LOCUS       NM_013068                564 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus fatty acid binding protein 2 (Fabp2), mRNA.
ACCESSION   NM_013068
VERSION     NM_013068.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 564)
  AUTHORS   Zenger,S., Demir Piroglu,I., Cevik,A., Ozcabi,Y., Fakioglu,D.,
            Senol,M., Altintas,M.M., Bildik,N. and Yucel,T.
  TITLE     The importance of serum intestinal fatty acid-binding protein for
            the early diagnosis of acute mesenteric ischemia
  JOURNAL   Ulus Travma Acil Cerrahi Derg 27 (3), 278-283 (2021)
   PUBMED   33884597
  REMARK    GeneRIF: The importance of serum intestinal fatty acid-binding
            protein for the early diagnosis of acute mesenteric ischemia.',
            trans 'Akut mezenter iskeminin erken tanisinda serum intestinal yag
            asidi baglayici proteininin onemi.
REFERENCE   2  (bases 1 to 564)
  AUTHORS   Sahin,A., Altay,D.A., Demir,S., Yulug,E., Mentese,A., Tatli,O.,
            Karaca,Y., Ardic,S., Gunduz,A. and Turedi,S.
  TITLE     Comparison of the diagnostic values of vascular adhesion protein-1
            and intestinal fatty acid-binding protein in the diagnosis of acute
            mesenteric ischemia
  JOURNAL   Eur J Trauma Emerg Surg 45 (3), 545-553 (2019)
   PUBMED   29600311
  REMARK    GeneRIF: In acute mesenteric ischemia, Fabp2 levels are
            significantly increased and correlated with ischemic changes.
REFERENCE   3  (bases 1 to 564)
  AUTHORS   Popescu,G.A., Jung,I., Cordos,B.A., Azamfirei,L., Hutanu,A. and
            Gurzu,S.
  TITLE     Intestinal fatty acid-binding protein, as a marker of anastomotic
            leakage after colonic resection in rats
  JOURNAL   Rom J Morphol Embryol 59 (4), 1075-1081 (2018)
   PUBMED   30845287
  REMARK    GeneRIF: The aim of this experimental study was to determine if the
            type of termino-terminal anastomosis of the colon affect the
            process of healing of the intestinal mucosa and if the severity of
            the anastomotic leakage (AL) can be predicted based on the
            circulating level of intestinal fatty acid-binding protein.
REFERENCE   4  (bases 1 to 564)
  AUTHORS   Zhang,H., Li,Y., Hu,J., Shen,W.J., Singh,M., Hou,X., Bittner,A.,
            Bittner,S., Cortez,Y., Tabassum,J., Kraemer,F.B. and Azhar,S.
  TITLE     Effect of Creosote Bush-Derived NDGA on Expression of Genes
            Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats:
            Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic
            Steatosis
  JOURNAL   PLoS One 10 (9), e0138203 (2015)
   PUBMED   26394137
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 564)
  AUTHORS   Kaieda,S. and Halle,B.
  TITLE     Time Scales of Conformational Gating in a Lipid-Binding Protein
  JOURNAL   J Phys Chem B 119 (25), 7957-7967 (2015)
   PUBMED   26012957
  REMARK    GeneRIF: Study characterized internal-water exchange and associated
            conformational dynamics in rIFABP by recording the water 2H and 17O
            MRD profiles for the apo and palmitate-bound forms
REFERENCE   6  (bases 1 to 564)
  AUTHORS   Scapin,G., Gordon,J.I. and Sacchettini,J.C.
  TITLE     Refinement of the structure of recombinant rat intestinal fatty
            acid-binding apoprotein at 1.2-A resolution
  JOURNAL   J Biol Chem 267 (6), 4253-4269 (1992)
   PUBMED   1740465
REFERENCE   7  (bases 1 to 564)
  AUTHORS   Green,R.P., Cohn,S.M., Sacchettini,J.C., Jackson,K.E. and
            Gordon,J.I.
  TITLE     The mouse intestinal fatty acid binding protein gene: nucleotide
            sequence, pattern of developmental and regional expression, and
            proposed structure of its protein product
  JOURNAL   DNA Cell Biol 11 (1), 31-41 (1992)
   PUBMED   1739433
REFERENCE   8  (bases 1 to 564)
  AUTHORS   Sacchettini,J.C., Gordon,J.I. and Banaszak,L.J.
  TITLE     Refined apoprotein structure of rat intestinal fatty acid binding
            protein produced in Escherichia coli
  JOURNAL   Proc Natl Acad Sci U S A 86 (20), 7736-7740 (1989)
   PUBMED   2682622
REFERENCE   9  (bases 1 to 564)
  AUTHORS   Sacchettini,J.C., Gordon,J.I. and Banaszak,L.J.
  TITLE     Crystal structure of rat intestinal fatty-acid-binding protein.
            Refinement and analysis of the Escherichia coli-derived protein
            with bound palmitate
  JOURNAL   J Mol Biol 208 (2), 327-339 (1989)
   PUBMED   2671390
REFERENCE   10 (bases 1 to 564)
  AUTHORS   Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
            Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M35992.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: K01180.1, M35992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..564
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="fatty acid binding protein 2"
                     /db_xref="GeneID:25598"
                     /db_xref="RGD:2591"
     exon            1..79
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..411
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /note="FABPI; I-FABP; intestinal-type fatty acid-binding
                     protein; intestinal fatty acid binding protein; fatty acid
                     binding protein 1; fatty acid binding protein 2,
                     intestinal"
                     /codon_start=1
                     /product="fatty acid-binding protein, intestinal"
                     /protein_id="NP_037200.1"
                     /db_xref="GeneID:25598"
                     /db_xref="RGD:2591"
                     /translation="MAFDGTWKVDRNENYEKFMEKMGINVVKRKLGAHDNLKLTITQE
                     GNKFTVKESSNFRNIDVVFELGVDFAYSLADGTELTGTWTMEGNKLVGKFKRVDNGKE
                     LIAVREISGNELIQTYTYEGVEAKRIFKKE"
     exon            80..252
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            253..360
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
     exon            361..564
                     /gene="Fabp2"
                     /gene_synonym="FABP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctgaca tcatggcatt tgatggcact tggaaagtag accggaatga gaactatgaa
       61 aagttcatgg agaaaatggg cattaacgtg gtgaagagga agcttggagc tcatgacaac
      121 ttgaaactga cgatcacaca ggaaggaaat aaattcacag tcaaagaatc aagcaacttc
      181 cgaaacattg atgttgtgtt tgaactcggc gtcgactttg cctatagtct agcagatgga
      241 acagaactca ctgggacctg gaccatggag ggaaataaac ttgttggaaa attcaaacgt
      301 gtagacaatg gaaaggagct gattgctgtc cgagagattt ctggtaacga actaatccaa
      361 acctacacat atgaaggagt ggaggccaag cggatcttta agaaggaata ggccagcttc
      421 ttggagcctg gcgcaatgca gaagggctag cttggtgtcg gattcctttc tccatctcgc
      481 tgataatgca ggctcactca ctgtgtcatg agcactgctt ccaagccttg tcagagccaa
      541 agaagtaaaa gttgattagg actt
//
