LOCUS       NM_152937                716 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Fas associated via death domain (Fadd), mRNA.
ACCESSION   NM_152937
VERSION     NM_152937.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 716)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 716)
  AUTHORS   Van Quickelberghe E, De Sutter D, van Loo G, Eyckerman S and
            Gevaert K.
  TITLE     A protein-protein interaction map of the TNF-induced NF-kappaB
            signal transduction pathway
  JOURNAL   Sci Data 5, 180289 (2018)
   PUBMED   30561431
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 716)
  AUTHORS   Hernandez-Hernandez E, Miralles A, Esteban S and Garcia-Fuster MJ.
  TITLE     Improved age-related deficits in cognitive performance and
            affective-like behavior following acute, but not repeated,
            8-OH-DPAT treatments in rats: regulation of hippocampal FADD
  JOURNAL   Neurobiol Aging 71, 115-126 (2018)
   PUBMED   30138765
  REMARK    GeneRIF: Study shows that hypothermic effects induced by acute
            8-OH-DPAT are associated with better cognitive scores and lower
            FADD content in the hippocampus of rats at different ages. In
            addition acute, but not repeated, 8-OH-DPAT treatments further
            decrease hippocampal FADD protein in rats at different ages.
REFERENCE   4  (bases 1 to 716)
  AUTHORS   Li C, Mo Z, Lei J, Li H, Fu R, Huang Y, Luo S and Zhang L.
  TITLE     Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain
            damage rat model via suppression of TRAIL signaling pathway
  JOURNAL   Int J Biochem Cell Biol 99, 169-177 (2018)
   PUBMED   29635023
REFERENCE   5  (bases 1 to 716)
  AUTHORS   Song XF, Tian H and Zhang ZX.
  TITLE     Differential activation of CD95-mediated apoptosis related proteins
            in proximal and distal tubules during rat renal development
  JOURNAL   Tissue Cell 48 (5), 417-424 (2016)
   PUBMED   27561622
  REMARK    GeneRIF: Western blotting demonstrated that expression of CD95,
            FasL and FADD was very weak during embryonic development, but
            rapidly increased at P14.
REFERENCE   6  (bases 1 to 716)
  AUTHORS   Estelles A, Charlton CA and Blau HM.
  TITLE     The phosphoprotein protein PEA-15 inhibits Fas- but increases
            TNF-R1-mediated caspase-8 activity and apoptosis
  JOURNAL   Dev Biol 216 (1), 16-28 (1999)
   PUBMED   10588860
REFERENCE   7  (bases 1 to 716)
  AUTHORS   Wang GH, Bertin J, Wang Y, Martin DA, Wang J, Tomaselli KJ,
            Armstrong RC and Cohen JI.
  TITLE     Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor
            necrosis factor receptor 1-induced apoptosis and contains death
            effector domains shared with other gamma-2 herpesviruses
  JOURNAL   J Virol 71 (11), 8928-8932 (1997)
   PUBMED   9343261
REFERENCE   8  (bases 1 to 716)
  AUTHORS   Shu HB, Halpin DR and Goeddel DV.
  TITLE     Casper is a FADD- and caspase-related inducer of apoptosis
  JOURNAL   Immunity 6 (6), 751-763 (1997)
   PUBMED   9208847
REFERENCE   9  (bases 1 to 716)
  AUTHORS   Boldin MP, Goncharov TM, Goltsev YV and Wallach D.
  TITLE     Involvement of MACH, a novel MORT1/FADD-interacting protease, in
            Fas/APO-1- and TNF receptor-induced cell death
  JOURNAL   Cell 85 (6), 803-815 (1996)
   PUBMED   8681376
REFERENCE   10 (bases 1 to 716)
  AUTHORS   Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH and
            Wallach D.
  TITLE     A novel protein that interacts with the death domain of Fas/APO1
            contains a sequence motif related to the death domain
  JOURNAL   J Biol Chem 270 (14), 7795-7798 (1995)
   PUBMED   7536190
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF406779.1.
            
            On Jun 10, 2007 this sequence version replaced NM_152937.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF406779.1, AJ441127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..716
                     /gene="Fadd"
                     /gene_synonym="Mort1"
                     /note="Fas associated via death domain"
                     /db_xref="GeneID:266610"
                     /db_xref="RGD:628700"
     exon            1..324
                     /gene="Fadd"
                     /gene_synonym="Mort1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..665
                     /gene="Fadd"
                     /gene_synonym="Mort1"
                     /note="protein FADD; Fas (TNFRSF6)-associated via death
                     domain"
                     /codon_start=1
                     /product="FAS-associated death domain protein"
                     /protein_id="NP_690920.1"
                     /db_xref="GeneID:266610"
                     /db_xref="RGD:628700"
                     /translation="MDPFLVLLHSLSSSLSGNDLTDLKFLCRERVSKRKLERVQSGLD
                     LFSVLLEQNDLERGHTGLLRELLASLGRHDLLQRLDDFEAGATTAATPGEADLRVAFD
                     IVCDNVGRDWKRLARELKVSEAKIDGIEERYPRSLSDRVRETLRVWKNVEKENASVAG
                     LVKALRACRLNLVADLVEEALMAQGSVSKSDDTSSALRDSTVSFSETP"
     exon            325..716
                     /gene="Fadd"
                     /gene_synonym="Mort1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgggatct ctgaggagta ccccggcgta ccactgccat ggacccattc ctggtgctgc
       61 tgcactcgct gtccagcagc ctgtcgggca acgatctgac ggatctcaag ttcctgtgcc
      121 gcgagcgcgt gagtaaacga aagctggagc gcgtgcagag tggcctggac ctgttctcgg
      181 tgctgctgga gcagaacgat ctggagcgcg ggcacaccgg gctgctgcgc gagttgctgg
      241 cctcgctggg cagacacgac ctactgcagc gcctggacga cttcgaggcg ggggcgacga
      301 ctgctgcaac cccgggggag gcagatctgc gggtggcatt tgacattgtg tgtgacaatg
      361 tggggagaga ctggaaaaga ctggcccgtg agctgaaggt gtctgaggcc aagattgatg
      421 gcattgagga gaggtacccc cgaagcctga gtgatcgggt aagggagact ctgcgagtct
      481 ggaagaatgt cgagaaggag aacgcctcgg tggctggact ggtcaaggca ctgcgggcct
      541 gccggctgaa cctggtggct gacctggtgg aagaagcatt gatggcccag ggatctgtga
      601 gcaagagtga tgatacatcc tcagcgctga gggattcaac tgtgtctttc tcagaaacac
      661 cctgacaagc ccgaggctcc tctcaggagt cactgtggac ttgatcacac catgat
//
