LOCUS       NM_001013876            1932 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FAM161 centrosomal protein A (Fam161a), mRNA.
ACCESSION   NM_001013876 XM_214102
VERSION     NM_001013876.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Karlstetter,M., Sorusch,N., Caramoy,A., Dannhausen,K.,
            Aslanidis,A., Fauser,S., Boesl,M.R., Nagel-Wolfrum,K., Tamm,E.R.,
            Jagle,H., Stoehr,H., Wolfrum,U. and Langmann,T.
  TITLE     Disruption of the retinitis pigmentosa 28 gene Fam161a in mice
            affects photoreceptor ciliary structure and leads to progressive
            retinal degeneration
  JOURNAL   Hum Mol Genet 23 (19), 5197-5210 (2014)
   PUBMED   24833722
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Di Gioia,S.A., Letteboer,S.J., Kostic,C., Bandah-Rozenfeld,D.,
            Hetterschijt,L., Sharon,D., Arsenijevic,Y., Roepman,R. and
            Rivolta,C.
  TITLE     FAM161A, associated with retinitis pigmentosa, is a component of
            the cilia-basal body complex and interacts with proteins involved
            in ciliopathies
  JOURNAL   Hum Mol Genet 21 (23), 5174-5184 (2012)
   PUBMED   22940612
  REMARK    GeneRIF: FAM161A-associated RP can be considered as a novel retinal
            ciliopathy and that its molecular pathogenesis may be related to
            other ciliopathies.
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Zach,F., Grassmann,F., Langmann,T., Sorusch,N., Wolfrum,U. and
            Stohr,H.
  TITLE     The retinitis pigmentosa 28 protein FAM161A is a novel ciliary
            protein involved in intermolecular protein interaction and
            microtubule association
  JOURNAL   Hum Mol Genet 21 (21), 4573-4586 (2012)
   PUBMED   22791751
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV115343.1, BC079233.1 and CR470815.1.
            
            On Jan 26, 2011 this sequence version replaced NM_001013876.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132290, SAMD00155305
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               CV115343.1         1-645
            646-1635            BC079233.1         540-1529
            1636-1803           CR470815.1         111-278             c
            1804-1932           BC079233.1         1696-1824
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..1932
                     /gene="Fam161a"
                     /gene_synonym="RGD1304999"
                     /note="FAM161 centrosomal protein A"
                     /db_xref="GeneID:289833"
                     /db_xref="RGD:1304999"
     exon            1..257
                     /gene="Fam161a"
                     /gene_synonym="RGD1304999"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..1727
                     /gene="Fam161a"
                     /gene_synonym="RGD1304999"
                     /note="family with sequence similarity 161, member A;
                     FAM161A, centrosomal protein"
                     /codon_start=1
                     /product="protein FAM161A"
                     /protein_id="NP_001013898.2"
                     /db_xref="GeneID:289833"
                     /db_xref="RGD:1304999"
                     /translation="MWQIRASAGCHSSPGKDKEVTLENTMNFSDIYHSDEEYFRKLKD
                     LRAAHAEAMVKLEKMYQDKLTMKDIQAALVGDDSSSSASEKSCSHPALSATSLSEPDL
                     DRSSSLSTTTDELPDLEKKTPGEIGTRSYAKELINNMWNDFSVEDYTQYDSDLQTAKK
