LOCUS       NM_012556                518 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fatty acid binding protein 1 (Fabp1), mRNA.
ACCESSION   NM_012556
VERSION     NM_012556.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 518)
  AUTHORS   Ohata,K., Sugaya,T., Nguyen,H.N., Hatanaka,Y., Uno,K., Tohma,M.,
            Oikawa,T., Nagabukuro,H., Kuniyeda,K., Kamijo-Ikemori,A.,
            Suzuki-Kemuriyama,N., Nakae,D., Noiri,E. and Miyajima,K.
  TITLE     Urinary liver-type fatty acid binding protein is increased in the
            early stages of the disease with a risk of acute kidney injury
            induced by histone
  JOURNAL   Nephrology (Carlton) 28 (6), 345-355 (2023)
   PUBMED   37076661
  REMARK    GeneRIF: Urinary liver-type fatty acid binding protein is increased
            in the early stages of the disease with a risk of acute kidney
            injury induced by histone.
REFERENCE   2  (bases 1 to 518)
  AUTHORS   Tanabe,J., Ogura,Y., Kosaki,K., Nagai,Y., Sugaya,T., Ohata,K.,
            Watanabe,S., Ichikawa,D., Inoue,K., Hoshino,S., Kimura,K.,
            Maeda,S., Shibagaki,Y. and Kamijo-Ikemori,A.
  TITLE     Relationship between Urinary Liver-Type Fatty Acid-Binding Protein
            (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats
  JOURNAL   J Diabetes Res 2020, 7614035 (2020)
   PUBMED   32405506
  REMARK    GeneRIF: Relationship between Urinary Liver-Type Fatty Acid-Binding
            Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii
            Fatty Rats.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 518)
  AUTHORS   Schroeder,F., McIntosh,A.L., Martin,G.G., Huang,H., Landrock,D.,
            Chung,S., Landrock,K.K., Dangott,L.J., Li,S., Kaczocha,M.,
            Murphy,E.J., Atshaves,B.P. and Kier,A.B.
  TITLE     Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A
            Variant: Roles in the Endocannabinoid System and Dyslipidemias
  JOURNAL   Lipids 51 (6), 655-676 (2016)
   PUBMED   27117865
  REMARK    GeneRIF: Studies show that despite overall tertiary structure
            similarity, the hFABP1 differs significantly from rat FABP1 in
            secondary structure, much larger ligand binding cavity, and
            affinities/specificities for some ligands. Moreover, while both
            mouse and hFABP1 mediate ligand induction of PPARA, they differ
            markedly in genes induced.
            Review article
REFERENCE   4  (bases 1 to 518)
  AUTHORS   McIntosh,A.L., Petrescu,A.D., Hostetler,H.A., Kier,A.B. and
            Schroeder,F.
  TITLE     Liver-type fatty acid binding protein interacts with hepatocyte
            nuclear factor 4alpha
  JOURNAL   FEBS Lett 587 (23), 3787-3791 (2013)
   PUBMED   24140341
  REMARK    GeneRIF: L-FABP structurally and functionally interacts with
            HNF4alpha.
REFERENCE   5  (bases 1 to 518)
  AUTHORS   Lagakos,W.S., Guan,X., Ho,S.Y., Sawicki,L.R., Corsico,B.,
            Kodukula,S., Murota,K., Stark,R.E. and Storch,J.
  TITLE     Liver fatty acid-binding protein binds monoacylglycerol in vitro
            and in mouse liver cytosol
  JOURNAL   J Biol Chem 288 (27), 19805-19815 (2013)
   PUBMED   23658011
  REMARK    GeneRIF: These results provide strong support for monoacylglycerol
            as a physiological ligand for LFABP and further suggest that LFABP
            functions in the efficient intracellular transport of MG
REFERENCE   6  (bases 1 to 518)
  AUTHORS   Myszka,D.G. and Swenson,R.P.
  TITLE     Identification by photoaffinity labeling of fatty acid-binding
            protein as a potential warfarin receptor in rat liver
  JOURNAL   J Biol Chem 266 (31), 20725-20731 (1991)
   PUBMED   1939124
REFERENCE   7  (bases 1 to 518)
  AUTHORS   Worrall,A.F., Evans,C. and Wilton,D.C.
