LOCUS       NM_001106401            3907 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ARB2 cotranscriptional regulator A (Arb2a), mRNA.
ACCESSION   NM_001106401 XM_215438
VERSION     NM_001106401.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3907)
  AUTHORS   Belanger,C., Berube-Simard,F.A., Leduc,E., Bernas,G., Campeau,P.M.,
            Lalani,S.R., Martin,D.M., Bielas,S., Moccia,A., Srivastava,A.,
            Silversides,D.W. and Pilon,N.
  TITLE     Dysregulation of cotranscriptional alternative splicing underlies
            CHARGE syndrome
  JOURNAL   Proc Natl Acad Sci U S A 115 (4), E620-E629 (2018)
   PUBMED   29311329
REFERENCE   2  (bases 1 to 3907)
  AUTHORS   Andersen,B., Pearse,R.V. 2nd, Schlegel,P.N., Cichon,Z.,
            Schonemann,M.D., Bardin,C.W. and Rosenfeld,M.G.
  TITLE     Sperm 1: a POU-domain gene transiently expressed immediately before
            meiosis I in the male germ cell
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11084-11088 (1993)
   PUBMED   7902581
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On Oct 4, 2007 this sequence version replaced XM_215438.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132279,
                              SAMD00132291 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3907
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q11"
     gene            1..3907
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /note="ARB2 cotranscriptional regulator A"
                     /db_xref="GeneID:294606"
                     /db_xref="RGD:1305526"
     exon            1..161
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            162..263
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1306
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /note="cotranscriptional regulator FAM172A; family with
                     sequence similarity 172, member A"
                     /codon_start=1
                     /product="cotranscriptional regulator ARB2A"
                     /protein_id="NP_001099871.1"
                     /db_xref="GeneID:294606"
                     /db_xref="RGD:1305526"
                     /translation="MKKDEPPFDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDL
                     HRWNQKRYEALGEIITRYVYELLESDCNLKKISIPVDATESEPKSFIFMSEDALTNPQ
                     KLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAVDEGYGVIVLNPNENYIEV
                     EKQKMHKQSSSDGTDEPAGKRERKDKVSKETKKRRDFYEKYRNPQKEKEMMQLFIREN
                     GSPEEHAVYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKSKVTAVALTDS
                     VHNVWHQEAGKSIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWK
                     SFPSIFKFFAEASEAKSSSQKPTLTRRSHRIKHEEL"
     exon            264..364
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            365..430
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            431..622
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            623..841
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            842..961
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1078
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1163
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..3907
                     /gene="Arb2a"
                     /gene_synonym="Fam172a; RGD1305526"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagtcccctg cagaccccgg aagtgcaact cgaacttggt tggggcgcgg atctcgagag
       61 aaaaagtcgg agccgggcgc gagggagttc gcccagagag ctggaaggcc acgcctcctc
      121 gtgcctaccc actcagcctt gcaactgggg acagagctca gatttgctgt ctaggatcga
      181 tttgaatgaa ctcatgaaaa aggacgaacc accttttgat tttccagata cactggaagg
      241 ctttgaatat gcttttaatg aaaaggggca gttaagacac ataaaaactg gagaaccatt
      301 tgtttttaac taccgagaag acttacacag gtggaaccag aaaagatatg aagctctggg
      361 tgagatcatc acaagatatg tttatgagct cctggaaagt gactgtaact tgaaaaaaat
      421 ctctattcca gtagatgcca ctgaaagtga accaaagagt tttatcttta tgagtgagga
      481 tgctttgaca aatccacaga aactgatggt tttaattcat ggtagtggtg ttgtcagggc
      541 aggtcagtgg gctagaaggc ttattattaa tgaagatctg gacagtggca cacagatacc
