LOCUS       NM_001399396            4278 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Fas associated factor family member 2 (Faf2),
            transcript variant 1, mRNA.
ACCESSION   NM_001399396 XM_006253617
VERSION     NM_001399396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4278)
  AUTHORS   Osorio,F.G., Soria-Valles,C., Santiago-Fernandez,O., Bernal,T.,
            Mittelbrunn,M., Colado,E., Rodriguez,F., Bonzon-Kulichenko,E.,
            Vazquez,J., Porta-de-la-Riva,M., Ceron,J., Fueyo,A., Li,J.,
            Green,A.R., Freije,J.M. and Lopez-Otin,C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
REFERENCE   2  (bases 1 to 4278)
  AUTHORS   Zhong,Y., Shen,H., Wang,Y., Yang,Y., Yang,P. and Fang,S.
  TITLE     Identification of ERAD components essential for dislocation of the
            null Hong Kong variant of alpha-1-antitrypsin (NHK)
  JOURNAL   Biochem Biophys Res Commun 458 (2), 424-428 (2015)
   PUBMED   25660456
REFERENCE   3  (bases 1 to 4278)
  AUTHORS   Xia,Y., Yan,L.H., Huang,B., Liu,M., Liu,X. and Huang,C.
  TITLE     Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8
            and disrupts endoplasmic reticulum-associated protein degradation
  JOURNAL   J Neurochem 129 (1), 99-106 (2014)
   PUBMED   24215460
REFERENCE   4  (bases 1 to 4278)
  AUTHORS   Olzmann,J.A., Richter,C.M. and Kopito,R.R.
  TITLE     Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated
            lipid droplet turnover
  JOURNAL   Proc Natl Acad Sci U S A 110 (4), 1345-1350 (2013)
   PUBMED   23297223
REFERENCE   5  (bases 1 to 4278)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
REFERENCE   6  (bases 1 to 4278)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 7, 2022 this sequence version replaced XM_006253617.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.60189.1,
                                           SRR26643298.68497.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                JAXUCZ010000017.1  9994456-9994541     c
            87-155              JAXUCZ010000017.1  9977163-9977231     c
            156-290             JAXUCZ010000017.1  9973864-9973998     c
            291-367             JAXUCZ010000017.1  9970245-9970321     c
            368-506             JAXUCZ010000017.1  9967380-9967518     c
            507-592             JAXUCZ010000017.1  9965778-9965863     c
            593-684             JAXUCZ010000017.1  9965604-9965695     c
            685-862             JAXUCZ010000017.1  9963676-9963853     c
            863-1034            JAXUCZ010000017.1  9960093-9960264     c
            1035-1178           JAXUCZ010000017.1  9959209-9959352     c
            1179-4278           JAXUCZ010000017.1  9952329-9955428     c
FEATURES             Location/Qualifiers
     source          1..4278
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..4278
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /note="Fas associated factor family member 2"
                     /db_xref="GeneID:291000"
                     /db_xref="RGD:1306577"
     exon            1..86
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1361
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     FAS-associated factor 2; UBX domain-containing protein 8;
                     protein expressed in T-cells and eosinophils in atopic
                     dermatitis; UBX domain containing 8"
                     /codon_start=1
                     /product="FAS-associated factor 2 isoform 1"