  TITLE     Synthesis of a gene for rat liver fatty-acid-binding protein and
            its expression in Escherichia coli
  JOURNAL   Biochem J 278 (Pt 2) (Pt 2), 365-368 (1991)
   PUBMED   1898328
REFERENCE   8  (bases 1 to 518)
  AUTHORS   Bassuk,J.A., Tsichlis,P.N. and Sorof,S.
  TITLE     Liver fatty acid binding protein is the mitosis-associated
            polypeptide target of a carcinogen in rat hepatocytes
  JOURNAL   Proc Natl Acad Sci U S A 84 (21), 7547-7551 (1987)
   PUBMED   3478711
REFERENCE   9  (bases 1 to 518)
  AUTHORS   Sweetser,D.A., Lowe,J.B. and Gordon,J.I.
  TITLE     The nucleotide sequence of the rat liver fatty acid-binding protein
            gene. Evidence that exon 1 encodes an oligopeptide domain shared by
            a family of proteins which bind hydrophobic ligands
  JOURNAL   J Biol Chem 261 (12), 5553-5561 (1986)
   PUBMED   3007511
REFERENCE   10 (bases 1 to 518)
  AUTHORS   McGuire,D.M., Chan,L., Smith,L.C., Towle,H.C. and Dempsey,M.E.
  TITLE     Translational control of the circadian rhythm of liver sterol
            carrier protein. Analysis of mRNA sequences with a specific cDNA
            probe
  JOURNAL   J Biol Chem 260 (9), 5435-5439 (1985)
   PUBMED   3838749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC086947.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012556.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086947.1, FQ209859.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..518
                     /gene="Fabp1"
                     /gene_synonym="Fabplg; L-FABP; p14; SCP; SCP."
                     /note="fatty acid binding protein 1"
                     /db_xref="GeneID:24360"
                     /db_xref="RGD:2590"
     exon            1..105
                     /gene="Fabp1"
                     /gene_synonym="Fabplg; L-FABP; p14; SCP; SCP."
                     /inference="alignment:Splign:2.1.0"
     CDS             39..422
                     /gene="Fabp1"
                     /gene_synonym="Fabplg; L-FABP; p14; SCP; SCP."
                     /note="Z-protein; squalene- and sterol-carrier protein;
                     liver-type fatty acid-binding protein; fatty acid binding
                     protein 1, liver"
                     /codon_start=1
                     /product="fatty acid-binding protein, liver"
                     /protein_id="NP_036688.1"
                     /db_xref="GeneID:24360"
                     /db_xref="RGD:2590"
                     /translation="MNFSGKYQVQSQENFEPFMKAMGLPEDLIQKGKDIKGVSEIVHE
                     GKKVKLTITYGSKVIHNEFTLGEECELETMTGEKVKAVVKMEGDNKMVTTFKGIKSVT
                     EFNGDTITNTMTLGDIVYKRVSKRI"
     exon            106..278
                     /gene="Fabp1"
                     /gene_synonym="Fabplg; L-FABP; p14; SCP; SCP."
                     /inference="alignment:Splign:2.1.0"
     exon            279..371
                     /gene="Fabp1"
                     /gene_synonym="Fabplg; L-FABP; p14; SCP; SCP."
                     /inference="alignment:Splign:2.1.0"
     exon            372..489
                     /gene="Fabp1"
                     /gene_synonym="Fabplg; L-FABP; p14; SCP; SCP."
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgtggtca gctgtggaaa ggaaacctca ttgccaccat gaacttctcc ggcaagtacc
       61 aagtgcagag ccaagagaac tttgagccct tcatgaaggc gatgggtctg cctgaggacc
      121 tcatccagaa agggaaggac atcaaggggg tgtcagaaat cgtgcatgaa gggaagaaag
      181 tcaaactcac catcacctat gggtccaagg tgatccacaa tgagttcacc ttgggggagg
      241 agtgcgaact ggagaccatg actggggaaa aggtcaaggc agtggttaag atggagggtg
      301 acaataaaat ggtgacaact ttcaaaggca taaagtccgt gactgaattc aatggagaca
      361 caatcaccaa taccatgaca ctgggtgaca tcgtctacaa gagagtcagc aagagaattt
      421 agacaaggct gtatttcata ttcttttaca gtataaaatt aatacaataa agttacctct
      481 gttttgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
