LOCUS       NM_130406               2306 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus Fas associated factor 1 (Faf1), mRNA.
ACCESSION   NM_130406
VERSION     NM_130406.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2306)
  AUTHORS   Sun,B., Zhou,J., Gao,Y., He,F., Xu,H., Chen,X., Zhang,W. and
            Chen,L.
  TITLE     Fas-Associated Factor 1 Promotes Hepatic Insulin Resistance via JNK
            Signaling Pathway
  JOURNAL   Oxid Med Cell Longev 2021, 3756925 (2021)
   PUBMED   33510836
  REMARK    GeneRIF: Fas-Associated Factor 1 Promotes Hepatic Insulin
            Resistance via JNK Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2306)
  AUTHORS   Franz,A., Pirson,P.A., Pilger,D., Halder,S., Achuthankutty,D.,
            Kashkar,H., Ramadan,K. and Hoppe,T.
  TITLE     Chromatin-associated degradation is defined by UBXN-3/FAF1 to
            safeguard DNA replication fork progression
  JOURNAL   Nat Commun 7, 10612 (2016)
   PUBMED   26842564
  REMARK    Erratum:[Nat Commun. 2016 May 17;7:11593. doi:
            10.1038/ncomms11593.. PMID: 27186651]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2306)
  AUTHORS   Yang,J. and Fuller,P.J.
  TITLE     Interactions of the mineralocorticoid receptor--within and without
  JOURNAL   Mol Cell Endocrinol 350 (2), 196-205 (2012)
   PUBMED   21784126
  REMARK    Review article
REFERENCE   4  (bases 1 to 2306)
  AUTHORS   Alexandru,G., Graumann,J., Smith,G.T., Kolawa,N.J., Fang,R. and
            Deshaies,R.J.
  TITLE     UBXD7 binds multiple ubiquitin ligases and implicates p97 in
            HIF1alpha turnover
  JOURNAL   Cell 134 (5), 804-816 (2008)
   PUBMED   18775313
REFERENCE   5  (bases 1 to 2306)
  AUTHORS   Kim,H.J., Song,E.J., Lee,Y.S., Kim,E. and Lee,K.J.
  TITLE     Human Fas-associated factor 1 interacts with heat shock protein 70
            and negatively regulates chaperone activity
  JOURNAL   J Biol Chem 280 (9), 8125-8133 (2005)
   PUBMED   15596450
REFERENCE   6  (bases 1 to 2306)
  AUTHORS   Song,E.J., Yim,S.H., Kim,E., Kim,N.S. and Lee,K.J.
  TITLE     Human Fas-associated factor 1, interacting with ubiquitinated
            proteins and valosin-containing protein, is involved in the
            ubiquitin-proteasome pathway
  JOURNAL   Mol Cell Biol 25 (6), 2511-2524 (2005)
   PUBMED   15743842
REFERENCE   7  (bases 1 to 2306)
  AUTHORS   Park,M.Y., Jang,H.D., Lee,S.Y., Lee,K.J. and Kim,E.
  TITLE     Fas-associated factor-1 inhibits nuclear factor-kappaB (NF-kappaB)
            activity by interfering with nuclear translocation of the RelA
            (p65) subunit of NF-kappaB
  JOURNAL   J Biol Chem 279 (4), 2544-2549 (2004)
   PUBMED   14600157
REFERENCE   8  (bases 1 to 2306)
  AUTHORS   Pantaleon,M., Kanai-Azuma,M., Mattick,J.S., Kaibuchi,K., Kaye,P.L.
            and Wood,S.A.
  TITLE     FAM deubiquitylating enzyme is essential for preimplantation mouse
            embryo development
  JOURNAL   Mech Dev 109 (2), 151-160 (2001)
   PUBMED   11731229
REFERENCE   9  (bases 1 to 2306)
  AUTHORS   Guerra,B., Boldyreff,B. and Issinger,O.G.