                     /protein_id="NP_001386325.1"
                     /db_xref="GeneID:291000"
                     /db_xref="RGD:1306577"
                     /translation="MAAPEEQDLTQEQTEKLLQFQDLTGIDSMEQCRLALEQHNWNME
                     AAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLP
                     FRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYS
                     QALSDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEG
                     YRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSE
                     RLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEER
                     RRQNLQEEKERKLECLPPEPSPDDPDSVKIIFKLPNDSRVERRFHFSQSLTVIHDFLF
                     SLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE"
     exon            87..155
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            156..290
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            291..367
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            368..506
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            507..592
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            593..684
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            685..862
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1034
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1178
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..4278
                     /gene="Faf2"
                     /gene_synonym="2210404d11rik; RGD1306577; Ubxd8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagcgtag aggcggcggc aaaatggcgg cgcctgagga gcaggatcta actcaggagc
       61 agaccgagaa gctgctgcag tttcaggatc tgactggcat agactccatg gagcagtgtc
      121 gccttgcctt ggaacagcat aactggaaca tggaggctgc cgtccaggac agactgaatg
      181 agcaagaggg tgtaccaagt gttttcaatc cacctccatc tcgaccccta caggttaata
      241 cagctgacca caggatctac agctacgttg tctcaagacc acaaccaagg ggcctgcttg
      301 gatggggtta ttacttgata atgcttccat tccggtttac ctattacacg atacttgata
      361 tatttaggtt tgctcttcgt tttatacggc ctgaccctcg cagccgggtc actgaccctg
      421 ttggggacat tgtttcattt atgcactctt ttgaagagaa atatgggagg gcacaccctg
      481 tcttctacca gggaacgtac agccaggcac ttagtgacgc caagcgggaa cttcgatttc
      541 ttttggttta tcttcatggg gatgaccacc aggactctga tgagttctgc cgcaatgctc
      601 tctgcgcacc tgaggtcatc tcgctgataa acagccggat gcttttttgg gcttgttcta
      661 caaacaaacc ggaggggtac agggtctccc aggctttacg agagaacacc tatccattcc
      721 tggctatgat tatgttgaag gaccggcgaa tgactgtggt aggaaggctc gaaggcctca
      781 ttcaacctga tgacctcatc aaccagttga cgttcattat ggatgcaaac cagacttacc
      841 tggtgtcaga acgcctagaa agggaagaaa ggaaccaaac ccaggtgctg agacaacagc
      901 aggatgaagc ctacctggct tctctcaggg cagaccagga gaaagagagg aagaaaaggg
      961 aggagagaga gcggaagcgc cggaaggagg aggaggtgca gcagcagaag ctggcggagg
     1021 agcgaaggcg gcagaactta caggaggaga aggagaggaa gctggagtgc ctgccccctg
     1081 agccctcccc agatgaccct gacagtgtca agatcatttt caagttaccc aatgattcca
     1141 gagtagagcg acgattccat ttttcacagt ctctaacagt catccacgac ttcttattct
     1201 ccttgaagga aagccctgaa aagtttcaga ttgaagccaa ttttccaaga cgggtacttc
     1261 cctgtgtccc ttcagaggaa tggcccaacc cccccaccct gcaggaggcg ggactaagcc
     1321 acacagaagt tctctttgtt caggacctga cagacgaatg acacttttct gcctccttct
     1381 tcccacccca atccctaaaa gaaatggaaa aacaaaaaca gagaacaaga gataaattca
     1441 tattattatt attattataa tacaatattt tttttaaaaa aactgctgca tcctgcggaa
