LOCUS       NM_080895                676 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus Fas apoptotic inhibitory molecule (Faim), mRNA.
ACCESSION   NM_080895
VERSION     NM_080895.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 676)
  AUTHORS   Liu,X., Hu,D., Zeng,Z., Zhu,W., Zhang,N., Yu,H., Chen,H., Wang,K.,
            Wang,Y., Wang,L., Zhao,J., Zhang,L., Wu,R., Hu,X. and Wang,J.
  TITLE     SRT1720 promotes survival of aged human mesenchymal stem cells via
            FAIM: a pharmacological strategy to improve stem cell-based therapy
            for rat myocardial infarction
  JOURNAL   Cell Death Dis 8 (4), e2731 (2017)
   PUBMED   28383554
  REMARK    GeneRIF: the anti-apoptotic effect of SRT1720 was mitigated by FAIM
            knockdown with a small interfering RNA-targeted FAIM. These results
            indicated that pretreatment with SRT1720 improves survival of aged
            hMSCs, and enhances their therapeutic efficacy for rat myocardial
            infarction (MI).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 676)
  AUTHORS   Sole,C., Dolcet,X., Segura,M.F., Gutierrez,H., Diaz-Meco,M.T.,
            Gozzelino,R., Sanchis,D., Bayascas,J.R., Gallego,C., Moscat,J.,
            Davies,A.M. and Comella,J.X.
  TITLE     The death receptor antagonist FAIM promotes neurite outgrowth by a
            mechanism that depends on ERK and NF-kapp B signaling
  JOURNAL   J Cell Biol 167 (3), 479-492 (2004)
   PUBMED   15520226
  REMARK    GeneRIF: Whereas FAIM overexpression greatly enhanced neurite
            outgrowth from PC12 cells and sympathetic neurons grown with nerve
            growth factor, reduction of endogenous FAIM levels by RNAi
            decreased neurite outgrowth in these cells
REFERENCE   3  (bases 1 to 676)
  AUTHORS   Schneider,T.J., Fischer,G.M., Donohoe,T.J., Colarusso,T.P. and
            Rothstein,T.L.
  TITLE     A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM)
            isolated from inducibly Fas-resistant B lymphocytes
  JOURNAL   J Exp Med 189 (6), 949-956 (1999)
   PUBMED   10075978
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_080895.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF412334.1, BE112969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000008.1  108423346-108423406
            62-194              JAXUCZ010000008.1  108429158-108429290
            195-423             JAXUCZ010000008.1  108429568-108429796
            424-473             JAXUCZ010000008.1  108436420-108436469
            474-676             JAXUCZ010000008.1  108438887-108439089
FEATURES             Location/Qualifiers
     source          1..676
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..676
                     /gene="Faim"
                     /note="Fas apoptotic inhibitory molecule"
                     /db_xref="GeneID:140930"
                     /db_xref="RGD:620572"
     exon            1..61
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     exon            62..194
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..623
                     /gene="Faim"
                     /codon_start=1
                     /product="fas apoptotic inhibitory molecule 1"
                     /protein_id="NP_543171.1"
                     /db_xref="GeneID:140930"
                     /db_xref="RGD:620572"
                     /translation="MTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRREW
                     MFKLVGKETFFVGAAKTKATINIDAISGFAYEYTLEIDGKSLKKYMENRSKTTNTWVL
                     HLDGEELRVVLEKDTMDVWCNGQRMETAGEFVDDGTETHFSVGNHDCYIKAVSSGKRR
                     EGIIHTLIVDNREIPELTQ"
     exon            195..423
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     exon            424..473
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
     exon            474..676
                     /gene="Faim"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcgac agctgctgac tacgtcgtgg gatcgggagc cggtggcggc gcgcggagca
       61 gccctctctg tagcctggaa aaaatgacag atctcgtagc tgtttgggac gtagcattaa
      121 gtgacggagt gcacaagatt gaatttgagc atgggaccac gtcaggcaaa cgagttgtgt
      181 acgtggatgg gaaggaagag ataagaagag agtggatgtt caaattggtg ggcaaagaaa
      241 cgttctttgt cggagctgca aagaccaaag ccaccataaa tatagacgcc ataagtggct
      301 tcgcctatga gtacacactg gagatcgacg ggaagagcct caagaagtac atggagaacc
      361 gatctaagac caccaacacc tgggtattgc acttggacgg cgaggaactg agagttgttc
      421 tggaaaaaga cactatggat gtatggtgca atggtcagag gatggagaca gcgggcgagt
      481 ttgtagatga cgggactgaa acacacttca gcgtggggaa ccacgactgt tacataaagg
      541 ccgtcagcag cgggaagagg agagaaggga tcatccacac gctcattgtg gataacaggg
      601 aaatcccaga gctcactcag tgacgctgtc ttagtgagtt ctgagctgaa gaggtgacct
      661 caggacccgc ccatgg
//
