LOCUS       NM_053445               3380 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus fatty acid desaturase 1 (Fads1), mRNA.
ACCESSION   NM_053445
VERSION     NM_053445.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3380)
  AUTHORS   Rioux,V., Pedrono,F., Blanchard,H., Duby,C., Boulier-Monthean,N.,
            Bernard,L., Beauchamp,E., Catheline,D. and Legrand,P.
  TITLE     Trans-vaccenate is Delta13-desaturated by FADS3 in rodents
  JOURNAL   J Lipid Res 54 (12), 3438-3452 (2013)
   PUBMED   24070791
REFERENCE   2  (bases 1 to 3380)
  AUTHORS   Omori,Y., Ohtani,T., Sakata,Y., Mano,T., Takeda,Y., Tamaki,S.,
            Tsukamoto,Y., Kamimura,D., Aizawa,Y., Miwa,T., Komuro,I., Soga,T.
            and Yamamoto,K.
  TITLE     L-Carnitine prevents the development of ventricular fibrosis and
            heart failure with preserved ejection fraction in hypertensive
            heart disease
  JOURNAL   J Hypertens 30 (9), 1834-1844 (2012)
   PUBMED   22796714
REFERENCE   3  (bases 1 to 3380)
  AUTHORS   Wadhwani,N.S., Manglekar,R.R., Dangat,K.D., Kulkarni,A.V. and
            Joshi,S.R.
  TITLE     Effect of maternal micronutrients (folic acid, vitamin B12) and
            omega 3 fatty acids on liver fatty acid desaturases and transport
            proteins in Wistar rats
  JOURNAL   Prostaglandins Leukot Essent Fatty Acids 86 (1-2), 21-27 (2012)
   PUBMED   22133376
  REMARK    GeneRIF: Data show that an imbalance of maternal micronutrients
            increases Delta5 desaturase activity but decreases mRNA levels,
            decreases Delta6 desaturase activity but not mRNA levels as
            compared to control.
REFERENCE   4  (bases 1 to 3380)
  AUTHORS   Extier,A., Langelier,B., Perruchot,M.H., Guesnet,P., Van
            Veldhoven,P.P., Lavialle,M. and Alessandri,J.M.
  TITLE     Gender affects liver desaturase expression in a rat model of n-3
            fatty acid repletion
  JOURNAL   J Nutr Biochem 21 (3), 180-187 (2010)
   PUBMED   19157821
  REMARK    GeneRIF: Regulation of 5-desaturase expression is different in
            female vs. male liver (but not cerebral cortex) during n-3 fatty
            acid repletion.
REFERENCE   5  (bases 1 to 3380)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3380)
  AUTHORS   Ves-Losada,A. and Brenner,R.R.
  TITLE     Fatty acid delta 5 desaturation in rat liver cell nuclei
  JOURNAL   Mol Cell Biochem 142 (2), 163-170 (1995)
   PUBMED   7770068
REFERENCE   7  (bases 1 to 3380)
  AUTHORS   Mills,D.E., Huang,Y.S., Narce,M. and Poisson,J.P.
  TITLE     Psychosocial stress, catecholamines, and essential fatty acid
            metabolism in rats
  JOURNAL   Proc Soc Exp Biol Med 205 (1), 56-61 (1994)
   PUBMED   8115350
REFERENCE   8  (bases 1 to 3380)
  AUTHORS   Irazu,C.E., Gonzalez-Rodriguez,S. and Brenner,R.R.
  TITLE     Delta 5 desaturase activity in rat kidney microsomes
  JOURNAL   Mol Cell Biochem 129 (1), 31-37 (1993)
   PUBMED   8177224
REFERENCE   9  (bases 1 to 3380)
  AUTHORS   Maniongui,C., Blond,J.P., Ulmann,L., Durand,G., Poisson,J.P. and
            Bezard,J.
  TITLE     Age-related changes in delta 6 and delta 5 desaturase activities in
            rat liver microsomes
  JOURNAL   Lipids 28 (4), 291-297 (1993)
   PUBMED   8487621
REFERENCE   10 (bases 1 to 3380)
  AUTHORS   Georges,B., Blond,J.P., Maniongui,C. and Bezard,J.
