LOCUS       NM_031344               1706 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus fatty acid desaturase 2 (Fads2), mRNA.
ACCESSION   NM_031344 XM_346570
VERSION     NM_031344.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Reyna Gallegos,S., Torres Arrunategui,G., Valenzuela,R.,
            Rincon-Cervera,M.A. and Villanueva Espinoza,M.E.
  TITLE     Adding a purple corn extract in rats supplemented with chia oil
            decreases gene expression of SREBP-1c and retains Delta5 and Delta6
            hepatic desaturase activity, unmodified the hepatic lipid profile
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 132, 1-7 (2018)
   PUBMED   29735017
  REMARK    GeneRIF: The effect of dietary plant extracts and vegetable oils on
            hepatic SREBP-1c, Delta5 and Delta6 desaturases has been reported.
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Rioux,V., Choque,B., Ezanno,H., Duby,C., Catheline,D. and
            Legrand,P.
  TITLE     Influence of the cis-9, cis-12 and cis-15 double bond position in
            octadecenoic acid (18:1) isomers on the rat FADS2-catalyzed
            Delta6-desaturation
  JOURNAL   Chem Phys Lipids 187, 10-19 (2015)
   PUBMED   25701799
  REMARK    GeneRIF: We first showed that both recombinant and native rat FADS2
            were able to Delta6-desaturate not only the cis9- but also the
            cis12- and cis15-18:1 isomers.
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Gonzalez,R.S., Rodriguez-Cruz,M., Maldonado,J. and Saavedra,F.J.
  TITLE     Role of maternal tissue in the synthesis of polyunsaturated fatty
            acids in response to a lipid-deficient diet during pregnancy and
            lactation in rats
  JOURNAL   Gene 549 (1), 7-23 (2014)
   PUBMED   25046614
  REMARK    GeneRIF: Results show that genes with the highest expression in the
            mammary gland, liver and adipose tissue were Elovl5, Fads2, and
            Fasn, respectively, in a low-lipid diet than in adequate-lipid
            diet.
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Le,C.H., Mulligan,C.M., Routh,M.A., Bouma,G.J., Frye,M.A.,
            Jeckel,K.M., Sparagna,G.C., Lynch,J.M., Moore,R.L., McCune,S.A.,
            Bristow,M., Zarini,S., Murphy,R.C. and Chicco,A.J.
  TITLE     Delta-6-desaturase links polyunsaturated fatty acid metabolism with
            phospholipid remodeling and disease progression in heart failure
  JOURNAL   Circ Heart Fail 7 (1), 172-183 (2014)
   PUBMED   24284026
  REMARK    GeneRIF: Delta-6-desaturase links polyunsaturated fatty acid
            metabolism with phospholipid remodeling and disease progression in
            heart failure.
            Erratum:[Circ Heart Fail. 2014 Mar 1;7(2):382]
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Hoile,S.P., Irvine,N.A., Kelsall,C.J., Sibbons,C., Feunteun,A.,
            Collister,A., Torrens,C., Calder,P.C., Hanson,M.A., Lillycrop,K.A.
            and Burdge,G.C.
  TITLE     Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and
            the epigenetic regulation of Fads2 in offspring liver
  JOURNAL   J Nutr Biochem 24 (7), 1213-1220 (2013)
   PUBMED   23107313
  REMARK    GeneRIF: epigenetic regulation of Fads2 may contribute to short-
            and long-term regulation of PUFA synthesis
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Tang,C., Cho,H.P., Nakamura,M.T. and Clarke,S.D.
  TITLE     Regulation of human delta-6 desaturase gene transcription:
            identification of a functional direct repeat-1 element
  JOURNAL   J Lipid Res 44 (4), 686-695 (2003)
   PUBMED   12562861
  REMARK    GeneRIF: n-6 and n-3 PUFAs suppressed the hepatic expression of
            Fads2 by inhibiting the rate of Fads2 gene transcription. In
            contrast, consumption of the PPARalpha activator WY 14,643
            significantly enhanced the transcription of hepatic DeFads2 by
            500%.
REFERENCE   7  (bases 1 to 1706)
  AUTHORS   Guillou,H., Rioux,V., Catheline,D., Thibault,J.N., Bouriel,M.,
            Jan,S., D'Andrea,S. and Legrand,P.
  TITLE     Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta
            6-desaturase
  JOURNAL   J Lipid Res 44 (3), 450-454 (2003)
   PUBMED   12562851
  REMARK    GeneRIF: rat Delta 6-desaturase, which acts on the 18- and
            24-carbon fatty acids of the n-6 and n-3 series, is also able to
            catalyze palmitic acid Delta 6 -desaturation
REFERENCE   8  (bases 1 to 1706)
  AUTHORS   D'andrea,S., Guillou,H., Jan,S., Catheline,D., Thibault,J.N.,
            Bouriel,M., Rioux,V. and Legrand,P.
