,M.J.,
            Bhaskar,S.S., Martelli-Junior,H., dos Santos Neto,P.E.,
            Mansilla,M.A., Murray,J.C., Coletta,R.D., Black,G.C. and Dixon,M.J.
  TITLE     Whole-Exome sequencing identifies FAM20A mutations as a cause of
            amelogenesis imperfecta and gingival hyperplasia syndrome
  JOURNAL   Am J Hum Genet 88 (5), 616-620 (2011)
   PUBMED   21549343
REFERENCE   9  (bases 1 to 2454)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   10 (bases 1 to 2454)
  AUTHORS   Nalbant,D., Youn,H., Nalbant,S.I., Sharma,S., Cobos,E., Beale,E.G.,
            Du,Y. and Williams,S.C.
  TITLE     FAM20: an evolutionarily conserved family of secreted proteins
            expressed in hematopoietic cells
  JOURNAL   BMC Genomics 6, 11 (2005)
   PUBMED   15676076
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 29, 2022 this sequence version replaced NM_001012237.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001521.1, SRR26643292.44093.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-969               JAXUCZ010000010.1  95196085-95197053   c
            970-1154            JAXUCZ010000010.1  95155466-95155650   c
            1155-1205           JAXUCZ010000010.1  95154811-95154861   c
            1206-1284           JAXUCZ010000010.1  95152702-95152780   c
            1285-1377           JAXUCZ010000010.1  95148199-95148291   c
            1378-1493           JAXUCZ010000010.1  95147365-95147480   c
            1494-1674           JAXUCZ010000010.1  95146757-95146937   c
            1675-1784           JAXUCZ010000010.1  95145205-95145314   c
            1785-1866           JAXUCZ010000010.1  95144476-95144557   c
            1867-1926           JAXUCZ010000010.1  95144010-95144069   c
            1927-2454           JAXUCZ010000010.1  95142458-95142985   c
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2454
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /note="FAM20A, golgi associated secretory pathway
                     pseudokinase"
                     /db_xref="GeneID:303635"
                     /db_xref="RGD:1306364"
     exon            1..969
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     CDS             566..2191
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /note="protein FAM20A; family with sequence similarity 20,
                     member A"
                     /codon_start=1
                     /product="pseudokinase FAM20A"
                     /protein_id="NP_001012237.1"
                     /db_xref="GeneID:303635"
                     /db_xref="RGD:1306364"
                     /translation="MPGLRRDRLLALLLLGALFSADLYFHLWPQVQRQLGPGERPAGC
                     PCSGRAPSTSLHSAAASRDPGTASHNFSGALPRVEHPSRGHPAPRSKLKALFAHSLYQ
                     VLEDPPLLGPEDWLLASQEALRYYRRKVARWNRRHRIYKEQFNLTSLDPPVQFRPEAS
                     WVQFHLGINSHGLYSRSSPVVSKLLHDMRHFPTISADHSQDEKALLGACDCSQIVKPS
                     GVHLKLVLRFSDFGKAMFKPMRQQREEETPEDFFYFIDFQRHNAEIAAFHLDRILDFR
                     RVPPTVGRLLNVTKEILEVTKNEILQSVFFVSPANNVCFFAKCPYMCKTEYAVCGNPH
                     LLEGSLSAFLPSLNLAPRLSVPNPWIRSYSLSGKEEWELNPLYCDTVKQIYPYNSSNR
                     LLGIIDMAVFDFLIGNMDRHHYEMFTKFGDDGYLIHLDNARGFGRHSQDELSILAPLS
                     QCCMIKRKTLLHLQLLAQAEYRLSDVMRESLLEDQLTPVLTEPHLLALDRRLQIILKT
                     VEDCIEAHGERRVIADGSAQHSAPDSGQANLTS"
     exon            970..1154
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1205
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1284
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1377
