LOCUS       NM_145878                661 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus fatty acid binding protein 5 (Fabp5), mRNA.
ACCESSION   NM_145878
VERSION     NM_145878.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 661)
  AUTHORS   Gordon,C., Trainor,J., Shah,R.J., Studholme,K., Gelman,A.,
            Doswell,F., Sadar,F., Giovannetti,A., Gershenson,J., Khan,A.,
            Nicholson,J., Huang,Z., Spurgat,M., Tang,S.J., Wang,H., Ojima,I.,
            Carlson,D., Komatsu,D.E. and Kaczocha,M.
  TITLE     Fatty acid binding protein 5 inhibition attenuates pronociceptive
            cytokine/chemokine expression and suppresses osteoarthritis pain: A
            comparative human and rat study
  JOURNAL   Osteoarthritis Cartilage 32 (3), 266-280 (2024)
   PUBMED   38035977
  REMARK    GeneRIF: Fatty acid binding protein 5 inhibition attenuates
            pronociceptive cytokine/chemokine expression and suppresses
            osteoarthritis pain: A comparative human and rat study.
REFERENCE   2  (bases 1 to 661)
  AUTHORS   Jones,M.J., Uzuneser,T.C., Clement,T., Wang,H., Ojima,I.,
            Rushlow,W.J. and Laviolette,S.R.
  TITLE     Inhibition of fatty acid binding protein-5 in the basolateral
            amygdala induces anxiolytic effects and accelerates fear memory
            extinction
  JOURNAL   Psychopharmacology (Berl) 241 (1), 119-138 (2024)
   PUBMED   37747506
  REMARK    GeneRIF: Inhibition of fatty acid binding protein-5 in the
            basolateral amygdala induces anxiolytic effects and accelerates
            fear memory extinction.
REFERENCE   3  (bases 1 to 661)
  AUTHORS   Uzuneser,T.C., Szkudlarek,H.J., Jones,M.J., Nashed,M.G.,
            Clement,T., Wang,H., Ojima,I., Rushlow,W.J. and Laviolette,S.R.
  TITLE     Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex
  JOURNAL   Cereb Cortex 33 (6), 2470-2484 (2023)
   PUBMED   35650684
  REMARK    GeneRIF: Identification of a novel fatty acid binding protein-5-CB2
            receptor-dependent mechanism regulating anxiety behaviors in the
            prefrontal cortex.
REFERENCE   4  (bases 1 to 661)
  AUTHORS   Melville,D., Gorur,A. and Schekman,R.
  TITLE     Fatty-acid binding protein 5 modulates the SAR1 GTPase cycle and
            enhances budding of large COPII cargoes
  JOURNAL   Mol Biol Cell 30 (3), 387-399 (2019)
   PUBMED   30485159
  REMARK    GeneRIF: FABP5 promotes the budding of particles approximately 150
            nm in diameter and modulates the kinetics of the SAR1 GTPase cycle.
REFERENCE   5  (bases 1 to 661)
  AUTHORS   Haj-Dahmane,S., Shen,R.Y., Elmes,M.W., Studholme,K., Kanjiya,M.P.,
            Bogdan,D., Thanos,P.K., Miyauchi,J.T., Tsirka,S.E., Deutsch,D.G.
            and Kaczocha,M.
  TITLE     Fatty-acid-binding protein 5 controls retrograde endocannabinoid
            signaling at central glutamate synapses
  JOURNAL   Proc Natl Acad Sci U S A 115 (13), 3482-3487 (2018)
   PUBMED   29531087
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4313. doi:
            10.1073/pnas.1805558115.. PMID: 31329664]
REFERENCE   6  (bases 1 to 661)
  AUTHORS   Odani,S., Namba,Y., Ishii,A., Ono,T. and Fujii,H.
  TITLE     Disulfide bonds in rat cutaneous fatty acid-binding protein
  JOURNAL   J Biochem 128 (3), 355-361 (2000)
   PUBMED   10965032
REFERENCE   7  (bases 1 to 661)
  AUTHORS   De Leon,M., Welcher,A.A., Nahin,R.H., Liu,Y., Ruda,M.A.,
            Shooter,E.M. and Molina,C.A.
  TITLE     Fatty acid binding protein is induced in neurons of the dorsal root
            ganglia after peripheral nerve injury
  JOURNAL   J Neurosci Res 44 (3), 283-292 (1996)
   PUBMED   8723767
REFERENCE   8  (bases 1 to 661)
  AUTHORS   Wen,Y., Li,G.W., Chen,P., Wong,E. and Bekhor,I.