                     NRKKPKAWTPRITVPVPFEMTVREQKRREKASDAQETREKMLKRNEDDAECKKKFRAN
                     PVPSRLLLPLYEDLVKQNEERRKKTRERSKAALLASQKPFKFIAREEQKQAIREKKLR
                     ELCRAKKKPKQFKARPVPRFIYRPPANVKPKREELYGDSRTQPKARDVLQSSPWPSHS
                     TYRAFRDPRSPAMPRGKHRHRRLSPSDQGLEKWKEPFSEQSFRNCPVLCDQCCLYESL
                     CDSNKRQKILADIRMGEEILKETRRPNPSPRHKSPRRSAHASARPCEYSPPMPTASSR
                     GREQAIRRSEKARMKEYWQELEEQDKKLQKRPMLFERVSQVVFIGI"
     exon            258..475
                     /gene="Fam161a"
                     /gene_synonym="RGD1304999"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1606
                     /gene="Fam161a"
                     /gene_synonym="RGD1304999"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1909
                     /gene="Fam161a"
                     /gene_synonym="RGD1304999"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgagcgag gcggcggcgc cagctcaccc gccccgggcc ggcgcgggcg ctcgggctcg
       61 gaggcggggc ggtggcttcg ccgcactagg ctatcagact ggctgctgcc aacctccacc
      121 tgcccgcaaa tcccatcaca ggagcaaggg cctcccagta cgaacgcgaa gaccccttat
      181 agttcttggt agcagcggcg ttggcggcgg ccgtggaaga gaaacagaag aaaaggatgt
      241 ggcagatacg ggcgtcggca ggctgtcaca gctctcctgg gaaggacaaa gaggtgacat
      301 tggagaacac tatgaacttc tctgatattt accactctga tgaagagtac ttcaggaaac
      361 tcaaagacct gagggctgcc catgcagagg ccatggtaaa attagagaaa atgtaccagg
      421 acaagctaac tatgaaggac atccaggcag cgctcgttgg ggatgattct tctagttctg
      481 catcggaaaa gagctgctca catcctgcct tgtcggcgac ctcgctttca gagcctgacc
      541 tagaccggtc gtcctccttg tccacaacta ctgatgagtt gcccgaccta gagaaaaaga
      601 ctcctgggga aatcggaaca aggtcctatg ccaaggagct cataaacaac atgtggaacg
      661 acttttctgt tgaagattat actcagtatg actctgacct ccaaacagcc aagaaaaaca
      721 ggaagaaacc taaagcctgg acgcccagga ttacagtgcc ggtgcccttt gaaatgacgg
      781 taagagagca gaagcggaga gagaaggcct cggatgctca ggaaaccagg gagaagatgc
      841 tcaagaggaa tgaggacgat gcagagtgta agaagaaatt ccgagccaat ccagttcctt
      901 cccgcctgct ccttcccctt tatgaggatc tagtcaagca gaacgaggag cgtcggaaga
      961 agacccggga gaggagcaaa gccgcactcc tggcctccca gaagcccttt aagttcattg
     1021 cgagggagga acagaagcaa gcaatccgtg agaagaagct gagagaactt tgtagggcta
     1081 agaagaaacc gaagcagttt aaagccaggc ctgtgcctcg ttttatttac agaccacctg
     1141 cgaatgtcaa gccaaagagg gaagagctct atggggacag caggacacag ccaaaggcca
     1201 gagatgtgct gcagagttcg ccttggccca gtcactccac ttacagagct ttcagggacc
     1261 ccagaagtcc tgcaatgcca aggggtaaac acaggcatag gcgcctgagc cccagtgacc
     1321 aaggcttgga gaaatggaag gaacccttct ctgaacagag ctttcggaac tgcccggtgc
     1381 tttgtgacca gtgttgtctt tacgaatcct tatgtgactc caataaaaga cagaaaatct
     1441 tggcagacat ccgaatgggt gaggaaattt tgaaagaaac acgcaggcct aatccttctc
     1501 ctaggcataa atcccccaga agaagcgcgc acgccagcgc caggccttgt gaatacagcc
     1561 ctccgatgcc caccgcgtct tcccgagggc gcgagcaagc catcagaagg agcgaaaagg
     1621 ccaggatgaa agaatattgg caagaattgg aggagcaaga taaaaaattg caaaagaggc
     1681 cgatgctgtt tgaaagagtc tcccaggttg tgtttattgg aatttagggc cgttaccagc
     1741 gtcctgtttc aggacctctg gcctccatgt gtgtactcca tctcgttgtg tcctacagtt
     1801 gccaagacat gccgtttctg gggcagcttc atccagtcca ccaaggaagt gattttgctt
     1861 aagatctgat gaggctcgca gctcaataaa gaacacgtcg ccaaccctaa aaaaaaaaaa
     1921 aaaaaaaaaa aa
//