  TITLE     Effect of simvastatin on desaturase activities in liver from lean
            and obese Zucker rats
  JOURNAL   Lipids 28 (1), 63-65 (1993)
   PUBMED   8446010
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB052085.1.
            
            On Dec 11, 2007 this sequence version replaced NM_053445.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052085.1, AF320509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3380
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3380
                     /gene="Fads1"
                     /note="fatty acid desaturase 1"
                     /db_xref="GeneID:84575"
                     /db_xref="RGD:621678"
     exon            1..289
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1420
                     /gene="Fads1"
                     /EC_number="1.14.19.44"
                     /note="D5D; delta(5) desaturase; delta(5) fatty acid
                     desaturase"
                     /codon_start=1
                     /product="acyl-CoA (8-3)-desaturase"
                     /protein_id="NP_445897.2"
                     /db_xref="GeneID:84575"
                     /db_xref="RGD:621678"
                     /translation="MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRK
                     VYNISDFSRRHPGGSRVISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPS
                     FEPTKNKALTDEFRELRATVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSL
                     VPFTLCAVLLSTVQAQAGWLQHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHM
                     HFQHHAKPNCFRKDPDINMHPLFFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPA
                     LLPLYFQWYIFYFVVQRKKWVDLAWMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLES
                     NWFVWVTQMNHIPMHIDHDRNVDWVSTQLQATCNVHQSAFNNWFSGHLNFQIEHHLFP
                     TMPRHNYHKVAPLVQSLCAKYGIKYESKPLLTAFADIVYSLKESGQLWLDAYLHQ"
     exon            290..400
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..598
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..700
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..829
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..890
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..967
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1065
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1162
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1242
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1368
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..3357
                     /gene="Fads1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3353
                     /gene="Fads1"
ORIGIN      
        1 gctggcgtgc gctgcctcgc agccccgagc gcgcgcctct ccagctcccg ctccggcttc
       61 cccaaccagg cttattatgg ctcccgaccc ggtgcagacc cctgacccgg cctccgccca
      121 gctccgccaa atgcgctact ttacttggga ggaggtggcg cagcgctccg ggagggagaa
      181 ggagcgatgg ctcgtgatcg accggaaggt gtacaacatc agcgacttca gtcgccgcca
      241 cccgggaggc tcccgggtca tcagccacta cgctggtcag gatgccacgg atccttttgt
      301 ggcattccac attaacaagg gccttgtgag aaagtatatg aactctcttc tgattggaga
      361 gctagctccg gagcagccca gctttgaacc caccaagaat aaggcgctca ctgatgaatt
      421 ccgggagctg cgggccacag tggagcgaat gggcctcatg aaagccaacc atctcttctt
      481 cctgttctat ctgctgcaca tcctgctgct ggacgtggcc gcctggctca ctctttggat
      541 ctttggaact tccttggtgc ccttcaccct ctgtgcagtg ctgctcagta cagttcaggc
      601 ccaggcaggt tggctacagc atgactttgg gcacctgtcc gtcttcagca cctcaacatg