  TITLE     The same rat Delta6-desaturase not only acts on 18- but also on
            24-carbon fatty acids in very-long-chain polyunsaturated fatty acid
            biosynthesis
  JOURNAL   Biochem J 364 (Pt 1), 49-55 (2002)
   PUBMED   11988075
  REMARK    GeneRIF: Delta6-desaturase acts on 24-carbon fatty acids in
            very-long-chain polyunsaturated fatty acid biosynthesis
REFERENCE   9  (bases 1 to 1706)
  AUTHORS   Aki,T., Shimada,Y., Inagaki,K., Higashimoto,H., Kawamoto,S.,
            Shigeta,S., Ono,K. and Suzuki,O.
  TITLE     Molecular cloning and functional characterization of rat delta-6
            fatty acid desaturase
  JOURNAL   Biochem Biophys Res Commun 255 (3), 575-579 (1999)
   PUBMED   10049752
REFERENCE   10 (bases 1 to 1706)
  AUTHORS   Cho,H.P., Nakamura,M.T. and Clarke,S.D.
  TITLE     Cloning, expression, and nutritional regulation of the mammalian
            Delta-6 desaturase
  JOURNAL   J Biol Chem 274 (1), 471-477 (1999)
   PUBMED   9867867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081776.1.
            
            On Sep 16, 2004 this sequence version replaced NM_031344.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081776.1, FQ210893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1706
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /note="fatty acid desaturase 2"
                     /db_xref="GeneID:83512"
                     /db_xref="RGD:68339"
     exon            1..373
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1501
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /EC_number="1.14.19.3"
                     /note="delta-6 fatty acid desaturase; D6D; delta(6)
                     desaturase; fatty acid desaturase 6"
                     /codon_start=1
                     /product="acyl-CoA 6-desaturase"
                     /protein_id="NP_112634.1"
                     /db_xref="GeneID:83512"
                     /db_xref="RGD:68339"
                     /translation="MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVY
                     NVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLD
                     RGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESIAWFILSYFGNGWIP
                     TVITAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHIVHKFVIGHLKGASANWWNHRHF
                     QHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIP
                     MYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGALVFLNFIRFLESHWF
                     VWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMP
                     RHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK"
     exon            374..484
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            485..682
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            683..784
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..910
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            911..971
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1048
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1146
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1243
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1323
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1449
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1617
                     /gene="Fads2"
                     /gene_synonym="Fadsd6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaaggcga ggggaggagg cgcggtggga ggaggagtag aagacaaaag ctgaaagcga
       61 ggagggcgcc taccgcacac tgcggccagg agagggaccg tcggtgctgc gagccgcggg
      121 cgcccggagg gccgtagcgc acgggtcatc cgggtagaca ggcagcatgg ggaagggagg
      181 taaccaggga gaggggagca ccgagctcca ggctccgatg cccaccttcc gctgggagga
      241 gattcagaag cacaacctgc gcaccgaccg gtggctcgtc atcgaccgca aggtctacaa
      301 cgttaccaaa tggtcccagc ggcacccagg ggggcaccgt gtcatcggac actattcggg
      361 agaagatgct acggatgcct tccgtgcctt ccacctggac ctggatttcg tgggcaagtt
      421 cttgaagccc ctgctgattg gtgagctggc cccagaggag cccagcctgg accggggcaa
      481 aagctctcag atcaccgagg acttcagggc cctgaagaag actgctgagg acatgaacct
      541 tttcaaaacc aaccacctgt tcttctttct cctcctgtcc cacatcatcg tcatggaaag
      601 catcgcctgg ttcatcctct cgtacttcgg caatggctgg attcccaccg tcatcacggc
      661 ctttgtcctt gctacctccc aggcccaagc tggatggcta caacatgatt atggccacct
      721 ttctgtctat aagaaatcca tatggaacca cattgtccac aagtttgtca ttggccactt
      781 aaagggtgcc tccgccaact ggtggaacca tcgacatttc cagcaccatg cgaagcccaa
      841 catcttccac aaggaccccg acataaagag cctgcacgtg tttgtccttg gagagtggca
      901 gcccctcgag tatggcaaga agaagctgaa atatctgccc tacaaccacc agcatgaata
      961 cttcttcctg atcggaccac cgctgctcat ccctatgtac ttccagtacc agatcatcat
     1021 gaccatgatc agacgcagag actgggtgga cttggcctgg gccatcagct actatgcacg
     1081 tttcttctac acctatatcc ctttctatgg catcttggga gccctggttt tcctcaactt
     1141 tatcaggttc ctggagagcc actggtttgt gtgggtcaca cagatgaacc acattgtcat
     1201 ggagattgat cttgatcact accgggactg gttcagcagc cagctggcag ccacctgcaa
     1261 tgtggagcag tccttcttca atgactggtt cagcgggcac ctcaatttcc agattgagca
     1321 ccacctcttc cccactatgc caagacacaa cttgcacaag attgccccac tggtgaagtc
     1381 tctctgcgcc aagcatggca ttgaatacca agagaagccg ctgctgaggg ccctgctcga
     1441 cattgtgagt tcactgaaga agtctgggga gctgtggctg gatgcctacc tccacaaatg
     1501 aagcagcaga cctcgtggca cccttgggaa gggggcacag ttgggtgaca gccagaggga
     1561 ggggagggct tttgttctga agggttctcg tgagactgaa gggtctgctg gctcacaaaa
     1621 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