  TITLE     FAS-associated factor 1 interacts with protein kinase CK2 in vivo
            upon apoptosis induction
  JOURNAL   Int J Oncol 19 (6), 1117-1126 (2001)
   PUBMED   11713579
REFERENCE   10 (bases 1 to 2306)
  AUTHORS   Chu,K., Niu,X. and Williams,L.T.
  TITLE     A Fas-associated protein factor, FAF1, potentiates Fas-mediated
            apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11894-11898 (1995)
   PUBMED   8524870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 1, 2020 this sequence version replaced NM_130406.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.23758.1,
                                           SRR26643285.20034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               JAXUCZ010000005.1  129654677-129654906
            231-299             JAXUCZ010000005.1  129696988-129697056
            300-346             JAXUCZ010000005.1  129732809-129732855
            347-549             JAXUCZ010000005.1  129741606-129741808
            550-641             JAXUCZ010000005.1  129752432-129752523
            642-733             JAXUCZ010000005.1  129758620-129758711
            734-839             JAXUCZ010000005.1  129774114-129774219
            840-926             JAXUCZ010000005.1  129811689-129811775
            927-1022            JAXUCZ010000005.1  129868361-129868456
            1023-1149           JAXUCZ010000005.1  129883847-129883973
            1150-1213           JAXUCZ010000005.1  129884894-129884957
            1214-1295           JAXUCZ010000005.1  129885864-129885945
            1296-1450           JAXUCZ010000005.1  129903226-129903380
            1451-1587           JAXUCZ010000005.1  129923318-129923454
            1588-1676           JAXUCZ010000005.1  129928983-129929071
            1677-1757           JAXUCZ010000005.1  129980463-129980543
            1758-1835           JAXUCZ010000005.1  129981805-129981882
            1836-2051           JAXUCZ010000005.1  129989655-129989870
            2052-2306           JAXUCZ010000005.1  130018350-130018604
FEATURES             Location/Qualifiers
     source          1..2306
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..2306
                     /gene="Faf1"
                     /note="Fas associated factor 1"
                     /db_xref="GeneID:140657"
                     /db_xref="RGD:70987"
     exon            1..230
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2135
                     /gene="Faf1"
                     /note="Fas (TNFRSF6) associated factor 1"
                     /codon_start=1
                     /product="FAS-associated factor 1"
                     /protein_id="NP_569090.2"
                     /db_xref="GeneID:140657"
                     /db_xref="RGD:70987"
                     /translation="MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGV
                     IPQENGILQSDFGGETMPGPTFDPASPPAPAPAPSSSAFRPVMPSRQIVERQPRMLDF
                     RVEYRDRNVDVVLEDSCTVGEIKQILENELQIPVPKMLLKGWKTGDVEDSTVLKSLHL
                     PKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTVQE
                     VKRNVYDLTSIPVRHQLWEGWPASATDDSMCLAESGLSYPCHRLTVGRRTSPVQTREQ
                     SEEQSTDVHMVSDSDGDDFEDASEFGVDDGEVFGMASSTMRKSPMMPENAENEGDALL
                     QFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQ
                     MLCAESIVSYLSQNFITWAWDLTKDANRARFLTMCNRHFGSVIAQTIRTQKTDQFPLF
                     LIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFSAQQQEDIKDEDEREARENVKR
                     EQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPEE
                     ENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEFKLLSTFPRRDVT
                     QLDPNKSLLEVNLFPQETLFLQAKE"
     exon            231..299
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..346
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..549
