LOCUS       NM_001369126            3526 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus fatty acid amide hydrolase (Faah), mRNA.
ACCESSION   NM_001369126 NM_024132 XM_003750001 XM_008776044
VERSION     NM_001369126.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3526)
  AUTHORS   Girella,A., Di Bartolomeo,M., Dainese,E., Buzzelli,V., Trezza,V.
            and D'Addario,C.
  TITLE     Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes
            Regulation is Modulated by Social Isolation in Rats
  JOURNAL   Neurochem Res 49 (5), 1278-1290 (2024)
   PUBMED   38368587
  REMARK    GeneRIF: Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1
            Genes Regulation is Modulated by Social Isolation in Rats.
REFERENCE   2  (bases 1 to 3526)
  AUTHORS   Woyach,V., Sherman,K., Hillard,C.J., Hopp,F.A., Hogan,Q.H. and
            Dean,C.
  TITLE     Fatty acid amide hydrolase activity in the dorsal periaqueductal
            gray attenuates neuropathic pain and associated dysautonomia
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 323 (5), R749-R762 (2022)
   PUBMED   36154489
  REMARK    GeneRIF: Fatty acid amide hydrolase activity in the dorsal
            periaqueductal gray attenuates neuropathic pain and associated
            dysautonomia.
REFERENCE   3  (bases 1 to 3526)
  AUTHORS   Alteba,S., Portugalov,A., Hillard,C.J. and Akirav,I.
  TITLE     Inhibition of Fatty Acid Amide Hydrolase (FAAH) During Adolescence
            and Exposure to Early Life Stress may Exacerbate Depression-like
            Behaviors in Male and Female Rats
  JOURNAL   Neuroscience 455, 89-106 (2021)
   PUBMED   33359656
  REMARK    GeneRIF: Inhibition of Fatty Acid Amide Hydrolase (FAAH) During
            Adolescence and Exposure to Early Life Stress may Exacerbate
            Depression-like Behaviors in Male and Female Rats.
REFERENCE   4  (bases 1 to 3526)
  AUTHORS   Ghorbani,M., Shahabi,P., Karimi,P., Soltani-Zangbar,H.,
            Morshedi,M., Bani,S., Jafarzadehgharehziaaddin,M.,
            Sadeghzadeh-Oskouei,B. and Ahmadalipour,A.
  TITLE     Impacts of epidural electrical stimulation on Wnt signaling, FAAH,
            and BDNF following thoracic spinal cord injury in rat
  JOURNAL   J Cell Physiol 235 (12), 9795-9805 (2020)
   PUBMED   32488870
  REMARK    GeneRIF: Impacts of epidural electrical stimulation on Wnt
            signaling, FAAH, and BDNF following thoracic spinal cord injury in
            rat.
REFERENCE   5  (bases 1 to 3526)
  AUTHORS   Amini,M., Saboory,E., Derafshpour,L., Fakhari,A., Wu,J.C.,
            Bruggeman,R., Asgharzadeh,F. and Ahmadalipour,A.
  TITLE     The impact of sleep deprivation on sexual behaviors and FAAH
            expression in the prefrontal cortex of male rats
  JOURNAL   Neurosci Lett 735, 135254 (2020)
   PUBMED   32682844
  REMARK    GeneRIF: The impact of sleep deprivation on sexual behaviors and
            FAAH expression in the prefrontal cortex of male rats.
REFERENCE   6  (bases 1 to 3526)
  AUTHORS   Bracey,M.H., Hanson,M.A., Masuda,K.R., Stevens,R.C. and
            Cravatt,B.F.
  TITLE     Structural adaptations in a membrane enzyme that terminates
            endocannabinoid signaling
  JOURNAL   Science 298 (5599), 1793-1796 (2002)
   PUBMED   12459591
  REMARK    GeneRIF: 2.8 angstrom crystal structure; structure of FAAH
            complexed with an arachidonyl inhibitor reveals how a set of
            structural alterations allows this enzyme to integrate into cell
            membranes and establish direct access to the bilayer from its
            active site
REFERENCE   7  (bases 1 to 3526)
  AUTHORS   Sipe,J.C., Chiang,K., Gerber,A.L., Beutler,E. and Cravatt,B.F.
  TITLE     A missense mutation in human fatty acid amide hydrolase associated
            with problem drug use
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8394-8399 (2002)
   PUBMED   12060782
REFERENCE   8  (bases 1 to 3526)
  AUTHORS   Thomas,E.A., Cravatt,B.F., Danielson,P.E., Gilula,N.B. and
            Sutcliffe,J.G.
  TITLE     Fatty acid amide hydrolase, the degradative enzyme for anandamide
            and oleamide, has selective distribution in neurons within the rat
            central nervous system
  JOURNAL   J Neurosci Res 50 (6), 1047-1052 (1997)
   PUBMED   9452020
REFERENCE   9  (bases 1 to 3526)
  AUTHORS   Giang,D.K. and Cravatt,B.F.
