LOCUS       NM_053365                651 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fatty acid binding protein 4 (Fabp4), mRNA.
ACCESSION   NM_053365 XM_346619
VERSION     NM_053365.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 651)
  AUTHORS   Gopalakrishnan,K., Mishra,J.S., Ross,J.R., Abbott,D.H. and Kumar,S.
  TITLE     Hyperandrogenism diminishes maternal-fetal fatty acid transport by
            increasing FABP4-mediated placental lipid accumulationdagger
  JOURNAL   Biol Reprod 107 (2), 514-528 (2022)
   PUBMED   35357467
  REMARK    GeneRIF: Hyperandrogenism diminishes maternal-fetal fatty acid
            transport by increasing FABP4-mediated placental lipid
            accumulationdagger.
REFERENCE   2  (bases 1 to 651)
  AUTHORS   Licero Campbell,J., Serrano-Illan,M., Descorbeth,M., Cordero,K.,
            Figueroa,J.D. and De Leon,M.
  TITLE     Fatty Acid-Binding Protein 4 Inhibition Promotes Locomotor and
            Autonomic Recovery in Rats following Spinal Cord Injury
  JOURNAL   J Neurotrauma 39 (15-16), 1099-1112 (2022)
   PUBMED   35297679
  REMARK    GeneRIF: Fatty Acid-Binding Protein 4 Inhibition Promotes Locomotor
            and Autonomic Recovery in Rats following Spinal Cord Injury.
REFERENCE   3  (bases 1 to 651)
  AUTHORS   Deng,T., Wang,Y., Wang,C. and Yan,H.
  TITLE     FABP4 silencing ameliorates hypoxia reoxygenation injury through
            the attenuation of endoplasmic reticulum stress-mediated apoptosis
            by activating PI3K/Akt pathway
  JOURNAL   Life Sci 224, 149-156 (2019)
   PUBMED   30904493
  REMARK    GeneRIF: High FABP4 expression is associated with myocardial
            ischemia reperfusion injury.
REFERENCE   4  (bases 1 to 651)
  AUTHORS   Stygar,D., Chelmecka,E., Sawczyn,T., Skrzep-Poloczek,B.,
            Poloczek,J. and Karcz,K.W.
  TITLE     Changes of Plasma FABP4, CRP, Leptin, and Chemerin Levels in
            relation to Different Dietary Patterns and Duodenal-Jejunal Omega
            Switch Surgery in Sprague-Dawley Rats
  JOURNAL   Oxid Med Cell Longev 2018, 2151429 (2018)
   PUBMED   29849871
  REMARK    GeneRIF: FABP4: significant differences between DJOS and SHAM were
            observed in animals maintained on CD/CD.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 651)
  AUTHORS   Okamura,Y., Otani,K., Sekiguchi,A., Kogane,T., Kakuda,C.,
            Sakamoto,Y., Kodama,T., Okada,M. and Yamawaki,H.
  TITLE     Vasculo-protective effect of BMS-309403 is independent of its
            specific inhibition of fatty acid-binding protein 4
  JOURNAL   Pflugers Arch 469 (9), 1177-1188 (2017)
   PUBMED   28405802
  REMARK    GeneRIF: SMCs do not express FABP4.
REFERENCE   6  (bases 1 to 651)
  AUTHORS   Gerbens,F., Jansen,A., van Erp,A.J., Harders,F., Meuwissen,T.H.,
            Rettenberger,G., Veerkamp,J.H. and te Pas,M.F.
  TITLE     The adipocyte fatty acid-binding protein locus: characterization
            and association with intramuscular fat content in pigs
  JOURNAL   Mamm Genome 9 (12), 1022-1026 (1998)
   PUBMED   9880671
REFERENCE   7  (bases 1 to 651)
  AUTHORS   Prinsen,C.F. and Veerkamp,J.H.
