LOCUS       NM_144756               1530 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus Fas apoptotic inhibitory molecule 2 (Faim2),
            mRNA.
ACCESSION   NM_144756
VERSION     NM_144756.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1530)
  AUTHORS   Shen,W., Liu,J., Fan,M., Wang,S., Zhang,Y., Wen,L., Wang,R.,
            Wei,W., Li,N., Zhang,Y. and Zhao,G.
  TITLE     MiR-3202 protects smokers from chronic obstructive pulmonary
            disease through inhibiting FAIM2: An in vivo and in vitro study
  JOURNAL   Exp Cell Res 362 (2), 370-377 (2018)
   PUBMED   29208459
REFERENCE   2  (bases 1 to 1530)
  AUTHORS   Urresti,J., Ruiz-Meana,M., Coccia,E., Arevalo,J.C., Castellano,J.,
            Fernandez-Sanz,C., Galenkamp,K.M., Planells-Ferrer,L.,
            Moubarak,R.S., Llecha-Cano,N., Reix,S., Garcia-Dorado,D.,
            Barneda-Zahonero,B. and Comella,J.X.
  TITLE     Lifeguard Inhibits Fas Ligand-mediated Endoplasmic
            Reticulum-Calcium Release Mandatory for Apoptosis in Type II
            Apoptotic Cells
  JOURNAL   J Biol Chem 291 (3), 1221-1234 (2016)
   PUBMED   26582200
REFERENCE   3  (bases 1 to 1530)
  AUTHORS   Merianda,T.T., Vuppalanchi,D., Yoo,S., Blesch,A. and Twiss,J.L.
  TITLE     Axonal transport of neural membrane protein 35 mRNA increases axon
            growth
  JOURNAL   J Cell Sci 126 (Pt 1), 90-102 (2013)
   PUBMED   23097042
  REMARK    GeneRIF: Data show that NMP35 supports axonal growth, and
            overexpression of an axonally targeted NMP35 mRNA is sufficient to
            increase axonal outgrowth.
REFERENCE   4  (bases 1 to 1530)
  AUTHORS   Boender,A.J., van Rozen,A.J. and Adan,R.A.
  TITLE     Nutritional state affects the expression of the obesity-associated
            genes Etv5, Faim2, Fto, and Negr1
  JOURNAL   Obesity (Silver Spring) 20 (12), 2420-2425 (2012)
   PUBMED   22627920
  REMARK    GeneRIF: expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is
            affected by nutritional state in these two areas, and the
            relationship between nutritional state and expression levels of
            obesity-associated genes in two brain areas relevant to feeding.
REFERENCE   5  (bases 1 to 1530)
  AUTHORS   Hurtado de Mendoza,T., Perez-Garcia,C.G., Kroll,T.T., Hoong,N.H.,
            O'Leary,D.D. and Verma,I.M.
  TITLE     Antiapoptotic protein Lifeguard is required for survival and
            maintenance of Purkinje and granular cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (41), 17189-17194 (2011)
   PUBMED   21957071
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11906]
REFERENCE   6  (bases 1 to 1530)
  AUTHORS   Reich,A., Spering,C., Gertz,K., Harms,C., Gerhardt,E.,
            Kronenberg,G., Nave,K.A., Schwab,M., Tauber,S.C., Drinkut,A.,
            Harms,K., Beier,C.P., Voigt,A., Gobbels,S., Endres,M. and
            Schulz,J.B.
  TITLE     Fas/CD95 regulatory protein Faim2 is neuroprotective after
            transient brain ischemia
  JOURNAL   J Neurosci 31 (1), 225-233 (2011)
   PUBMED   21209208
REFERENCE   7  (bases 1 to 1530)
  AUTHORS   Fernandez,M., Segura,M.F., Sole,C., Colino,A., Comella,J.X. and
            Cena,V.
  TITLE     Lifeguard/neuronal membrane protein 35 regulates Fas
            ligand-mediated apoptosis in neurons via microdomain recruitment
  JOURNAL   J Neurochem 103 (1), 190-203 (2007)
   PUBMED   17635665
REFERENCE   8  (bases 1 to 1530)
  AUTHORS   Beier,C.P., Wischhusen,J., Gleichmann,M., Gerhardt,E.,
            Pekanovic,A., Krueger,A., Taylor,V., Suter,U., Krammer,P.H.,
            Endres,M., Weller,M. and Schulz,J.B.
  TITLE     FasL (CD95L/APO-1L) resistance of neurons mediated by
            phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent
            expression of lifeguard/neuronal membrane protein 35
  JOURNAL   J Neurosci 25 (29), 6765-6774 (2005)
   PUBMED   16033886
  REMARK    GeneRIF: LFG mediated the FasL resistance of cerebellar granular
            cells to apoptosis
REFERENCE   9  (bases 1 to 1530)
  AUTHORS   Schweitzer,B., Suter,U. and Taylor,V.