  TITLE     Molecular characterization of human and mouse fatty acid amide
            hydrolases
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2238-2242 (1997)
   PUBMED   9122178
REFERENCE   10 (bases 1 to 3526)
  AUTHORS   Cravatt,B.F., Giang,D.K., Mayfield,S.P., Boger,D.L., Lerner,R.A.
            and Gilula,N.B.
  TITLE     Molecular characterization of an enzyme that degrades
            neuromodulatory fatty-acid amides
  JOURNAL   Nature 384 (6604), 83-87 (1996)
   PUBMED   8900284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Jul 6, 2022 this sequence version replaced
            NM_024132.3, XM_003750001.4, XM_008776044.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091148.1, U72497.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               JAXUCZ010000005.1  134735141-134735396 c
            257-370             JAXUCZ010000005.1  134727665-134727778 c
            371-505             JAXUCZ010000005.1  134725189-134725323 c
            506-639             JAXUCZ010000005.1  134724860-134724993 c
            640-846             JAXUCZ010000005.1  134724558-134724764 c
            847-887             JAXUCZ010000005.1  134724273-134724313 c
            888-1012            JAXUCZ010000005.1  134723924-134724048 c
            1013-1138           JAXUCZ010000005.1  134722639-134722764 c
            1139-1236           JAXUCZ010000005.1  134722095-134722192 c
            1237-1336           JAXUCZ010000005.1  134720850-134720949 c
            1337-1377           JAXUCZ010000005.1  134720546-134720586 c
            1378-1417           JAXUCZ010000005.1  134719814-134719853 c
            1418-1526           JAXUCZ010000005.1  134719266-134719374 c
            1527-1672           JAXUCZ010000005.1  134718595-134718740 c
            1673-3526           JAXUCZ010000005.1  134716545-134718398 c
FEATURES             Location/Qualifiers
     source          1..3526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..3526
                     /gene="Faah"
                     /note="fatty acid amide hydrolase"
                     /db_xref="GeneID:100911581"
                     /db_xref="RGD:61808"
     exon            1..256
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1801
                     /gene="Faah"
                     /EC_number="3.5.1.99"
                     /note="oleamide hydrolase 1; anandamide amidohydrolase 1;
                     anandamide amidase; fatty acid ester hydrolase"
                     /codon_start=1
                     /product="fatty-acid amide hydrolase 1"
                     /protein_id="NP_001356055.1"
                     /db_xref="GeneID:100911581"
                     /db_xref="RGD:61808"
                     /translation="MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRA
                     RQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLG
                     KAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNE
                     GMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSS
                     GGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAV
                     QLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDN
                     YTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNF
                     KGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHE
                     IEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVP
                     VTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMR
                     EVEQLMTPQKQPS"
     exon            257..370
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            371..505
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            506..639
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            640..846
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            847..887
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1012
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1138
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1236
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1336
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1377
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1417
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1526
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1672
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..3526