  TITLE     Transfection of L6 myoblasts with adipocyte fatty acid-binding
            protein cDNA does not affect fatty acid uptake but disturbs lipid
            metabolism and fusion
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 265-273 (1998)
   PUBMED   9425108
REFERENCE   8  (bases 1 to 651)
  AUTHORS   Fraser,H., Coles,S.M., Woodford,J.K., Frolov,A.A., Murphy,E.J.,
            Schroeder,F., Bernlohr,D.A. and Grund,V.
  TITLE     Fatty acid uptake in diabetic rat adipocytes
  JOURNAL   Mol Cell Biochem 167 (1-2), 51-60 (1997)
   PUBMED   9059981
REFERENCE   9  (bases 1 to 651)
  AUTHORS   Hotamisligil,G.S., Johnson,R.S., Distel,R.J., Ellis,R.,
            Papaioannou,V.E. and Spiegelman,B.M.
  TITLE     Uncoupling of obesity from insulin resistance through a targeted
            mutation in aP2, the adipocyte fatty acid binding protein
  JOURNAL   Science 274 (5291), 1377-1379 (1996)
   PUBMED   8910278
REFERENCE   10 (bases 1 to 651)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 14, 2022 this sequence version replaced NM_053365.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC084721.1, CO404896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000002.1  93488273-93488408
            137-309             JAXUCZ010000002.1  93490764-93490936
            310-411             JAXUCZ010000002.1  93491528-93491629
            412-651             JAXUCZ010000002.1  93492722-93492961
FEATURES             Location/Qualifiers
     source          1..651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..651
                     /gene="Fabp4"
                     /gene_synonym="Albp; aP2"
                     /note="fatty acid binding protein 4"
                     /db_xref="GeneID:79451"
                     /db_xref="RGD:69309"
     exon            1..136
                     /gene="Fabp4"
                     /gene_synonym="Albp; aP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..462
                     /gene="Fabp4"
                     /gene_synonym="Albp; aP2"
                     /note="AFABP; A-FABP; fatty acid binding protein 4,
                     adipocyte; adipocyte-type fatty acid-binding protein;
                     adipocyte lipid-binding protein"
                     /codon_start=1
                     /product="fatty acid-binding protein, adipocyte"
                     /protein_id="NP_445817.2"
                     /db_xref="GeneID:79451"
                     /db_xref="RGD:69309"
                     /translation="MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNLIIS
                     VEGDLVVIRSESTFKNTEISFKLGVEFDEITPDDRKVKSIITLDGGVLVHVQKWDGKS
                     TTIKRRRDGDKLVVECVMKGVTSTRVYERA"
     exon            137..309
                     /gene="Fabp4"
                     /gene_synonym="Albp; aP2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..411
                     /gene="Fabp4"
                     /gene_synonym="Albp; aP2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..651
                     /gene="Fabp4"
                     /gene_synonym="Albp; aP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atagcacctt ccccatcctg cagcctttct cacctggaag agaactcctt gaaggcttac
       61 aaaatgtgcg acgcctttgt ggggacctgg aaactcgtct ccagtgagaa cttcgatgat
      121 tacatgaaag aagtgggagt tggcttcgcc accaggaaag tggccggtat ggccaagccc
      181 aacttgatca tcagcgtaga aggggacttg gtcgtcatcc ggtcagagag tacttttaaa
      241 aacaccgaga tttccttcaa actgggcgtg gaattcgatg aaatcacccc agatgacagg
      301 aaagtgaaga gcatcataac cctggatggt ggggtcctgg tacatgtgca gaagtgggat
      361 ggaaagtcga ccaccataaa gaggagacga gatggtgaca agctggtggt ggaatgtgtc
      421 atgaaaggcg tgacttctac aagagtttac gaaagggcat gagccaaggg acgaggccct
      481 ggactgaaat ttgcatcaaa ctctacaata gttgatggga tttgttggtt ttgttttttt
      541 ttttttaaga tacgattttc cactaattag caagcaatta cttttttctg aagctgggat
      601 tttattggat atggttatgc tggttaaata aaaccttttt agacttagaa a
//