  TITLE     Neural membrane protein 35/Lifeguard is localized at postsynaptic
            sites and in dendrites
  JOURNAL   Brain Res Mol Brain Res 107 (1), 47-56 (2002)
   PUBMED   12414123
  REMARK    GeneRIF: NMP35 protein occurs throughout the brain and spinal cord,
            especially in dendrites of several neuronal cell types and in the
            surrounding neuropil. NMP35 co-localizes with the glutamate
            receptor GluR2 and the presynaptic vesicle protein synaptophysin.
REFERENCE   10 (bases 1 to 1530)
  AUTHORS   Schweitzer,B., Taylor,V., Welcher,A.A., McClelland,M. and Suter,U.
  TITLE     Neural membrane protein 35 (NMP35): a novel member of a gene family
            which is highly expressed in the adult nervous system
  JOURNAL   Mol Cell Neurosci 11 (5-6), 260-273 (1998)
   PUBMED   9698393
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087606.1.
            
            On Dec 26, 2004 this sequence version replaced NM_144756.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087606.1, AF044201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132292,
                                           SAMD00132295 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1530
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /note="Fas apoptotic inhibitory molecule 2"
                     /db_xref="GeneID:246274"
                     /db_xref="RGD:628744"
     exon            1..89
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1025
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /note="lifeguard; neural membrane protein 35; protein
                     lifeguard 2-like"
                     /codon_start=1
                     /product="protein lifeguard 2"
                     /protein_id="NP_653357.1"
                     /db_xref="GeneID:246274"
                     /db_xref="RGD:628744"
                     /translation="MTQGKLSVANKAPGTEGQQQANGEKKDAPAVPSAPPSYEEATSG
                     EGLKAGAFPQGPTAVPLHPSWAYVDPSSSSGYEGGFPAGHHELFSTFSWDDQKVRQLF
                     IRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSG
                     PRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTIFSFQTKF
                     DFTSCHGVLFVLLMTLFFSGLLLAILLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLL
                     MGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE"
     exon            90..285
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            286..389
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            390..454
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            455..508
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            509..559
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            560..599
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            600..637
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            638..725
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            726..821
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            822..875
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1487
                     /gene="Faim2"
                     /gene_synonym="Lfg; NMP35"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacgcagg caggctgcgg tgacccaagc ggccaccccc cgcttcaggg accccttcct
       61 cgagagacga caccatgacc cagggaaagc tctctgtggc taacaaggcc cctgggactg
      121 aggggcagca gcaggcaaat ggagagaaga aggatgcccc agcagtgccc tcggcaccac
      181 cctcctacga ggaggccacc tctggagagg ggctgaaggc aggggccttc ccccagggtc
      241 ccacagctgt accactccat ccaagctggg cctatgtgga ccccagcagc agctctggct
      301 atgaaggtgg tttccctgca ggacaccatg agcttttcag caccttcagc tgggatgacc
      361 agaaagttcg tcagcttttc atcagaaagg tctataccat cctgttggtt cagctgctgg
      421 tgaccttggc tgtggtggct ctctttacct tctgtgacgt cgttaaggac tatgtccagg
      481 ccaacccagg ctggtactgg gcatcctatg ccgtattctt tgcaacatac ctgactctgg
      541 cttgctgttc tgggcccagg agacacttcc cttggaacct gattctgctg accatcttta
      601 ccctgtccat ggcctacctc actgggatgc tgtccagtta ctacaacacc acgtctgtcc
      661 tgctgtgcct gggcatcaca gctcttgtct gcctctcagt caccatcttc agtttccaga
      721 ccaagtttga cttcacctcc tgtcacggtg tgctatttgt actgctcatg actctcttct
      781 tcagtggact cctcctcgcc atcctcctgc ccttccaata tgtcccctgg ctccacgccg
      841 tctatgctgt gctaggagcg ggtgtgttca cgttgttcct ggcatttgat acccagctgc
      901 tgatgggtaa ccgtcgacac tcgctgagtc ctgaggagta tatttttgga gccctcaaca
      961 tctacctaga cattatctat atcttcacct tcttcctgca gctttttggc accaaccggg
     1021 aatgaggagc cctcccccca cccccgccct cctccagaga atgcccctcc cctgtcctgt
     1081 gaccctctca gagctcctgc aagaccagac ataaacttgc tgcagccagc ttgtgtgcag
     1141 ccgctccctc ctgcagccag ccctcacctc gagccctctg cagcttgtac atatgccatc
     1201 cttggagccc cgcagatctg aggccacacc atcccctgtg gtgcccccag cacccgattg
     1261 catcttccaa gtggcacagt catggctgag ggcatctctg ggtttgcaga gaccccagaa
     1321 atgagtggga ggagcccaga ggtgggaagg agcccccagg aagcctggct gagactgtga
     1381 ctccccacca ccaagtcttg tagggctcca ttttctcttt cagttcaagg aaccaagctt
     1441 tgtaagaaaa aaagaaaaaa gactgagggg acatggctgg aacttgaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