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1493
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1674
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1784
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1866
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1926
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2454
                     /gene="Fam20a"
                     /gene_synonym="RGD1306364"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctgcctc taggagtcta ggcgcaaaga caagctcgcc ccgaggcgcc cctgcttcaa
       61 ttctccattc cctccgctcc tggcagcctg gggcacggga gtccctgccg cctgcaggag
      121 gagccgctag agctgtctca gcagctgcgg agcgacagca tccttggaag agacgcccca
      181 ggctacgcag actctccagt cttttcctag gggggcgaga gctccctttc gctccctcca
      241 gtgatcgccc ctacccggtc accagagcca gccagcactc gtgtcccggg gacctttcca
      301 cctgagcggc ccctgaagga gggggtcaca gggcaaagag actcaaataa caaccgggta
      361 gccagggaac cccaaccccg cgtctctact gggcgagaaa gacgacgctg tcaacactgt
      421 gagcttcctg cacgcggtcc ccaagttcag gggagacacc cttccaggag gagctaatcc
      481 cctgtgtgag cattccagcc ccatccggac tccaggagct tcttccgtct gcaccctaag
      541 tgttttccgg gtctctgctt gggccatgcc cggactgcgc agggaccgcc tgctggccct
      601 gctgctcctg ggcgcgctct tctctgccga cctctacttc cacctctggc cgcaagtgca
      661 gcgccagctc gggccgggag agcgccccgc tggctgcccg tgctccggcc gcgccccctc
      721 cacgtcccta cactcagccg cagcctcccg ggaccctggc accgcctcgc acaacttttc
      781 aggagccttg ccccgggttg agcatcccag ccgcggccac cctgccccgc gctctaagct
      841 gaaggccctc ttcgcccact cgctctacca agtcctggag gatccgcctc tcctgggacc
      901 cgaagactgg ctcctggcca gccaggaggc gctgcggtat taccggagga aggtggcccg
      961 ctggaacaga cggcacagga tatacaaaga acaattcaac ctcacctcct tggatccccc
     1021 agtgcagttt cgaccagagg ccagctgggt ccagttccac ttggggatca acagccacgg
     1081 gctgtactcc aggtccagcc ctgtcgtcag caagctcctc catgacatga ggcacttccc
     1141 caccatcagc gctgatcaca gccaggatga aaaagccttg ctgggggcct gtgactgctc
     1201 ccagattgtg aaacccagtg gggtccacct gaaactggtt ctgaggttct cagacttcgg
     1261 gaaagccatg ttcaaaccca tgagacagca gcgagaggag gagacacccg aggacttctt
     1321 ctacttcata gactttcaga gacacaacgc tgagatcgca gctttccacc tggacaggat
     1381 tctggacttc cgacgggtgc cacccaccgt agggagacta ttgaatgtca ccaaggaaat
     1441 cctggaggtc accaagaatg aaatcctgca gagcgttttc tttgtgtctc cagctaacaa
     1501 cgtgtgcttc ttcgccaagt gtccgtacat gtgcaagacg gagtatgctg tctgcggcaa
     1561 cccacacctg ctggaaggtt ccctctccgc cttcctgcca tccctcaacc tggcccccag
     1621 actgtctgtg cccaacccct ggatccgttc ctactcactg tcaggaaaag aggagtggga
     1681 gctcaacccc ctctactgtg acacggtaaa gcagatctac ccatataaca gcagcaacag
     1741 gcttctcggc atcatcgaca tggccgtctt tgacttcctg attggaaaca tggaccgaca
     1801 ccattatgag atgttcacca agtttgggga tgatgggtac cttattcatc ttgacaatgc
     1861 cagagggttc ggacggcatt cccaggacga actctctatc ctcgcccctc tctcgcagtg
     1921 ctgcatgata aaaaggaaaa cactcttgca ccttcagctg ctggctcaag ctgagtacag
     1981 gctcagcgat gtgatgcggg agtcactact ggaagatcag ctcacccctg tcctcacgga
     2041 accccacctc ctggccctgg accgcagact ccagatcatc cttaagacag tggaggactg
     2101 catagaggcc cacggagagc gaagagtcat agctgatggg tcagcacaac attcagctcc
     2161 agactctggc caggctaatc tgacaagcta acggcagcaa gcgtggggcc tcagaacaca
     2221 actggagcca gcacttcact tcgtgctgat ttgtaggccc ctgctgcccc attccaccct
     2281 ggggtgctgg aggccgagtc acaagctcag ggaggaggca ggaacacttt gaaaaagcac
     2341 acgggatcca ccaaacctca tctttaccct tgggtggagg ccactgcttt tacagtgcac
     2401 tggctggggc tctctcttgg ctccatgagg gctgcagact atcttctaag caca
//
