LOCUS       NM_030832                602 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fatty acid binding protein 7 (Fabp7), mRNA.
ACCESSION   NM_030832
VERSION     NM_030832.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 602)
  AUTHORS   Han,X., Li,H., Zhang,Y., Qin,J., Yang,Q., Wang,L., Yuan,M. and
            Xia,C.
  TITLE     Brain lipid-binding protein promotes proliferation and modulates
            cell cycle in C6 rat glioma cells
  JOURNAL   Int J Oncol 51 (5), 1439-1448 (2017)
   PUBMED   29048614
  REMARK    GeneRIF: The results of the xenograft model assay showed that
            exogenous BLBP also stimulated tumor formation and downregulated
            p21 and p16. In conclusion, our study demonstrated that exogenous
            BLBP promoted proliferation of the C6 cells in vitro and
            facilitated tumor formation in vivo. Therefore, BLBP expression in
            glioma cells may promote cell growth by inhibiting the tumor
            suppressors.
REFERENCE   2  (bases 1 to 602)
  AUTHORS   Serinagaoglu,Y., Pare,J., Giovannini,M. and Cao,X.
  TITLE     Nf2-Yap signaling controls the expansion of DRG progenitors and
            glia during DRG development
  JOURNAL   Dev Biol 398 (1), 97-109 (2015)
   PUBMED   25433207
REFERENCE   3  (bases 1 to 602)
  AUTHORS   Young,J.K., Heinbockel,T. and Gondre-Lewis,M.C.
  TITLE     Astrocyte fatty acid binding protein-7 is a marker for neurogenic
            niches in the rat hippocampus
  JOURNAL   Hippocampus 23 (12), 1476-1483 (2013)
   PUBMED   23996503
  REMARK    GeneRIF: The data of this study suggested that regional
            accumulations of FABP7+ astrocytes may represent reservoirs of
            cells having the potential for neurogenesis.
REFERENCE   4  (bases 1 to 602)
  AUTHORS   Watanabe,A., Toyota,T., Owada,Y., Hayashi,T., Iwayama,Y.,
            Matsumata,M., Ishitsuka,Y., Nakaya,A., Maekawa,M., Ohnishi,T.,
            Arai,R., Sakurai,K., Yamada,K., Kondo,H., Hashimoto,K., Osumi,N.
            and Yoshikawa,T.
  TITLE     Fabp7 maps to a quantitative trait locus for a schizophrenia
            endophenotype
  JOURNAL   PLoS Biol 5 (11), e297 (2007)
   PUBMED   18001149
REFERENCE   5  (bases 1 to 602)
  AUTHORS   Arai,Y., Funatsu,N., Numayama-Tsuruta,K., Nomura,T., Nakamura,S.
            and Osumi,N.
  TITLE     Role of Fabp7, a downstream gene of Pax6, in the maintenance of
            neuroepithelial cells during early embryonic development of the rat
            cortex
  JOURNAL   J Neurosci 25 (42), 9752-9761 (2005)
   PUBMED   16237179
  REMARK    GeneRIF: Fabp7 is a downstream gene of Pax6 transcription factor in
            the developing rat cortex and essential for maintenance of
            neuroepithelial cells during early cortical development.
REFERENCE   6  (bases 1 to 602)
  AUTHORS   Eiraku,M., Tohgo,A., Ono,K., Kaneko,M., Fujishima,K., Hirano,T. and
            Kengaku,M.
  TITLE     DNER acts as a neuron-specific Notch ligand during Bergmann glial
            development
  JOURNAL   Nat Neurosci 8 (7), 873-880 (2005)
   PUBMED   15965470
REFERENCE   7  (bases 1 to 602)
  AUTHORS   Liang,Y., Diehn,M., Watson,N., Bollen,A.W., Aldape,K.D.,
            Nicholas,M.K., Lamborn,K.R., Berger,M.S., Botstein,D., Brown,P.O.
            and Israel,M.A.