                     /gene="Faah"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcggagctg ttggtttgtg cgagccgagt tctctcgggt ggcggtcggc tgcaggagat
       61 catggtgctg agcgaagtgt ggaccacgct gtctggggtc tccggggttt gcctagcctg
      121 cagcttgttg tcggcggcgg tggtcctgcg atggaccggg cgccagaagg cccggggcgc
      181 ggcgaccagg gcgcggcaga agcagcgagc cagcctggag accatggaca aggcggtgca
      241 gcgcttccgg ctgcagaatc ctgacctgga ctcggaggcc ttgctgaccc tgcccctact
      301 ccaactggta cagaagttac agagtggaga gctgtcccca gaggctgtgt tctttactta
      361 cctgggaaag gcctgggaag tgaacaaagg gaccaactgc gtgacctcct atctgaccga
      421 ctgtgagact cagctgtccc aggccccacg gcagggcctg ctctatggtg tccctgtgag
      481 cctcaaggaa tgcttcagct acaagggcca cgactccaca ctgggcttga gcctgaatga
      541 gggcatgcca tcggaatctg actgtgtggt ggtgcaagtg ttgaagctgc agggagctgt
      601 gccctttgtg cataccaatg tcccccagtc catgttaagc tttgactgca gtaaccctct
      661 ctttggccag accatgaacc catggaagtc ctccaagagc ccaggaggtt cctcaggggg
      721 tgagggggct ctcattggat ctggaggttc ccctctgggt ttaggcactg acattggcgg
      781 cagcatccgg ttcccttctg ccttctgcgg catctgtggc ctcaagccta ctggcaaccg
      841 cctcagcaag agtggcctga agggctgtgt ctatggacag acggcagtgc agctttctct
      901 tggccccatg gcccgggatg tggagagcct ggcgctatgc ctgaaagctc tactgtgtga
      961 gcacttgttc accttggacc ctaccgtgcc tcccttgccc ttcagagagg aggtctatag
     1021 aagttctaga cccctgcgtg tggggtacta tgagactgac aactatacca tgcccagccc
     1081 agctatgagg agggctctga tagagaccaa gcagagactt gaggctgctg gccacacgct
     1141 gattcccttc ttacccaaca acatacccta cgccctggag gtcctgtctg cgggcggcct
     1201 gttcagtgac ggtggccgca gttttctcca aaacttcaaa ggtgactttg tggatccctg
     1261 cttgggagac ctgatcttaa ttctgaggct gcccagctgg tttaaaagac tgctgagcct
     1321 cctgctgaag cctctgtttc ctcggctggc agcctttctc aacagtatgc gtcctcggtc
     1381 agctgaaaag ctgtggaaac tgcagcatga gattgagatg tatcgccagt ctgtgattgc
     1441 ccagtggaaa gcgatgaact tggatgtgct gctgaccccc atgttgggcc ctgctctgga
     1501 tttgaacaca ccgggcagag ccacaggggc tatcagctac accgttctct acaactgcct
     1561 ggacttccct gcgggggtgg tgcctgtcac cactgtgacc gccgaggacg atgcccagat
     1621 ggaactctac aaaggctact ttggggatat ctgggacatc atcctgaaga aggccatgaa
     1681 aaatagtgtc ggtctgcctg tggctgtgca gtgcgtggct ctgccctggc aggaagagct
     1741 gtgtctgagg ttcatgcggg aggtggaaca gctgatgacc cctcaaaagc agccatcgtg
     1801 agggtcgttc atccgccagc tctggaggac ctaaggccca tgcgctgtgc actgtagccc
     1861 catgtattca ggagccacca cccacgaggg aacgcccagc acagggaaga ggtgtctacc
     1921 tgccctcccc tggactcctg cagccacaac caagtctgga ccttcctccc cgttatggtc
     1981 tactttccat cctgattccc tgctttttat ggcagccagc aggaatgacg tgggccaagg
     2041 atcaccaaca ttcaaaaaca atgcgtttat ctattttctg ggtatctcca ttagggccct
     2101 gggaaccaga gtgctgggaa ggctgtccag accctccaga gctggctgta accacatcac
     2161 tctcctgctc caaagcctcc ctagtgctgt cacccacaag atagacacag ggacatgtcc
     2221 ttggcacttg actcctgtcc ttcctttctt attcagattg accccagcct tgatggaccc
     2281 tgcccctgca cttccttcct cagtccacct ctctgccgac acgccctttt tatggctcct
     2341 ctatttgttg tggagacaag gtttctctca gtagccctgg ctgtccagga cctcactctg
     2401 tagatgaggc tggctttcaa ctcacaaggc tgcctgcctg ggtgctggga ttaaaggcgt
     2461 atgccaccac agcctggtct gttgggttat cttttagggt catctctgtg acccgtcttc
     2521 tacttatata tccacaaatc agaacactgg accagggaag aagttgtcac gctggatacc
     2581 tgccagggaa cacgtctaga gacagcagtg tcatccattt gagcttccca gccaaatatg
     2641 tctccagtct atacttgtta gcttgccagt attggcctgt cttccgaagt ctcctacatg
     2701 cggtaaccta ggatacctta agtgagtgat accacttgta gtctgggctc tatcattgta
     2761 tgcctagcac ccagcatggt cccgggcact tagtgggcag ccagggaagg cttggaggga
     2821 tggcagcttt atcctagcaa atccattttg tcacgtcctg attacttcct gtgtcaccca
     2881 taatagggaa tttcccaggt tgtctctgac ctgcttccct tatctaacct actttcttca
     2941 ctttgattca tggccacagg gacaaatatc tcctcgtctg tgatcaacct agaactttct
     3001 tttggtctag aaagctgcat gcatcaactt ccaccaaccc tgagctcctc caccctttct
     3061 tcgtccagcc cataagcgca ttaagttcct cccacactat gctcagggta accagacaga
     3121 aacagtccct gcttgaatgg ttttttattc taccagcaac tgtgtaatta catcttgtgt
     3181 cccaagtgct ataaagcaga agtccctggg tatgttgtca tcaagcatgt gtgtcaggga
     3241 gtgcttcctg tgcgaagtga cgcgtaagct ggaaagtgca tggtcagtgg gagctaagga
     3301 gtgagtattt caagaagggc ggcgttgatg taagtgctgc tgatgtaatg ggataaggac
     3361 aggtgaaggg agggagaact ccgcctgcca tcattgaatt gagggcccac tgtttgccag
     3421 acacttttca aaaggctgcc gaggtccgtc cttgctttta ggggactcat tttctagaca
     3481 ggggccatgc aaattcgacc ataaataaaa taatttctgc tgataa
//