      601 ttttattaag agagctgtgg atgaaggtta tggagtcata gtcctcaacc caaatgaaaa
      661 ctatatagaa gtggaaaagc agaaaatgca taaacaatca tcttctgatg gcacagatga
      721 gccagcaggg aagcgggaaa ggaaagataa ggtctccaag gaaacaaaga agcgccgcga
      781 tttctacgag aagtaccgta acccccaaaa ggagaaagaa atgatgcagt tgtttatcag
      841 ggaaaatggt tctccagaag aacatgcagt ctatgtgtgg gaccatttca tagcccaggc
      901 tgctgctgag aatgtattct ttgttgctca tagctatgga ggacttgctt ttgttgaact
      961 gatgatccaa cgagaagcag atgtaaaaag taaggtgact gctgtggcat tgacagactc
     1021 tgttcacaat gtgtggcatc aagaagctgg caaaagcatc cgagaatgga tgagagagaa
     1081 ctgttgcaac tgggtctcca gctcagaacc cttagataca tcagtggagt ccatgctgcc
     1141 tgactgtccc agagtgtctg caggcaccga ccgtcacgag ctcacttcgt ggaagagctt
     1201 cccgtccatc ttcaagttct tcgcggaagc ctcagaagcc aagagcagct cgcagaagcc
     1261 gaccctgacg cggcgctcgc accggatcaa gcacgaggag ctgtgagcgc gcagccgccc
     1321 gccgcgcccg cacgctgccc gcagcctccc ggcccccatt agattgcttt cttcctccag
     1381 cgcagggtcg tgatgtgtcc gtctaaatag cgttttgcat tatttctaga tgagtgcaac
     1441 tgtcaaagca atatggcttc ggtggccgcg ctgccagtgc cagagcgggc ctcgcgctgc
     1501 agggcccggg gccgacccag gcagacgacc gaggcagaca gcgccgggtg cgccagggcc
     1561 tggcgctcct attgccaggc tgatccgcgg ggcgcggctg gccgagcggc gtctgcgcgg
     1621 tcctatcgcc cgctgcagcg cggccgctgt tgcccagcct caatcgtgcc catttttatt
     1681 cccctttaaa ccgagcaagc ttttttattc taaacctcaa acttcgattt ttaaccgggt
     1741 ttttccctcg ggtcatctta tgagcccctg tcttttatac aaagccacaa acccaggcac
     1801 tagaaatgcc aactttaaat tcaaaacatg atggactgtg tagtttggag agtacaattg
     1861 ttctctcgtt gtaacgactt attttcactt caagacccaa agaaaaactt tgcataaagt
     1921 accaaatccg aatcctcttt tctgcacagt tgaattccag tctttatatc tctgatttca
     1981 ggagagaatg tccaaatgag aaacataaat agatctttta gatgtaagta taagccccca
     2041 ttttcagtga atttccaagt tacttataag agctgacctt actattaaaa tatataacgt
     2101 gatgaatgac cttgtaattt agatgataca cttaaggtta tgtgctccgg ggcagagccg
     2161 gggtggtagg ttgtgatcct tactaactgt actctaacct ttcttatagt gtgtcctttc
     2221 agaaaatgac actgcatacc tcttccttcc aaaaggccaa ggagggttaa aatggttatt
     2281 tccctctaca gtaggaaaag agaagcctag tgtgaatgag tttctcttgt ccaaaatgtt
     2341 tagtgttctc ttcctgtgat agggttctgc cctgtaattc caacagttag gtcctttaac
     2401 ccaacactgt taacaactgg ccaacactgt gaagtacaaa ggataaaatg tgttgacatt
     2461 ttactggctt tcaaataaaa atatgaagta ttgaattttt taattagtga agattatatc
     2521 aggtggatga gattgtgatt taatacatcc atccttttta aaatgaattc aacaagtaat
     2581 gtgtctgcct tgtttgagac catgagacag tataatcaaa atgagtctga gttactaaca
     2641 ccagggaagg aaatctgagc tcagggggaa tattgtcata tgaactgatt ttagcaggtt
     2701 tcaaactggt aacatctcat tctgtttacg aatacataca ttcagtagtt ctgtagtgac
     2761 agtaaagtcc tcagtgacca tggctgggca tcttctgata ttccttaggc agaaacacct
     2821 taggaaaaat caaaacagca ttttatacag cttcttccaa aaatgtcaag cacattgtac
     2881 tggcatagtg accctttgca tttctgattt tagaaggatt gatgaactct gaaaataatg
     2941 atgtcttccc agtgactggg cttaaaaaat tggtgtgtgt tgagtatatc ttaccaaatg
     3001 ttataaactg tctgctgttc tcagcatgtg aaaattttct taagaaactg attttgcaac
     3061 attaaagggg ggaaacctat gcagtttaaa tttgctaaac ttctgcagat aaactaaagc
     3121 caagtaacta tgctcggctc atggaccaaa tagacatctc ctgtttctcc cttccaggtt
     3181 cctctgtgca gctctgaaat cttgtttaga aaaagtctct gtttccttgg gatgagaact
     3241 ttataatcac tgaattgttc gcttggcatc tgtctagtaa agagctattt acaagattac
     3301 attttgtaaa tgtctgttac tacttgtgtg tccctgctat agcaacccag aaggagccag
     3361 gcacagcatc ccagatcacc agctgatgag tgacaagtga ttccttacaa tgtaggattt
     3421 cttgacctgt tgagtgggtt gctgttggta tatctgtact gatgttattc actcggcttt
     3481 ctttggataa caacaatcag ttggcagtac cctgcctgca tggaggccag agctgttctg
     3541 gtctcttcct atttttattt tcttaaagag attttaggca cctagtggta gaaaggtagg
     3601 gtgtgagttt tttttttttt tctttaactt cttatacttc gttcttaaag taaatagatg
     3661 gagaaagaca taaattggaa attcaaaaga gtctgattca gcgaggcagt tgctttggag
     3721 ctttttaggg tacataacac acagtccttt ggatgtttgc tagacgtcga cttgtaataa
     3781 ttgtcctttt ctcacattac tgccttgtgc tttctgaaac gcatttttgt ttgtttatac
     3841 atcaaaaata ataaagtgcg gagcctcctg taatcttgct taccatttta aaataaaaat
     3901 ttccaac
//