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..641
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..733
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..839
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..926
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1022
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1149
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1213
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1295
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1450
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1587
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1676
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1757
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1835
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2051
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2306
                     /gene="Faf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggttaccga gtgcatgagc acctagtctc ccgcgctgcc ccgcccgccg gcccgccggc
       61 cctcccgccg gctcgcccgc cagcccctcg ccacccggcg gcggccgcag cttcggccgc
      121 aggaggcgcc gtctcgctcc caggtgcgcg cttcgttccc ggagccgcgg agctcggcgg
      181 ccgccatggc gtccaacatg gaccgggaga tgatccttgc ggattttcag gcatgtactg
      241 gtattgaaaa cattgatgaa gctattacac tgcttgagca aaataactgg gacttggtgg
      301 cagctatcaa tggtgtaata ccccaggaaa atggcattct acaaagtgac tttggaggtg
      361 agaccatgcc aggacccaca tttgacccag caagtccacc tgctccagct ccagctccct
      421 cttcttccgc gttccgacct gtaatgccat ccaggcagat cgtagaaagg cagccgcgca
      481 tgctcgactt cagagttgaa tacagggaca ggaatgttga tgtggtactt gaagacagct
      541 gtactgttgg agagattaaa cagattctag aaaatgaact tcagatacct gtgcctaaaa
      601 tgctgttgaa aggctggaag actggagatg tggaagacag tacggtctta aaatcactac
      661 acttgccaaa aaacaacagt ctttatgtcc ttacaccaga cttaccacca ccttcatcat
      721 ccagtcatgc tggtgccctg caggaatcat taaatcaaaa cttcatgctg atcatcaccc
      781 accgagaggt ccagcgggag tacaacctga acttctcagg aagcagtacc gttcaagagg
      841 taaagagaaa tgtgtatgat ctgacaagca tacctgttcg acatcagtta tgggaaggct
      901 ggccagcttc tgccactgat gattcaatgt gtcttgctga atcagggctc tcttatccct
      961 gccatcgact cactgtggga cgaagaactt cacctgtaca gacccgtgag caatcagaag
     1021 agcaaagcac ggatgttcat atggttagtg atagtgatgg agatgacttt gaagatgctt
     1081 cagaatttgg agtggatgac ggagaagtat ttggcatggc atcatctacc atgagaaaat
     1141 ctccaatgat gccagaaaac gcagaaaatg aaggagatgc cttattacaa tttacagcag
     1201 agttttcttc aagatatggt gactgccatc ctgtattttt tattggctca ttagaagctg
     1261 ctttccaaga ggccttctat gtgaaagcca gagacagaaa gcttcttgct atctacctcc
     1321 accatgatga aagtgtacta accaacgtgt tctgctcaca aatgctttgt gctgaatcca
     1381 ttgtttctta tctgagtcaa aattttataa cctgggcttg ggatctgaca aaggacgcca
     1441 acagagcaag atttctgaca atgtgcaata gacactttgg cagcgttatt gcacaaacca
     1501 ttcggactca aaagacagat cagtttccac ttttcctgat tatcatggga aagcgatcat
     1561 ctaatgaagt gctaaatgtg atacaaggta atacaacagt ggatgagtta atgatgagac
     1621 tcatggctgc catggagatt ttctcagctc aacaacagga agacataaag gatgaggatg
     1681 aacgtgaagc cagagaaaat gtgaagagag agcaagatga ggcttatcgc ctttcccttg
     1741 aagccgacag ggcaaagaga gaagctcatg agagagagat ggcagaacag tttcgtttgg
     1801 agcagattcg caaagagcaa gaagaggaac gcgaggccat cagactctcc ttagaacaag
     1861 ccctgcctcc agagccagag gaggaaaatg cggagcctgt tagcaagctt cggattcgaa
     1921 cccccagtgg cgagttcctg gaacgccgtt tcctggccag caataagctc cagattgtct
     1981 ttgattttgt ggcttccaag ggatttcctt gggatgagtt caagttactg agcacctttc
     2041 ctaggagaga cgtaactcag ctagacccca ataagtcatt attggaggta aacttgttcc
     2101 ctcaagaaac ccttttcctt caagcaaaag agtaaacatg actgagaggt ggaggcagcc
     2161 actcctgaca agccagcggc acgcgtcaag agacgggctc ctcaccagcc cacctacatg
     2221 ctcgtgtcac tcagttcaat gtcacctctg cctcttgcaa gattgctgga aaaaagtaat
     2281 aaacatagct acttaaaatt tccatc
//