     1501 ggatcggaaa ccatgctgcc tgcaagaggc acagcctgtg tgcgtgtgca aggccggcag
     1561 tgaatgcacc tgcccagcag actcgccttc cacagccgcc tctccatcct ccagtgaaga
     1621 cttcacctcc aacccatccc tccgcccacg tggggaagga gacattccca ctgtttctca
     1681 gtcattcttg cttttgtaga aaagaaaaaa agaaacccac catcagctcc agcagcagct
     1741 cctgaggacc tgcttctcct acttccagag gaagagggga gagaaggatg gactgactgc
     1801 ccacagttca tgaataactt tgtttctgtt tgctttgtaa tgataatgac caaaggagtg
     1861 aggctgactt aggtgtattt tttcctcaga tttgataaag agccagtgcc ctgggctcca
     1921 tggcccacgg cggtgtaata aaggtgccct gggctcattt gtgcttcctt ctgccactgt
     1981 tcctctcacg gtcccagagg tatcccattt ggagcaatga gaggaagtct gggattgtga
     2041 cccacaaaag gctgtgtgtg gggtgtgtgt tccctttaca cacacataca gcttctcctt
     2101 ggcatctgta ccaggtggtg gtgaaggggt ctcagccaaa ggacagcagc tcctgcttcc
     2161 cctctgactg cacacactgc tcttcccggc tttcctaact tgccgagctc ggtgcctttc
     2221 cagaggacta gggcccgggc cctccgtccc acctgcggag gctcgtcctg tttgagtgca
     2281 catatgataa tgatgtttaa ggatatagac ccatcgcagg catggtggtg tgctgggagg
     2341 cagaggcagc agatctctga attccaggcc agcctggtct acagagtgag gaggccctgt
     2401 ctcaaagttt tgaaccagaa actttgaaag agaaattgga ctcccagcct gtgtgtgttg
     2461 ttggaaagca catttcatgg caccagagac agtttgcagc cttcctcttg ccgtggtgaa
     2521 gcaacaggag ccttttcccc cttgaaatgt ctcgtctgtg attgagtttt tggtagtggg
     2581 tatgtggttg agccatgtat gagcacatgc cagtgtgtgc tgacaagtgt tccagtatgg
     2641 gcttgctgtg ctggtacagg cttgacactg ccgctctctg aggttcctgt agttcactag
     2701 tgtgtggggg cattccagtc cggagaaagc atagcttgtg ttggtcacct ccaagagacc
     2761 ctctaaagcc acttctctct gtgacagtcc tgtgcttctg ttctctgcag ctctctgttg
     2821 ttagaggacg gcttgtggag tcatttggaa aacctgagca gatccctgag gccttagcac
     2881 agggctctga ttctaccttg ggaagtgtta gcgcagctag gccggctgga actacagtga
     2941 taggttgaga ggacgctcag gagaagtctg tcttgctgac atcgatgcag agaggctttc
     3001 ccacttggag ccaccctccc agcttgtagt ccctgtctga ctgcccggca catgggcatg
     3061 tgtactgtgg cagtgtcttg ttcatggctg cttggggaag ttctgatttt ccctcttaat
     3121 ctcgttctgt aatgtgtaca ttttaatttt atgccttttg ccttttgata actgcaaaaa
     3181 tatactagat gccagactaa taaaaaaggg gtccactctt gccacaactc tgagggcagc
     3241 ctgttcatgt cctggaggct ttacccgtca cctgtccccc tcccttagtt ttcctctcag
     3301 ctttttgaga taggttctga tggcccaaag tggcctcaaa ctctacatac ccaaggctgg
     3361 ccttgaacta ccctcctgct tcccactcct gtggtgcaaa tgtgggtatg caccaccacg
     3421 tgaggctctc cagcagctgt gaaacacttt cgtgttcttg ctgtcccctg ttctgctgtc
     3481 ttgaggccat ttctctccct gggtgagctg tagacttcac ctttcgtccc ccaggccagt
     3541 tctgtctggg actccctaaa cctatgagct agaagagacc ttcgaccatt tgctgctgtt
     3601 taaattgctt ccaaaagatc ccaccaattg ttccaaagtc gtcatggaca gtggaagcat
     3661 ttgtttccag ttgtgcccct ccatcccctg tcagatggcc tcggctgaat gaccatgggg
     3721 atgaccaagc aacaatgcct gagtgagttg aatttttgca gcctcagtct ggtcttttct
     3781 tcctctgcag aattgtctgt ggcagatagg ttttgttttt gttttcctcc ttgcttgctt
     3841 ccactatgag atgcagagaa ggcaagagaa ttcctatttc tttaaaaact tacacaaaaa
     3901 agaaaaaaac cctagaattt tccaactgat cagttattat gaaaattgct gacagtgcca
     3961 aggccaagga aagaatgtca gaggcgactg agaggcgcag cagccccaga gcacatattc
     4021 agagggtgtc acctggcact gaacagggac ctccaccttc cagctggttg gcttttctgt
     4081 ttgtcagggg ggaggttttg acttgtgaag aacgcagcaa cagaagatgc atccacagag
     4141 atgcagtgcc ccacctgtac tgcacctgag tagttaataa tttcctgaag aaatctagtg
     4201 tacttcaaat tttttcataa aggtttacat tgtattgtag gttaatatta aacgttttat
     4261 aacaaaaaat gtataaaa
//