      661 gaatcacctg gtacatcatt ttgtcattgg ccacctgaag ggggccccag ccagctggtg
      721 gaaccacatg catttccagc accacgccaa gcccaactgc ttccgcaaag accccgatat
      781 caacatgcat cccctcttct tcgccctggg gaaggtcctt tctgtggagc ttgggaaaga
      841 aaagaagaag cacatgccat acaaccatca gcacaagtac ttcttcctga ttggaccccc
      901 agccttgctg cctctctact tccagtggta cattttctat tttgttgttc agcggaagaa
      961 atgggtggac ttggcctgga tgctcagctt ctatgttcgt gtcttcttca cttacatgcc
     1021 gctgctgggg ctgaaaggcc tcctatgtct tttcttcatt gtcaggttcc tggagagcaa
     1081 ctggtttgtg tgggtgacgc agatgaacca tatccccatg cacattgatc atgaccggaa
     1141 tgtggactgg gtctccaccc agctacaggc aacctgcaac gttcaccagt cagccttcaa
     1201 caactggttc agtggccacc tcaatttcca gattgaacac cacctcttcc ctacgatgcc
     1261 acgacacaac taccacaagg tggcacccct ggtacaatct ctgtgcgcca agtacggcat
     1321 caagtatgag tccaagcccc tgctcacggc cttcgcggac attgtttact ccctgaagga
     1381 gtcaggacag ctctggctgg atgcttacct tcaccaatag cagcagacct ccacatggag
     1441 gaggaaaagg acgactggag ccaaagcagg agtttgaggg acaatgccac tatgaatcta
     1501 atgtttaaag ggttagggaa cgtagatatt tctactcaca cctgccccct tggccttcta
     1561 ggtaccaaac ttgagagcgg agaactgttg gggcagggat gcaaaattgt tgtttcttct
     1621 actttggtag gggcaaatgg tggtacctac agagccctgc acgaagtagg gaccccacac
     1681 tagatatccc ctcttgtaaa gcacgagccc aactcactgg ctatctgatt ctcaccctcc
     1741 tttttagtcc gaggaacagt gtgacccctt ggaacgagat ttagaaagag ggcattcatg
     1801 cacagaattc tggggcctgg cacagctccc tgcccaggag ctcagcttgc tgctgagggc
     1861 tgggtgtgac catgtctgcc tccggctgct gggagaagct gtttttcagt ctcagaagca
     1921 ggcggggcaa aggccaggac tgtggtttgg gaggcatttg gccctggaag atcctggcac
     1981 acacaattcc tgagtctcat tccattcggg ttccagagag aacattagat ctttagatct
     2041 tagctcttga caaaatgtga tggcagagtt accggccttt gattcacctc ttctaatcag
     2101 tccccaagga atacataaac aaagaacaag agaggtcttt cctcctaatg aagactccca
     2161 gagtttcctt ttgctcccca acctgtagtt ctaagttcaa caaaacagtc atcaacaaaa
     2221 gtgacggagg cttccatcag tgtcagggct ctgtgcagac ccagaatccc tgttccctat
     2281 gtcatgttcc agcattgtat agcacggttc catgtcacaa acagaaaggt caggaacact
     2341 gaggtctgtg aatgtcactg ctgcagcgag gtcatgtcac tcctctgtct actctgtcaa
     2401 gtgtcttact ctactggacg ccagatagaa acttaaggta acttctgaca tgtgtcagtc
     2461 taacaataaa ctagggcttc gtcatcttct ggttggtaaa agatgtggtc cagagaacgt
     2521 aggaacatgc ctggagagac ctaatgtgct cttgttctgc aaacccatgg gcattatttc
     2581 cctctccgct caagagctca tactggaagc atgctgacca cctggctgga attcgaaaac
     2641 ctcaagcctg aaggcaaagt gcagcacatg tctgtggaga aatggcaagc ggtcgagatg
     2701 agggtgtaaa ggatattggg gtatggcata aagacaggca ggttgcagaa aagctcagat
     2761 ctttccccgt ggttgactgt gctagaaaaa ctgtttgaag cagggcgtag ggaaaagcgg
     2821 gattaaagag tactaccttt attagctcct tccctccaga ataggtgcaa atccctcccc
     2881 atgcccattt cctgccacct ggggtaagga tgtggcactg ccagtctgtc aagcccactg
     2941 actttgagtc ttcagctgcc agtctgggca aataccagcg agctctgttg aaccaagacc
     3001 aggccttcag agcatctgaa ccactgtggc cttctctcct cagccttcac tgtggctttt
     3061 gcctagccac gggggacatg gagcaaccag actcagaatg tgacagtgat gaaatgaggt
     3121 atctcaaatc cactgacaga taagaaaaca gggttagagg gaaagtcacc tctgtcacgt
     3181 agaggcagaa tatatgaact taactctagt ttccatgtct gtctttatta ccttcatctt
     3241 tctacttcct ggccacaggc atttcactta attgagccta atgtcagtat ctgtgtgtgt
     3301 caatgtcgtt accacattct gatgaagcta aaaaataaaa tttaatttgg gccaaaaaaa
     3361 aaaaaaaaaa aaaaaaaaaa
//