  TITLE     Gene expression profiling reveals molecularly and clinically
            distinct subtypes of glioblastoma multiforme
  JOURNAL   Proc Natl Acad Sci U S A 102 (16), 5814-5819 (2005)
   PUBMED   15827123
REFERENCE   8  (bases 1 to 602)
  AUTHORS   Williams,S.E., Mann,F., Erskine,L., Sakurai,T., Wei,S., Rossi,D.J.,
            Gale,N.W., Holt,C.E., Mason,C.A. and Henkemeyer,M.
  TITLE     Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic
            chiasm
  JOURNAL   Neuron 39 (6), 919-935 (2003)
   PUBMED   12971893
REFERENCE   9  (bases 1 to 602)
  AUTHORS   Hartfuss,E., Galli,R., Heins,N. and Gotz,M.
  TITLE     Characterization of CNS precursor subtypes and radial glia
  JOURNAL   Dev Biol 229 (1), 15-30 (2001)
   PUBMED   11133151
REFERENCE   10 (bases 1 to 602)
  AUTHORS   Bennett,E., Stenvers,K.L., Lund,P.K. and Popko,B.
  TITLE     Cloning and characterization of a cDNA encoding a novel fatty acid
            binding protein from rat brain
  JOURNAL   J Neurochem 63 (5), 1616-1624 (1994)
   PUBMED   7931318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U02096.1.
            
            On Aug 31, 2012 this sequence version replaced NM_030832.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U02096.1, CB719459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               U02096.1           2-603
FEATURES             Location/Qualifiers
     source          1..602
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..602
                     /gene="Fabp7"
                     /note="fatty acid binding protein 7"
                     /db_xref="GeneID:80841"
                     /db_xref="RGD:69312"
     exon            1..154
                     /gene="Fabp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..480
                     /gene="Fabp7"
                     /note="BLBP; B-FABP; brain lipid-binding protein;
                     brain-type fatty acid-binding protein; fatty acid binding
                     protein 7, brain"
                     /codon_start=1
                     /product="fatty acid-binding protein, brain"
                     /protein_id="NP_110459.1"
                     /db_xref="GeneID:80841"
                     /db_xref="RGD:69312"
                     /translation="MVDAFCATWKLTDSQNFDEYMKALGVGFATRQVGNVTKPTVIIS
                     QEGGKVVIRTQCTFKNTEISFQLGEEFEETSIDDRNCKSVIRLDGDKLIHVQKWDGKE
                     TNCVREIKDGKMVVTLTFGDVVAVRCYEKA"
     exon            155..327
                     /gene="Fabp7"
                     /inference="alignment:Splign:2.1.0"
     exon            328..429
                     /gene="Fabp7"
                     /inference="alignment:Splign:2.1.0"
     exon            430..602
                     /gene="Fabp7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagttttgt gaattacggt agtgggtaag acctgagttc ctccagctcc tacctacttt
       61 cagctgacta gaagggcaag gatggtagat gctttctgtg ccacctggaa gctgacagac
      121 agccagaatt ttgatgagta catgaaggct ctgggcgtgg gctttgccac taggcaagtg
      181 ggaaatgtga ccaaaccaac ggtgattatc agtcaggaag gcggcaaagt ggtgatccgg
      241 acacaatgca cattcaagaa cacagagatc agtttccagc tgggagaaga gtttgaggaa
      301 acaagcatag atgacaggaa ctgtaagtct gtgattcggt tggatggaga caagctcatt
      361 catgtgcaga agtgggatgg caaagaaaca aattgtgtca gagaaattaa ggatggcaaa
      421 atggttgtga ctctcacctt tggggatgtc gttgctgttc gctgttatga aaaggcatag
      481 aagaaatgcc gggtcttttg aaaacttggt ttcctgaagt tccagagtta tccagctact
      541 gaagcactgg tcactaatta taagtttgtc tttggtgtgg aggcagaaaa ttataattta
      601 ag
//