  TITLE     Lens epithelial cell mRNA, II. Expression of a mRNA encoding a
            lipid-binding protein in rat lens epithelial cells
  JOURNAL   Gene 158 (2), 269-274 (1995)
   PUBMED   7607553
REFERENCE   9  (bases 1 to 661)
  AUTHORS   Siegenthaler,G., Hotz,R., Chatellard-Gruaz,D., Didierjean,L.,
            Hellman,U. and Saurat,J.H.
  TITLE     Purification and characterization of the human epidermal fatty
            acid-binding protein: localization during epidermal cell
            differentiation in vivo and in vitro
  JOURNAL   Biochem J 302 (Pt 2) (Pt 2), 363-371 (1994)
   PUBMED   8092987
REFERENCE   10 (bases 1 to 661)
  AUTHORS   Watanabe,R., Fujii,H., Odani,S., Sakakibara,J., Yamamoto,A., Ito,M.
            and Ono,T.
  TITLE     Molecular cloning of a cDNA encoding a novel fatty acid-binding
            protein from rat skin
  JOURNAL   Biochem Biophys Res Commun 200 (1), 253-259 (1994)
   PUBMED   8166694
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_145878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U13253.1, CB783254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000002.1  93675996-93676111   c
            117-289             JAXUCZ010000002.1  93673579-93673751   c
            290-391             JAXUCZ010000002.1  93673168-93673269   c
            392-661             JAXUCZ010000002.1  93672451-93672720   c
FEATURES             Location/Qualifiers
     source          1..661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..661
                     /gene="Fabp5"
                     /gene_synonym="C-FABP; DA11; E-FABP"
                     /note="fatty acid binding protein 5"
                     /db_xref="GeneID:140868"
                     /db_xref="RGD:70997"
     exon            1..116
                     /gene="Fabp5"
                     /gene_synonym="C-FABP; DA11; E-FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..445
                     /gene="Fabp5"
                     /gene_synonym="C-FABP; DA11; E-FABP"
                     /note="fatty acid-binding protein, epidermal; cutaneous
                     fatty acid-binding protein; fatty acid binding protein 5,
                     epidermal; epidermal-type fatty acid-binding protein"
                     /codon_start=1
                     /product="fatty acid-binding protein 5"
                     /protein_id="NP_665885.2"
                     /db_xref="GeneID:140868"
                     /db_xref="RGD:70997"
                     /translation="MASLKDLEGKWRLVESHGFEDYMKELGVGLALRKMGAMAKPDCI
                     ITLDGNNLTVKTESTVKTTVFSCTLGEKFDETTADGRKTETVCTFTDGALVQHQKWEG
                     KESTITRKLKDGKMVVECVMNNAICTRVYEKVQ"
     exon            117..289
                     /gene="Fabp5"
                     /gene_synonym="C-FABP; DA11; E-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            290..391
                     /gene="Fabp5"
                     /gene_synonym="C-FABP; DA11; E-FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            392..661
                     /gene="Fabp5"
                     /gene_synonym="C-FABP; DA11; E-FABP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgtctcct tgctgctttt gtgctctccc gctcgccatg gccagcctta aggacctgga
       61 agggaagtgg cgtctggtgg aaagccacgg gtttgaggac tacatgaagg aactaggagt
      121 agggctggct cttaggaaga tgggtgccat ggccaaacca gactgcatca ttaccctcga
      181 cggcaacaac ctcaccgtca aaactgagag cacggtgaag acgaccgtgt tttcttgcac
      241 cttgggagag aagtttgatg aaaccacagc tgatggcagg aaaactgaga cggtctgcac
      301 cttcacagac ggtgccctgg tccagcacca gaagtgggaa gggaaagaaa gcacgataac
      361 gagaaaactg aaggacggga agatggtggt ggagtgcgtc atgaacaatg ccatctgtac
      421 tcgggtctat gagaaggtac aatgaggact ggctaactcg tcatcctgga cagcagtcag
      481 ctggctgagg gaataagctc aattcaatga gcaggtcgta cagaaccaca ctgcttcact
      541 tctttggttt tatttttcat gacttttcat catagacact ttacccgaaa cccatgtcag
      601 accgttggtt tacccaggat cattcctttg gttagtaaat aaatgcgttt gtgctaattc
      661 a
//
